Disease on EC 2.7.1.134 - inositol-tetrakisphosphate 1-kinase

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Cystic Fibrosis

Integration of inositol phosphate signaling pathways via human ITPK1.

Dehydration

OsITL1 gene encoding an inositol 1,3,4-trisphosphate 5/6-kinase is a negative regulator of osmotic stress signaling.

Neoplasms

Increased levels of inositol hexakisphosphate (InsP6) protect HEK293 cells from tumor necrosis factor (alpha)- and Fas-induced apoptosis.

Inositol 1,3,4-trisphosphate 5/6-kinase inhibits tumor necrosis factor-induced apoptosis.

Neural Tube Defects

Expression of inositol 1,3,4-trisphosphate 5/6-kinase (ITPK1) and its role in neural tube defects.

Neural tube defects in mice with reduced levels of inositol 1,3,4-trisphosphate 5/6-kinase.