Reference on EC 2.7.1.153 - phosphatidylinositol-4,5-bisphosphate 3-kinase and Organism(s) Mus musculus and UniProt Accession P42337
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AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Hawkins, P.T.; Jackson, T.R.; Stephens, L.R.
Platelet-derived growth factor stimulates synthesis of PtdIns(3,4,5)P3 by activating a PtdIns(4,5)P2 3-OH kinase
Nature
358
157-159
1992
Mus musculus
Klippel, A.; Escobedo, J.A.; Hirano, M.; Williams, L.T.
The interaction of small domains between the subunits of phosphatidylinositol 3-kinase determines enzyme activity
Mol. Cell. Biol.
14
2675-2685
1994
Mus musculus (P42337), Mus musculus
Luo, J.; Field, S.J.; Lee, J.Y.; Engelman, J.A.; Cantley, L.C.
The p85 regulatory subunit of phosphoinositide 3-kinase down-regulates IRS-1 signaling via the formation of a sequestration complex
J. Cell Biol.
170
455-464
2005
Mus musculus
Ueki, K.; Fruman, D.A.; Brachmann, S.M.; Tseng, Y.H.; Cantley, L.C.; Kahn, C.R.
Molecular balance between the regulatory and catalytic subunits of phosphoinositide 3-kinase regulates cell signaling and survival
Mol. Cell. Biol.
22
965-977
2002
Mus musculus
Patton, D.T.; Garcon, F.; Okkenhaug, K.
The PI3K p110delta controls T-cell development, differentiation and regulation
Biochem. Soc. Trans.
35
167-171
2007
Mus musculus (O35904)
Liu, L.; Puri, K.D.; Penninger, J.M.; Kubes, P.
Leukocyte PI3Kgamma and PI3Kdelta have temporally distinct roles for leukocyte recruitment in vivo
Blood
110
1191-1198
2007
Mus musculus (O35904), Mus musculus (Q9JHG7)
Papakonstanti, E.A.; Ridley, A.J.; Vanhaesebroeck, B.
The p110delta isoform of PI 3-kinase negatively controls RhoA and PTEN
EMBO J.
26
3050-3061
2007
Mus musculus (O35904)
Nashed, B.F.; Zhang, T.; Al-Alwan, M.; Srinivasan, G.; Halayko, A.J.; Okkenhaug, K.; Vanhaesebroeck, B.; Hayglass, K.T.; Marshall, A.J.
Role of the phosphoinositide 3-kinase p110delta in generation of type 2 cytokine responses and allergic airway inflammation
Eur. J. Immunol.
37
416-424
2007
Mus musculus (O35904)
Okkenhaug, K.; Patton, D.T.; Bilancio, A.; Garcon, F.; Rowan, W.C.; Vanhaesebroeck, B.
The p110delta isoform of phosphoinositide 3-kinase controls clonal expansion and differentiation of Th cells
J. Immunol.
177
5122-5128
2006
Mus musculus (O35904)
Llorian, M.; Stamataki, Z.; Hill, S.; Turner, M.; Martensson, I.L.
The PI3K p110delta is required for down-regulation of RAG expression in immature B cells
J. Immunol.
178
1981-1985
2007
Mus musculus (O35904)
Eickholt, B.J.; Ahmed, A.I.; Davies, M.; Papakonstanti, E.A.; Pearce, W.; Starkey, M.L.; Bilancio, A.; Need, A.C.; Smith, A.J.; Hall, S.M.; Hamers, F.P.; Giese, K.P.; Bradbury, E.J.; Vanhaesebroeck, B.
Control of axonal growth and regeneration of sensory neurons by the p110delta PI 3-kinase
PLoS ONE
2
e869
2007
Mus musculus
Okkenhaug, K.; Ali, K.; Vanhaesebroeck, B.
Antigen receptor signalling: a distinctive role for the p110delta isoform of PI3K
Trends Immunol.
28
80-87
2007
Mus musculus (O35904)
Randis, T.M.; Puri, K.D.; Zhou, H.; Diacovo, T.G.
Role of PI3Kdelta and PI3Kgamma in inflammatory arthritis and tissue localization of neutrophils
Eur. J. Immunol.
38
1215-1224
2008
Mus musculus
Shiroki, F.; Matsuda, S.; Doi, T.; Fujiwara, M.; Mochizuki, Y.; Kadowaki, T.; Suzuki, H.; Koyasu, S.
The p85alpha regulatory subunit of class IA phosphoinositide 3-kinase regulates beta-selection in thymocyte development
J. Immunol.
178
1349-1356
2007
Mus musculus
Farghaly, H.S.; Blagbrough, I.S.; Medina-Tato, D.A.; Watson, M.L.
Interleukin 13 increases contractility of murine tracheal smooth muscle by a phosphoinositide 3-kinase p110delta-dependent mechanism
Mol. Pharmacol.
73
1530-1537
2008
Mus musculus
Geering, B.; Cutillas, P.R.; Nock, G.; Gharbi, S.I.; Vanhaesebroeck, B.
Class IA phosphoinositide 3-kinases are obligate p85-p110 heterodimers
Proc. Natl. Acad. Sci. USA
104
7809-7814
2007
Mus musculus
Renner, O.; Blanco-Aparicio, C.; Grassow, M.; Canamero, M.; Leal, J.F.; Carnero, A.
Activation of phosphatidylinositol 3-kinase by membrane localization of p110alpha predisposes mammary glands to neoplastic transformation
Cancer Res.
68
9643-9653
2008
Homo sapiens, Mus musculus
Hwang, M.K.; Song, N.R.; Kang, N.J.; Lee, K.W.; Lee, H.J.
