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Reference on EC 2.7.1.138 - ceramide kinase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Bajjalieh, S.M.; Martin, T.F.J.; Floor, E.
Synaptic vesicle ceramide kinase. A calcium-stimulated lipid kinase that co-purifies with brain synaptic vesicles
J. Biol. Chem.
264
14354-14360
1989
Rattus norvegicus
Manually annotated by BRENDA team
Kolesnick, R.N.; Hemer, M.R.
Characterization of a ceramide kinase activity from human leukemia (HL-60) cells. Separation from diacylglycerol kinase activity
J. Biol. Chem.
265
18803-18808
1990
Homo sapiens
Manually annotated by BRENDA team
Bajjalieh, S.; Batchelor, R.
Ceramide kinase
Methods Enzymol.
311
207-215
2000
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Sugiura, M.; Kono, K.; Liu, H.; Shimizugawa, T.; Minekura, H.; Spiegel, S.; Kohama, T.
Ceramide kinase, a novel lipid kinase. Molecular cloning and functional characterization
J. Biol. Chem.
277
23294-23300
2002
Homo sapiens (Q8TCT0), Homo sapiens
Manually annotated by BRENDA team
Bektas, M.; Jolly, P.S.; Milstien, S.; Spiegel, S.
A specific ceramide kinase assay to measure cellular levels of ceramide
Anal. Biochem.
320
259-265
2003
Homo sapiens (Q8TCT0), Homo sapiens
Manually annotated by BRENDA team
Pettus, B.J.; Bielawska, A.; Spiegel, S.; Roddy, P.; Hannun, Y.A.; Chalfant, C.E.
Ceramide kinase mediates cytokine- and calcium ionophore-induced arachidonic acid release
J. Biol. Chem.
278
38206-38213
2003
Homo sapiens
Manually annotated by BRENDA team
Carre, A.; Graf, C.; Stora, S.; Mechtcheriakova, D.; Csonga, R.; Urtz, N.; Billich, A.; Baumruker, T.; Bornancin, F.
Ceramide kinase targeting and activity determined by its N-terminal pleckstrin homology domain
Biochem. Biophys. Res. Commun.
324
1215-1219
2004
Homo sapiens
Manually annotated by BRENDA team
Yokota, H.; Yatomi, Y.; Mashige, F.; Nakahara, K.
Expression of ceramide kinase in hematopoietic cells
Eur. J. Haematol.
73
307-308
2004
Homo sapiens
Manually annotated by BRENDA team
Kim, T.J.; Mitsutake, S.; Kato, M.; Igarashi, Y.
The leucine 10 residue in the pleckstrin homology domain of ceramide kinase is crucial for its catalytic activity
FEBS Lett.
579
4383-4388
2005
Mus musculus
Manually annotated by BRENDA team
Baumruker, T.; Bornancin, F.; Billich, A.
The role of sphingosine and ceramide kinases in inflammatory responses
Immunol. Lett.
96
175-185
2005
Homo sapiens
Manually annotated by BRENDA team
Mitsutake, S.; Kim, T.J.; Inagaki, Y.; Kato, M.; Yamashita, T.; Igarashi, Y.
Ceramide kinase is a mediator of calcium-dependent degranulation in mast cells
J. Biol. Chem.
279
17570-17577
2004
Mus musculus
Manually annotated by BRENDA team
Mitsutake, S.; Igarashi, Y.
Calmodulin is involved in the Ca2+-dependent activation of ceramide kinase as a calcium-sensor
J. Biol. Chem.
280
40436-40441
2005
Mus musculus
Manually annotated by BRENDA team
Wijesinghe, D.S.; Massiello, A.; Subramanian, P.; Szulc, Z.; Bielawska, A.; Chalfant, C.E.
Substrate specificity of human ceramide kinase
J. Lipid Res.
46
2706-2716
2005
Homo sapiens
Manually annotated by BRENDA team
Van Overloop, H.; Gijsbers, S.; Van Veldhoven, P.P.
Further characterization of mammalian ceramide kinase. Substrate delivery and (stereo)specificity, tissue distribution and subcellular localization studies
J. Lipid Res.
47
268-283
2006
Mus musculus, Rattus norvegicus, Homo sapiens (Q8TCT0), Homo sapiens
Manually annotated by BRENDA team
Kim, T.J.; Mitsutake, S.; Igarashi, Y.
