Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

Disease on EC 2.7.1.107 - diacylglycerol kinase (ATP)

Please use the Disease Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acne Vulgaris
Presented at the 16(th) DGK Symposium, March 2-4, 2005, Leipzig, Germany - Received the Award for the Best Poster Presentation 1 Influencing the equilibrium of the cutaneous ecosystem to improve the properties of skin prone to acne.
Acquired Immunodeficiency Syndrome
Regulation of Lipid Signaling by Diacylglycerol Kinases during T Cell Development and Function.
Role of diacylglycerol kinases in T cell development and function.
Adenocarcinoma of Lung
Survival trees for analyzing clinical outcome in lung adenocarcinomas based on gene expression profiles: identification of neogenin and diacylglycerol kinase alpha expression as critical factors.
Aggressive Periodontitis
Alternative Splicing Generates a Diacylglycerol Kinase ? (DGK?) Transcript That Acts as a Dominant Negative Modulator of Superoxide Production in Localized Aggressive Periodontitis.
Evidence of an association between functional abnormalities and defective diacylglycerol kinase activity in peripheral blood neutrophils from patients with localized juvenile periodontitis.
Identification of mRNAs for the various diacylglycerol kinase isoforms in neutrophils from patients with localized aggressive periodontitis.
Anemia, Aplastic
Dysregulated miR34a/diacylglycerol kinase ? interaction enhances T-cell activation in acquired aplastic anemia.
Arrhythmias, Cardiac
[Abstracts of the 34th Autumn Conference of the DGK and 21st Annual Convention of the Working Group for Cardiac Pacemakers and Arrhythmia. October 7-9, 2010. Nürmberg, Germany].
[Abstracts of the Fall Meeting of the DGK and the Annual Meeting of the Working Group for Pacemakers and Arrhythmia. October 10-12, 2013. Dresden, Germany ].
Arthritis, Juvenile
Diacylglycerol Kinase ? Regulates Macrophage Responses in Juvenile Arthritis and Cytokine Storm Syndrome Mouse Models.
Asthma
Analyses of shared genetic factors between asthma and obesity in children.
Autocrine regulation of airway smooth muscle contraction by diacylglycerol kinase.
Diacylglycerol kinase ? promotes allergic airway inflammation and airway hyperresponsiveness through distinct mechanisms.
Atrial Fibrillation
Diacylglycerol kinase zeta inhibits G(alpha)q-induced atrial remodeling in transgenic mice.
Atypical Hemolytic Uremic Syndrome
DGKE and atypical HUS.
Long-term outcomes and response to treatment in diacylglycerol kinase epsilon nephropathy.
Loss of diacylglycerol kinase ? causes thrombotic microangiopathy by impairing endothelial VEGFA signaling.
Blindness
Constitutive activity of the light-sensitive channels TRP and TRPL in the Drosophila diacylglycerol kinase mutant, rdgA.
Brain Injuries, Traumatic
Brain trauma induces expression of diacylglycerol kinase zeta in microglia.
Breast Neoplasms
Diacylglycerol kinase is required for HGF-induced invasiveness and anchorage-independent growth of MDA-MB-231 breast cancer cells.
Temporal production of the signaling lipid phosphatidic acid by phospholipase D2 determines the output of extracellular signal-regulated kinase signaling in cancer cells.
Carcinogenesis
DGKZ Acts as a Potential Oncogene in Osteosarcoma Proliferation Through Its Possible Interaction With ERK1/2 and MYC Pathway.
Diacylglycerol kinase ?1 is a high affinity isozyme for diacylglycerol.
Diacylglycerol kinases: why so many of them?
Downregulation of Diacylglycerol kinase zeta (DGKZ) suppresses tumorigenesis and progression of cervical cancer by facilitating cell apoptosis and cell cycle arrest.
Effect of amount and types of dietary fat on intestinal bacterial 7 alpha-dehydroxylase and phosphatidylinositol-specific phospholipase C and colonic mucosal diacylglycerol kinase and PKC activities during stages of colon tumor promotion.
Mechanisms in the chemoprevention of colon cancer: modulation of protein kinase C, tyrosine protein kinase and diacylglycerol kinase activities by 1,4-phenylenebis-(methylene)selenocyanate and impact of low-fat diet.
Carcinoma
Chrysin serves as a novel inhibitor of DGK?/FAK interaction to suppress the malignancy of esophageal squamous cell carcinoma (ESCC).
NK-cell dysfunction in human renal carcinoma reveals diacylglycerol kinase as key regulator and target for therapeutic intervention.
The diacylglycerol kinase ? (DGK?)/Akt/NF-?B feedforward loop promotes esophageal squamous cell carcinoma (ESCC) progression via FAK-dependent and FAK-independent manner.
The diacylglycerol kinase ?/atypical PKC/?1 integrin pathway in SDF-1? mammary carcinoma invasiveness.
