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ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
?
ATP + 1,2-dibutanoylphosphatidylinositol 4,5-diphosphate
ADP + 1,2-dibutanoylphosphatidylinositol 3,4,5-trisphosphate
-
-
-
-
?
ATP + 1,2-dioctanoylphosphatidylinositol 4,5-diphosphate
ADP + 1,2-dioctanoylphosphatidylinositol 3,4,5-trisphosphate
-
-
-
-
?
ATP + 1-O-octadecyl-2-O-methyl-rac-3-glycerophospho-myo-inositol
ADP + ?
-
-
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol
ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
ATP + phosphatidylinositol-4,5-bisphosphate
ADP + phosphatidylinositol-3,4,5-trisphosphate
-
-
-
-
?
ATP + phosphatidylinositol-4-phosphate
ADP + phosphatidylinositol-3,4-bisphosphate
-
-
-
-
?
additional information
?
-
ATP + 1-phosphatidyl-1D-myo-inositol
ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
-
-
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol
ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
?
additional information
?
-
-
-
-
-
?
additional information
?
-
-
PI-3-kinase might be involved in the induction of erythroid differentiation, possibly engaging a protein kinase C z as downstream effector
-
-
?
additional information
?
-
-
the enzyme catalyzes the formation of 3'-phosphoinositides, which appear to promote cellular responses to growth factors and such membrane trafficking events as insulin-stimulated translocation of intracellular glucose transporters
-
-
?
additional information
?
-
-
may play a role in phosphatidylinositol 3-kinase-mediated signaling in the immune system
-
-
?
additional information
?
-
may play a role in phosphatidylinositol 3-kinase-mediated signaling in the immune system
-
-
?
additional information
?
-
-
phosphatidylinositol 3-kinase-mediated signaling in the immune system
-
-
?
additional information
?
-
phosphatidylinositol 3-kinase-mediated signaling in the immune system
-
-
?
additional information
?
-
-
phosphatidylinositol 3-kinase acts at an intracellular membrane site to enhance GLUT4 exocytosis in 3T3-L1 cells
-
-
?
additional information
?
-
-
insulin stimulation of fatty acid synthase promoter is mediated by the PI 3-kinase pathway
-
-
?
additional information
?
-
-
enzyme might contribute to the antiproliferative activity of the antitumor ether lipid analogs
-
-
?
additional information
?
-
-
differential regulation of insulin receptor substrate-1 and insulin receptor substrate-2 and phosphatidylinositol 3-kinase isoforms in liver and muscle of the obese diabetic mouse
-
-
?
additional information
?
-
-
insulin activates ATP-sensitive K+ channels in pancreatic B-cells through a phosphatidylinositol 3-kinase-dependent pathway
-
-
?
additional information
?
-
-
reduced expression of the murine p85a subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes
-
-
?
additional information
?
-
-
enzyme could be involved in stimulated glucose transport in muscle
-
-
?
additional information
?
-
-
the isozyme gamma stimulates the protein kinases Erk, JNK, and PKB and thus plays a role in cellular signaling, overview
-
-
?
additional information
?
-
-
phosphoinositide quantification via labeled and/or tagged ligands binding to the pleckstrin homology PH domain of the enzyme in competition with phosphoinositides, overview
-
-
?
additional information
?
-
-
the enzyme shows both lipid and protein kinase activity
-
-
?
additional information
?
-
-
leptin activates leptin receptor and results in the actvation of insulin receptor substrate-1, phosphatidylinositol 3-kinase, Akt, NF-kappaB, and p300, leading to up-regulation of IL-6 expression
-
-
?
additional information
?
-
-
type 2 diabetes impairs insulin receptor substrate-2-mediated phosphatidylinositol 3-kinase activity in primary macrophages to induce a state of cytokine resistance to IL-4 in association with overexpression of suppressor of cytokine signaling-3
-
-
?
additional information
?
