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Information on EC 2.7.1.154 - phosphatidylinositol-4-phosphate 3-kinase and Organism(s) Homo sapiens and UniProt Accession O75747

for references in articles please use BRENDA:EC2.7.1.154
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EC Tree
IUBMB Comments
This enzyme also phosphorylates PtdIns to PtdIns3P. Three mammalian isoforms have been found to date.
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Select one or more organisms in this record: ?
This record set is specific for:
Homo sapiens
UNIPROT: O75747
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Word Map
The taxonomic range for the selected organisms is: Homo sapiens
The enzyme appears in selected viruses and cellular organisms
Synonyms
phosphoinositide 3-kinases, pi3k-c2alpha, pi3k-c2beta, class ii pi3k, pik3c2g, class ii phosphoinositide 3-kinase, pi3kc2beta, pi3kc2a, pi3kc2b, phosphatidylinositol-4-phosphate 3-kinase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
class II phosphoinositide 3-kinase
-
class II PI3K
-
C2-domain-containing phosphoinositide 3-kinase
-
-
-
-
C2-PI3K
-
-
-
-
class II phosphoinositide 3-kinase
class II phosphoinositide 3-kinase C2alpha
-
-
-
-
class II phosphoinositide 3-kinase C2beta
class II phosphoinositide 3-kinases PI3K-C2alpha
-
class II PI3K
class II PI3K-C2alpha
-
class-I PI 3-kinase
-
class-II PI 3-kinase
-
HsC3-PI3K
-
-
-
-
kinase (phosphorylating), phosphatidylinositol 4-phosphate 3-
-
-
-
-
p170
-
-
-
-
phosphatidylinositol 3-kinase class 2 beta
-
phosphatidylinositol 3-kinase class II alpha
-
phosphoinositide 3-kinase
phosphoinositide 3-kinase C2beta
phosphoinositide 3-kinase-C2-beta
-
-
-
-
phosphoinositide 3-kinase-C2-gamma
-
-
-
-
PI 3-kinase C2alpha
-
-
-
-
PI 3-kinase C2beta
-
-
-
-
PI 3-kinase C2gamma
-
-
-
-
PI3K
-
-
PI3K-C2alpha
PI3K-C2beta
PI3K-C2gamma
-
-
-
-
PI3KC2beta
PI3K_C2alpha
-
-
PtdIns-3-kinase C2alpha
-
-
-
-
PtdIns-3-kinase C2beta
-
-
-
-
PtdIns-3-kinase C2gamma
-
-
-
-
type II phosphoinositide 3-kinase
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho-group transfer
-
-
-
-
PATHWAY SOURCE
PATHWAYS
-
-
SYSTEMATIC NAME
IUBMB Comments
ATP:1-phosphatidyl-1D-myo-inositol-4-phosphate 3-phosphotransferase
This enzyme also phosphorylates PtdIns to PtdIns3P. Three mammalian isoforms have been found to date.
CAS REGISTRY NUMBER
COMMENTARY hide
141176-94-5
-
67053-99-0
cf. EC 2.7.1.137
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate
show the reaction diagram
ATP + phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
show the reaction diagram
-
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate
show the reaction diagram
ATP + 1-phosphatidyl-1D-myo-inositol-4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate
show the reaction diagram
ATP + phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
show the reaction diagram
ATP + phosphoinositides
ADP + ?
show the reaction diagram
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate
show the reaction diagram
-
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate
show the reaction diagram
ATP + phosphoinositides
ADP + ?
show the reaction diagram
enzyme plays a role in cellular signalling pathways, e.g. the insulin signalling pathways acting via class Ia and PI3K-C2alpha isozymes synthesizing 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate and affecting the glucose metabolism, the enzyme antagonizes with phosphatases both regulating the signalling pathways together, the enzyme is also involved in insulin resistance in peripheral tissues, overview
-
-
?
additional information
?
