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Information on EC 2.7.1.130 - tetraacyldisaccharide 4'-kinase

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EC Tree
IUBMB Comments
Involved with EC 2.3.1.129 (acyl-[acyl-carrier-protein]---UDP-N-acetylglucosamine O-acyltransferase) and EC 2.4.1.182 (lipid-A-disaccharide synthase) in the biosynthesis of the phosphorylated glycolipid, lipid A, in the outer membrane of Gram-negative bacteria.
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Word Map
The enzyme appears in viruses and cellular organisms
Synonyms
lipid a 4'-kinase, tetraacyldisaccharide 4'-kinase, membrane-bound tetraacyldisaccharide-1-phosphate 4'-kinase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + 2-deoxy-2-([(3R)-3-hydroxyacyl]amino)-3-O-[(3R)-3-hydroxyacyl]-beta-D-glucopyranosyl-(1->6)-2-deoxy-3-O-[(3R)-3-hydroxyacyl]-2-([(3R)-3-hydroxyacyl]amino)-1-O-phospho-alpha-D-glucopyranose = ADP + 2-deoxy-2-([(3R)-3-hydroxyacyl]amino)-3-O-[(3R)-3-hydroxyacyl]-4-O-phospho-beta-D-glucopyranosyl-(1->6)-2-deoxy-3-O-[(3R)-3-hydroxyacyl]-2-([(3R)-3-hydroxyacyl]amino)-1-O-phospho-alpha-D-glucopyranose
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ATP + a lipid A disaccharide = ADP + a lipid IVA
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