show all | hide all No of entries

Information on EC 2.7.1.160 - 2'-phosphotransferase

for references in articles please use BRENDA:EC2.7.1.160
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
IUBMB Comments
Catalyses the final step of tRNA splicing in the yeast Saccharomyces cerevisiae . The reaction takes place in two steps: in the first step, the 2'-phosphate on the RNA substrate is ADP-ribosylated, causing the relase of nicotinamide and the formation of the reaction intermediate, ADP-ribosylated tRNA . In the second step, dephosphorylated (mature) tRNA is formed along with ADP ribose 1''-2''-cyclic phosphate. Highly specific for oligonucleotide substrates bearing an internal 2'-phosphate. Oligonucleotides with only a terminal 5'- or 3'-phosphate are not substrates .
Specify your search results
Select one or more organisms in this record:
Word Map
  • 2.7.1.160
  • 2'-phosphate
  • adp-ribose
  • 2.7.1.23
  • pre-trnas
  • 2'-phosphorylated
  • phosphodiester
  • aeropyrum
  • phosphoramidite
  • trnatyr
  • flaviolin
  • trinucleotide
  • anticodon
  • 2'-monophosphate
  • pernix
  • yeast-like
  • adp-ribosylated
  • intron-containing
  • regiospecificity
  • macrolide
The expected taxonomic range for this enzyme is: Archaea, Bacteria, Eukaryota
Synonyms
tpt1p, trpt1, human trpt1, yeast 2'-phosphotransferase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2'-phospho-[ligated tRNA] + NAD+ = mature tRNA + ADP-ribose 1'',2''-phosphate + nicotinamide
show the reaction diagram
-
-
-
-
PATHWAY SOURCE
PATHWAYS
MetaCyc
Select items on the left to see more content.