Carcinoma, Hepatocellular
Combination therapy for hepatocellular carcinoma with diacylglycerol kinase alpha inhibition and anti-programmed cell death-1 ligand blockade.
Diacylglycerol kinase ? predicts prognosis and functions as a tumor suppressor by negatively regulating glucose transporter 1 in hepatocellular carcinoma.
Diacylglycerol kinase alpha enhances hepatocellular carcinoma progression by activation of Ras-Raf-MEK-ERK pathway.
Molecular cloning of a diacylglycerol kinase isozyme predominantly expressed in human retina with a truncated and inactive enzyme expression in most other human cells.
Palmitic acid- and/or palmitoleic acid-containing phosphatidic acids are generated by diacylglycerol kinase ? in starved Jurkat T cells.
Carcinoma, Renal Cell
NK-cell dysfunction in human renal carcinoma reveals diacylglycerol kinase as key regulator and target for therapeutic intervention.
Carcinoma, Squamous Cell
ATP- and EGF-stimulated phosphatidulinositol synthesis by two different pathways, phospholipase D and diacylglycerol kinase, in A-431 epidermoid carcinoma cells.
Carcinosarcoma
Shape changes and chemokinesis of Walker carcinosarcoma cells: effects of protein kinase inhibitors (HA-1004, polymyxin B, sangivamycin and tamoxifen) and an inhibitor of diacylglycerol kinase (R 59022).
Cardiomegaly
Cardiac-specific overexpression of diacylglycerol kinase zeta attenuates left ventricular remodeling and improves survival after myocardial infarction.
Cardiac-specific overexpression of diacylglycerol kinase zeta prevents Gq protein-coupled receptor agonist-induced cardiac hypertrophy in transgenic mice.
Diacylglycerol kinase zeta attenuates pressure overload-induced cardiac hypertrophy.
Diacylglycerol kinase zeta rescues G alpha q-induced heart failure in transgenic mice.
Diacylglycerol kinase-epsilon restores cardiac dysfunction under chronic pressure overload: a new specific regulator of Galpha(q) signaling cascade.
Diacylglycerol kinases as emerging potential drug targets for a variety of diseases.
Diacylglycerol Kinases as Emerging Potential Drug Targets for a Variety of Diseases: An Update.
Differential regulation of diacylglycerol kinase isozymes in cardiac hypertrophy.
Role of diacylglycerol kinase in cellular regulatory processes: a new regulator for cardiomyocyte hypertrophy.
Cerebral Infarction
Brain trauma induces expression of diacylglycerol kinase zeta in microglia.
Diacylglycerol kinase zeta is involved in the process of cerebral infarction.
Chagas Disease
Shedding light on lipid metabolism in Kinetoplastida: A phylogenetic analysis of phospholipase D protein homologs.
Cholera
Role of protein kinase C in transforming growth factor-beta 1 induction of carcinoembryonic antigen in human colon carcinoma cells.
Colonic Neoplasms
Increased diacylglycerol kinase ? expression in human metastatic colon cancer cells augments Rho GTPase activity and contributes to enhanced invasion.
Mechanisms in the chemoprevention of colon cancer: modulation of protein kinase C, tyrosine protein kinase and diacylglycerol kinase activities by 1,4-phenylenebis-(methylene)selenocyanate and impact of low-fat diet.
Overexpression of DGKI in Gastric Cancer Predicts Poor Prognosis.
Colorectal Neoplasms
Epigenetic silencing of diacylglycerol kinase gamma in colorectal cancer.
Cystic Fibrosis
The cubicon method for concentrating membrane proteins in the cubic mesophase.
Dental Caries
Kinase activity of the dgk gene product is involved in the virulence of Streptococcus mutans.
deoxyguanosine kinase deficiency
Abnormal neurological features predict poor survival and should preclude liver transplantation in patients with deoxyguanosine kinase deficiency.
Diabetes Mellitus
Diacylglycerol kinase zeta inhibits myocardial atrophy and restores cardiac dysfunction in streptozotocin-induced diabetes mellitus.
Diabetes Mellitus, Type 2
Chronic administration of myristic acid improves hyperglycaemia in the Nagoya-Shibata-Yasuda mouse model of congenital type 2 diabetes.
Creatine kinase muscle type specifically interacts with saturated fatty acid- and/or monounsaturated fatty acid-containing phosphatidic acids.
Diacylglycerol Signaling Pathway in Pancreatic ?-Cells: An Essential Role of Diacylglycerol Kinase in the Regulation of Insulin Secretion.
Downregulation of diacylglycerol kinase delta contributes to hyperglycemia-induced insulin resistance.
Myristic Acid Enhances Diacylglycerol Kinase ?-Dependent Glucose Uptake in Myotubes.
Myristic acid specifically stabilizes diacylglycerol kinase ? protein in C2C12 skeletal muscle cells.
New Era of Diacylglycerol Kinase, Phosphatidic Acid and Phosphatidic Acid-Binding Protein.
Regulation of diacylglycerol kinase ?2 expression in C2C12 skeletal muscle cells by free fatty acids.
