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Information on EC 2.7.1.159 - inositol-1,3,4-trisphosphate 5/6-kinase and Organism(s) Oryza sativa and UniProt Accession Q10PL5

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IUBMB Comments
In humans, this enzyme, along with EC 2.7.1.127 (inositol-trisphosphate 3-kinase), EC 2.7.1.140 (inositol-tetrakisphosphate 5-kinase) and EC 2.7.1.158 (inositol pentakisphosphate 2-kinase) is involved in the production of inositol hexakisphosphate (InsP6). InsP6 is involved in many cellular processes, including mRNA export from the nucleus . Yeasts do not have this enzyme, so produce InsP6 from Ins(1,4,5)P3 by the actions of EC 2.7.1.151 (inositol-polyphosphate multikinase) and EC 2.7.1.158 (inositol-pentakisphosphate 2-kinase) . The enzymes from animals and plants also have the activity of EC 2.7.1.134, inositol-tetrakisphosphate 1-kinase.
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Oryza sativa
UNIPROT: Q10PL5
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The taxonomic range for the selected organisms is: Oryza sativa
The enzyme appears in selected viruses and cellular organisms
Synonyms
5/6-kinase, gmitpk2, ositl1, 5/6 kinase, atitpk4, inositol 1,3,4-triphosphate 5/6-kinase, at2g43980, ins(1,3,4)p3 5/6-kinase, inositol 1,3,4 trisphosphate kinase-2, inositol-1,3,4-trisphosphate 5/6-kinase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
1,3,4-trisphosphate 5/6-kinase
A1KXK8
-
5/6-kinase
A1KXK8
-
OsITL1
A1KXK8
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Phosphorylation
A1KXK8
-
PATHWAY SOURCE
PATHWAYS
-
-, -, -, -, -
SYSTEMATIC NAME
IUBMB Comments
ATP:1D-myo-inositol 1,3,4-trisphosphate 5-phosphotransferase
In humans, this enzyme, along with EC 2.7.1.127 (inositol-trisphosphate 3-kinase), EC 2.7.1.140 (inositol-tetrakisphosphate 5-kinase) and EC 2.7.1.158 (inositol pentakisphosphate 2-kinase) is involved in the production of inositol hexakisphosphate (InsP6). InsP6 is involved in many cellular processes, including mRNA export from the nucleus [2]. Yeasts do not have this enzyme, so produce InsP6 from Ins(1,4,5)P3 by the actions of EC 2.7.1.151 (inositol-polyphosphate multikinase) and EC 2.7.1.158 (inositol-pentakisphosphate 2-kinase) [2]. The enzymes from animals and plants also have the activity of EC 2.7.1.134, inositol-tetrakisphosphate 1-kinase.
CAS REGISTRY NUMBER
COMMENTARY hide
288307-53-9
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
1D-myo-inositol 1,3,4-trisphosphate + ATP
1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP
show the reaction diagram
A1KXK8
key enzyme in the inositol phosphate pathway and a negative regulator of osmotic stress signaling
-
-
?
1D-myo-inositol 1,3,4-trisphosphate + ATP
1D-myo-inositol 1,3,4,6-tetrakisphosphate + ADP
show the reaction diagram
A1KXK8
key enzyme in the inositol phosphate pathway and a negative regulator of osmotic stress signaling
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
1D-myo-inositol 1,3,4-trisphosphate + ATP
1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP
show the reaction diagram
A1KXK8
key enzyme in the inositol phosphate pathway and a negative regulator of osmotic stress signaling
-
-
?
1D-myo-inositol 1,3,4-trisphosphate + ATP
1D-myo-inositol 1,3,4,6-tetrakisphosphate + ADP
show the reaction diagram
A1KXK8
key enzyme in the inositol phosphate pathway and a negative regulator of osmotic stress signaling
-
-
?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
ATP
A1KXK8
-
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
NaCl
A1KXK8
Induced gene expression in rice by 200 mM. Level of relative germination in the two T3 transgenic tobacco lines overexpressing the OsITL1 gene is approximately 20-30% lower than that in the wild-type lines in the presence of 100 mM NaCl. In presence of 150 or 200 mM NaCl, seedling development is more significantly inhibited in transgenic tobacco plants than in wild-type plants. Transgenic plants that overexpress OsITL1 are more sensitive to NaCl stress during seed germination and early seedling development. The leaves of the transgenic seedlings show complete bleaching or extensive chlorosis after 7 days of exposure to 200 Mm NaCl
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
additional information
A1KXK8
dehydration induces gene expression
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
putative
UniProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
A1KXK8
use for extraction of the OsITL1 gene
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
T-DNA insertion in a gene encoding a putative inositol 1,3,4-trisphosphate 5/6-kinase, i.e. ITPK2, dsm3, leads to a drought- and salt-hypersensitive mutant. Under drought stress conditions, the mutant has significantly less accumulation of osmolytes such as proline and soluble sugar and shows significantly reduced root volume, spikelet fertility, biomass, and grain yield with concomittant increase in malondialdehyde level Overexpression of DSM3 in rice results in drought- and salt-hypersensitive phenotypes and physiological changes similar to those in the mutant. Inositol trisphosphate level is decreased in the overexpressors under normal condition and drought stress
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
38700
A1KXK8
predicted
38800
x * 38800, calculated
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
x * 38800, calculated
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
Cloning and transformation of tobacco plants (Nicotiana tabacum L. cv. K326)
A1KXK8
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
transcript level is induced about tenfold by drought and salt treatments and about 29fold induced by by abscisic acid, but only slightly induced by heat shock
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Niu, X.; Chen, Q.; Wang, X.
OsITL1 gene encoding an inositol 1,3,4-trisphosphate 5/6-kinase is a negative regulator of osmotic stress signaling
Biotechnol. Lett.
30
1687-1692
2008
Oryza sativa (A1KXK8)
Manually annotated by BRENDA team
Du, H.; Liu, L.; You, L.; Yang, M.; He, Y.; Li, X.; Xiong, L.
Characterization of an inositol 1,3,4-trisphosphate 5/6-kinase gene that is essential for drought and salt stress responses in rice
Plant Mol. Biol.
77
547-563
2011
Oryza sativa (Q10PL5)
Manually annotated by BRENDA team