Information on EC 2.7.1.174 - diacylglycerol kinase (CTP)

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IUBMB Comments
Requires Ca2+ or Mg2+ for activity. Involved in synthesis of membrane phospholipids and the neutral lipid triacylglycerol. Unlike the diacylglycerol kinases from bacteria, plants, and animals [cf. EC 2.7.1.107, diacylglycerol kinase (ATP)], the enzyme from Saccharomyces cerevisiae utilizes CTP. The enzyme can also use dCTP, but not ATP, GTP or UTP.
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The enzyme appears in viruses and cellular organisms
Synonyms
CTP-dependent DAG kinase, CTP-dependent diacylglycerol kinase, DAG kinase, DGK1, Dgk1p, diacylglycerol kinase (CTP dependent), More, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
CTP + 1,2-diacyl-sn-glycerol = CDP + 1,2-diacyl-sn-glycerol 3-phosphate
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