Role of Diacylglycerol Kinases in Glucose and Energy Homeostasis.
Sphingomyelin synthase-related protein generates diacylglycerol via the hydrolysis of glycerophospholipids in the absence of ceramide.
Diabetic Cardiomyopathies
Diacylglycerol kinase zeta inhibits myocardial atrophy and restores cardiac dysfunction in streptozotocin-induced diabetes mellitus.
Diabetic Nephropathies
Diacylglycerol Kinase alpha is Involved in the Vitamin E-Induced Amelioration of Diabetic Nephropathy in Mice.
Hepatic expression profiling shows involvement of PKC epsilon, DGK eta, Tnfaip, and Rho kinase in type 2 diabetic nephropathy rats.
Screening of subtype specific activators and inhibitors for diacylglycerol kinase.
diacylglycerol kinase (atp) deficiency
Deoxyguanosine kinase deficiency presenting as neonatal hemochromatosis.
Deoxynucleoside salvage enzymes and tissue specific mitochondrial DNA depletion.
Deoxyribonucleoside kinases in mitochondrial DNA depletion.
Diacylglycerol kinase delta regulates protein kinase C and epidermal growth factor receptor signaling.
Diacylglycerol kinase zeta regulates microbial recognition and host resistance to Toxoplasma gondii.
Downregulation of diacylglycerol kinase delta contributes to hyperglycemia-induced insulin resistance.
Enhanced T cell responses due to diacylglycerol kinase zeta deficiency.
Epileptogenesis in diacylglycerol kinase epsilon deficiency up-regulates COX-2 and tyrosine hydroxylase in hippocampus.
Low level of mitochondrial deoxyguanosine kinase is the dominant factor in acquired resistance to 9-beta-D-arabinofuranosylguanine cytotoxicity.
Mitochondrial deoxyribonucleotide pools in deoxyguanosine kinase deficiency.
Molecular insight into mitochondrial DNA depletion syndrome in two patients with novel mutations in the deoxyguanosine kinase and thymidine kinase 2 genes.
Neonatal liver failure due to deoxyguanosine kinase deficiency.
The Deoxynucleoside Triphosphate Triphosphohydrolase Activity of SAMHD1 Protein Contributes to the Mitochondrial DNA Depletion Associated with Genetic Deficiency of Deoxyguanosine Kinase.
Diffuse Cerebral Sclerosis of Schilder
Defects in maintenance of mitochondrial DNA are associated with intramitochondrial nucleotide imbalances.
Dirofilariasis
Development of New Recombinant DgK Antigen for Diagnosis of Dirofilaria immitis Infections in Dogs Using ELISA Technique and Its Comparison to Molecular Methods
Dyslexia
SNP variations in the 7q33 region containing DGKI are associated with dyslexia in the Finnish and German populations.
Encephalomyelitis
The expression of diacylglycerol kinase isoforms ? and ? correlates with the progression of experimental autoimmune encephalomyelitis in rats.
Encephalomyelitis, Autoimmune, Experimental
The expression of diacylglycerol kinase isoforms ? and ? correlates with the progression of experimental autoimmune encephalomyelitis in rats.
Endometrial Neoplasms
Diacylglycerol kinase ? mediates 17-?-estradiol-induced proliferation, motility, and anchorage-independent growth of Hec-1A endometrial cancer cell line through the G protein-coupled estrogen receptor GPR30.
Epilepsy
Diacylglycerol kinase (DGKA) regulates the effect of the epilepsy and bipolar disorder treatment valproic acid in Dictyostelium discoideum.
Diacylglycerol kinases as emerging potential drug targets for a variety of diseases.
Diacylglycerol Kinases as Emerging Potential Drug Targets for a Variety of Diseases: An Update.
Endocannabinoids and diacylglycerol kinase activity.
Escherichia coli Infections
Irreversible severe kidney injury and anuria in a 3-month-old girl with atypical haemolytic uraemic syndrome under administration of eculizumab.
Esophageal Squamous Cell Carcinoma
Chrysin serves as a novel inhibitor of DGK?/FAK interaction to suppress the malignancy of esophageal squamous cell carcinoma (ESCC).
The diacylglycerol kinase ? (DGK?)/Akt/NF-?B feedforward loop promotes esophageal squamous cell carcinoma (ESCC) progression via FAK-dependent and FAK-independent manner.
Eye Diseases
Chromosomal localization of three mouse diacylglycerol kinase (DAGK) genes: genes sharing sequence homology to the Drosophila retinal degeneration A (rdgA) gene.
Fragile X Syndrome
New Era of Diacylglycerol Kinase, Phosphatidic Acid and Phosphatidic Acid-Binding Protein.
Glioblastoma
CRISPR/Cas9-Mediated Knockout of DGK Improves Antitumor Activities of Human T Cells.
DGK? Plays Crucial Roles in the Proliferation and Tumorigenicity of Human glioblastoma.
