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ATP + 2-(acetylamino)-2-deoxy-D-allopyranose
ADP + 2-(acetylamino)-2-deoxy-D-allopyranose 1-phosphate
22% phosphorylation yield
-
-
?
ATP + 2-deoxy-2-azido-D-mannose
ADP + 2-deoxy-2-azido-alpha-D-mannose 1-phosphate
ATP + 2-deoxy-2-fluoro-D-mannose
ADP + 2-deoxy-2-fluoro-alpha-D-mannose 1-phosphate
ATP + 2-deoxy-D-glucose
ADP + 2-deoxy-alpha-D-glucose 1-phosphate
ATP + 4- deoxy-N-acetyl-D-glucosamine
ADP + 4-deoxy-N-acetyl-alpha-D-glucosamine 1-phosphate
-
50% phosphorylation yield
-
-
?
ATP + 4-deoxy-4-azido-N-acetyl-D-galactosamine
ADP + 4-deoxy-4-azido-N-acetyl-alpha-D-galactosamine 1-phosphate
-
73% phosphorylation yield
-
-
?
ATP + 4-deoxy-D-mannose
ADP + 4-deoxy-alpha-D-mannose 1-phosphate
ATP + 6-deoxy-6-azido-N-acetyl-D-galactosamine
ADP + 6-deoxy-6-azido-N-acetyl-alpha-D-galactosamine 1-phosphate
-
42% phosphorylation yield
-
-
?
ATP + 6-deoxy-6-azido-N-acetyl-D-glucosamine
ADP + 6-deoxy-6-azido-N-acetyl-alpha-D-glucosamine 1-phosphate
ATP + 6-deoxy-6-methyl-N-acetyl-D-glucosamine
ADP + 6-deoxy-6-methyl-N-acetyl-alpha-D-glucosamine 1-phosphate
ATP + 6-deoxy-N-acetyl-D-galactosamine
ADP + 6-deoxy-N-acetyl-alpha-D-galactosamine 1-phosphate
-
37% phosphorylation yield
-
-
?
ATP + 6-deoxy-N-acetyl-D-glucosamine
ADP + 6-deoxy-N-acetyl-alpha-D-glucosamine 1-phosphate
75% phosphorylation yield
-
-
?
ATP + 6-methyl-N-acetyl-D-mannosamine
ADP + 6-methyl-N-acetyl-alpha-D-mannosamine 1-phosphate
ATP + D-galactopyranose
ADP + alpha-D-galactopyranose 1-phosphate
-
below 5% phosphorylation yield
-
-
?
ATP + D-galactosamine
ADP + D-galactosamine 1-phosphate
ATP + D-galactose
ADP + D-galactose 1-phosphate
ATP + D-glucosamine
ADP + D-glucosamine 1-phosphate
-
-
-
?
ATP + D-glucose
ADP + D-glucose 1-phosphate
low activity
-
-
?
ATP + D-mannosamine
ADP + alpha-D-mannosamine 1-phosphate
-
-
-
?
ATP + D-mannose
ADP + alpha-D-mannose 1-phosphate
ATP + D-talose
?
phosphorylation at 3% of the activity with N-acetylglucosamine
-
-
?
ATP + mannose
ADP + mannose 1-phosphate
-
-
-
?
ATP + N-acetyl-alpha-D-galactosamine
ADP + N-acetyl-alpha-D-galactosamine 1-phosphate
ATP + N-acetyl-alpha-D-glucosamine
ADP + N-acetyl-alpha-D-glucosamine 1-phosphate
ATP + N-acetyl-D-galactosamine
ADP + N-acetyl-alpha-D-galactosamine 1-phosphate
ATP + N-acetyl-D-glucosamine
ADP + N-acetyl-alpha-D-glucosamine 1-phosphate
ATP + N-acetyl-D-hexosamine
ADP + N-acetyl-alpha-D-hexosamine 1-phosphate
ATP + N-acetyl-D-mannosamine
?
phosphorylation at 15% of the activity with N-acetylglucosamine
-
-
?
ATP + N-acetyl-D-mannosamine
ADP + ?
-
-
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-alpha-D-mannosamine 1-phosphate
low activity
-
-
?
ATP + N-azidoacetyl-D-galactosamine
ADP + N-azidoacetyl-alpha-D-galactosamine 1-phosphate
-
65% phosphorylation yield
-
-
?
ATP + N-azidoacetyl-D-glucosamine
ADP + N-azidoacetyl-alpha-D-glucosamine 1-phosphate
87% phosphorylation yield
-
-
?
ATP + N-benzoyl-alpha-D-galactosamine
ADP + N-benzoyl-alpha-D-galactosamine 1-phosphate
ATP + N-butanoyl-D-galactosamine
ADP + N-butanoyl-alpha-D-galactosamine 1-phosphate
ATP + N-butanoyl-D-glucosamine
ADP + N-butanoyl-alpha-D-glucosamine 1-phosphate
ATP + N-phenylacetyl-D-galactosamine
ADP + N-phenylacetyl-alpha-D-galactosamine 1-phosphate
-
77% phosphorylation yield
-
-
?
ATP + N-phenylacetyl-D-glucosamine
ADP + N-phenylacetyl-alpha-D-glucosamine 1-phosphate
88% phosphorylation yield
-
-
?
ATP + N-propionyl-D-galactosamine
ADP + N-propionyl-alpha-D-galactosamine 1-phosphate
-
85% phosphorylation yield
-
-
?
ATP + N-propionyl-D-glucosamine
ADP + N-propionyl-alpha-D-glucosamine 1-phosphate
86% phosphorylation yield
-
-
?
ATP + N-trifluoroacetyl-alpha-D-galactosamine
ADP + N-trifluoroacetyl-alpha-D-galactosamine 1-phosphate
-
0.75 microM, 21.8% conversion
-
-
?
ATP + N-trifluoroacetyl-D-glucosamine
ADP + N-trifluoroacetyl-alpha-D-glucosamine 1-phosphate
-
recombinant enzyme
-
-
?
GTP + N-acetyl-alpha-D-glucosamine
GDP + N-acetyl-alpha-D-glucosamine 1-phosphate
GTP shows about 45% of the activity with ATP
-
-
?
ITP + N-acetyl-alpha-D-glucosamine
IDP + N-acetyl-alpha-D-glucosamine 1-phosphate
ITP shows about 30% of the activity with ATP
-
-
?
additional information
?
-
ATP + 2-deoxy-2-azido-D-mannose

