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Information on EC 2.7.1.137 - phosphatidylinositol 3-kinase and Organism(s) Mus musculus and UniProt Accession P42337

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IUBMB Comments
One mammalian isoform is known.
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Select one or more organisms in this record:
This record set is specific for:
Mus musculus
UNIPROT: P42337
Word Map
The taxonomic range for the selected organisms is: Mus musculus
The enzyme appears in selected viruses and cellular organisms
Synonyms
pi3k, pi3 kinase, vps34, phosphoinositide-3-kinase, ptdins 3-kinase, phosphatidylinositol 3 kinase, phosphatidylinositide 3-kinase, pik3c3, hvps34, class iii pi3k, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
class III phosphoinositide 3-kinase
306015
-
kinase (phosphorylating), phosphatidylinositol 3-
-
-
-
-
kinase, phosphatidylinositol 3- (phosphorylating)
-
-
-
-
mammalian vacuolar protein sorting 34 homologue
306015
-
p85/p110 phosphoinositide 3-kinase
-
-
-
-
phosphatidylinositide 3-kinase C2alpha
244
-
phosphatidylinositol 3'-kinase
-
-
-
-
phosphatidylinositol 3-kinase
-
-
-
-
phosphoinositide 3'-kinase
-
-
-
-
phosphoinositide 3-kinase
phosphoinositide 3-kinase gamma
244
-
PI 3-kinase
PI3 kinase
244
-
PI3Kalpha
244
-
PI3Kbeta
244
-
PI3Kgamma
244
-
PIK3C3
306015
-
PtdIns 3'-kinase
-
-
-
-
PtdIns 3-kinase
244
-
VPS34
306015
-
additional information
244
the phosphatidylinositol 3-kinase, PI3K, family is a family of conserved lipid and protein kinases that are ubiquitously expressed in many cells, including the heart
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
-
-
-
-
PATHWAY SOURCE
PATHWAYS
SYSTEMATIC NAME
IUBMB Comments
ATP:1-phosphatidyl-1D-myo-inositol 3-phosphotransferase
One mammalian isoform is known.
CAS REGISTRY NUMBER
COMMENTARY hide
115926-52-8
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
show the reaction diagram
-
-
?
ATP + 1,2-dibutanoylphosphatidylinositol 4,5-diphosphate
ADP + 1,2-dibutanoylphosphatidylinositol 3,4,5-trisphosphate
show the reaction diagram
-
-
-
-
?
ATP + 1,2-dioctanoylphosphatidylinositol 4,5-diphosphate
ADP + 1,2-dioctanoylphosphatidylinositol 3,4,5-trisphosphate
show the reaction diagram
-
-
-
-
?
ATP + 1-O-octadecyl-2-O-methyl-rac-3-glycerophospho-myo-inositol
ADP + ?
show the reaction diagram
-
-
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol
ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
show the reaction diagram
-
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
show the reaction diagram
ATP + phosphatidylinositol-4,5-bisphosphate
ADP + phosphatidylinositol-3,4,5-trisphosphate
show the reaction diagram
-
-
-
-
?
ATP + phosphatidylinositol-4-phosphate
ADP + phosphatidylinositol-3,4-bisphosphate
show the reaction diagram
-
-
-
-
?
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + 1-phosphatidyl-1D-myo-inositol
ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
show the reaction diagram
-
-
-
-
?
ATP + phosphatidylinositol-4,5-bisphosphate
ADP + phosphatidylinositol-3,4,5-trisphosphate
show the reaction diagram
-
-
-
-
?
ATP + phosphatidylinositol-4-phosphate
ADP + phosphatidylinositol-3,4-bisphosphate
show the reaction diagram
-
-
-
-
?
additional information
?