-
-
lutein inhibits NF-kappaB-dependent gene expression through redox-based regulation of the phosphatidylinositol 3-kinase/PTEN/Akt and NF-kappaB-inducing kinase pathways
-
-
?
additional information
?
-
-
raloxifene exerts its anti-inflammatory action in LPS-stimulated macrophages by blocking the PI 3-kinase-Akt-NF-kappaB signaling cascade, and eventually reduces expression of pro-inflammatory genes such as the nitric oxide synthase gene
-
-
?
additional information
?
-
-
activated PDGFRbeta interacts with PI3 kinase, which binds to the phosphorylated Tyr739 and Tyr750 residues, in the signaling cascade in vascular smooth muscle cells. disruption of PDGFRbeta-PI3K signaling in mice reduces atherosclerosis. PDGF-BB-induced chemotaxis is inhibited by blocking PI3K activation through PDGFRbeta
-
-
?
additional information
?
-
-
PI3K signaling, overview
-
-
?
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(+/-)-2-[hydroxy[tetrahydro-2-(octadecyloxy)methylfuran-2-yl]methoxyl]phosphinyloxy-N,N,N-trimethylethaniminium hydroxide
-
-
(1E,4S,4aR,5R,6aS,7S)-5-(acetyloxy)-1-{[[3-(dimethylamino)propyl](methyl)amino]methylene}-11-hydroxy-4-(methoxymethyl)-4a,6a-dimethyl-2,10-dioxo-1,2,4,4a,5,6,6a,7,8,9,9a,10-dodecahydroindeno[4,5-h]isochromen-7-yl-(1R,2R,4S)-4-{(2R)-2-[(3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,27-dihydroxy-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-1,5,11,28,29-pentaoxo-1,4,5,6,9,10,11,12,13,14,21,22,23,24,25,26,27,28,29,31,32,33,34,34a-tetracosahydro-3H-23,27-epoxypyrido[2,1-c][1,4]oxazacyclohentriacontin-3-yl]propyl}-2-methoxycyclohexyl octanedioate
-
-
(1E,4S,4aR,5R,6aS,7S,9aR)-1-({[3-(dimethylamino)propyl](methyl)amino}methylidene)-7,11-dihydroxy-4-(methoxymethyl)-4a,6a,9a-trimethyl-2,10-dioxo-1,2,4,4a,5,6,6a,7,8,9,9a,10-dodecahydroindeno[4,5-h]isochromen-5-yl acetate
-
-
(3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,27-dihydroxy-3-{(2R)-1-[(1S,3R)-3-hydroxycyclohexyl]propan-2-yl}-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-hexadecahydro-3H-23,27-epoxypyrido[2,1-c][1,4]oxazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone
-
-
1-O-octadecyl-2-O-methyl-rac-3-glycerophospho-myo-inositol
-
-
1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine
-
noncompetitive with ATP
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one
-
i.e. LY294002
3-Methyladenine
-
treatment in full medium for a prolonged period of time leads to marked increases of the autophagic markers in cells. The increase of autophagic markers is the result of enhanced autophagic flux. The autophagy promotion activity is due to its differential temporal effects on class I and class III PI3K enzymes. 3-Methyladenine blocks class I PI3K persistently, whereas its suppressive effect on class III PI3K is transient. Treatment with 3-methyladenine in full medium significantly reduces the level of phosphatidylinositol 3-phosphate, the product of class III PI3K, at early time points, but almost completely blocks the product of phosphatidylinositol 3,4,5-trisphosphate up to 9 h
hexadecylphosphocholine
-
-
PI3Kalpha inhibitor IV
-
-
-
PI3Kbeta inhibitor VI
-
i.e. TGX-221
-
PI3Kgamma inhibitor