ADP + 2-deoxy-2-azido-alpha-D-mannose 1-phosphate
-
0.75 microM, 40.2% conversion
-
-
?
ATP + 2-deoxy-2-azido-D-mannose
ADP + 2-deoxy-2-azido-alpha-D-mannose 1-phosphate
-
0.75 microM, 53.3% conversion
-
-
?
ATP + 2-deoxy-2-azido-D-mannose
ADP + 2-deoxy-2-azido-alpha-D-mannose 1-phosphate
-
0.75 microM, 53.3% conversion
-
-
?
ATP + 2-deoxy-2-fluoro-D-mannose

ADP + 2-deoxy-2-fluoro-alpha-D-mannose 1-phosphate
-
0.75 microM, 47.0% conversion
-
-
?
ATP + 2-deoxy-2-fluoro-D-mannose
ADP + 2-deoxy-2-fluoro-alpha-D-mannose 1-phosphate
-
0.75 microM, 44.4% conversion
-
-
?
ATP + 2-deoxy-D-glucose

ADP + 2-deoxy-alpha-D-glucose 1-phosphate
-
0.75 microM, 28.4% conversion
-
-
?
ATP + 2-deoxy-D-glucose
ADP + 2-deoxy-alpha-D-glucose 1-phosphate
-
0.75 microM, 44.8% conversion
-
-
?
ATP + 4-deoxy-D-mannose

ADP + 4-deoxy-alpha-D-mannose 1-phosphate
-
0.75 microM, 23.9% conversion
-
-
?
ATP + 4-deoxy-D-mannose
ADP + 4-deoxy-alpha-D-mannose 1-phosphate
-
0.75 microM, 37.1% conversion
-
-
?
ATP + 6-deoxy-6-azido-N-acetyl-D-glucosamine