The interaction between the pleckstrin homology domain of ceramide kinase and phosphatidylinositol 4,5-bisphosphate regulates the plasma membrane targeting and ceramide 1-phosphate levels
Biochem. Biophys. Res. Commun.
342
611-617
2006
Homo sapiens
Manually annotated by BRENDA team
Inagaki, Y.; Mitsutake, S.; Igarashi, Y.
Identification of a nuclear localization signal in the retinitis pigmentosa-mutated RP26 protein, ceramide kinase-like protein
Biochem. Biophys. Res. Commun.
343
982-987
2006
Homo sapiens
Manually annotated by BRENDA team
Graf, C.; Rovina, P.; Tauzin, L.; Schanzer, A.; Bornancin, F.
Enhanced ceramide-induced apoptosis in ceramide kinase overexpressing cells
Biochem. Biophys. Res. Commun.
354
309-314
2007
Homo sapiens, Homo sapiens (Q8TCT0)
Manually annotated by BRENDA team
Rovina, P.; Jaritz, M.; Hoefinger, S.; Graf, C.; Devay, P.; Billich, A.; Baumruker, T.; Bornancin, F.
A critical beta6-beta7 loop in the pleckstrin homology domain of ceramide kinase
Biochem. J.
400
255-265
2006
Homo sapiens (Q8TCT0)
Manually annotated by BRENDA team
Van Overloop, H.; Denizot, Y.; Baes, M.; Van Veldhoven, P.P.
On the presence of C2-ceramide in mammalian tissues: possible relationship to etherphospholipids and phosphorylation by ceramide kinase
Biol. Chem.
388
315-324
2007
Homo sapiens
Manually annotated by BRENDA team
Mitra, P.; Maceyka, M.; Payne, S.G.; Lamour, N.; Milstien, S.; Chalfant, C.E.; Spiegel, S.
Ceramide kinase regulates growth and survival of A549 human lung adenocarcinoma cells
FEBS Lett.
581
735-740
2007
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Lamour, N.F.; Stahelin, R.V.; Wijesinghe, D.S.; Maceyka, M.; Wang, E.; Allegood, J.C.; Merrill, A.H.; Cho, W.; Chalfant, C.E.
Ceramide kinase uses ceramide provided by ceramide transport protein: localization to organelles of eicosanoid synthesis
J. Lipid Res.
48
1293-1304
2007
Homo sapiens
Manually annotated by BRENDA team
Don, A.S.; Rosen, H.
A fluorescent plate reader assay for ceramide kinase
Anal. Biochem.
375
265-271
2008
Homo sapiens
Manually annotated by BRENDA team
Graf, C.; Rovina, P.; Bornancin, F.
A secondary assay for ceramide kinase inhibitors based on cell growth inhibition by short-chain ceramides
Anal. Biochem.
384(1)
166-169
2008
Homo sapiens (Q8TCT0)
Manually annotated by BRENDA team
Munagala, N.; Nguyen, S.; Lam, W.; Lee, J.; Joly, A.; McMillan, K.; Zhang, W.
Identification of small molecule ceramide kinase inhibitors using a homogeneous chemiluminescence high throughput assay
Assay Drug Dev. Technol.
5
65-74
2007
Homo sapiens
Manually annotated by BRENDA team
Mitsutake, S.; Yokose, U.; Kato, M.; Matsuoka, I.; Yoo, J.M.; Kim, T.J.; Yoo, H.S.; Fujimoto, K.; Ando, Y.; Sugiura, M.; Kohama, T.; Igarashi, Y.
The generation and behavioral analysis of ceramide kinase-null mice, indicating a function in cerebellar Purkinje cells
Biochem. Biophys. Res. Commun.
363
519-524
2007
Mus musculus
Manually annotated by BRENDA team
Van Overloop, H.; Van Veldhoven, P.P.
Ceramide-dependent release of ceramide kinase from cultured cells
Biochem. Biophys. Res. Commun.
364
169-174
2007
Cricetulus griseus
Manually annotated by BRENDA team
Lidome, E.; Graf, C.; Jaritz, M.; Schanzer, A.; Rovina, P.; Nikolay, R.; Bornancin, F.