-
-
-
PWT-458
-
i.e. poly(oxy-1,2-ethanediyl)-, R-[2-[[2-[[(1S,6bR,9S,9aS,11R,11bR)-11-(acetyloxy)-1,6,6b,7,8,9,9a,10,11,11b-decahydro-1-(methoxymethyl)-9a,11b-dimethyl-3,6-dioxo-3Hfuro[4,3,2-de]indeno[4,5-h]-2-benzopyran-9-yl]oxy]-2-oxoethyl]thio]ethyl]-omega-methoxy
PX-866
-
i.e. acetic acid 4-diallylaminomethylene-6-hydroxy-1-alpha-methoxymethyl-10beta,13beta-dimethyl-3,7,17-trioxo-1,3,4,7,10,11beta,12,13,14alpha,15,16,17-dodecahydro-2-oxacyclopenta[a]phenanthren-11-yl ester
LY294002
-
-
LY294002
-
specific inhibition
LY294002
-
preclinical evidence for the in vivo efficacy for LY294002 in the treatment of follicular thyroid cancer
LY294002
-
significantly inhibits retinal neovascularization in a mouse model of retinal neovascularization
LY294002
-
a PI3K antagonist
Wortmannin
-
-
Wortmannin
-
specific irreversible inhibition, binds covalently to the active site, mixed type inhibition, IC50 is 12 nM
Wortmannin
-
a PI3K antagonist
Wortmannin
-
an irreversible inhibitor with pan-PI3K activity
Wortmannin
-
treatment with wortmannin results in sustained reduction of phosphatidylinositol 3-phosphate and a transient effect on production of phosphatidylinositol 3,4,5-trisphosphate with recovery after 9 h
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Aksoy, I.A.; Ramsey, M.J.; Fruman, D.A.; Aksoy, S.; Cantley, L.C.; Tucker, J.D.; Roberts, T.M.
Mouse Phosphoinositide 3-Kinase p110a Gene: Cloning, Structural Organization, and Localization to Chromosome 3 Band B
Biochem. Biophys. Res. Commun.
262
438-442
1999
Mus musculus
brenda
Bartlett, S.E.; Reynolds, A.J.; Tan, T.; Heydon, K.; Hendry, I.A.
Differential mRNA expression and subcellular locations of PI3-kinase isoforms in sympathetic and sensory neurons
J. Neurosci. Res.
56
44-53
1999
Mus musculus
brenda
Berggren, M.I.; Gallegos, A.; Dressler, L.A.; Modest, E.J.; Powis, G.
Inhibition of the signalling enzyme phosphatidylinositol-3-kinase by antitumor ether lipid analogs
Cancer Res.
53
4297-4302
1993
Bos taurus, Mus musculus
brenda
Cataldi, A.; Di Pietro, R.; Centurione, L.; Grilli, A.; Cutroneo, G.; Miscia, S.
Phosphatidylinositol-3-kinase activation and atypical protein kinase C z phosphorylation characterize the DMSO signaling in erythroleukemia cells
Cell. Signal.
12
667-672
2000
Mus musculus
brenda
Chantry, D.; Vojtek, A.; Kashishian, A.; Holtzman, D.A.; Wood, C.; Gray, P.W.; Cooper, J.A.; Hoekstra, M.F.
p110delta, a novel phosphatidylinositol 3-kinase catalytic subunit that associates with p85 and is expressed predominantly in leukocytes
J. Biol. Chem.
272
19236-19241
1997
Homo sapiens, Homo sapiens (O00329), Mus musculus, Mus musculus (O35940)
brenda
Domin, J.; Dhand, R.; Waterfield, M.D.
Binding to the platelet-derived growth factor receptor transiently activates the p85a-p110a phosphoinositide 3-kinase complex in vivo
J. Biol. Chem.
271
21614-21621
1996
Mus musculus
brenda
Karnitz, L.M.; Sutor, S.L.; Abraham, R.T.
The Src-Family Kinase, Fyn, Regulates the Activation of Phosphatidylinositol 3-Kinase in an Interleukin 2-responsive T cell Line
J. Exp. Med.
179
1799-1808
1994
Mus musculus
brenda
Kerouz, N.J.; Horsch, D.; Pons, S.; Kahn, C.R.