ADP + 6-deoxy-6-azido-N-acetyl-alpha-D-glucosamine 1-phosphate
34% phosphorylation yield
-
-
?
ATP + 6-deoxy-6-azido-N-acetyl-D-glucosamine
ADP + 6-deoxy-6-azido-N-acetyl-alpha-D-glucosamine 1-phosphate
-
0.75 microM, 23.4% conversion
-
-
?
ATP + 6-deoxy-6-azido-N-acetyl-D-glucosamine
ADP + 6-deoxy-6-azido-N-acetyl-alpha-D-glucosamine 1-phosphate
-
0.75 microM, 23.4% conversion
-
-
?
ATP + 6-deoxy-6-azido-N-acetyl-D-glucosamine
ADP + 6-deoxy-6-azido-N-acetyl-alpha-D-glucosamine 1-phosphate
-
0.75 microM, 37.2% conversion
-
-
?
ATP + 6-deoxy-6-azido-N-acetyl-D-glucosamine
ADP + 6-deoxy-6-azido-N-acetyl-alpha-D-glucosamine 1-phosphate
-
0.75 microM, 37.2% conversion
-
-
?
ATP + 6-deoxy-6-methyl-N-acetyl-D-glucosamine

ADP + 6-deoxy-6-methyl-N-acetyl-alpha-D-glucosamine 1-phosphate
-
0.75 microM, 36.3% conversion
-
-
?
ATP + 6-deoxy-6-methyl-N-acetyl-D-glucosamine
ADP + 6-deoxy-6-methyl-N-acetyl-alpha-D-glucosamine 1-phosphate
-
0.75 microM, 41.8% conversion
-
-
?
ATP + 6-methyl-N-acetyl-D-mannosamine

ADP + 6-methyl-N-acetyl-alpha-D-mannosamine 1-phosphate
-
0.75 microM, 28.6% conversion
-
-
?
ATP + 6-methyl-N-acetyl-D-mannosamine
ADP + 6-methyl-N-acetyl-alpha-D-mannosamine 1-phosphate
-
0.75 microM, 32.6% conversion
-
-
?
ATP + D-galactosamine

ADP + D-galactosamine 1-phosphate
low activity
-
-
?
ATP + D-galactosamine
ADP + D-galactosamine 1-phosphate
low activity
-
-
?
ATP + D-galactose

ADP + D-galactose 1-phosphate
low activity
-
-
?
ATP + D-galactose
ADP + D-galactose 1-phosphate
low activity
-
-
?
ATP + D-mannose

?
phosphorylation at 1.6% of the activity with N-acetylglucosamine
-
-
?
ATP + D-mannose
?
phosphorylation at 1.6% of the activity with N-acetylglucosamine
-
-
?
ATP + D-mannose

ADP + alpha-D-mannose 1-phosphate
-
0.75 microM, 37.1% conversion
-
-
?
ATP + D-mannose
ADP + alpha-D-mannose 1-phosphate
-
0.75 microM, 68.0% conversion
-
-
?
ATP + N-acetyl-alpha-D-galactosamine

ADP + N-acetyl-alpha-D-galactosamine 1-phosphate
-
-
-
-
?
ATP + N-acetyl-alpha-D-galactosamine
ADP + N-acetyl-alpha-D-galactosamine 1-phosphate
the enzyme is involved in the lacto-N-biose I/galacto-N-biose degradation pathway
-
-
?
ATP + N-acetyl-alpha-D-galactosamine
ADP + N-acetyl-alpha-D-galactosamine 1-phosphate
phosphorylation at 60% of the activity with N-acetylglucosamine
-
-
?
ATP + N-acetyl-alpha-D-galactosamine
ADP + N-acetyl-alpha-D-galactosamine 1-phosphate
lacto-N-biose I/galacto-N-biose metabolic pathway
-
-
?
ATP + N-acetyl-alpha-D-galactosamine
ADP + N-acetyl-alpha-D-galactosamine 1-phosphate
-
-
-
-
?
ATP + N-acetyl-alpha-D-galactosamine
ADP + N-acetyl-alpha-D-galactosamine 1-phosphate
the enzyme is involved in the lacto-N-biose I/galacto-N-biose degradation pathway
-
-
?
ATP + N-acetyl-alpha-D-galactosamine
ADP + N-acetyl-alpha-D-galactosamine 1-phosphate
phosphorylation at 60% of the activity with N-acetylglucosamine
-
-
?
ATP + N-acetyl-alpha-D-galactosamine
ADP + N-acetyl-alpha-D-galactosamine 1-phosphate
lacto-N-biose I/galacto-N-biose metabolic pathway
-
-
?
ATP + N-acetyl-alpha-D-galactosamine
ADP + N-acetyl-alpha-D-galactosamine 1-phosphate
-
-
-
-
?
ATP + N-acetyl-alpha-D-galactosamine
ADP + N-acetyl-alpha-D-galactosamine 1-phosphate
-
-
-
-
?
ATP + N-acetyl-alpha-D-glucosamine

