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Information on EC 2.7.1.148 - 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase
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EC Tree
2.7.1.148 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinaseIUBMB Comments
The enzyme from Escherichia coli requires Mg2+ or Mn2+. Forms part of an alternative nonmevalonate pathway for terpenoid biosynthesis (for diagram, click here).
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Word Map
- 2.7.1.148
-
isoprenoids
- mevalonate
-
isopentenyl
- malaria
- 2-phosphate
-
antimalarial
-
dimethylallyl
- plasmodium
-
non-mevalonate
- jasmonate
- drug development
- 1-deoxy-d-xylulose
-
terpenoids
-
nonhydrolyzable
-
solvent-mediated
-
mevalonate-independent
-
gametocytic
-
apicomplexan
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water-mediated
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2,4-cyclodiphosphate
-
2-hydroxyl
-
dmapp
- medicine
The enzyme appears in viruses and cellular organisms
Reaction Schemes
Synonyms
cdp-me, 4-diphosphocytidyl-2-c-methyl-d-erythritol kinase, 4-diphosphocytidyl-2c-methyl-d-erythritol kinase, twcmk, cdp-me kinase, pvispe, gbcmk1, gbcmk2, cccmk1, 4-(cytidine 5'-diphospho)-2-c-methyl-d-erythritol kinase, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase
4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase
-
-
-
-
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase
4-diphosphocytidyl-2-C-methylerythritol 2-kinase
-
-
-
-
4-diphosphocytidyl-2C-methyl-D-erythritol 2-kinase
-
-
-
-
4-diphosphocytidyl-2C-methyl-D-erythritol kinase
BsIspE
CDP-ME
CDP-ME kinase
CDPME kinase
CDPMEK
-
-
-
-
CMK
GbCMK1
Isoenzyme with 433 amino acids. The identity between GbCMK2 and GbCMK1 is 62.7%.
GbCMK2
isoenzyme with 428 amino acids. The identity between GbCMK2 and GbCMK1 is 62.7%.
IspDF
-
in Agrobacterium tumefaciens the ispD and ispF genes are fused to encode a bifunctional enzyme that catalyzes the first (synthesis of 4-diphosphocytidyl-2-C-methyl D-erythritol) and third (synthesis of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate) steps of isoprenoid biosynthetic pathway
IspE
PvIspE
Ripening-associated protein pTOM41
-
-
-
-
additional information
4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase
Thermus thermophilus HB8 / ATCC 27634 / DSM 579
-
-
-
CDP-ME kinase
-
-
-
-
CMK
-
-
-
-
additional information
-
the enzyme belongs to the galactose kinase/homoserine kinase/mevalonate kinase phosphomevalonate kinase superfamily
additional information
Thermus thermophilus HB8 / ATCC 27634 / DSM 579
-
enzyme belongs to the GHMK super family
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol = ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol = ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
-
-
-
-
ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol = ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
reaction mechanism
-
ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol = ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
reaction mechanism involves K8 and D125
-
ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol = ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
catalyzes the fourth step of 2-C-methyl-D-erythritol 4-phosphate pathway
ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol = ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
reaction mechanism involves K8 and D125
Thermus thermophilus HB8 / ATCC 27634 / DSM 579
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-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
phospho group transfer
-
-
-
-
Phosphorylation
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PATHWAY SOURCE
PATHWAYS
BRENDA
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SYSTEMATIC NAME
IUBMB Comments
ATP:4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol 2-phosphotransferase
The enzyme from Escherichia coli requires Mg2+ or Mn2+. Forms part of an alternative nonmevalonate pathway for terpenoid biosynthesis (for diagram, click here).
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CAS REGISTRY NUMBER
COMMENTARY
263016-77-9
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol + ATP
2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol + ADP
-
-
-
ir
4-diphosphocytidyl-2C-methyl-D-erythritol + ATP
4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate + ADP
non-mevalonate pathway of isoprenoid precursor synthesis
-
-
ir
ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
-
-
-
?
ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
-
-
-
?
ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
Bacillus subtilis DSM 23778
-
-
-
?
ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
-
-
-
?
ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
-
-
-
-
?
ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
-
-
-
?
ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
-
fourth reaction step of the 2-C-methyl-D-erythritol 4-phosphate pathway
-
-
?
ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
-
the enzyme is essential in the nonmevalonate pathway of isopentenyl diphosphate and dimethylallyl diphosphate biosynthesis
-
-
?
ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
-
i.e. CDP-ME
-
-
?
ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
-
non-mevalonate pathway for isoprenoid biosynthesis
-
-
?
ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
-
-
-
-
?
ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
-
-
-
?
ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
-
-
-
?
ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
-
-
-
?
ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
-
-
-
?
ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
-
-
-
?
ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
involved in terpenoid biosynthesis via deoxyxylulose phosphate pathway
-
-
?
ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
-
the enzyme is essential in the nonmevalonate pathway of isopentenyl diphosphate and dimethylallyl diphosphate biosynthesis, pathway overview
-
-
?
ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
-
i.e. CDP-ME, the cytosine group plays an essential role in substrate recognition by the enzyme
-
-
?
ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
Thermus thermophilus HB8 / ATCC 27634 / DSM 579
-
the enzyme is essential in the nonmevalonate pathway of isopentenyl diphosphate and dimethylallyl diphosphate biosynthesis, pathway overview
-
-
?
ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
Thermus thermophilus HB8 / ATCC 27634 / DSM 579
-
i.e. CDP-ME, the cytosine group plays an essential role in substrate recognition by the enzyme
-
-
?
ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
-
-
-
-
?
additional information
?
-
-
in Agrobacterium tumefaciens the ispD and ispF genes are fused to encode a bifunctional enzyme that catalyzes the first (synthesis of 4-diphosphocytidyl-2-C-methyl D-erythritol) and third (synthesis of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate) steps of isoprenoid biosynthetic pathway. Enzyme-generated intermediates are not transferred from the IspD active site in IspDF to the active site of IspE or from the active site in IspE to the active site of the IspF module of IspDF
-
-
?
additional information
?
-
no conversion of isopentenyl phosphate into isopentenyl diphosphate
-
-
?
additional information
?
-
-
no conversion of isopentenyl phosphate into isopentenyl diphosphate
-
-
?
additional information
?
-
-
no activity with 4-(adenine 5'-phosphate)-2-C-methyl-D-erythritol and 4-(uridine 5'-phosphate)-2-C-methyl-D-erythritol
-
-
?
additional information
?
-
Thermus thermophilus HB8 / ATCC 27634 / DSM 579
-
no activity with 4-(adenine 5'-phosphate)-2-C-methyl-D-erythritol and 4-(uridine 5'-phosphate)-2-C-methyl-D-erythritol
-
-
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol + ATP
2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol + ADP
-
-
-
ir
4-diphosphocytidyl-2C-methyl-D-erythritol + ATP
4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate + ADP
non-mevalonate pathway of isoprenoid precursor synthesis
-
-
ir
ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
additional information
?
-
-
in Agrobacterium tumefaciens the ispD and ispF genes are fused to encode a bifunctional enzyme that catalyzes the first (synthesis of 4-diphosphocytidyl-2-C-methyl D-erythritol) and third (synthesis of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate) steps of isoprenoid biosynthetic pathway. Enzyme-generated intermediates are not transferred from the IspD active site in IspDF to the active site of IspE or from the active site in IspE to the active site of the IspF module of IspDF
-
-
?
ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
-
-
-
?
ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
-
-
-
?
ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
Bacillus subtilis DSM 23778
-
-
-
?
ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
-
-
-
?
ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
-
-
-
-
?
ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
-
-
-
?
ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
-
fourth reaction step of the 2-C-methyl-D-erythritol 4-phosphate pathway
-
-
?
ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
-
the enzyme is essential in the nonmevalonate pathway of isopentenyl diphosphate and dimethylallyl diphosphate biosynthesis
-
-
?
ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
-
non-mevalonate pathway for isoprenoid biosynthesis
-
-
?
ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
-
-
-
?
ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
-
-
-
?
ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
involved in terpenoid biosynthesis via deoxyxylulose phosphate pathway
-
-
?
ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
-
the enzyme is essential in the nonmevalonate pathway of isopentenyl diphosphate and dimethylallyl diphosphate biosynthesis, pathway overview
-
-
?
ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
Thermus thermophilus HB8 / ATCC 27634 / DSM 579
-
the enzyme is essential in the nonmevalonate pathway of isopentenyl diphosphate and dimethylallyl diphosphate biosynthesis, pathway overview
-
-
?