-
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Ca2+
phosphorylation of phosphatidylinositol but not phosphatidylinositol 4-phosphate in presence of Ca2+
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(5Z)-5-[[5-(4-fluoro-2-hydroxyphenyl)furan-2-yl]methylidene]-1,3-thiazolidine-2,4-dione
-
2-amino-N-[(1S)-1-[8-[(1-methyl-1H-pyrazol-4-yl)ethynyl]-1-oxo-2-phenyl-1,2-dihydroisoquinolin-3-yl]ethyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide
-
3-amino-N-[3-(3,5-dimethoxyanilino)pyrazin-2-yl]benzene-1-sulfonamide
-
5-[2,6-bis(morpholin-4-yl)pyrimidin-4-yl]-4-(trifluoromethyl)pyridin-2-amine
-
6-[5-(2,2-dimethylpropane-1-sulfonyl)pyridin-3-yl]-8-fluoro[1,2,4]triazolo[1,5-a]pyridin-2-amine
-
(2S)-N1-[4-methyl-5-[3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl]pyrrolidine-1,2-dicarboxamide
-
2-([(1R)-1-[7-methyl-2-(morpholin-4-yl)-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl]ethyl]amino)benzoic acid
-
2-methyl-1-[[2-methyl-3-(trifluoromethyl)phenyl]methyl]-6-(morpholin-4-yl)-1H-benzimidazole-4-carboxylic acid
-
3-amino-N-[3-(3,5-dimethoxyanilino)pyrazin-2-yl]benzene-1-sulfonamide
-
3-[4-(morpholin-4-yl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]phenol
-
4-[(3-chloro-4-fluorophenyl)methyl]-6-[(Z)-(4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene)methyl]-2H-1,4-benzoxazin-3(4H)-one
-
5-[2,6-bis(morpholin-4-yl)pyrimidin-4-yl]-4-(trifluoromethyl)pyridin-2-amine
-
8-[(1R)-1-(3,5-difluoroanilino)ethyl]-N,N-dimethyl-2-(morpholin-4-yl)-4-oxo-4H-1-benzopyran-6-carboxamide
-
adipokines
block insulin signalling via PI3K isozymes
-
Caffeine
might inhibit the enzyme
ceramide
selective inhibition of PI3KC2beta
cytokines
block insulin signalling via PI3K isozymes
-
LY294002
N-(5-[4-chloro-3-[(2-hydroxyethyl)sulfamoyl]phenyl]-4-methyl-1,3-thiazol-2-yl)acetamide
-
N-(7,8-dimethoxy-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl)pyridine-3-carboxamide
-
N-[2-[3-[(benzenesulfonyl)amino]phenyl]-4-(morpholin-4-yl)quinazolin-6-yl]acetamide
-
N-[3-(2-chloro-5-hydroxyanilino)pyrazin-2-yl]benzenesulfonamide
-
N-[4-(morpholin-4-yl)-2-[3-[(naphthalene-2-sulfonyl)amino]phenyl]quinazolin-6-yl]acetamide
-
naringenin
might inhibit the enzyme
Wortmannin
[6-(2-amino-1,3-benzoxazol-5-yl)imidazo[1,2-a]pyridin-3-yl](morpholin-4-yl)methanone
-
additional information
-
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
growth factors
addition of serum to growth-factor-deficient medium increases PI3K-C2alpha expression
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Insulin
-
-
ITSN1
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lysophosphatidic acid
activates PI3KC2beta in SKOV3 cells
monocyte chemotactic peptide-1
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agonist-induced activation
-
additional information
-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.015 - 0.12
ATP
0.064 - 0.122
phosphatidylinositol
0.025
phosphatidylinositol 4-phosphate
-
pH 7.5, 30°C, in presence of phosphatidylserine
IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.019
LY294002
Homo sapiens
-
IC50: 0.019 mM, maximal inhibition at 1 mM
0.0000016 - 0.00042
Wortmannin
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
moderate expression of PI3K-C2alpha andPI3K-C2beta
Manually annotated by BRENDA team
-
moderate expression of PI3K-C2alpha
Manually annotated by BRENDA team
isozyme PI3K-C2beta is overexpressed in human breast cancer cell lines
Manually annotated by BRENDA team
-