A conserved cysteine motif essential for ceramide kinase function
Biochimie
90
1560-1565
2008
Homo sapiens (Q8TCT0), Homo sapiens
Manually annotated by BRENDA team
Kumada, H.; Mitsutake, S.; Inagaki, Y.; Mitsunaga, S.; Tsuchikawa, H.; Katsumura, S.; Igarashi, Y.
Kinetics of the ceramide kinase inhibitor K1, a suppressor of mast-cell activation
Biosci. Biotechnol. Biochem.
71
2581-2584
2007
Rattus norvegicus
Manually annotated by BRENDA team
Lamour, N.F.; Chalfant, C.E.
Ceramide kinase and the ceramide-1-phosphate/cPLA2alpha interaction as a therapeutic target
Curr. Drug Targets
9
674-682
2008
Homo sapiens
Manually annotated by BRENDA team
Saxena, S.; Banerjee, M.; Shirumalla, R.K.; Ray, A.
Ceramide kinase: a potential anti-inflammatory target?
Curr. Opin. Investig. Drugs
9
455-462
2008
Homo sapiens
Manually annotated by BRENDA team
Tsuji, K.; Mitsutake, S.; Yokose, U.; Sugiura, M.; Kohama, T.; Igarashi, Y.
Role of ceramide kinase in peroxisome proliferator-activated receptor beta-induced cell survival of mouse keratinocytes
FEBS J.
275
3815-3826
2008
Mus musculus
Manually annotated by BRENDA team
Date, T.; Mitsutake, S.; Igarashi, Y.
Ceramide kinase expression is altered during macrophage-like cell differentiation of the leukemia cell line HL-60
In Vitro Cell. Dev. Biol. Anim.
43
321-323
2007
Homo sapiens
Manually annotated by BRENDA team
Boath, A.; Graf, C.; Lidome, E.; Ullrich, T.; Nussbaumer, P.; Bornancin, F.
Regulation and traffic of ceramide 1-phosphate produced by ceramide kinase: comparative analysis to glucosylceramide and sphingomyelin
J. Biol. Chem.
283
8517-8526
2008
Mus musculus
Manually annotated by BRENDA team
Graf, C.; Zemann, B.; Rovina, P.; Urtz, N.; Schanzer, A.; Reuschel, R.; Mechtcheriakova, D.; Mueller, M.; Fischer, E.; Reichel, C.; Huber, S.; Dawson, J.; Meingassner, J.G.; Billich, A.; Niwa, S.; Badegruber, R.; Van Veldhoven, P.P.; Kinzel, B.; Baumruker, T.; Bornancin, F.
Neutropenia with impaired immune response to Streptococcus pneumoniae in ceramide kinase-deficient mice
J. Immunol.
180
3457-3466
2008
Mus musculus
Manually annotated by BRENDA team
Hinkovska-Galcheva, V.; Clark, A.; VanWay, S.; Huang, J.B.; Hiraoka, M.; Abe, A.; Borofsky, M.; Kunkel, R.G.; Shanley, T.; Shayman, J.A.; Lanni, F.; Petty, H.R.; Boxer, L.A.
Ceramide kinase promotes Ca2+ signaling near IgG-opsonized targets and enhances phagolysosomal fusion in COS-1 cells
J. Lipid Res.
49
531-542
2008
Homo sapiens
Manually annotated by BRENDA team
Wijesinghe, D.S.; Lamour, N.F.; Gomez-Munoz, A.; Chalfant, C.E.
Ceramide kinase and ceramide-1-phosphate
Methods Enzymol.
434
265-292
2007
Homo sapiens
Manually annotated by BRENDA team
Graf, C.; Klumpp, M.; Habig, M.; Rovina, P.; Billich, A.; Baumruker, T.; Oberhauser, B.; Bornancin, F.
Targeting ceramide metabolism with a potent and specific ceramide kinase inhibitor
Mol. Pharmacol.
74
925-932
2008
Homo sapiens
Manually annotated by BRENDA team
Rovina, P.; Schanzer, A.; Graf, C.; Mechtcheriakova, D.; Jaritz, M.; Bornancin, F.
Subcellular localization of ceramide kinase and ceramide kinase-like protein requires interplay of their Pleckstrin Homology domain-containing N-terminal regions together with C-terminal domains
Biochim. Biophys. Acta
1791
1023-1030
2009
Homo sapiens (Q8TCT0)
Manually annotated by BRENDA team
Shimizu, M.; Tada, E.; Makiyama, T.; Yasufuku, K.; Moriyama, Y.; Fujino, H.; Nakamura, H.; Murayama, T.