Diacylglycerol kinase ? is a critical signaling node and novel therapeutic target in glioblastoma and other cancers.
Targeting the mesenchymal subtype in glioblastoma and other cancers via inhibition of diacylglycerol kinase alpha.
Glioma
Diacylglycerol molecular species in plasma membrane and microsomes change transiently with endothelin-1 treatment of glioma cells.
Effects of bradykinin, GTP gamma S, R59022 and N-ethylmaleimide on inositol phosphate production in NG108-15 cells.
Glomerulonephritis, Membranoproliferative
Long-term outcomes and response to treatment in diacylglycerol kinase epsilon nephropathy.
The Phenotypic Spectrum of Nephropathies Associated with Mutations in Diacylglycerol Kinase ?.
glycerol kinase deficiency
Glycerol hypersensitivity in a Drosophila model for glycerol kinase deficiency is affected by mutations in eye pigmentation genes.
Glycogen Storage Disease Type V
Muscle glycogenosis and mitochondrial hepatopathy in an infant with mutations in both the myophosphorylase and deoxyguanosine kinase genes.
Heart Diseases
Diacylglycerol kinases: at the hub of cell signalling.
Heart Failure
Diacylglycerol Kinase ? Inhibits Ventricular Tachyarrhythmias in a Mouse Model of Heart Failure.
Diacylglycerol kinase zeta inhibits G(alpha)q-induced atrial remodeling in transgenic mice.
Diacylglycerol kinase zeta rescues G alpha q-induced heart failure in transgenic mice.
Diacylglycerol kinase-epsilon restores cardiac dysfunction under chronic pressure overload: a new specific regulator of Galpha(q) signaling cascade.
Role of diacylglycerol kinase in cellular regulatory processes: a new regulator for cardiomyocyte hypertrophy.
Hemolytic-Uremic Syndrome
Outcome of diacylglycerol kinase epsilon-mediated hemolytic uremic syndrome in an infant.
Herpes Simplex
Cloning and expression of human deoxyguanosine kinase cDNA.
Stereoisomeric selectivity of human deoxyribonucleoside kinases.
Herpes Zoster
Expression and localization of the diacylglycerol kinase family and of phosphoinositide signaling molecules in adrenal gland.
Hyperglycemia
d-Alpha-tocopherol prevents the hyperglycemia induced activation of diacylglycerol (DAG)-protein kinase C (PKC) pathway in vascular smooth muscle cell by an increase of DAG kinase activity.
Hypersensitivity
Altered Lipid Synthesis by Lack of Yeast Pah1 Phosphatidate Phosphatase Reduces Chronological Life Span.
Disruption of Glycerol Metabolism by RNAi Targeting of Genes Encoding Glycerol Kinase Results in a Range of Phenotype Severity in Drosophila.
Goalpha and diacylglycerol kinase negatively regulate the Gqalpha pathway in C. elegans.
Hypertension
A central role for protein kinase C overactivity in diabetic glomerulosclerosis: implications for prevention with antioxidants, fish oil, and ACE inhibitors.
Diacylglycerol kinases as emerging potential drug targets for a variety of diseases.
Diacylglycerol Kinases as Emerging Potential Drug Targets for a Variety of Diseases: An Update.
Hypospadias
Association between diacylglycerol kinase kappa variants and hypospadias susceptibility in a Han Chinese population.
Common variants in DGKK are strongly associated with risk of hypospadias.
DGKK Variants and hypospadias in Han Chinese: association and meta-analysis.
Diacylglycerol kinase K variants impact hypospadias in a California study population.
Expression Analysis of DGKK during External Genitalia Formation.
Further Evidence of the Association of the Diacylglycerol Kinase Kappa (DGKK) Gene With Hypospadias.
The role of genetic variation in DGKK on moderate and severe hypospadias.
[Single nucleotide polymorphisms of the DGKK gene and hypospadias in Chinese children].
Infarction, Middle Cerebral Artery
Diacylglycerol kinase zeta is involved in the process of cerebral infarction.
Infections
Development of New Recombinant DgK Antigen for Diagnosis of Dirofilaria immitis Infections in Dogs Using ELISA Technique and Its Comparison to Molecular Methods
Diacylglycerol kinase zeta regulates microbial recognition and host resistance to Toxoplasma gondii.
Diacylglycerol kinases in immune cell function and self-tolerance.
Irreversible severe kidney injury and anuria in a 3-month-old girl with atypical haemolytic uraemic syndrome under administration of eculizumab.
Phospholipase C/diacylglycerol kinase-mediated signalling is required for benzothiadiazole-induced oxidative burst and hypersensitive cell death in rice suspension-cultured cells.
Selective immunostaining of Mehlis' gland of Opisthorchis viverrini by antibody against rat diacylglycerol kinase.
Unexpected positive control of NF?B and miR-155 by DGK? and ? ensures effector and memory CD8+ T Cell differentiation.