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Mg2+
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
ethyl [4-amino-2-oxo-5-(3-[[(2,2,2-trifluoroethyl)sulfonyl]amino]prop-1-en-1-yl)pyrimidin-1(2H)-yl]acetate
-
mixed type
N-[3-(4-amino-1-benzyl-2-oxo-1,2-dihydropyrimidin-5-yl)prop-2-en-1-yl]ethanesulfonamide
-
mixed-type
N-[3-[4-amino-2-oxo-1-(1H-pyrazol-5-ylmethyl)-1,2-dihydropyrimidin-5-yl]prop-2-en-1-yl]ethanesulfonamide
-
competitive
N-[3-[4-amino-2-oxo-1-(tetrahydro-2-thienyl)-1,2-dihydropyrimidin-5-yl]prop-2-en-1-yl]-1,1,1-trifluoromethanesulfonamide
-
competitive
N-[3-[4-amino-2-oxo-1-(tetrahydro-2-thienyl)-1,2-dihydropyrimidin-5-yl]prop-2-en-1-yl]-2,2,2-trifluoroethanesulfonamide
-
competitive
N-[3-[4-amino-2-oxo-1-(tetrahydro-2-thienyl)-1,2-dihydropyrimidin-5-yl]prop-2-en-1-yl]benzenesulfonamide
-
competitive
N-[3-[4-amino-2-oxo-1-(tetrahydro-2-thienyl)-1,2-dihydropyrimidin-5-yl]prop-2-en-1-yl]cyclopropanesulfonamide
-
competitive
N-[3-[4-amino-2-oxo-1-(tetrahydro-2-thienyl)-1,2-dihydropyrimidin-5-yl]prop-2-en-1-yl]ethanesulfonamide
-
competitive
N-[3-[4-amino-2-oxo-1-(tetrahydro-2-thienyl)-1,2-dihydropyrimidin-5-yl]prop-2-en-1-yl]methanesulfonamide
-
competitive
N-[3-[4-amino-2-oxo-1-(tetrahydro-2-thienyl)-1,2-dihydropyrimidin-5-yl]prop-2-en-1-yl]propane-1-sulfonamide
-
mixed-type
N-[3-[4-amino-2-oxo-1-(tetrahydrofuran-2-ylmethyl)-1,2-dihydropyrimidin-5-yl]prop-2-en-1-yl]-2,2,2-trifluoroethanesulfonamide
-
competitive
6-(benzylsulfanyl)-2-(2-hydroxyphenyl)-4-oxo-3,4-dihydro-2H-1,3-thiazine-5-carbonitrile
-
at an external concentration of 50 microM, compound is able to inhibit the growth of Escherichia coli in culture for at least six hours
6-(benzylsulfanyl)-2-(2-hydroxyphenyl)-4-oxo-3,4-dihydro-2H-1,3-thiazine-5-carbonitrile
-
-
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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
light
Selective increase in the transcript abundance of GbCMK2 in the radicles by induction of light.
-
methyl jasmonate
Selective increase in the transcript abundance of GbCMK2 in adicles.
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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Malaria
Structure of 4-diphosphocytidyl-2-C- methylerythritol synthetase involved in mevalonate- independent isoprenoid biosynthesis.
Tuberculosis
Crystal structure of 4-diphosphocytidyl-2-C-methyl-d-erythritol kinase (IspE) from Mycobacterium tuberculosis.
Tuberculosis
Crystallization and preliminary X-ray analysis of 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (IspE) from Mycobacterium tuberculosis.