-
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(+/-)-2-[hydroxy[tetrahydro-2-(octadecyloxy)methylfuran-2-yl]methoxyl]phosphinyloxy-N,N,N-trimethylethaniminium hydroxide
-
-
(1E,4S,4aR,5R,6aS,7S)-5-(Acetyloxy)-1-{[[3-(dimethylamino)propyl](methyl)amino]methylene}-11-hydroxy-4-(methoxymethyl)-4a,6a-dimethyl-2,10-dioxo-1,2,4,4a,5,6,6a,7,8,9,9a,10-dodecahydroindeno[4,5-h]isochromen-7-yl-(1R,2R,4S)-4-{(2R)-2-[(3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,27-dihydroxy-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-1,5,11,28,29-pentaoxo-1,4,5,6,9,10,11,12,13,14,21,22,23,24,25,26,27,28,29,31,32,33,34,34a-tetracosahydro-3H-23,27-epoxypyrido[2,1-c][1,4]oxazacyclohentriacontin
-
-
-
(1E,4S,4aR,5R,6aS,7S,9aR)-1-({[3-(dimethylamino)propyl](methyl)amino}methylidene)-7,11-dihydroxy-4-(methoxymethyl)-4a,6a,9a-trimethyl-2,10-dioxo-1,2,4,4a,5,6,6a,7,8,9,9a,10-dodecahydroindeno[4,5-h]isochromen-5-yl acetate
-
-
(3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,27-dihydroxy-3-{(2R)-1-[(1S,3R)-3-hydroxycyclohexyl]propan-2-yl}-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-hexadecahydro-3H-23,27-epoxypyrido[2,1-c][1,4]oxazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone
-
-
1-O-octadecyl-2-O-methyl-rac-3-glycerophospho-myo-inositol
-
-
1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine
-
noncompetitive with ATP
17-hydroxywortmannin
-
-
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one
-
i.e. LY294002
3-Methyladenine
-
treatment in full medium for a prolonged period of time leads to marked increases of the autophagic markers in cells. The increase of autophagic markers is the result of enhanced autophagic flux. The autophagy promotion activity is due to its differential temporal effects on class I and class III PI3K enzymes. 3-Methyladenine blocks class I PI3K persistently, whereas its suppressive effect on class III PI3K is transient. Treatment with 3-methyladenine in full medium significantly reduces the level of phosphatidylinositol 3-phosphate, the product of class III PI3K, at early time points, but almost completely blocks the product of phosphatidylinositol 3,4,5-trisphosphate up to 9 h
EDTA
-
-
hexadecylphosphocholine
-
-
LY294002
PI3Kalpha inhibitor IV
-
-
-
PI3Kbeta inhibitor VI
-
i.e. TGX-221
-
PI3Kgamma inhibitor
-
-
-
PWT-458
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i.e. poly(oxy-1,2-ethanediyl)-, R-[2-[[2-[[(1S,6bR,9S,9aS,11R,11bR)-11-(acetyloxy)-1,6,6b,7,8,9,9a,10,11,11b-decahydro-1-(methoxymethyl)-9a,11b-dimethyl-3,6-dioxo-3Hfuro[4,3,2-de]indeno[4,5-h]-2-benzopyran-9-yl]oxy]-2-oxoethyl]thio]ethyl]-omega-methoxy
PX-866
-
i.e. acetic acid 4-diallylaminomethylene-6-hydroxy-1-alpha-methoxymethyl-10beta,13beta-dimethyl-3,7,17-trioxo-1,3,4,7,10,11beta,12,13,14alpha,15,16,17-dodecahydro-2-oxacyclopenta[a]phenanthren-11-yl ester
staurosporine
-
-
Wortmannin
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
activated PDGFRbeta
-
PI3K binding to the cytoplasmic domain of activated PDGFRbeta receptors requires phosphorylation at residues 739 and 750 and this interaction in turn activates the kinase
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G-protein betagamma subunits
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betagamma subunits of heterotrimeric G-protein
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low density lipoprotein receptor-related protein 1
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LRP1, positively regulates PI3K activation. LRP1-deficient smooth muscle cells show disorganized actin in the form of membrane ruffling and enhanced cell migration, and show abnormal activation of TGFbeta signaling
-
pioglitazone
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a thiazolidinedione, activates PI3K 2-2.5fold at 0.002-0.010 mM, activates adiponectin secretion from adipocytes in vivo
additional information
-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.05