Insulin Resistance
Complementary measures for promoting insulin sensitivity in skeletal muscle.
Diacylglycerol kinase as a possible therapeutic target for neuronal diseases.
Diacylglycerol Kinase Malfunction in Human Disease and the Search for Specific Inhibitors.
Downregulation of diacylglycerol kinase delta contributes to hyperglycemia-induced insulin resistance.
Establishment of a novel hepatic steatosis cell model by Cas9/sgRNA-mediated DGK? gene knockout.
Knockdown of diacylglycerol kinase delta inhibits adipocyte differentiation and alters lipid synthesis.
mRNA expression of diacylglycerol kinase isoforms in insulin-sensitive tissues: effects of obesity and insulin resistance.
Role of Diacylglycerol Kinases in Glucose and Energy Homeostasis.
Intellectual Disability
Fragile X Mental Retardation Protein (FMRP) controls diacylglycerol kinase activity in neurons.
Kearns-Sayre Syndrome
Neuropathology of mitochondrial diseases.
Leishmaniasis
Shedding light on lipid metabolism in Kinetoplastida: A phylogenetic analysis of phospholipase D protein homologs.
Lethargy
Calcium/calmodulin-dependent protein kinase II regulates Caenorhabditis elegans locomotion in concert with a G(o)/G(q) signaling network.
Leukemia
Ceramide is a competitive inhibitor of diacylglycerol kinase in vitro and in intact human leukemia (HL-60) cells.
Characterization of a ceramide kinase activity from human leukemia (HL-60) cells. Separation from diacylglycerol kinase activity.
Diacylglycerol kinase-alpha mediates hepatocyte growth factor-induced epithelial cell scatter by regulating Rac activation and membrane ruffling.
Real-time quantitative PCR assays for deoxycytidine kinase, deoxyguanosine kinase and 5'-nucleotidase mRNA measurement in cell lines and in patients with leukemia.
Regulatory role of diacylglycerol kinase gamma in macrophage differentiation of leukemia cells.
[18F]CFA as a clinically translatable probe for PET imaging of deoxycytidine kinase activity.
Leukemia, Erythroblastic, Acute
Nuclear Localization of Diacylglycerol Kinase Alpha in K562 Cells Is Involved in Cell Cycle Progression.
Leukemia, Myeloid, Acute
Knockdown of diacylglycerol kinase zeta (DGKZ) induces apoptosis and G2/M phase arrest in human acute myeloid leukemia HL-60 cells through MAPK/survivin/caspase pathway.
Liver Failure
Neonatal liver failure due to deoxyguanosine kinase deficiency.
Liver Neoplasms
Establishment of a novel hepatic steatosis cell model by Cas9/sgRNA-mediated DGK? gene knockout.
Lung Neoplasms
Diacylglycerol kinase ? modulates oncogenic properties of lung cancer cells.
High-throughput functional genomic methods to analyze the effects of dietary lipids.
Lymphoma
Diacylglycerol kinase-alpha mediates hepatocyte growth factor-induced epithelial cell scatter by regulating Rac activation and membrane ruffling.
Lymphoma, T-Cell
Phosphatidic acid is required for the constitutive ruffling and macropinocytosis of phagocytes.
Lymphoproliferative Disorders
Diacylglycerol Kinase alpha in X Linked Lymphoproliferative Disease Type 1.
Melanoma
Combined inhibition/silencing of diacylglycerol kinase ? and ? simultaneously and synergistically enhances interleukin-2 production in T cells and induces cell death of melanoma cells.
Diacylglycerol kinase ?-selective inhibitors induce apoptosis and reduce viability of melanoma and several other cancer cell lines.
Diacylglycerol kinase alpha suppresses tumor necrosis factor-alpha-induced apoptosis of human melanoma cells through NF-kappaB activation.
Nucleoside Analog Activity in Malignant Melanoma Cell Lines.
Palmitic acid- and/or palmitoleic acid-containing phosphatidic acids are generated by diacylglycerol kinase ? in starved Jurkat T cells.
Muscular Diseases
Molecular insight into mitochondrial DNA depletion syndrome in two patients with novel mutations in the deoxyguanosine kinase and thymidine kinase 2 genes.
Myocardial Infarction
Cardiac-specific overexpression of diacylglycerol kinase zeta attenuates left ventricular remodeling and improves survival after myocardial infarction.
Gene expression and in situ localization of diacylglycerol kinase isozymes in normal and infarcted rat hearts: effects of captopril treatment.
Role of diacylglycerol kinase in cellular regulatory processes: a new regulator for cardiomyocyte hypertrophy.
Neoplasms
A novel diacylglycerol kinase ?-selective inhibitor, CU-3, induces cancer cell apoptosis and enhances immune response.
Activation of alpha-diacylglycerol kinase is critical for the mitogenic properties of anaplastic lymphoma kinase.
Alteration of AKAP220, an upstream component of the Rb pathway, in oral carcinogenesis.