Differential regulation of insulin receptor substrates-1 and -2 (IRS-1 and IRS-2) and phosphatidylinositol 3-kinase isoforms in liver and muscle of the obese diabetic (ob/ob) mouse
J. Clin. Invest.
100
3164-3172
1997
Mus musculus
brenda
Khan, F.A.; Goforth, P.B.; Zhang, M.; Satin, L.S.
Insulin activates ATP-sensitive K+ channels in pancreatic b-cells through a phosphatidylinositol 3-kinase-dependent pathway
Diabetes
50
2192-2198
2001
Mus musculus
brenda
Le Marchand-Brustel, Y.; Heydrick, S.J.; Jullien, D.; Gautier, N.; Van Obberghen, E.
Effect of insulin and insulin-like growth factor-I on glucose transport and its transporters in soleus muscle of lean and obese mice
Metab. Clin. Exp.
44
18-23
1995
Mus musculus
brenda
Lu, P.J.; Hsu, A.L.; Wang, D.S.; Yan, H.Y.; Yin, H.L.; Chen, C.S.
Phosphoinositide 3-kinase in rat liver nuclei
Biochemistry
37
5738-5745
1998
Mus musculus
brenda
Mauvais-Jarvis, F.; Ueki, K.; Fruman, D.A.; Hirshman, M.F.; Sakamoto, K.; Goodyear, L.J.; Iannacone, M.; Accili, D.; Cantley, L.C.; Kahn, C.R.
Reduced expression of the murine p85a subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes
J. Clin. Invest.
109
141-149
2002
Mus musculus
brenda
Minshall, C.; Arkins, S.; Freund, G.G.; Kelley, K.W.
Requirement for phosphatidylinositol 3'-kinase to protect hemopoietic progenitors against apoptosis depends upon the extracellular survival factor
J. Immunol.
156
939-947
1996
Mus musculus
brenda
Miyakawa, Y.; Rojnuckarin, P.; Habib, T.; Kaushansky, K.
Thrombopoietin induces phosphoinositol 3-kinase activation through SHP2, Gab, and insulin receptor substrate proteins in BAF3 cells and primary murine megakaryocytes
J. Biol. Chem.
276
2494-2502
2001
Mus musculus
brenda
Virbasius, J.V.; Guilherme, A.; Czech, M.P.
Mouse p170 is a novel phosphatidylinositol 3-kinase containing a C2 domain
J. Biol. Chem.
271
13304-13307
1996
Mus musculus
brenda
Wang, D.; Sul, H.S.
Insulin stimulation of the fatty acid synthase promoter is mediated by the phosphatidylinositol 3-kinase pathway. Involvement of protein kinase B/Akt
J. Biol. Chem.
273
25420-25426
1998
Mus musculus
brenda
Wang, Q.; Bilan, P.J.; Tsakiridis, T.; Hinek, A.; Klip, A.
Actin filaments participate in the relocalization of phosphatidylinositol 3-kinase to glucose transporter-containing compartments and in the stimulation of glucose uptake in 3T3-L1 adipocytes
Biochem. J.
331
917-928
1998
Mus musculus
-
brenda
Yang, J.; Clarke, J.F.; Ester, C.J.; Young, P.W.; Kasuga, M.; Holman, G.D.
Phosphatidylinositol 3-kinase acts at an intracellular membrane site to enhance GLUT4 exocytosis in 3T3-L1 cells
Biochem. J.
313
125-131
1996
Mus musculus
-
brenda
Klippel, A.; Escobedo, J.A.; Hirano, M.; Williams, L.T.
The interaction of small domains between the subunits of phosphatidylinositol 3-kinase determines enzyme activity
Mol. Cell. Biol.
14
2675-2685
1994
Mus musculus (P42337), Mus musculus
brenda
Misawa, H.; Ohtsubo, M.; Copeland, N.G.; Gilbert, D.J.; Jenkins, N.A.; Yoshimura, A.