1,2-dioctanoylphosphatidylinositol 4,5-diphosphate
-
pH 7.4, recombinant enzyme
0.035
ATP
-
pH 7.4, recombinant enzyme
Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0056
LY294002
-
pH 7.4, recombinant enzyme
0.0038
staurosporine
-
pH 7.4, recombinant enzyme
IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.000012
Wortmannin
Mus musculus
-
specific irreversible inhibition, binds covalently to the active site, mixed type inhibition, IC50 is 12 nM
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
-
assay method development and optimization, phosphoinositide quantification via labeled and/or tagged ligands binding to the pleckstrin homology PH domain of the recombinant enzyme in competition with phosphoinositides, overview
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7.4
-
assay at
7.5
-
kinase assay at
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
30
-
kinase assay at
37
-
assay at
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
SwissProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
microglial cell
Manually annotated by BRENDA team
the regulatory subunit p87PIKAP and the catalytic subunit p101 are both expressed
Manually annotated by BRENDA team
isoform P110d
Manually annotated by BRENDA team
-
,sympathetic superior cervical ganglia and sensory trigeminal ganglia. In cultured sympathetic superior cervical ganglia and dorsal root ganglia neurons, p110a, b, and g immunoreactivity is in the sympathetic superior cervical ganglia and DRG growth cones, and predominantly in puncta throughout the growth cone varicosity
Manually annotated by BRENDA team
-
IL-3-dependent FDCP-1/Mac-1 murine hemopoietic progenitors
Manually annotated by BRENDA team
-
a primary cell type in the liver responsible for excess collagen deposition during fibrosis
Manually annotated by BRENDA team
a N-terminal truncated form is found in lung
Manually annotated by BRENDA team
the regulatory subunit p87PIKAP and the catalytic subunit p101 are both expressed
Manually annotated by BRENDA team
-
primary
Manually annotated by BRENDA team
-
insulinoma cell
Manually annotated by BRENDA team
-
of obese diabetic mouse
Manually annotated by BRENDA team
-
isozyme phosphatidylinositol 3-kinase gamma
Manually annotated by BRENDA team
the regulatory subunit p87PIKAP and the catalytic subunit p101 are both expressed
Manually annotated by BRENDA team
-
the phosphatidylinositol 3-kinase-mediated production of interferon-beta is critical for the lipopolysaccharide inhibition of osteoclastogenesis
Manually annotated by BRENDA team
-
T cell line CTLL-2
Manually annotated by BRENDA team
additional information
-
the phosphatidylinositol 3-kinase, PI3K, family is a family of conserved lipid and protein kinases that are ubiquitously expressed in many cells, including the heart
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
-
p110a is localized predominantly at the plasma membrane, while p110b and g is localized in the perinuclear region of the cells
-
Manually annotated by BRENDA team
colocalization with synaptic marker, synaptophysin at day 21 in vitro
Manually annotated by BRENDA team
additional information
-
actin filaments facilitate the insulin-mediated association of the p85-p110 PI 3-kinase with glucose-transporter-containing compartments
-
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
enzyme PIK3C3 plays a role, such as endocytic trafficking, in synapses
malfunction
physiological function
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
Sequence
PK3CA_MOUSE
1068
0
124412
Swiss-Prot
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
85000
1 * 85000 + 1 * 110000; 85000 Da subunit, previously thought to have only a linking role in localizing the p110 catalytic subunit, is an important component of the catalytic complex
110000
1 * 85000 + 1 * 110000
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
dimer
1 * 85000 + 1 * 110000
additional information
