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ATP + 1,2-diacylglycerol
ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
-
-
?
ATP + 1,2-diacyl-sn-glycerol
ADP + 1,2-diacyl-sn-glycerol 3-phosphate
ATP + 1,2-diacylglycerol
ADP + 1,2-diacyl-sn-glycerol 3-phosphate
ATP + 1,2-diarachidonoyl-glycerol
ADP + 1,2-diarachidonoyl-glycerol 3-phosphate
-
-
-
-
?
ATP + 1,2-didecanoylglycerol
ADP + 1,2-didecanoylglycerol 3-phosphate
-
enzyme type I: activity is 157% of the activity with rac-1,2-dioleoylglycerol, enzyme type II: activity is 141% of the activity with rac-1,2-dioleoylglycerol
-
-
?
ATP + 1,2-didodecanoylglycerol
ADP + 1,2-didodecanoylglycerol 3-phosphate
-
enzyme type I: activity is 107% of the activity with rac-1,2-dioleoylglycerol, enzyme type II: activity is 227% of the activity with rac-1,2-dioleoylglycerol
-
-
?
ATP + 1,2-dihexadecanoylglycerol
ADP + 1,2-dihexadecanoylglycerol 3-phosphate
-
enzyme type I: activity is 198% of the activity with rac-1,2-dioleoylglycerol, enzyme type II: activity is 231% of the activity with rac-1,2-dioleoylglycerol
-
-
?
ATP + 1,2-dioctanoylglycerol
ADP + 1,2-dioctanoylglycerol 3-phosphate
ATP + 1,2-ditetradecanoylglycerol
ADP + 1,2-ditetradecanoylglycerol 3-phosphate
-
enzyme type I: activity is 200% of the activity with rac-1,2-dioleoylglycerol, enzyme type II: activity is 262% of the activity with rac-1,2-dioleoylglycerol
-
-
?
ATP + 1-palmitoyl-2-arachidonoyl-sn-glycerol
ADP + 1-palmitoyl-2-arachidonoyl-sn-glycerol 3-phosphate
-
enzyme type I: activity is 181% of the activity with rac-1,2-dioleoylglycerol, enzyme type II: activity is 116% of the activity with rac-1,2-dioleoylglycerol
-
-
?
ATP + 1-palmitoyl-2-linoleoyl-sn-glycerol
ADP + 1-palmitoyl-2-linoleoyl-sn-glycerol 3-phosphate
-
enzyme type I: activity is 116% of the activity with rac-1,2-dioleoylglycerol, enzyme type II: activity is 86% of the activity with rac-1,2-dioleoylglycerol
-
-
?
ATP + 1-palmitoyl-2-oleoyl-sn-glycerol
ADP + 1-palmitoyl-2-oleoyl-sn-glycerol 3-phosphate
ATP + 1-stearoyl-2-arachidonoyl-sn-glycerol
ADP + 1-stearoyl-2-arachidonoyl-sn-glycerol 3-phosphate
-
-
-
-
?
ATP + ceramide
ADP + ceramide 3-phosphate
ATP + rac-1,2-dioleoylglycerol
ADP + rac-1,2-dioleoylglycerol 3-phosphate
-
-
-
-
?
ATP + sn-1,2-dioleoylglycerol
ADP + sn-1,2-dioleoylglycerol 3-phosphate
GTP + 1,2-diacyl-sn-glycerol
GDP + 1,2-diacyl-sn-glycerol 3-phosphate
-
-
-
-
?
additional information
?
-
ATP + 1,2-diacyl-sn-glycerol
ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
-
-
-
?
ATP + 1,2-diacyl-sn-glycerol
ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
the enzyme is involved in resynthesis of phosphatidylinositol by converting a second messenger diacylglycerol to phosphatidic acid
-
-
?
ATP + 1,2-diacylglycerol
ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
-
-
-
?
ATP + 1,2-diacylglycerol
ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
-
-
?
ATP + 1,2-diacylglycerol
ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
-
i.e. phosphatidic acid
-
?