Analytical Method for Diacylglycerol Kinase ? Activity in Cells Using Protein Myristoylation and Liquid Chromatography-Tandem Mass Spectrometry.
Assignment of 20 microsatellite markers to the porcine linkage map.
Biological regulation of diacylglycerol kinases in normal and neoplastic tissues: New opportunities for cancer immunotherapy.
Combination therapy for hepatocellular carcinoma with diacylglycerol kinase alpha inhibition and anti-programmed cell death-1 ligand blockade.
Combined inhibition/silencing of diacylglycerol kinase ? and ? simultaneously and synergistically enhances interleukin-2 production in T cells and induces cell death of melanoma cells.
CRISPR/Cas9-Mediated Knockout of DGK Improves Antitumor Activities of Human T Cells.
Diacylglycerol kinase ? (DGK?) and Casitas b-lineage proto-oncogene b-deficient mice have similar functional outcomes in T cells but DGK?-deficient mice have increased T cell activation and tumor clearance.
Diacylglycerol kinase ? controls RCP-dependent integrin trafficking to promote invasive migration.
Diacylglycerol kinase ? is a critical signaling node and novel therapeutic target in glioblastoma and other cancers.
Diacylglycerol kinase ? predicts prognosis and functions as a tumor suppressor by negatively regulating glucose transporter 1 in hepatocellular carcinoma.
Diacylglycerol kinase ? promotes 3D cancer cell growth and limits drug sensitivity through functional interaction with Src.
Diacylglycerol kinase ?-selective inhibitors induce apoptosis and reduce viability of melanoma and several other cancer cell lines.
Diacylglycerol kinase alpha enhances protein kinase Czeta-dependent phosphorylation at Ser311 of p65/RelA subunit of nuclear factor-kappaB.
Diacylglycerol kinase alpha suppresses tumor necrosis factor-alpha-induced apoptosis of human melanoma cells through NF-kappaB activation.
Diacylglycerol kinase alpha, from negative modulation of T cell activation to control of cancer progression.
Diacylglycerol kinase control of protein kinase C.
Diacylglycerol kinase iota regulates Ras guanyl-releasing protein 3 and inhibits Rap1 signaling.
Diacylglycerol Kinase Malfunction in Human Disease and the Search for Specific Inhibitors.
Diacylglycerol kinase zeta regulates microbial recognition and host resistance to Toxoplasma gondii.
Diacylglycerol kinases as emerging potential drug targets for a variety of diseases.
Diacylglycerol Kinases as Emerging Potential Drug Targets for a Variety of Diseases: An Update.
Diacylglycerol kinases in cancer.
Diacylglycerol kinases: at the hub of cell signalling.
Downregulation of Diacylglycerol kinase zeta (DGKZ) suppresses tumorigenesis and progression of cervical cancer by facilitating cell apoptosis and cell cycle arrest.
Dual activities of ritanserin and R59022 as DGK? inhibitors and serotonin receptor antagonists.
Effect of amount and types of dietary fat on intestinal bacterial 7 alpha-dehydroxylase and phosphatidylinositol-specific phospholipase C and colonic mucosal diacylglycerol kinase and PKC activities during stages of colon tumor promotion.
Haemolytic uraemic syndrome.
Immune checkpoint blockade opens a new way to cancer immunotherapy.
Mechanisms in the chemoprevention of colon cancer: modulation of protein kinase C, tyrosine protein kinase and diacylglycerol kinase activities by 1,4-phenylenebis-(methylene)selenocyanate and impact of low-fat diet.
Molecular Pathways: Targeting Diacylglycerol Kinase Alpha in Cancer.
New Era of Diacylglycerol Kinase, Phosphatidic Acid and Phosphatidic Acid-Binding Protein.
NK-cell dysfunction in human renal carcinoma reveals diacylglycerol kinase as key regulator and target for therapeutic intervention.
Not expecting the unexpected: diacylglycerol kinase alpha as a cancer target.
Overexpression of DGKI in Gastric Cancer Predicts Poor Prognosis.
Protein kinase C mediates human neutrophil cytotoxicity.
Role of diacylglycerol kinases in T cell development and function.
Role of protein kinase C in chick embryo skeletal myoblast fusion.
Shape changes and chemokinesis of Walker carcinosarcoma cells: effects of protein kinase inhibitors (HA-1004, polymyxin B, sangivamycin and tamoxifen) and an inhibitor of diacylglycerol kinase (R 59022).
Subcellular Localization Relevance and Cancer-Associated Mechanisms of Diacylglycerol Kinases.
Synergistic control of T cell development and tumor suppression by diacylglycerol kinase alpha and zeta.
T cells deficient in diacylglycerol kinase-? are resistant to PD-1 inhibition and help create persistent host immunity to leukemia.
Targeting the mesenchymal subtype in glioblastoma and other cancers via inhibition of diacylglycerol kinase alpha.
Temporal production of the signaling lipid phosphatidic acid by phospholipase D2 determines the output of extracellular signal-regulated kinase signaling in cancer cells.