85000 Da subunit, previously thought to have only a linking role in localizing the p110 catalytic subunit, is an important component of the catalytic complex
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phosphoprotein
CRYSTALLIZATION/commentary
ORGANISM
UNIPROT
LITERATURE
vapor diffusion hanging drop method. Crystal structure of the C2 domain
-
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
PURIFICATION/commentary
ORGANISM
UNIPROT
LITERATURE
recombinant GRP1 domain, comprising residues 263-380, from Escherichia coli by glutathione affinity chromatography
-
CLONED/commentary
ORGANISM
UNIPROT
LITERATURE
cloning, structural organization, and chromosomal localization of the mouse PI3-kinase p110a gene
-
expression of the GRP1 domain, comprising residues 263-380, in Escherichia coli
-
expression of wild-type and mutant HA-tagged PI3K isozyme gamma and of subunit p110 in COS-7 cells, stimulation of the protein kinases Erk, JNK, and PKB
-
PI 3-kinase p170
-
PI3K-C2 gamma gene locus is mapped to the distal region of mouse chromosome 6 in a region of homology with human chromosome 12p
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
drug development
-
reduction of PI3K/PKCdelta activity represents a therapeutic target to downregulate adhesion molecule L1, CHL1, expression and thus benefit axonal regeneration after spinal cord injury
medicine
-
preclinical evidence for the in vivo efficacy for the phosphatidylinositol 3-kinase inhibitor LY294002 in the treatment of follicular thyroid cancer
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Aksoy, I.A.; Ramsey, M.J.; Fruman, D.A.; Aksoy, S.; Cantley, L.C.; Tucker, J.D.; Roberts, T.M.
Mouse Phosphoinositide 3-Kinase p110a Gene: Cloning, Structural Organization, and Localization to Chromosome 3 Band B
Biochem. Biophys. Res. Commun.
262
438-442
1999
Mus musculus
Manually annotated by BRENDA team
Bartlett, S.E.; Reynolds, A.J.; Tan, T.; Heydon, K.; Hendry, I.A.
Differential mRNA expression and subcellular locations of PI3-kinase isoforms in sympathetic and sensory neurons
J. Neurosci. Res.
56
44-53
1999
Mus musculus
Manually annotated by BRENDA team
Berggren, M.I.; Gallegos, A.; Dressler, L.A.; Modest, E.J.; Powis, G.
Inhibition of the signalling enzyme phosphatidylinositol-3-kinase by antitumor ether lipid analogs
Cancer Res.
53
4297-4302
1993
Bos taurus, Mus musculus
Manually annotated by BRENDA team
Cataldi, A.; Di Pietro, R.; Centurione, L.; Grilli, A.; Cutroneo, G.; Miscia, S.
Phosphatidylinositol-3-kinase activation and atypical protein kinase C z phosphorylation characterize the DMSO signaling in erythroleukemia cells
Cell. Signal.
12
667-672
2000
Mus musculus
Manually annotated by BRENDA team
Chantry, D.; Vojtek, A.; Kashishian, A.; Holtzman, D.A.; Wood, C.; Gray, P.W.; Cooper, J.A.; Hoekstra, M.F.
p110delta, a novel phosphatidylinositol 3-kinase catalytic subunit that associates with p85 and is expressed predominantly in leukocytes
J. Biol. Chem.
272
19236-19241
1997
Homo sapiens, Homo sapiens (O00329), Mus musculus, Mus musculus (O35940)
Manually annotated by BRENDA team
Domin, J.; Dhand, R.; Waterfield, M.D.
Binding to the platelet-derived growth factor receptor transiently activates the p85a-p110a phosphoinositide 3-kinase complex in vivo
J. Biol. Chem.
271
21614-21621
1996
Mus musculus
Manually annotated by BRENDA team
Karnitz, L.M.; Sutor, S.L.; Abraham, R.T.
The Src-Family Kinase, Fyn, Regulates the Activation of Phosphatidylinositol 3-Kinase in an Interleukin 2-responsive T cell Line
J. Exp. Med.
179
1799-1808
1994
Mus musculus
Manually annotated by BRENDA team
Kerouz, N.J.; Horsch, D.; Pons, S.; Kahn, C.R.
Differential regulation of insulin receptor substrates-1 and -2 (IRS-1 and IRS-2) and phosphatidylinositol 3-kinase isoforms in liver and muscle of the obese diabetic (ob/ob) mouse
J. Clin. Invest.
100
3164-3172
1997
Mus musculus
Manually annotated by BRENDA team
Khan, F.A.; Goforth, P.B.; Zhang, M.; Satin, L.S.