Effects of ceramide, ceramidase inhibition and expression of ceramide kinase on cytosolic phospholipase A2alpha; additional role of ceramide-1-phosphate in phosphorylation and Ca2+ signaling
Cell. Signal.
21
440-447
2009
Homo sapiens
Manually annotated by BRENDA team
Ruckhaeberle, E.; Karn, T.; Rody, A.; Hanker, L.; Gaetje, R.; Metzler, D.; Holtrich, U.; Kaufmann, M.
Gene expression of ceramide kinase, galactosyl ceramide synthase and ganglioside GD3 synthase is associated with prognosis in breast cancer
J. Cancer Res. Clin. Oncol.
135
1005-1013
2009
Homo sapiens
Manually annotated by BRENDA team
Murakami, M.; Ito, H.; Hagiwara, K.; Yoshida, K.; Sobue, S.; Ichihara, M.; Takagi, A.; Kojima, T.; Tanaka, K.; Tamiya-Koizumi, K.; Kyogashima, M.; Suzuki, M.; Banno, Y.; Nozawa, Y.; Murate, T.
ATRA inhibits ceramide kinase transcription in a human neuroblastoma cell line, SH-SY5Y cells: The role of COUP-TFI
J. Neurochem.
112
511-520
2010
Homo sapiens (Q8TCT0), Homo sapiens
Manually annotated by BRENDA team
Chen, W.Q.; Graf, C.; Zimmel, D.; Rovina, P.; Krapfenbauer, K.; Jaritz, M.; Parker, P.J.; Lubec, G.; Bornancin, F.
Ceramide kinase profiling by mass spectrometry reveals a conserved phosphorylation pattern downstream of the catalytic site
J. Proteome Res.
9
420-429
2010
Homo sapiens (Q8TCT0)
Manually annotated by BRENDA team
Niwa, S.; Graf, C.; Bornancin, F.
Ceramide kinase deficiency impairs microendothelial cell angiogenesis in vitro
Microvasc. Res.
77
389-393
2009
Mus musculus
Manually annotated by BRENDA team
Dasgupta, U.; Bamba, T.; Chiantia, S.; Karim, P.; Tayoun, A.N.; Yonamine, I.; Rawat, S.S.; Rao, R.P.; Nagashima, K.; Fukusaki, E.; Puri, V.; Dolph, P.J.; Schwille, P.; Acharya, J.K.; Acharya, U.
Ceramide kinase regulates phospholipase C and phosphatidylinositol 4, 5, bisphosphate in phototransduction
Proc. Natl. Acad. Sci. USA
106
20063-20068
2009
Drosophila melanogaster
Manually annotated by BRENDA team
Bini, F.; Frati, A.; Garcia-Gil, M.; Battistini, C.; Granado, M.; Martinesi, M.; Mainardi, M.; Vannini, E.; Luzzati, F.; Caleo, M.; Peretto, P.; Gomez-Munoz, A.; Meacci, E.
New signalling pathway involved in the anti-proliferative action of vitamin D3 and its analogues in human neuroblastoma cells. A role for ceramide kinase
Neuropharmacology
63
524-537
2012
Homo sapiens (Q8TCT0), Homo sapiens
Manually annotated by BRENDA team
Mitsutake, S.; Kumada, H.; Soga, M.; Hurue, Y.; Asanuma, F.; Nagira, M.; Deguchi, M.; Date, T.; Yokose, U.; Inagaki, Y.; Sugiura, M.; Kohama, T.; Igarashi, Y.
Ceramide kinase is not essential but might act as an Ca2+-sensor for mast cell activation
Prostaglandins Other Lipid Mediat.
93
109-112
2010
Mus musculus (Q8K4Q7)
Manually annotated by BRENDA team
Payne, A.W.; Pant, D.K.; Pan, T.C.; Chodosh, L.A.
Ceramide kinase promotes tumor cell survival and mammary tumor recurrence
Cancer Res.
74
6352-6363
2014
Homo sapiens (Q8TCT0), Homo sapiens
Manually annotated by BRENDA team
Pastukhov, O.; Schwalm, S.; Roemer, I.; Zangemeister-Wittke, U.; Pfeilschifter, J.; Huwiler, A.