low amount of isozyme p85, isozyme PI3K-C2beta and isozyme PI3K-C2alpha in bronchial epithelium
Manually annotated by BRENDA team
-
moderate expression of PI3K-C2alpha and PI3K-C2beta
Manually annotated by BRENDA team
-
of Fallopian tube, moderate expression of PI3K-C2alpha and weak expression of PI3K-C2beta
Manually annotated by BRENDA team
-
PI3K-C2alpha
Manually annotated by BRENDA team
-
moderate expression of PI3K-C2alpha and weak expression of PI3K-C2beta
Manually annotated by BRENDA team
high expression level of PI3KC2beta
Manually annotated by BRENDA team
-
isozyme PI3K-C2alpha, high amount of isozyme p85, and low amount of isozyme PI3K-C2beta
Manually annotated by BRENDA team
-
isozyme PI3K-C2alpha in smooth muscle layer, mononuclear cells, and lining epithelium, isozyme p85 and isozyme PI3K-C2beta in lining epithelium and mononuclear cells
Manually annotated by BRENDA team
-
strong expression of PI3K-C2alpha
Manually annotated by BRENDA team
-
strong expression of PI3K-C2alpha and moderate expression of PI3K-C2beta
Manually annotated by BRENDA team
-
isozyme PI3K-C2alpha in bile ducts, no isozyme PI3K-C2beta and isozyme p85
Manually annotated by BRENDA team
-
isozyme p85, isozyme PI3K-C2beta and isozyme PI3K-C2alpha in alveolar macrophages
Manually annotated by BRENDA team
-
moderate expression of PI3K-C2alpha
Manually annotated by BRENDA team
-
non-myelinated, moderate expression of PI3K-C2beta
Manually annotated by BRENDA team
-
moderate expression of PI3K-C2alpha and PI3K-C2beta
Manually annotated by BRENDA team
expression at low level
Manually annotated by BRENDA team
-
fibromuscular stroma, moderate expression of PI3K-C2alpha
Manually annotated by BRENDA team
-
isozyme PI3K-C2alpha inbasal epithelium and fibromuscular stroma, no isozyme PI3K-C2beta and isozyme p85
Manually annotated by BRENDA team
expression at low level
Manually annotated by BRENDA team
-
isozyme p85 in Langerhans cells, dermal macrophages, and in low amounts in sebaceous glands, hair follicles, and sweat gland, isozyme PI3K-C2beta and isozyme PI3K-C2alpha in dermal macrophages, low amount of isozyme PI3K-C2alpha in sweat gland
Manually annotated by BRENDA team
-
different cell lines overexpress different isozymes, e.g. cell lines H-69, HC-33, H-510, H-1045, and H-209
Manually annotated by BRENDA team
-
strong expression of PI3K-C2beta
Manually annotated by BRENDA team
-
isozyme PI3K-C2beta and isozyme PI3K-C2alpha, and high amount of isozyme p85 in peptic cells
Manually annotated by BRENDA team
-
monocyte
Manually annotated by BRENDA team
-
isozyme PI3K-C2alpha in cervical smooth muscle, no isozyme PI3K-C2beta and isozyme p85
Manually annotated by BRENDA team
-
isozyme p85 in proliferative endometrium and in low amounts in secretory endometrium, isozyme PI3K-C2alpha in myometrium, no isozyme PI3K-C2beta
Manually annotated by BRENDA team
additional information
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
predominantly localised to intracellular membranes
Manually annotated by BRENDA team
predominantly localised to intracellular membranes
Manually annotated by BRENDA team
additional information
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
PIK3C2G, the gene encoding PI3KC2gamma, acts mainly as a tumor suppressor gene. Low PI3KC2gamma expression influences colorectal cancer (CRC) development, with low copy number of PIK3C2G associated with a 2.5fold increase in the risk of death
evolution
three enzymes belong to the class II subfamily, PI3K-C2alpha, beta, and gamma
malfunction
