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Information on EC 2.7.1.137 - phosphatidylinositol 3-kinase and Organism(s) Drosophila melanogaster and UniProt Accession P91634

for references in articles please use BRENDA:EC2.7.1.137
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EC Tree
IUBMB Comments
One mammalian isoform is known.
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This record set is specific for:
Drosophila melanogaster
UNIPROT: P91634
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Word Map
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The taxonomic range for the selected organisms is: Drosophila melanogaster
The enzyme appears in selected viruses and cellular organisms
Synonyms
pi3k, phosphatidylinositol 3-kinase, pi3 kinase, vps34, phosphoinositide-3-kinase, phosphatidylinositol 3 kinase, ptdins 3-kinase, pik3c3, phosphatidylinositide 3-kinase, hvps34, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phosphoinositide 3-kinase Dp110
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kinase (phosphorylating), phosphatidylinositol 3-
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-
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kinase, phosphatidylinositol 3- (phosphorylating)
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-
-
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p85/p110 phosphoinositide 3-kinase
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-
-
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phosphatidylinositol 3'-kinase
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-
-
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phosphatidylinositol 3-kinase
-
-
-
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phosphoinositide 3'-kinase
-
-
-
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phosphoinositide 3-kinase
-
-
-
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PI 3-kinase
-
-
-
-
PI3K
-
-
-
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PtdIns 3'-kinase
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
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-
-
-
PATHWAY SOURCE
PATHWAYS
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-
SYSTEMATIC NAME
IUBMB Comments
ATP:1-phosphatidyl-1D-myo-inositol 3-phosphotransferase
One mammalian isoform is known.
CAS REGISTRY NUMBER
COMMENTARY hide
115926-52-8
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
show the reaction diagram
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
show the reaction diagram
ATP + phosphatidylinositol 4-phosphate
ADP + phosphatidylinositol 3,4-bisphosphate
show the reaction diagram
-
-
-
?
additional information
?
-
role for Dp110 in growth control during Drosophila development
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-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
additional information
?
-
role for Dp110 in growth control during Drosophila development
-
-
?
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Wortmannin
IC50 10 nM
IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.00001
Wortmannin
Drosophila melanogaster
IC50 10 nM
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
P91634_DROME
1088
0
127006
TrEMBL
other Location (Reliability: 2)
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expression of the complete coding sequence as a glutathione S-transferase fusion protein in Sf9 cells
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Vanhaesebroeck, B.; Leevers, S.J.; Ahmadi, K.; Timms, J.; Katso, R.; Driscoll, P.C.; Woscholski, R.; Parker, P.J.; Waterfield, M.D.
Synthesis and function of 3-phosphorylated inositol lipids
Annu. Rev. Biochem.
70
535-602
2001
Caenorhabditis elegans, Dictyostelium discoideum, Drosophila melanogaster
Manually annotated by BRENDA team
Molz, L.; Chen, Y.W.; Hirano, M.; Williams, L.T.
CpK is a novel class of Drosophila PtdIns 3-kinase containing a C2 domain
J. Biol. Chem.
271
13892-13899
1996
Drosophila sp. (in: flies), Drosophila melanogaster (Q9VTN5)
Manually annotated by BRENDA team
Leevers, S.J.; Weinkove, D.; MacDougall, L.K.; Hafen, E.; Waterfield, M.D.
The Drosophila phosphoinositide 3-kinase Dp110 promotes cell growth
EMBO J.
15
6584-6594
1996
Drosophila melanogaster (P91634)
Manually annotated by BRENDA team
Linassier, C.; MacDougall, L.K.; Domin, J.; Waterfield, M.D.
Molecular cloning and biochemical characterization of a Drosophila phosphatidylinositol-specific phosphoinositide 3-kinase
Biochem. J.
321
849-856
1997
Drosophila melanogaster (P91635)
-
Manually annotated by BRENDA team
MacDougall, L.K.; Domin, J.; Waterfield, M.D.
A family of phosphoinositide 3-kinases in Drosophila identifies a new mediator of signal transduction
Curr. Biol.
5
1404-1415
1995
Drosophila melanogaster (Q9VTN5)
Manually annotated by BRENDA team