Where do substrates of diacylglycerol kinases come from? Diacylglycerol kinases utilize diacylglycerol species supplied from phosphatidylinositol turnover-independent pathways.
Nephrotic Syndrome
Long-term outcomes and response to treatment in diacylglycerol kinase epsilon nephropathy.
Neuroblastoma
Diacylglycerol kinase ? generates dipalmitoyl-phosphatidic acid species during neuroblastoma cell differentiation.
Effects of bradykinin, GTP gamma S, R59022 and N-ethylmaleimide on inositol phosphate production in NG108-15 cells.
Induction of filopodia-like protrusions in N1E-115 neuroblastoma cells by diacylglycerol kinase ? independent of its enzymatic activity: potential novel function of the C-terminal region containing the catalytic domain of diacylglycerol kinase ?.
Phosphoinositide-derived diacylglycerol conversion to phosphatidic acid is a receptor-dependent and compartmentalized phenomenon in human neuroblastoma.
Obesity
An in vivo screen for neuronal genes involved in obesity identifies Diacylglycerol kinase as a regulator of insulin secretion.
Analyses of shared genetic factors between asthma and obesity in children.
Deletion of diacylglycerol kinase ? confers susceptibility to obesity via reduced lipolytic activity in murine adipocytes.
Diacylglycerol kinase zeta in hypothalamus interacts with long form leptin receptor. Relation to dietary fat and body weight regulation.
Downregulation of diacylglycerol kinase delta contributes to hyperglycemia-induced insulin resistance.
mRNA expression of diacylglycerol kinase isoforms in insulin-sensitive tissues: effects of obesity and insulin resistance.
Role of Diacylglycerol Kinases in Glucose and Energy Homeostasis.
Optic Atrophy, Autosomal Dominant
Mapping and genomic characterization of the gene encoding diacylglycerol kinase gamma (DAGK3): assessment of its role in dominant optic atrophy (OPA1).
Ovarian Neoplasms
DGKA Provides Platinum Resistance in Ovarian Cancer Through Activation of c-JUN-WEE1 Signaling.
Pancreatic Neoplasms
Enhanced cytotoxicity of nucleoside analogs by overexpression of mitochondrial deoxyguanosine kinase in cancer cell lines.
Parkinson Disease
Analysis of the genotype of diacylglycerol kinase delta single-nucleotide polymorphisms in Parkinson disease in the Han Chinese population.
Association study of MCCC1/LAMP3 and DGKQ variants with Parkinson's disease in patients of Malay ancestry.
Peanut Hypersensitivity
Diacylglycerol kinase ? deficiency in a non-CD4(+) T-cell compartment leads to increased peanut hypersensitivity.
plasmin deficiency
HUS and atypical HUS.
Pre-Eclampsia
Analysis of the Epigenome in Multiplex Pre-eclampsia Families Identifies SORD, DGKI, and ICA1 as Novel Candidate Risk Genes.
Proteinuria
Podocyte dysfunction in atypical haemolytic uraemic syndrome.
Purpura, Thrombotic Thrombocytopenic
Complement activation in diseases presenting with thrombotic microangiopathy.
Irreversible severe kidney injury and anuria in a 3-month-old girl with atypical haemolytic uraemic syndrome under administration of eculizumab.
Radiation Fibrosis Syndrome
BET-bromodomain inhibitors modulate epigenetic patterns at the diacylglycerol kinase alpha enhancer associated with radiation-induced fibrosis.
Diacylglycerol Kinase Alpha in Radiation-Induced Fibrosis: Potential as a Predictive Marker or Therapeutic Target.
Epigenetic Modulation of Radiation-Induced Diacylglycerol Kinase Alpha Expression Prevents Pro-Fibrotic Fibroblast Response.
Epigenetic regulation of diacylglycerol kinase alpha promotes radiation-induced fibrosis.
Retinal Degeneration
A 104-kDa diacylglycerol kinase containing ankyrin-like repeats localizes in the cell nucleus.
Chromosomal localization of three mouse diacylglycerol kinase (DAGK) genes: genes sharing sequence homology to the Drosophila retinal degeneration A (rdgA) gene.
Constitutive activity of the light-sensitive channels TRP and TRPL in the Drosophila diacylglycerol kinase mutant, rdgA.
Diacylglycerol kinase defect in a Drosophila retinal degeneration mutant rdgA.
Drosophila retinal degeneration A gene encodes an eye-specific diacylglycerol kinase with cysteine-rich zinc-finger motifs and ankyrin repeats.
Functional INAD complexes are required to mediate degeneration in photoreceptors of the Drosophila rdgA mutant.
Immunolocalization of Drosophila eye-specific diacylgylcerol kinase, rdgA, which is essential for the maintenance of the photoreceptor.
Mapping and genomic characterization of the gene encoding diacylglycerol kinase gamma (DAGK3): assessment of its role in dominant optic atrophy (OPA1).