ADP + N-acetyl-alpha-D-glucosamine 1-phosphate
-
-
-
-
?
ATP + N-acetyl-alpha-D-glucosamine
ADP + N-acetyl-alpha-D-glucosamine 1-phosphate
-
-
-
?
ATP + N-acetyl-alpha-D-glucosamine
ADP + N-acetyl-alpha-D-glucosamine 1-phosphate
the enzyme is involved in the lacto-N-biose I/galacto-N-biose degradation pathway
-
-
?
ATP + N-acetyl-alpha-D-glucosamine
ADP + N-acetyl-alpha-D-glucosamine 1-phosphate
-
0.75 microM, 42.3% conversion
-
-
?
ATP + N-acetyl-alpha-D-glucosamine
ADP + N-acetyl-alpha-D-glucosamine 1-phosphate
-
0.75 microM, 42.3% conversion
-
-
?
ATP + N-acetyl-alpha-D-glucosamine
ADP + N-acetyl-alpha-D-glucosamine 1-phosphate
-
0.75 microM, 35.4% conversion
-
-
?
ATP + N-acetyl-alpha-D-glucosamine
ADP + N-acetyl-alpha-D-glucosamine 1-phosphate
-
0.75 microM, 35.4% conversion
-
-
?
ATP + N-acetyl-D-galactosamine

ADP + N-acetyl-alpha-D-galactosamine 1-phosphate
best substrate
-
-
?
ATP + N-acetyl-D-galactosamine
ADP + N-acetyl-alpha-D-galactosamine 1-phosphate
-
78% phosphorylation yield
-
-
?
ATP + N-acetyl-D-galactosamine
ADP + N-acetyl-alpha-D-galactosamine 1-phosphate
78% phosphorylation yield
-
-
?
ATP + N-acetyl-D-galactosamine
ADP + N-acetyl-alpha-D-galactosamine 1-phosphate
best substrate
-
-
?
ATP + N-acetyl-D-galactosamine
ADP + N-acetyl-alpha-D-galactosamine 1-phosphate
-
-
-
-
?
ATP + N-acetyl-D-galactosamine
ADP + N-acetyl-alpha-D-galactosamine 1-phosphate
-
-
-
-
?
ATP + N-acetyl-D-glucosamine

ADP + N-acetyl-alpha-D-glucosamine 1-phosphate
-
-
-
-
?
ATP + N-acetyl-D-glucosamine
ADP + N-acetyl-alpha-D-glucosamine 1-phosphate
high activity
-
-
?
ATP + N-acetyl-D-glucosamine
ADP + N-acetyl-alpha-D-glucosamine 1-phosphate
90% phosphorylation yield
-
-
?
ATP + N-acetyl-D-glucosamine
ADP + N-acetyl-alpha-D-glucosamine 1-phosphate
high activity
-
-
?
ATP + N-acetyl-D-glucosamine
ADP + N-acetyl-alpha-D-glucosamine 1-phosphate
-
-
-
-
?
ATP + N-acetyl-D-glucosamine
ADP + N-acetyl-alpha-D-glucosamine 1-phosphate
-
-
-
-
?
ATP + N-acetyl-D-glucosamine
ADP + N-acetyl-alpha-D-glucosamine 1-phosphate
-
-
-
-
?
ATP + N-acetyl-D-glucosamine
ADP + N-acetyl-alpha-D-glucosamine 1-phosphate
-
recombinant enzyme
-
-
?
ATP + N-acetyl-D-hexosamine

