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Information on EC 2.7.1.153 - phosphatidylinositol-4,5-bisphosphate 3-kinase

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EC Tree
IUBMB Comments
This enzyme also catalyses the phosphorylation of PtdIns4P to PtdIns(3,4)P2, and of PtdIns to PtdIns3P. Four mammalian isoforms are known to exist.
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UNIPROT: P27986
Word Map
The enzyme appears in viruses and cellular organisms
Synonyms
pik3ca, pi 3-kinase, phosphoinositide 3-kinase, pi3-kinase, pi3-k, pi-3k, phosphatidylinositol 3'-kinase, p110alpha, pi 3-k, pi3kgamma, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
class I phosphoinositide 3-kinase
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class I PI3K
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kinase (phosphorylating), phosphatidylinositol 4,5-diphosphate 3-
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p101-PI3K
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p110delta
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P120-PI3K
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phosphatidylinositol (4,5)-bisphosphate 3-hydroxykinase
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phosphatidylinositol 3-hydroxyl kinase
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PI3K
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PI3Kbeta
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PI3Kgamma
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PtdIns(4,5)P2 3-OH kinase
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PtdIns-3-kinase p101
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PtdIns-3-kinase p110
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PtdInsP 3-OH-kinase
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type I phosphoinositide 3-kinase
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho-group transfer
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PATHWAY SOURCE
PATHWAYS
SYSTEMATIC NAME
IUBMB Comments
ATP:1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate 3-phosphotransferase
This enzyme also catalyses the phosphorylation of PtdIns4P to PtdIns(3,4)P2, and of PtdIns to PtdIns3P. Four mammalian isoforms are known to exist.
CAS REGISTRY NUMBER
COMMENTARY hide
103843-30-7
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115926-52-8
cf. EC 2.7.1.137