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Information on EC 2.7.1.150 - 1-phosphatidylinositol-3-phosphate 5-kinase and Organism(s) Saccharomyces cerevisiae and UniProt Accession P34756

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Saccharomyces cerevisiae
UNIPROT: P34756 not found.
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The taxonomic range for the selected organisms is: Saccharomyces cerevisiae
The enzyme appears in selected viruses and cellular organisms
Synonyms
pikfyve, ste12, fab1p, pip5k3, fab1/pikfyve, phosphatidylinositol 3-phosphate 5-kinase, ppk-3, phosphatidylinositol-3-phosphate-5-kinase pikfyve, ptdins3p 5-kinase, cgfab1, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phosphatidylinositol 5-OH kinase
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PtdIns3P 5-OH kinase
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Fab1p
kinase (phosphorylating), phosphatidylinositol 3-phosphate 5-
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phosphatidylinositol 3-phosphate 5-kinase
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Phosphatidylinositol-3-phosphate 5-kinase
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PI(3)P-5-kinase
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PI3P 5-kinase
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PtdIns(3) 5-kinase
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PtdIns3P 5-kinase
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type III PIP kinase
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additional information
the enzyme belongs to the type III PIPkin family
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho-group transfer
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PATHWAY SOURCE
PATHWAYS
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SYSTEMATIC NAME
IUBMB Comments
ATP:1-phosphatidyl-1D-myo-inositol-3-phosphate 5-phosphotransferase
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CAS REGISTRY NUMBER
COMMENTARY hide
190606-24-7
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate
show the reaction diagram
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
show the reaction diagram
recombinant enzyme
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-
?
ATP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate
show the reaction diagram
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate
show the reaction diagram
regulation of 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate synthesis involving osmotic stress, overview, enzymes hydrolyzing the product are counteracting, overview
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-
?
ATP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate
show the reaction diagram
additional information
?
-
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Mg2+
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maximal activity at 1.5 mM
Mn2+
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maximal activity at 1.5 mM
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
additional information
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
gene FAB1
SwissProt
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
the PIPkin type III family enzyme consists of 4 typical domains: the FYVE RING Zn-finger domain, the TCP-I/chaperone-like domain, the PIPkin domain, and the cysteine-rich domain
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
D2134R
site-directed mutagenesis, in vivo abrogation of lipid kinase activity of the enzyme
K2059M
site-directed mutagenesis, in vitro abrogation of lipid kinase activity of the enzyme
additional information
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
gene FAB1, DNA sequence determination and analysis, functional expression as fusion protein
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Cooke, F.T.; Dove, S.K.; McEwen, R.K.; Painter, G.; Holmes, A.B.; Hall, M.N.; Michell, R.H.; Parker, P.J.
The stress-activated phosphatidylinositol 3-phosphate 5-kinase Fab1p is essential for vacuole function in S. cerevisiae
Curr. Biol.
8
1219-1222
1998
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Gary, J.D.; Sato, T.K.; Stefan, C.J.; Bonangelino, C.J.; Weisman, L.S.; Emr, S.D.
Regulation of fab1 phosphatidylinositol 3-phosphate 5-kinase pathway by vac7 protein and fig4, a polyphosphoinositide phosphatase family member
Mol. Biol. Cell
13
1238-1251
2002
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Cooke, F.T.
Phosphatidylinositol 3,5-bisphosphate: metabolism and function
Arch. Biochem. Biophys.
407
143-151
2002
Arabidopsis thaliana, Caenorhabditis elegans, Candida albicans, Drosophila melanogaster, Homo sapiens, Mus musculus, Oryza sativa, Schizosaccharomyces pombe, Saccharomyces cerevisiae (P34756)
Manually annotated by BRENDA team
Dove, S.K.; McEwen, R.K.; Mayes, A.; Hughes, D.C.; Beggs, J.D.; Michell, R.H.
Vac14 controls PtdIns(3,5)P2 synthesis and Fab1-dependent protein trafficking to the multivesicular body
Curr. Biol.
12
885-893
2002
Saccharomyces cerevisiae, Schizosaccharomyces pombe
Manually annotated by BRENDA team
Duex, J.E.; Tang, F.; Weisman, L.S.
The Vac14p-Fig4p complex acts independently of Vac7p and couples PI3,5P2 synthesis and turnover
J. Cell Biol.
172
693-704
2006
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Phelan, J.P.; Millson, S.H.; Parker, P.J.; Piper, P.W.; Cooke, F.T.
Fab1p and AP-1 are required for trafficking of endogenously ubiquitylated cargoes to the vacuole lumen in S. cerevisiae
J. Cell Sci.
119
4225-4234
2006
Saccharomyces cerevisiae
Manually annotated by BRENDA team