Insulin activates ATP-sensitive K+ channels in pancreatic b-cells through a phosphatidylinositol 3-kinase-dependent pathway
Diabetes
50
2192-2198
2001
Mus musculus
Manually annotated by BRENDA team
Le Marchand-Brustel, Y.; Heydrick, S.J.; Jullien, D.; Gautier, N.; Van Obberghen, E.
Effect of insulin and insulin-like growth factor-I on glucose transport and its transporters in soleus muscle of lean and obese mice
Metab. Clin. Exp.
44
18-23
1995
Mus musculus
Manually annotated by BRENDA team
Lu, P.J.; Hsu, A.L.; Wang, D.S.; Yan, H.Y.; Yin, H.L.; Chen, C.S.
Phosphoinositide 3-kinase in rat liver nuclei
Biochemistry
37
5738-5745
1998
Mus musculus
Manually annotated by BRENDA team
Mauvais-Jarvis, F.; Ueki, K.; Fruman, D.A.; Hirshman, M.F.; Sakamoto, K.; Goodyear, L.J.; Iannacone, M.; Accili, D.; Cantley, L.C.; Kahn, C.R.
Reduced expression of the murine p85a subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes
J. Clin. Invest.
109
141-149
2002
Mus musculus
Manually annotated by BRENDA team
Minshall, C.; Arkins, S.; Freund, G.G.; Kelley, K.W.
Requirement for phosphatidylinositol 3'-kinase to protect hemopoietic progenitors against apoptosis depends upon the extracellular survival factor
J. Immunol.
156
939-947
1996
Mus musculus
Manually annotated by BRENDA team
Miyakawa, Y.; Rojnuckarin, P.; Habib, T.; Kaushansky, K.
Thrombopoietin induces phosphoinositol 3-kinase activation through SHP2, Gab, and insulin receptor substrate proteins in BAF3 cells and primary murine megakaryocytes
J. Biol. Chem.
276
2494-2502
2001
Mus musculus
Manually annotated by BRENDA team
Virbasius, J.V.; Guilherme, A.; Czech, M.P.
Mouse p170 is a novel phosphatidylinositol 3-kinase containing a C2 domain
J. Biol. Chem.
271
13304-13307
1996
Mus musculus
Manually annotated by BRENDA team
Wang, D.; Sul, H.S.
Insulin stimulation of the fatty acid synthase promoter is mediated by the phosphatidylinositol 3-kinase pathway. Involvement of protein kinase B/Akt
J. Biol. Chem.
273
25420-25426
1998
Mus musculus
Manually annotated by BRENDA team
Wang, Q.; Bilan, P.J.; Tsakiridis, T.; Hinek, A.; Klip, A.
Actin filaments participate in the relocalization of phosphatidylinositol 3-kinase to glucose transporter-containing compartments and in the stimulation of glucose uptake in 3T3-L1 adipocytes
Biochem. J.
331
917-928
1998
Mus musculus
-
Manually annotated by BRENDA team
Yang, J.; Clarke, J.F.; Ester, C.J.; Young, P.W.; Kasuga, M.; Holman, G.D.
Phosphatidylinositol 3-kinase acts at an intracellular membrane site to enhance GLUT4 exocytosis in 3T3-L1 cells
Biochem. J.
313
125-131
1996
Mus musculus
-
Manually annotated by BRENDA team
Klippel, A.; Escobedo, J.A.; Hirano, M.; Williams, L.T.
The interaction of small domains between the subunits of phosphatidylinositol 3-kinase determines enzyme activity
Mol. Cell. Biol.
14
2675-2685
1994
Mus musculus, Mus musculus (P42337)
Manually annotated by BRENDA team
Misawa, H.; Ohtsubo, M.; Copeland, N.G.; Gilbert, D.J.; Jenkins, N.A.; Yoshimura, A.