ADP + N-acetyl-alpha-D-hexosamine 1-phosphate
-
-
-
?
ATP + N-acetyl-D-hexosamine
ADP + N-acetyl-alpha-D-hexosamine 1-phosphate
-
-
-
-
?
ATP + N-acetyl-D-hexosamine
ADP + N-acetyl-alpha-D-hexosamine 1-phosphate
-
-
-
-
?
ATP + N-acetyl-D-hexosamine
ADP + N-acetyl-alpha-D-hexosamine 1-phosphate
-
-
-
-
?
ATP + N-acetyl-D-hexosamine
ADP + N-acetyl-alpha-D-hexosamine 1-phosphate
-
-
-
-
?
ATP + N-benzoyl-alpha-D-galactosamine

ADP + N-benzoyl-alpha-D-galactosamine 1-phosphate
-
0.75 microM, 51.9% conversion
-
-
?
ATP + N-benzoyl-alpha-D-galactosamine
ADP + N-benzoyl-alpha-D-galactosamine 1-phosphate
-
0.75 microM, 62.2% conversion
-
-
?
ATP + N-butanoyl-D-galactosamine

ADP + N-butanoyl-alpha-D-galactosamine 1-phosphate
-
86% phosphorylation yield
-
-
?
ATP + N-butanoyl-D-galactosamine
ADP + N-butanoyl-alpha-D-galactosamine 1-phosphate
-
0.75 microM, 24.0% conversion
-
-
?
ATP + N-butanoyl-D-galactosamine
ADP + N-butanoyl-alpha-D-galactosamine 1-phosphate
-
0.75 microM, 24.0% conversion
-
-
?
ATP + N-butanoyl-D-glucosamine

ADP + N-butanoyl-alpha-D-glucosamine 1-phosphate
87% phosphorylation yield
-
-
?
ATP + N-butanoyl-D-glucosamine
ADP + N-butanoyl-alpha-D-glucosamine 1-phosphate
-
0.75 microM, 35.0% conversion
-
-
?
ATP + N-butanoyl-D-glucosamine
ADP + N-butanoyl-alpha-D-glucosamine 1-phosphate
-
0.75 microM, 35.0% conversion
-
-
?
ATP + N-butanoyl-D-glucosamine
ADP + N-butanoyl-alpha-D-glucosamine 1-phosphate
-
0.75 microM, 20.9% conversion
-
-
?
ATP + N-butanoyl-D-glucosamine
ADP + N-butanoyl-alpha-D-glucosamine 1-phosphate
-
0.75 microM, 20.9% conversion
-
-
?
additional information

?
-
slightly active with D-talose, D-mannose, GTP, ITP
-
-
-
additional information
?
-
enzyme demonstrates a relaxed specificity when modifications are of the N-acyl type but also shows a much more limited tolerance for 6-modifications, N-acetylglucosamine 3- and 4-epimers can also be recognized by this enzyme
-
-
-
additional information
?
-
substrate binding structures, overview. No activity with glucuronic acid, galacturonic acid, 6-azidoglucose, 6-GlcNAc, 3-glucosamine, 4-glucosamine, and 6-glucosamine
-
-
-
additional information
?
-
-
slightly active with D-talose, D-mannose, GTP, ITP
-
-
-
additional information
?
-
slightly active with D-talose, D-mannose, GTP, ITP
-
-
-
additional information
?
-
substrate binding structures, overview. No activity with glucuronic acid, galacturonic acid, 6-azidoglucose, 6-GlcNAc, 3-glucosamine, 4-glucosamine, and 6-glucosamine
-
-
-
additional information
?
-
-
substrate binding structures, overview
-
-
-
additional information
?
-
-
substrate binding structures, overview
-
-
-
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D208 A
-
site-directed mutagenesis, the mutant shows reduced activity and altered substrate specificity compared to the wild-type
D208A
-
site-directed mutagenesis, the mutant shows altered activity and kinetics compared to the wild-type enzyme
D208A/K210A
-
site-directed mutagenesis, the mutant shows reduced activity and altered substrate specificity compared to the wild-type
D208A/K210L
-
site-directed mutagenesis, the mutant shows highly reduced activity and altered substrate specificity compared to the wild-type
D208L
-
site-directed mutagenesis, the mutant shows highly reduced activity and altered substrate specificity compared to the wild-type
D228A
-
site-directed mutagenesis, the mutant shows altered activity and kinetics compared to the wild-type enzyme
I146E
-
site-directed mutagenesis, the mutant shows reduced activity and altered substrate specificity compared to the wild-type
I146E/T231E
-
site-directed mutagenesis, the mutant shows reduced activity and altered substrate specificity compared to the wild-type
K210E
-
site-directed mutagenesis, the mutant shows reduced highly activity and altered substrate specificity compared to the wild-type
K210L
-
site-directed mutagenesis, the mutant shows reduced activity and altered substrate specificity compared to the wild-type
N213A
-
site-directed mutagenesis, the mutant shows altered activity and kinetics compared to the wild-type enzyme
Q48A
-
site-directed mutagenesis, the mutant shows reduced activity and altered substrate specificity compared to the wild-type
R306A
-
site-directed mutagenesis, the mutant shows reduced activity and altered substrate specificity compared to the wild-type
R306A/Y317A
-
site-directed mutagenesis, the mutant shows reduced activity and altered substrate specificity compared to the wild-type
R306E
-
site-directed mutagenesis, the mutant shows highly reduced activity but unaltered substrate specificity compared to the wild-type
R306E/Y317F
-
site-directed mutagenesis, the mutant shows highly reduced activity but unaltered substrate specificity compared to the wild-type
T231 E
-
site-directed mutagenesis, the mutant shows reduced activity and altered substrate specificity compared to the wild-type
Y317A
-
site-directed mutagenesis, the mutant shows similar activity but slightly altered substrate specificity compared to the wild-type
Y317F
-
site-directed mutagenesis, the mutant shows similar activity but slightly altered substrate specificity compared to the wild-type
D208A
-
site-directed mutagenesis, the mutant shows altered activity and kinetics compared to the wild-type enzyme
-
D228A
-
site-directed mutagenesis, the mutant shows altered activity and kinetics compared to the wild-type enzyme
-
K210A
-
site-directed mutagenesis, the mutant shows altered activity and kinetics compared to the wild-type enzyme
-
N213A
-
site-directed mutagenesis, the mutant shows altered activity and kinetics compared to the wild-type enzyme
-
Q48A
-
site-directed mutagenesis, the mutant shows reduced activity and altered substrate specificity compared to the wild-type
-
R306A
-
site-directed mutagenesis, the mutant shows reduced activity and altered substrate specificity compared to the wild-type
-
R306E
-
site-directed mutagenesis, the mutant shows highly reduced activity but unaltered substrate specificity compared to the wild-type
-
Y317A
-
site-directed mutagenesis, the mutant shows similar activity but slightly altered substrate specificity compared to the wild-type
-
Y317F
-
site-directed mutagenesis, the mutant shows similar activity but slightly altered substrate specificity compared to the wild-type
-
K210A

-
site-directed mutagenesis, the mutant shows reduced activity and altered substrate specificity compared to the wild-type
K210A
-
site-directed mutagenesis, the mutant shows altered activity and kinetics compared to the wild-type enzyme
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Nishimoto, M.; Kitaoka, M.
Identification of N-acetylhexosamine 1-kinase in the complete lacto-N-biose I/galacto-N-biose metabolic pathway in Bifidobacterium longum
Appl. Environ. Microbiol.
73
6444-6449
2007
Bifidobacterium longum, Bifidobacterium longum (E8MF12), Bifidobacterium longum JCM 1217, Bifidobacterium longum JCM 1217 (E8MF12)
brenda
Cai, L.; Guan, W.; Wang, W.; Zhao, W.; Kitaoka, M.; Shen, J.; ONeil, C.; Wang, P.G.
Substrate specificity of N-acetylhexosamine kinase towards N-acetylgalactosamine derivatives
Bioorg. Med. Chem. Lett.
19
5433-5435
2009
Bifidobacterium longum
brenda
Cai, L.; Guan, W.; Kitaoka, M.; Shen, J.; Xia, C.; Chen, W.; Wang, P.G.
A chemoenzymatic route to N-acetylglucosamine-1-phosphate analogues: substrate specificity investigations of N-acetylhexosamine 1-kinase
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