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Information on EC 2.7.1.137 - phosphatidylinositol 3-kinase and Organism(s) Sus scrofa and UniProt Accession O02697

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IUBMB Comments
One mammalian isoform is known.
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This record set is specific for:
Sus scrofa
UNIPROT: O02697
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The taxonomic range for the selected organisms is: Sus scrofa
The enzyme appears in selected viruses and cellular organisms
Synonyms
pi3k, phosphatidylinositol 3-kinase, pi3 kinase, vps34, phosphoinositide-3-kinase, phosphatidylinositol 3 kinase, ptdins 3-kinase, pik3c3, phosphatidylinositide 3-kinase, hvps34, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
kinase (phosphorylating), phosphatidylinositol 3-
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-
-
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kinase, phosphatidylinositol 3- (phosphorylating)
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-
-
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p110g-related PI 3-kinase
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p85/p110 phosphoinositide 3-kinase
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-
-
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phosphatidylinositol 3'-kinase
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-
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phosphatidylinositol 3-kinase
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-
-
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phosphoinositide 3'-kinase
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-
-
-
phosphoinositide 3-kinase
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-
-
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PI 3-kinase
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-
-
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PI3K
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-
-
-
PtdIns 3'-kinase
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-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
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-
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PATHWAY SOURCE
PATHWAYS
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-
SYSTEMATIC NAME
IUBMB Comments
ATP:1-phosphatidyl-1D-myo-inositol 3-phosphotransferase
One mammalian isoform is known.
CAS REGISTRY NUMBER
COMMENTARY hide
115926-52-8
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
show the reaction diagram
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
show the reaction diagram
ATP + phosphatidylinositol 4,5-bisphosphate
ADP + phosphatidylinositol 3,4,5-trisphosphate
show the reaction diagram
-
-
-
-
?
ATP + phosphatidylinositol 4-phosphate
ADP + phosphatidylinositol 3,4-bisphosphate
show the reaction diagram
-
-
-
-
?
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
LY294002
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IC50 values: 2 mM
Wortmannin
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IC50: 10 nM
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
25 - 44
ATP
64
phosphatidylinositol
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-
15
phosphatidylinositol 4,5-bisphosphate
-
-
10
phosphatidylinositol 4-phosphate
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-
IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2
LY294002
Sus scrofa
-
IC50 values: 2 mM
0.00001
Wortmannin
Sus scrofa
-
IC50: 10 nM
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
SwissProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
PK3CG_PIG
1102
0
126658
Swiss-Prot
other Location (Reliability: 2)
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Tang, X.; Downes, C.P.
Purification and characterization of Gbg-responsive phosphoinositide 3-kinases from pig platelet cytosol
J. Biol. Chem.
272
14193-14199
1997
Sus scrofa
Manually annotated by BRENDA team
Stephens, L.R.; Eguinoa, A.; Erdjument-Bromage, H.; Lui, M.; Cooke, F.; Coadwell, J.; Smrcka, A.S.; Thelen, M.; Cadwallader, K.; Tempst, P.; Hawkins, P.T.
The G beta gamma sensitivity of a PI3K is dependent upon a tightly associated adaptor, p101
Cell
89
105-114
1997
Sus scrofa (O02696), Sus scrofa (O02697), Sus scrofa
Manually annotated by BRENDA team