Cloning and characterization of a novel class II phosphoinositide 3-kinase containing C2 domain
Biochem. Biophys. Res. Commun.
244
531-539
1998
Mus musculus, Mus musculus (O70167)
Manually annotated by BRENDA team
Pietrucha, R.; Rubio, I.; Wymann, M.P.; Wetzker, R.
Phosphoinositide 3-kinase gamma mediates Jun kinase activation via its lipid-kinase activity
Adv. Enzyme Regul.
44
299-308
2004
Mus musculus
Manually annotated by BRENDA team
Gray, A.; Olsson, H.; Batty, I.H.; Priganica, L.; Peter Downes, C.
Nonradioactive methods for the assay of phosphoinositide 3-kinases and phosphoinositide phosphatases and selective detection of signaling lipids in cell and tissue extracts
Anal. Biochem.
313
234-245
2003
Mus musculus
Manually annotated by BRENDA team
El-Kholy, W.; Macdonald, P.E.; Lin, J.H.; Wang, J.; Fox, J.M.; Light, P.E.; Wang, Q.; Tsushima, R.G.; Wheeler, M.B.
The phosphatidylinositol 3-kinase inhibitor LY294002 potently blocks K(V) currents via a direct mechanism
FASEB J.
17
720-722
2003
Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Liu, L.; Song, X.; He, D.; Komma, C.; Kita, A.; Virbasius, J.V.; Huang, G.; Bellamy, H.D.; Miki, K.; Czech, M.P.; Zhou, G.W.
Crystal structure of the C2 domain of class II phosphatidylinositide 3-kinase C2alpha
J. Biol. Chem.
281
4254-4260
2006
Mus musculus
Manually annotated by BRENDA team
Voigt, P.; Dorner, M.B.; Schaefer, M.
Characterization of p87PIKAP, a novel regulatory subunit of phosphoinositide 3-kinase gamma that is highly expressed in heart and interacts with PDE3B
J. Biol. Chem.
281
9977-9986
2006
Mus musculus (Q3U6Q4)
Manually annotated by BRENDA team
O'Connor, J.C.; Sherry, C.L.; Guest, C.B.; Freund, G.G.
Type 2 diabetes impairs insulin receptor substrate-2-mediated phosphatidylinositol 3-kinase activity in primary macrophages to induce a state of cytokine resistance to IL-4 in association with overexpression of suppressor of cytokine signaling-3
J. Immunol.
178
6886-6893
2007
Mus musculus
Manually annotated by BRENDA team
Tang, C.H.; Lu, D.Y.; Yang, R.S.; Tsai, H.Y.; Kao, M.C.; Fu, W.M.; Chen, Y.F.
Leptin-induced IL-6 production is mediated by leptin receptor, insulin receptor substrate-1, phosphatidylinositol 3-kinase, Akt, NF-kappaB, and p300 pathway in microglia
J. Immunol.
179
1292-1302
2007
Mus musculus
Manually annotated by BRENDA team
Furuya, F.; Lu, C.; Willingham, M.C.; Cheng, S.Y.
Inhibition of phosphatidylinositol 3-kinase delays tumor progression and blocks metastatic spread in a mouse model of thyroid cancer
Carcinogenesis
28
2451-2458
2007
Mus musculus
Manually annotated by BRENDA team
Kim, J.H.; Na, H.J.; Kim, C.K.; Kim, J.Y.; Ha, K.S.; Lee, H.; Chung, H.T.; Kwon, H.J.; Kwon, Y.G.; Kim, Y.M.
The non-provitamin A carotenoid, lutein, inhibits NF-kappaB-dependent gene expression through redox-based regulation of the phosphatidylinositol 3-kinase/PTEN/Akt and NF-kappaB-inducing kinase pathways: Role of H2O2 in NF-kappaB activation
Free Radic. Biol. Med.
45
885-896
2008
Mus musculus
Manually annotated by BRENDA team
Lee, Y.; Huang, H.; Kim, H.J.; Park, C.K.; Kim, H.H.