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.2
4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
-
pH not specified in the publication, 22°C
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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.0042
ethyl [4-amino-2-oxo-5-(3-[[(2,2,2-trifluoroethyl)sulfonyl]amino]prop-1-en-1-yl)pyrimidin-1(2H)-yl]acetate
-
competitive inhibition constant
0.0037
N-[3-(4-amino-1-benzyl-2-oxo-1,2-dihydropyrimidin-5-yl)prop-2-en-1-yl]ethanesulfonamide
-
competitive inhibition constant
0.0016
N-[3-[4-amino-2-oxo-1-(1H-pyrazol-5-ylmethyl)-1,2-dihydropyrimidin-5-yl]prop-2-en-1-yl]ethanesulfonamide
-
competitive inhibition constant
0.0012
N-[3-[4-amino-2-oxo-1-(tetrahydro-2-thienyl)-1,2-dihydropyrimidin-5-yl]prop-2-en-1-yl]-1,1,1-trifluoromethanesulfonamide
-
competitive inhibition constant
0.00036
N-[3-[4-amino-2-oxo-1-(tetrahydro-2-thienyl)-1,2-dihydropyrimidin-5-yl]prop-2-en-1-yl]-2,2,2-trifluoroethanesulfonamide
-
competitive inhibition constant
0.0163
N-[3-[4-amino-2-oxo-1-(tetrahydro-2-thienyl)-1,2-dihydropyrimidin-5-yl]prop-2-en-1-yl]benzenesulfonamide
-
competitive inhibition constant
0.00029
N-[3-[4-amino-2-oxo-1-(tetrahydro-2-thienyl)-1,2-dihydropyrimidin-5-yl]prop-2-en-1-yl]cyclopropanesulfonamide
-
competitive inhibition constant
0.00064
N-[3-[4-amino-2-oxo-1-(tetrahydro-2-thienyl)-1,2-dihydropyrimidin-5-yl]prop-2-en-1-yl]ethanesulfonamide
-
competitive inhibition constant
0.0026
N-[3-[4-amino-2-oxo-1-(tetrahydro-2-thienyl)-1,2-dihydropyrimidin-5-yl]prop-2-en-1-yl]methanesulfonamide
-
competitive inhibition constant
0.0082
N-[3-[4-amino-2-oxo-1-(tetrahydro-2-thienyl)-1,2-dihydropyrimidin-5-yl]prop-2-en-1-yl]propane-1-sulfonamide
-
competitive inhibition constant
0.0323
N-[3-[4-amino-2-oxo-1-(tetrahydrofuran-2-ylmethyl)-1,2-dihydropyrimidin-5-yl]prop-2-en-1-yl]-2,2,2-trifluoroethanesulfonamide
-
competitive inhibition constant
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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.009 - 0.018
6-(benzylsulfanyl)-2-(2-hydroxyphenyl)-4-oxo-3,4-dihydro-2H-1,3-thiazine-5-carbonitrile
0.0055
(4E)-3-methyl-4-[(5-phenylfuran-2-yl)methylidene]-1,2-oxazol-5(4H)-one
Escherichia coli
-
pH not specified in the publication, 22°C
0.006
(4E)-3-methyl-4-[(5-phenylfuran-2-yl)methylidene]-1,2-oxazol-5(4H)-one
Yersinia pestis
-
pH not specified in the publication, 22°C
0.007
(4Z)-4-(furan-2-ylmethylidene)-3-phenyl-1,2-oxazol-5(4H)-one
Escherichia coli
-
pH not specified in the publication, 22°C
0.012
(4Z)-4-(furan-2-ylmethylidene)-3-phenyl-1,2-oxazol-5(4H)-one
Yersinia pestis
-
pH not specified in the publication, 22°C
0.008
(4Z)-4-[(5-methylfuran-2-yl)methylidene]-3-phenyl-1,2-oxazol-5(4H)-one
Escherichia coli
-
pH not specified in the publication, 22°C
0.013
(4Z)-4-[(5-methylfuran-2-yl)methylidene]-3-phenyl-1,2-oxazol-5(4H)-one
Yersinia pestis
-
pH not specified in the publication, 22°C
0.009
6-(benzylsulfanyl)-2-(2-hydroxyphenyl)-4-oxo-3,4-dihydro-2H-1,3-thiazine-5-carbonitrile
Yersinia pestis
-
pH not specified in the publication, 22°C
0.018
6-(benzylsulfanyl)-2-(2-hydroxyphenyl)-4-oxo-3,4-dihydro-2H-1,3-thiazine-5-carbonitrile
Escherichia coli
-
pH not specified in the publication, 22°C
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
additional information
-
spectrophotometric and HPLC-based assay development for determination of product ADP with use of pyruvate kinase and L-lactate dehydrogenase as auxiliary enzymes
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
7.5
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TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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pI VALUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
clinical blood samples of Plasmodium vivax positive patients collected from seven malaria endemic geographical regions of India with entirely different topography viz. Delhi (New Delhi), Nadiad (Gujarat), Rourkela (Orissa), Goa (Goa), Mangaluru (Karnataka), Chennai (Tamil Nadu) and Sonapur (Assam)
UniProt
brenda
clinical blood samples of Plasmodium vivax positive patients collected from seven malaria endemic geographical regions of India with entirely different topography viz. Delhi (New Delhi), Nadiad (Gujarat), Rourkela (Orissa), Goa (Goa), Mangaluru (Karnataka), Chennai (Tamil Nadu) and Sonapur (Assam)
UniProt
brenda
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
5 embryos are pooled to prepare a RNA sample, used for complementation assay
brenda
5 embryos are pooled to prepare a RNA sample, used for complementation assay
brenda
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LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE