Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

Filter enzyme data
show all tables | show all data
hide all tables
No. of entries

Information on EC 2.7.1.160 - 2'-phosphotransferase

for references in articles please use BRENDA:EC2.7.1.160

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
IUBMB Comments

Catalyses the final step of tRNA splicing in the yeast Saccharomyces cerevisiae . The reaction takes place in two steps: in the first step, the 2′-phosphate on the RNA substrate is ADP-ribosylated, causing the relase of nicotinamide and the formation of the reaction intermediate, ADP-ribosylated tRNA . In the second step, dephosphorylated (mature) tRNA is formed along with ADP ribose 1′′-2′′-cyclic phosphate. Highly specific for oligonucleotide substrates bearing an internal 2′-phosphate. Oligonucleotides with only a terminal 5′- or 3′-phosphate are not substrates .

The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea

Synonyms
2'-phosphotransferase, trpt1, rsltpt1, tpt1p, trna 2'-phosphotransferase, human trpt1, apetpt1, rna 2'-phosphotransferase, yeast 2'-phosphotransferase, nad+-dependent 2'-phosphotransferase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2'-phospho-[ligated tRNA] + NAD+ = mature tRNA + ADP-ribose 1'',2''-phosphate + nicotinamide
show the reaction diagram
-
-
-
-
PATHWAY SOURCE
PATHWAYS
MetaCyc
tRNA splicing I
Highest Expressing Human Cell Lines
Cell Line Links Gene Links