The phosphatidylinositol 3-kinase-mediated production of interferon-beta is critical for the lipopolysaccharide inhibition of osteoclastogenesis
Life Sci.
83
369-376
2008
Mus musculus
Manually annotated by BRENDA team
Lee, S.A.; Park, S.H.; Kim, B.C.
Raloxifene, a selective estrogen receptor modulator, inhibits lipopolysaccharide-induced nitric oxide production by inhibiting the phosphatidylinositol 3-kinase/Akt/nuclear factor-kappa B pathway in RAW264.7 macrophage cells
Mol. Cells
26
48-52
2008
Mus musculus
Manually annotated by BRENDA team
Yu, W.Z.; Zou, H.; Li, X.X.; Yan, Z.; Dong, J.Q.
Effects of the phosphatidylinositol 3-kinase inhibitor in a mouse model of retinal neovascularization
Ophthalmic Res.
40
19-25
2008
Mus musculus
Manually annotated by BRENDA team
Ban, K.; Cooper, A.J.; Samuel, S.; Bhatti, A.; Patel, M.; Izumo, S.; Penninger, J.M.; Backx, P.H.; Oudit, G.Y.; Tsushima, R.G.
Phosphatidylinositol 3-kinase gamma is a critical mediator of myocardial ischemic and adenosine-mediated preconditioning
Circ. Res.
103
643-653
2008
Mus musculus, Mus musculus C57BL/6
Manually annotated by BRENDA team
Wu, J.; Wrathall, J.R.; Schachner, M.
Phosphatidylinositol 3-kinase/protein kinase Cdelta activation induces close homolog of adhesion molecule L1 (CHL1) expression in cultured astrocytes
Glia
58
315-328
2010
Mus musculus, Mus musculus C57BL/6
Manually annotated by BRENDA team
Son, G.; Hines, I.N.; Lindquist, J.; Schrum, L.W.; Rippe, R.A.
Inhibition of phosphatidylinositol 3-kinase signaling in hepatic stellate cells blocks the progression of hepatic fibrosis
Hepatology
50
1512-1523
2009
Mus musculus
Manually annotated by BRENDA team
Ayral-Kaloustian, S.; Gu, J.; Lucas, J.; Cinque, M.; Gaydos, C.; Zask, A.; Chaudhary, I.; Wang, J.; Di, L.; Young, M.; Ruppen, M.; Mansour, T.S.; Gibbons, J.J.; Yu, K.
Hybrid inhibitors of phosphatidylinositol 3-kinase (PI3K) and the mammalian target of rapamycin (mTOR): design, synthesis, and superior antitumor activity of novel wortmannin-rapamycin conjugates
J. Med. Chem.
53
452-459
2009
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Pereira, R.I.; Leitner, J.W.; Erickson, C.; Draznin, B.
Pioglitazone acutely stimulates adiponectin secretion from mouse and human adipocytes via activation of the phosphatidylinositol 3-kinase
Life Sci.
83
638-643
2008
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Zhou, L.; Takayama, Y.; Boucher, P.; Tallquist, M.; Herz, J.
LRP1 regulates architecture of the vascular wall by controlling PDGFRbeta-dependent phosphatidylinositol 3-kinase activation
PLoS ONE
4
e6922
2009
Mus musculus
Manually annotated by BRENDA team
Wu, Y.; Tan, H.; Shui, G.; Bauvy, C.; Huang, Q.; Wenk, M.; Ong, C.; Codogno, P.; Shen, H.
Dual role of 3-methyladenine in modulation of autophagy via different temporal patterns of inhibition on class I and III phosphoinositide 3-kinase
J. Biol. Chem.
285
10850-10861
2010
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Inaguma, Y.; Ito, H.; Iwamoto, I.; Matsumoto, A.; Yamagata, T.; Tabata, H.; Nagata, K.
Morphological characterization of class III phosphoinositide 3-kinase during mouse brain development
Med. Mol. Morphol.
49
28-33
2016
Mus musculus, Mus musculus (Q6PF93)
Manually annotated by BRENDA team
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