metabolism
knockdown studies of endogenous PI3K isoforms and clathrin heavy chain (CHC) mediated by small interfering RNA (siRNA) demonstrate that the class II PI3K PI3K-C2alpha and PI3K-C2beta, but not the class I or III PI3K, are required for pinocytosis, based on an evaluation of fluorescein-5-isothiocyanate (FITC)-dextran uptake in endothelial cells. Pinocytosis is partially dependent on both clathrin and dynamin, and both PI3K-C2alpha and PI3K-C2beta are required for clathrin-mediated, but not clathrin-nonmediated, FITC-dextran uptake at the step leading up to its delivery to early endosomes. PI3K-C2alpha and PI3K-C2beta play differential, indispensable roles in clathrin-mediated pinocytosis
physiological function
additional information
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
P3C2G_HUMAN
1445
0
165715
Swiss-Prot
other Location (Reliability: 1)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
110000
x * 110000, catalytic subunit, + x * 85000, catalytically inactive adaptor subunit
182000
x * 182000, calculation from nucleotide sequence
190000
85000
x * 110000, catalytic subunit, + x * 85000, catalytically inactive adaptor subunit
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phosphoprotein
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expression of class IA and class II isozymes in HEK293 cells alter the regulation of protein kinases in response to growth factors as part of signalling cascades, overview
-
gene PIK3C2B, quantitative expression analysis
Glu-tagged PI 3-kinase C2beta protein is expressed in both HEK293 cells and Sf9 cells
suppression of expression of recombinant alpha-isoform of class II PI3K and endogenous enzyme in transfected CHO-R1 cells by expression of antisense constructs or DNA fragmentation leads to apoptotic cells death, overview
the region of human PI3K-C2alpha cDNA corresponding to residues 2-144 is cloned into the SmaI-ECoRI sites of pGEX-2T, the fusion protein is expressed in Escherichia coli BL21, transfection to COS cells
-
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
PI3KC2alpha mRNA is downregulated in islets from type 2 diabetic patients compared to nondiabetic individuals
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
diagnostics
PI3KC2gamma is a potential novel biomarker, whose expression levels may predict CRC recurrence and patient survival
drug development
PI3KC2alpha may be a suitable drug target for the prevention and treatment of thrombosis and cardiovascular disease
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Arcaro, A.; Zvelebil, M.J.; Wallasch, C.; Ullrich, A.; Waterfield, M.D.; Domin, J.
Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors
Mol. Cell. Biol.
20
3817-3830
2000
Homo sapiens, Homo sapiens PI3K-C2alpha
Manually annotated by BRENDA team
Arcaro, A.; Volinia, S.; Zvelebil, M.J.; Stein, R.; Watton, S.J.; Layton, M.J.; Gout, I.; Ahmadi, K.; Downward, J.; Waterfield, M.D.
Human phosphoinositide 3-kinase C2b, the role of calcium and the C2 domain in enzyme activity
J. Biol. Chem.
273
33082-33090
1998
Homo sapiens (O00750), Homo sapiens
Manually annotated by BRENDA team
Domin, J.; Pages, F.; Volinia, S.; Rittenhouse, S.E.; Zvelebil, M.J.; Stein, R.C.; Waterfield, M.D.
Cloning of a human phosphoinositide 3-kinase with a C2 domain that displays reduced sensitivity to the inhibitor wortmannin
Biochem. J.
326
139-147
1997
Homo sapiens, Homo sapiens PI3K-C2alpha
-
Manually annotated by BRENDA team
Virbasius, J.V.; Guilherme, A.; Czech, M.P.
Mouse p170 is a novel phosphatidylinositol 3-kinase containing a C2 domain
J. Biol. Chem.
271
13304-13307
1996
Homo sapiens, Homo sapiens PI3K-C2alpha, Mus musculus
Manually annotated by BRENDA team
Brown, R.A.; Ho, L.K.; Weber-Hall, S.J.; Shipley, J.M.; Fry, M.J.
Identification and cDNA cloning of a novel mammalian C2 domain-containing phosphoinositide 3-kinase, HsC2-PI3K
Biochem. Biophys. Res. Commun.
233
537-544
1997
Homo sapiens (O00750)
Manually annotated by BRENDA team
Rozycka, M.; Lu, Y.J.; Brown, R.A.; Lau, M.R.; Shipley, J.M.; Fry, M.J.
cDNA cloning of a third human C2-domain-containing class II phosphoinositide 3-kinase, PI3K-C2gamma, and chromosomal assignment of this gene (PIK3C2G) to 12p12
Genomics
54
569-574
1998
Homo sapiens (O75747), Homo sapiens
Manually annotated by BRENDA team
Gaidarov, I.; Smith, M.E.K.; Domin, J.; Keen, J.H.
The class II phosphoinositide 3-kinase C2alpha is activated by clathrin and regulates clathrin-mediated membrane trafficking
Mol. Cell
7
443-449
2001
Homo sapiens, Homo sapiens PI3K-C2alpha
Manually annotated by BRENDA team
Turner, S.J.; Domin, J.; Waterfield, M.D.; Ward, S.G.; Westwick, J.
The CC chemokine monocyte chemotactic peptide-1 activates both the class I p85/p110 phosphatidylinositol 3-kinase and the class II PI3K-C2alpha
J. Biol. Chem.
273
25987-25995
1998
Homo sapiens, Homo sapiens PI3K-C2alpha
Manually annotated by BRENDA team
Domin, J.; Gaidarov, I.; Smith, M.E.K.; Keen, J.H.; Waterfield, M.D.
The class II phosphoinositide 3-kinase PI3K-C2alpha is concentrated in the trans-Golgi network and present in clathrin-coated vesicles
J. Biol. Chem.
275
11943-11950
2000
Cricetulus griseus, Cricetulus griseus PI3K-C2alpha, Homo sapiens, Homo sapiens PI3K-C2alpha, Rattus norvegicus
Manually annotated by BRENDA team
Wheeler, M.; Domin, J.
Recruitment of the class II phosphoinositide 3-kinase C2beta to the epidermal growth factor receptor: role of Grb2
Mol. Cell. Biol.
21
6660-6667
2001
Homo sapiens
Manually annotated by BRENDA team
El Sheikh, S.S.; Domin, J.; Tomtitchong, P.; Abel, P.; Stamp, G.; Lalani, E.N.
Topographical expression of class IA and class II phosphoinositide 3-kinase enzymes in normal human tissues is consistent with a role in differentiation
BMC Clin. Pathol.
3
4
2003
Homo sapiens
Manually annotated by BRENDA team
Shepherd, P.R.
Mechanisms regulating phosphoinositide 3-kinase signalling in insulin-sensitive tissues
Acta Physiol. Scand.
183
3-12
2005
Homo sapiens (O00443), Mus musculus (Q61194), Homo sapiens PI3K-C2alpha (O00443)
Manually annotated by BRENDA team
Kang, S.; Song, J.; Kang, J.; Kang, H.; Lee, D.; Lee, Y.; Park, D.
Suppression of the alpha-isoform of class II phosphoinositide 3-kinase gene expression leads to apoptotic cell death
Biochem. Biophys. Res. Commun.
329
6-10
2005
Homo sapiens (O00443)
Manually annotated by BRENDA team
Arcaro, A.; Khanzada, U.K.; Vanhaesebroeck, B.; Tetley, T.D.; Waterfield, M.D.; Seckl, M.J.