Cloning and characterization of a novel class II phosphoinositide 3-kinase containing C2 domain
Biochem. Biophys. Res. Commun.
244
531-539
1998
Mus musculus (O70167), Mus musculus
brenda
Pietrucha, R.; Rubio, I.; Wymann, M.P.; Wetzker, R.
Phosphoinositide 3-kinase gamma mediates Jun kinase activation via its lipid-kinase activity
Adv. Enzyme Regul.
44
299-308
2004
Mus musculus
brenda
Gray, A.; Olsson, H.; Batty, I.H.; Priganica, L.; Peter Downes, C.
Nonradioactive methods for the assay of phosphoinositide 3-kinases and phosphoinositide phosphatases and selective detection of signaling lipids in cell and tissue extracts
Anal. Biochem.
313
234-245
2003
Mus musculus
brenda
El-Kholy, W.; Macdonald, P.E.; Lin, J.H.; Wang, J.; Fox, J.M.; Light, P.E.; Wang, Q.; Tsushima, R.G.; Wheeler, M.B.
The phosphatidylinositol 3-kinase inhibitor LY294002 potently blocks K(V) currents via a direct mechanism
FASEB J.
17
720-722
2003
Mus musculus, Rattus norvegicus
brenda
Liu, L.; Song, X.; He, D.; Komma, C.; Kita, A.; Virbasius, J.V.; Huang, G.; Bellamy, H.D.; Miki, K.; Czech, M.P.; Zhou, G.W.
Crystal structure of the C2 domain of class II phosphatidylinositide 3-kinase C2alpha
J. Biol. Chem.
281
4254-4260
2006
Mus musculus
brenda
Voigt, P.; Dorner, M.B.; Schaefer, M.
Characterization of p87PIKAP, a novel regulatory subunit of phosphoinositide 3-kinase gamma that is highly expressed in heart and interacts with PDE3B
J. Biol. Chem.
281
9977-9986
2006
Mus musculus (Q3U6Q4)
brenda
O'Connor, J.C.; Sherry, C.L.; Guest, C.B.; Freund, G.G.
Type 2 diabetes impairs insulin receptor substrate-2-mediated phosphatidylinositol 3-kinase activity in primary macrophages to induce a state of cytokine resistance to IL-4 in association with overexpression of suppressor of cytokine signaling-3
J. Immunol.
178
6886-6893
2007
Mus musculus
brenda
Tang, C.H.; Lu, D.Y.; Yang, R.S.; Tsai, H.Y.; Kao, M.C.; Fu, W.M.; Chen, Y.F.
Leptin-induced IL-6 production is mediated by leptin receptor, insulin receptor substrate-1, phosphatidylinositol 3-kinase, Akt, NF-kappaB, and p300 pathway in microglia
J. Immunol.
179
1292-1302
2007
Mus musculus
brenda
Furuya, F.; Lu, C.; Willingham, M.C.; Cheng, S.Y.
Inhibition of phosphatidylinositol 3-kinase delays tumor progression and blocks metastatic spread in a mouse model of thyroid cancer
Carcinogenesis
28
2451-2458
2007
Mus musculus
brenda
Kim, J.H.; Na, H.J.; Kim, C.K.; Kim, J.Y.; Ha, K.S.; Lee, H.; Chung, H.T.; Kwon, H.J.; Kwon, Y.G.; Kim, Y.M.
The non-provitamin A carotenoid, lutein, inhibits NF-kappaB-dependent gene expression through redox-based regulation of the phosphatidylinositol 3-kinase/PTEN/Akt and NF-kappaB-inducing kinase pathways: Role of H2O2 in NF-kappaB activation
Free Radic. Biol. Med.
45
885-896
2008
Mus musculus
brenda
Lee, Y.; Huang, H.; Kim, H.J.; Park, C.K.; Kim, H.H.