Activation of phosphatidylinositol 3-kinase is required for tumor necrosis factor-alpha-induced upregulation of matrix metalloproteinase-9: its direct inhibition by quercetin
Int. J. Biochem. Cell Biol.
41
1592-1600
2009
Mus musculus
Li, Y.; Anderson, D.H.; Liu, Q.; Zhou, Y.
Mechanism of influenza A virus NS1 protein interaction with the p85beta, but not the p85alpha, subunit of phosphatidylinositol 3-kinase (PI3K) and up-regulation of PI3K activity
J. Biol. Chem.
283
23397-23409
2008
Bos taurus, Mus musculus
Martin, A.L.; Schwartz, M.D.; Jameson, S.C.; Shimizu, Y.
Selective regulation of CD8 effector T cell migration by the p110 gamma isoform of phosphatidylinositol 3-kinase
J. Immunol.
180
2081-2088
2008
Mus musculus, Mus musculus C57BL/6
Kaur, S.; Sassano, A.; Joseph, A.M.; Majchrzak-Kita, B.; Eklund, E.A.; Verma, A.; Brachmann, S.M.; Fish, E.N.; Platanias, L.C.
Dual regulatory roles of phosphatidylinositol 3-kinase in IFN signaling
J. Immunol.
181
7316-7323
2008
Mus musculus
Liu, D.; Zhang, T.; Marshall, A.J.; Okkenhaug, K.; Vanhaesebroeck, B.; Uzonna, J.E.
The p110delta isoform of phosphatidylinositol 3-kinase controls susceptibility to Leishmania major by regulating expansion and tissue homing of regulatory T cells
J. Immunol.
183
1921-1933
2009
Mus musculus
Thomas, M.S.; Mitchell, J.S.; DeNucci, C.C.; Martin, A.L.; Shimizu, Y.
The p110gamma isoform of phosphatidylinositol 3-kinase regulates migration of effector CD4 T lymphocytes into peripheral inflammatory sites
J. Leukoc. Biol.
84
814-823
2008
Mus musculus
Gavard, J.; Hou, X.; Qu, Y.; Masedunskas, A.; Martin, D.; Weigert, R.; Li, X.; Gutkind, J.S.
A role for a CXCR2/phosphatidylinositol 3-kinase gamma signaling axis in acute and chronic vascular permeability
Mol. Cell. Biol.
29
2469-2480
2009
Homo sapiens, Mus musculus
Chen, B.C.; Kang, J.C.; Lu, Y.T.; Hsu, M.J.; Liao, C.C.; Chiu, W.T.; Yeh, F.L.; Lin, C.H.
Rac1 regulates peptidoglycan-induced nuclear factor-kappaB activation and cyclooxygenase-2 expression in RAW 264.7 macrophages by activating the phosphatidylinositol 3-kinase/Akt pathway
Mol. Immunol.
46
1179-1188
2009
Mus musculus
Yang, Y.; Iwanaga, K.; Raso, M.G.; Wislez, M.; Hanna, A.E.; Wieder, E.D.; Molldrem, J.J.; Wistuba, I.I.; Powis, G.; Demayo, F.J.; Kim, C.F.; Kurie, J.M.
Phosphatidylinositol 3-kinase mediates bronchioalveolar stem cell expansion in mouse models of oncogenic K-ras-induced lung cancer
PLoS ONE
3
e2220
2008
Mus musculus
Furuya, F.; Lu, C.; Guigon, C.J.; Cheng, S.Y.
Nongenomic activation of phosphatidylinositol 3-kinase signaling by thyroid hormone receptors
Steroids
74
628-634
2009
Mus musculus
Marwick, J.A.; Chung, K.F.; Adcock, I.M.
Phosphatidylinositol 3-kinase isoforms as targets in respiratory disease
Ther. Adv. Respir. Dis.
2009
1-16
2010
Homo sapiens, Mus musculus
Zwaenepoel, O.; Tzenaki, N.; Vergetaki, A.; Makrigiannakis, A.; Vanhaesebroeck, B.; Papakonstanti, E.A.
Functional CSF-1 receptors are located at the nuclear envelope and activated via the p110delta isoform of PI 3-kinase
FASEB J.
26
691-706
2012
Mus musculus
Wu, Y.; Tan, H.; Shui, G.; Bauvy, C.; Huang, Q.; Wenk, M.; Ong, C.; Codogno, P.; Shen, H.
Dual role of 3-methyladenine in modulation of autophagy via different temporal patterns of inhibition on class I and III phosphoinositide 3-kinase
J. Biol. Chem.
285
10850-10861
2010
Homo sapiens, Mus musculus
Vantler, M.; Jesus, J.; Leppaenen, O.; Scherner, M.; Berghausen, E.M.; Mustafov, L.; Chen, X.; Kramer, T.; Zierden, M.; Gerhardt, M.; Ten Freyhaus, H.; Blaschke, F.; Sterner-Kock, A.; Baldus, S.; Zhao, J.J.; Rosenkranz, S.
Class IA phosphatidylinositol 3-kinase isoform p110alpha mediates vascular remodeling
Arterioscler. Thromb. Vasc. Biol.
35
1434-1444
2015
Rattus norvegicus, Rattus norvegicus (A0A0G2K344), Rattus norvegicus (Q9Z1L0), Homo sapiens (O00329), Homo sapiens (P42336), Homo sapiens (P42338), Homo sapiens, Mus musculus (O35904), Mus musculus (P42337), Mus musculus
Gupta, V.K.; Rajala, A.; Rajala, R.V.
Non-canonical regulation of phosphatidylinositol 3-kinase gamma isoform activity in retinal rod photoreceptor cells
Cell Commun. Signal.
13
7-7
2015
Mus musculus (Q9JHG7)