Two distinct phosphoinositide 3-kinases mediate polypeptide growth factor-stimulated PKB activation
EMBO J.
21
5097-5108
2002
Homo sapiens
Manually annotated by BRENDA team
Falasca, M.; Maffucci, T.
Role of class II phosphoinositide 3-kinase in cell signalling
Biochem. Soc. Trans.
35
211-214
2007
Caenorhabditis elegans, Drosophila melanogaster, Homo sapiens, Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Traer, C.J.; Foster, F.M.; Abraham, S.M.; Fry, M.J.
Are class II posphoinositide 3-kinases potential targets for anticancer therapies?
Bull. Cancer
93
E53-E58
2006
Homo sapiens (O00443), Homo sapiens (O00750), Homo sapiens (O75747)
Manually annotated by BRENDA team
Katso, R.M.; Pardo, O.E.; Palamidessi, A.; Franz, C.M.; Marinov, M.; De Laurentiis, A.; Downward, J.; Scita, G.; Ridley, A.J.; Waterfield, M.D.; Arcaro, A.
Phosphoinositide 3-kinase C2beta regulates cytoskeletal organization and cell migration via Rac-dependent mechanisms
Mol. Biol. Cell
17
3729-3744
2006
Homo sapiens
Manually annotated by BRENDA team
Russo, A.; Okur, M.N.; Bosland, M.; OBryan, J.P.
Phosphatidylinositol 3-kinase, class 2 beta (PI3KC2beta) isoform contributes to neuroblastoma tumorigenesis
Cancer Lett.
359
262-268
2015
Homo sapiens (O00750), Homo sapiens
Manually annotated by BRENDA team
Aki, S.; Yoshioka, K.; Okamoto, Y.; Takuwa, N.; Takuwa, Y.
Phosphatidylinositol 3-kinase class II alpha-isoform PI3K-C2alpha is required for transforming growth factor beta-induced Smad signaling in endothelial cells
J. Biol. Chem.
290
6086-6105
2015
Homo sapiens (O00443)
Manually annotated by BRENDA team
Chikh, A.; Ferro, R.; Abbott, J.J.; Pineiro, R.; Buus, R.; Iezzi, M.; Ricci, F.; Bergamaschi, D.; Ostano, P.; Chiorino, G.; Lattanzio, R.; Broggini, M.; Piantelli, M.; Maffucci, T.; Falasca, M.
Class II phosphoinositide 3-kinase C2alpha regulates a novel signaling pathway involved in breast cancer progression
Oncotarget
7
18325-18345
2016
Homo sapiens (O00750), Homo sapiens
Manually annotated by BRENDA team
Mavrommati, I.; Cisse, O.; Falasca, M.; Maffucci, T.
Novel roles for class II phosphoinositide 3-kinase C2beta in signalling pathways involved in prostate cancer cell invasion
Sci. Rep.
6
23277
2016
Homo sapiens (O00750), Homo sapiens
Manually annotated by BRENDA team
Falasca, M.; Hamilton, J.R.; Selvadurai, M.; Sundaram, K.; Adamska, A.; Thompson, P.E.
Class II phosphoinositide 3-kinases as novel drug targets
J. Med. Chem.
60
47-65
2017
Mus musculus (E9QAN8), Mus musculus (O70167), Mus musculus (Q61194), Homo sapiens (O00443), Homo sapiens (O00750), Homo sapiens (O75747)
Manually annotated by BRENDA team
Aung, K.T.; Yoshioka, K.; Aki, S.; Ishimaru, K.; Takuwa, N.; Takuwa, Y.
The class II phosphoinositide 3-kinases PI3K-C2alpha and PI3K-C2beta differentially regulate clathrin-dependent pinocytosis in human vascular endothelial cells
J. Physiol. Sci.
69
263-280
2019
Homo sapiens (O00443), Homo sapiens (O00750), Homo sapiens
Manually annotated by BRENDA team