Ceramide kinase contributes to proliferation but not to prostaglandin E2 formation in renal mesangial cells and fibroblasts
Cell. Physiol. Biochem.
34
119-133
2014
Rattus norvegicus (D3Z9Y3), Mus musculus (Q8K4Q7)
Manually annotated by BRENDA team
Mietla, J.A.; Wijesinghe, D.S.; Hoeferlin, L.A.; Shultz, M.D.; Natarajan, R.; Fowler, A.A.; Chalfant, C.E.
Characterization of eicosanoid synthesis in a genetic ablation model of ceramide kinase
J. Lipid Res.
54
1834-1847
2013
Mus musculus (Q8K4Q7), Mus musculus, Mus musculus BALB/c (Q8K4Q7)
Manually annotated by BRENDA team
Wijesinghe, D.S.; Brentnall, M.; Mietla, J.A.; Hoeferlin, L.A.; Diegelmann, R.F.; Boise, L.H.; Chalfant, C.E.
Ceramide kinase is required for a normal eicosanoid response and the subsequent orderly migration of fibroblasts
J. Lipid Res.
55
1298-1309
2014
Mus musculus (Q8K4Q7), Homo sapiens (Q8TCT0), Homo sapiens, Mus musculus BALB/c (Q8K4Q7)
Manually annotated by BRENDA team
Simanshu, D.K.; Kamlekar, R.K.; Wijesinghe, D.S.; Zou, X.; Zhai, X.; Mishra, S.K.; Molotkovsky, J.G.; Malinina, L.; Hinchcliffe, E.H.; Chalfant, C.E.; Brown, R.E.; Patel, D.J.
Non-vesicular trafficking by a ceramide-1-phosphate transfer protein regulates eicosanoids
Nature
500
463-467
2013
Homo sapiens (Q8TCT0), Homo sapiens
Manually annotated by BRENDA team
Yu, J.; Kim, H.M.; Kim, K.P.; Son, Y.; Kim, M.S.; Park, K.S.
Ceramide kinase regulates the migration of bone marrow-derived mesenchymal stem cells
Biochem. Biophys. Res. Commun.
508
361-367
2019
Mus musculus (Q8K4Q7)
Manually annotated by BRENDA team
Hori, M.; Gokita, M.; Yasue, M.; Honda, T.; Kohama, T.; Mashimo, M.; Nakamura, H.; Murayama, T.
Down-regulation of ceramide kinase via proteasome and lysosome pathways in PC12 cells by serum withdrawal its protection by nerve growth factor and role in exocytosis
Biochim. Biophys. Acta
1867
118714
2020
Homo sapiens (Q8TCT0)
Manually annotated by BRENDA team
Won, J.H.; Kim, S.K.; Shin, I.C.; Ha, H.C.; Jang, J.M.; Back, M.J.; Kim, D.K.
Dopamine transporter trafficking is regulated by neutral sphingomyelinase 2/ceramide kinase
Cell. Signal.
44
171-187
2018
Mus musculus (Q8K4Q7), Mus musculus, Mus musculus C57BL/6 (Q8K4Q7)
Manually annotated by BRENDA team
Kukreti, H.; Amuthavalli, K.
MicroRNA-34a causes ceramide accumulation and effects insulin signaling pathway by targeting ceramide kinase (CERK) in aging skeletal muscle
J. Cell. Biochem.
121
3070-3089
2020
Mus musculus (Q8K4Q7), Mus musculus, Mus musculus C57BL/6J (Q8K4Q7)
Manually annotated by BRENDA team
Newcomb, B.; Rhein, C.; Mileva, I.; Ahmad, R.; Clarke, C.J.; Snider, J.; Obeid, L.M.; Hannun, Y.A.
Identification of an acid sphingomyelinase ceramide kinase pathway in the regulation of the chemokine CCL5
J. Lipid Res.
59
1219-1229
2018
Homo sapiens (Q8TCT0)
Manually annotated by BRENDA team
Yang, Y.B.; Yin, J.; Huang, L.Q.; Li, J.; Chen, D.K.; Yao, N.
Salt enhances disease resistance and suppresses cell death in ceramide kinase mutants
Plant Physiol.
181
319-331
2019
Arabidopsis thaliana (Q6USK2)
Manually annotated by BRENDA team