The phosphatidylinositol 3-kinase-mediated production of interferon-beta is critical for the lipopolysaccharide inhibition of osteoclastogenesis
Life Sci.
83
369-376
2008
Mus musculus
brenda
Lee, S.A.; Park, S.H.; Kim, B.C.
Raloxifene, a selective estrogen receptor modulator, inhibits lipopolysaccharide-induced nitric oxide production by inhibiting the phosphatidylinositol 3-kinase/Akt/nuclear factor-kappa B pathway in RAW264.7 macrophage cells
Mol. Cells
26
48-52
2008
Mus musculus
brenda
Yu, W.Z.; Zou, H.; Li, X.X.; Yan, Z.; Dong, J.Q.
Effects of the phosphatidylinositol 3-kinase inhibitor in a mouse model of retinal neovascularization
Ophthalmic Res.
40
19-25
2008
Mus musculus
brenda
Ban, K.; Cooper, A.J.; Samuel, S.; Bhatti, A.; Patel, M.; Izumo, S.; Penninger, J.M.; Backx, P.H.; Oudit, G.Y.; Tsushima, R.G.
Phosphatidylinositol 3-kinase gamma is a critical mediator of myocardial ischemic and adenosine-mediated preconditioning
Circ. Res.
103
643-653
2008
Mus musculus, Mus musculus C57BL/6
brenda
Wu, J.; Wrathall, J.R.; Schachner, M.
Phosphatidylinositol 3-kinase/protein kinase Cdelta activation induces close homolog of adhesion molecule L1 (CHL1) expression in cultured astrocytes
Glia
58
315-328
2010
Mus musculus, Mus musculus C57BL/6
brenda
Son, G.; Hines, I.N.; Lindquist, J.; Schrum, L.W.; Rippe, R.A.
Inhibition of phosphatidylinositol 3-kinase signaling in hepatic stellate cells blocks the progression of hepatic fibrosis
Hepatology
50
1512-1523
2009
Mus musculus
brenda
Ayral-Kaloustian, S.; Gu, J.; Lucas, J.; Cinque, M.; Gaydos, C.; Zask, A.; Chaudhary, I.; Wang, J.; Di, L.; Young, M.; Ruppen, M.; Mansour, T.S.; Gibbons, J.J.; Yu, K.
Hybrid inhibitors of phosphatidylinositol 3-kinase (PI3K) and the mammalian target of rapamycin (mTOR): design, synthesis, and superior antitumor activity of novel wortmannin-rapamycin conjugates
J. Med. Chem.
53
452-459
2009
Homo sapiens, Mus musculus
brenda
Pereira, R.I.; Leitner, J.W.; Erickson, C.; Draznin, B.
Pioglitazone acutely stimulates adiponectin secretion from mouse and human adipocytes via activation of the phosphatidylinositol 3-kinase
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Homo sapiens, Mus musculus
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Zhou, L.; Takayama, Y.; Boucher, P.; Tallquist, M.; Herz, J.
LRP1 regulates architecture of the vascular wall by controlling PDGFRbeta-dependent phosphatidylinositol 3-kinase activation
PLoS ONE
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Mus musculus
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Wu, Y.; Tan, H.; Shui, G.; Bauvy, C.; Huang, Q.; Wenk, M.; Ong, C.; Codogno, P.; Shen, H.
Dual role of 3-methyladenine in modulation of autophagy via different temporal patterns of inhibition on class I and III phosphoinositide 3-kinase
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Homo sapiens, Mus musculus
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Inaguma, Y.; Ito, H.; Iwamoto, I.; Matsumoto, A.; Yamagata, T.; Tabata, H.; Nagata, K.
Morphological characterization of class III phosphoinositide 3-kinase during mouse brain development
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2016
Mus musculus (Q6PF93), Mus musculus
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Backer, J.M.
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Saccharomyces cerevisiae (P22543), Mus musculus (Q6PF93), Homo sapiens (Q8NEB9)
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