Retinal Neovascularization
Diacylglycerol Kinase (DGK) Inhibitor II (R59949) Could Suppress Retinal Neovascularization and Protect Retinal Astrocytes in an Oxygen-Induced Retinopathy Model.
Retinitis Pigmentosa
Characterization of the human diacylglycerol kinase epsilon gene and its assessment as a candidate for inherited retinitis pigmentosa.
The cloning and characterization of a novel human diacylglycerol kinase, DGKiota.
Retinoblastoma
Nuclear diacylglycerol kinase-zeta is a negative regulator of cell cycle progression in C2C12 mouse myoblasts.
Nuclear Localization of Diacylglycerol Kinase Alpha in K562 Cells Is Involved in Cell Cycle Progression.
Protein kinase C inhibits binding of diacylglycerol kinase-zeta to the retinoblastoma protein.
The retinoblastoma family proteins bind to and activate diacylglycerol kinase zeta.
TIS21/BTG2/PC3 and cyclin D1 are key determinants of nuclear diacylglycerol kinase-zeta-dependent cell cycle arrest.
Tis21/btg2/pc3 and cyclin d1 are key determinants of nuclear diacylglycerol kinase-zeta-dependent cell cycle arrest.
Sarcoma, Avian
Phosphatidylinositol kinase activities in normal and Rous sarcoma virus-transformed cells.
Seizures
Diacylglycerol kinase (DGKA) regulates the effect of the epilepsy and bipolar disorder treatment valproic acid in Dictyostelium discoideum.
Diacylglycerol kinase epsilon modulates rapid kindling epileptogenesis.
Diacylglycerol kinase epsilon regulates seizure susceptibility and long-term potentiation through arachidonoyl- inositol lipid signaling.
Diacylglycerol kinases as emerging potential drug targets for a variety of diseases.
Disruption of diacylglycerol kinase delta (DGKD) associated with seizures in humans and mice.
Epileptogenesis in diacylglycerol kinase epsilon deficiency up-regulates COX-2 and tyrosine hydroxylase in hippocampus.
Excitotoxicity by kainate-induced seizure causes diacylglycerol kinase ? to shuttle from the nucleus to the cytoplasm in hippocampal neurons.
Lipid signaling in experimental epilepsy.
Shock, Septic
Diacylglycerol kinase zeta regulates microbial recognition and host resistance to Toxoplasma gondii.
Starvation
Cross-phenotype association tests uncover genes mediating nutrient response in Drosophila.
Tachycardia
Diacylglycerol Kinase ? Inhibits Ventricular Tachyarrhythmias in a Mouse Model of Heart Failure.
Tachycardia, Ventricular
Diacylglycerol Kinase ? Inhibits Ventricular Tachyarrhythmias in a Mouse Model of Heart Failure.
Thrombotic Microangiopathies
Long-term outcomes and response to treatment in diacylglycerol kinase epsilon nephropathy.
Loss of diacylglycerol kinase ? causes thrombotic microangiopathy by impairing endothelial VEGFA signaling.
Toxoplasmosis
Diacylglycerol kinase zeta regulates microbial recognition and host resistance to Toxoplasma gondii.
Diacylglycerol kinases in immune cell function and self-tolerance.
Trypanosomiasis
Shedding light on lipid metabolism in Kinetoplastida: A phylogenetic analysis of phospholipase D protein homologs.
Tuberculosis
M. tuberculosis Rv2252 encodes a diacylglycerol kinase involved in the biosynthesis of phosphatidylinositol mannosides (PIMs).
[Developmental metabolism of Mycobacterium tuberculosis of H37Rv and L strains, cultured on DGK medium; general metabolic characteristics of Mycobacterium tuberculosis.]
[Microcultures of Mycobacterium tuberculosis obtained on the synthetic medium DGK.]
[Organic catabolites of strain H37Rv Mycobacterium tuberculosis cultured in DGK medium.]
Tyrosinemias
Deoxyguanosine kinase deficiency presenting as neonatal hemochromatosis.
Uterine Cervical Neoplasms
Downregulation of Diacylglycerol kinase zeta (DGKZ) suppresses tumorigenesis and progression of cervical cancer by facilitating cell apoptosis and cell cycle arrest.
Vesicular Stomatitis
Diacylglycerol kinase delta suppresses ER-to-Golgi traffic via its SAM and PH domains.
Whooping Cough
Crystal-induced neutrophil activation. I. Initiation and modulation of calcium mobilization and superoxide production by microcrystals.
Inositol 1,4,5-trisphosphate-independent Ca(2+) mobilization triggered by a lipid factor isolated from vitreous body.
Intracellular calcium mobilization and phospholipid degradation in sphingosylphosphorylcholine-stimulated human airway epithelial cells.
Role of protein kinase C in transforming growth factor-beta 1 induction of carcinoembryonic antigen in human colon carcinoma cells.
Wilms Tumor
New frontiers on the molecular underpinnings of hypospadias according to severity.