ATP + 1,2-diacylglycerol
ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
second messenger and intermediate in lipid synthesis
-
-
?
ATP + 1,2-diacylglycerol
ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
termination of diacylglycerol signaling, isozymes DGKalpha, DGKbeta, and DGKgamma play a pivotal role in development and metabolism of brain
-
-
?
ATP + 1,2-dioctanoylglycerol
ADP + 1,2-dioctanoylglycerol 3-phosphate
-
-
-
-
?
ATP + 1,2-dioctanoylglycerol
ADP + 1,2-dioctanoylglycerol 3-phosphate
-
enzyme type I: activity is 149% of the activity with rac-1,2-dioleoylglycerol, enzyme type II: activity is 114% of the activity with rac-1,2-dioleoylglycerol
-
-
?
ATP + 1-palmitoyl-2-oleoyl-sn-glycerol
ADP + 1-palmitoyl-2-oleoyl-sn-glycerol 3-phosphate
-
-
-
-
?
ATP + 1-palmitoyl-2-oleoyl-sn-glycerol
ADP + 1-palmitoyl-2-oleoyl-sn-glycerol 3-phosphate
-
about 60% of the activity with 1-palmitoyl-2-arachidonoyl-sn-glycerol
-
-
?
ATP + ceramide
ADP + ceramide 3-phosphate
-
no activity
-
-
?
ATP + ceramide
ADP + ceramide 3-phosphate
-
hardly utilized
-
-
?
ATP + sn-1,2-dioleoylglycerol
ADP + sn-1,2-dioleoylglycerol 3-phosphate
-
-
-
-
?
ATP + sn-1,2-dioleoylglycerol
ADP + sn-1,2-dioleoylglycerol 3-phosphate
-
enzyme type I: activity is 18% of the activity with rac-1,2-dioleoylglycerol, enzyme type II: activity is 19% of the activity with rac-1,2-dioleoylglycerol
-
-
?
additional information
?
-
-
enzyme form I and II show a preference for diacylglycerol substrates with saturated acyl chains of 10-12 carbon atoms
-
-
?
additional information
?
-
-
diacylglycerol emulsion
-
-
?
additional information
?
-
-
the enzyme is active in mixed micelles containing octyl glucoside and dioleoylglycerol
-
-
?
additional information
?
-
-
DGKzeta blocks cardiac hypertrophic programs in response to endothelin-1 in neonatal rat cardiomyocytes. DGKzeta blocks cardiac hypertrophy induced by G protein-coupled receptor agonists and pressure overload in vivo. DGKzeta attenuates ventricular remodeling and improves survival after myocardial infarction
-
-
?
additional information
?
-
-
diacylglycerol kinase is involved in the regulation of oxidative stress-induced intestinal cell injury
-
-
?
additional information
?
-
the enzyme also shows 1-monoacylglycerol kinase (1-MGK) and low 2-monoacylglycerol kinase (2-MGK) activities, cf. EC 2.7.1.94
-
-
?
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Younes, A.; Kahn, D.W.; Besterman, J.M.; Bittman, R.; Byun, H.S.; Kolesnick, R.N.
Ceramide is a competitive inhibitor of diacylglycerol kinase in vitro and in intact human leukemia (HL-60) cells
J. Biol. Chem.
267
842-847
1992
Rattus norvegicus
brenda
Kato, M.; Takenawa, T.
Purification and characterization of membrane-bound and cytosolic forms of diacylglycerol kinase from rat brain
J. Biol. Chem.
265
794-800
1990
Rattus norvegicus
brenda
Stathopoulos, V.M.; Coco-Maroney, A.; Wei, C.W.; Goth, M.; Zaricznyj, C.; Macara, I.G.
Identification of two cytosolic diacylglycerol kinase isoforms in rat brain, and in NIH-3T3 and ras-transformed fibroblasts
Biochem. J.
272
569-575
1990
Rattus norvegicus
brenda
Kanoh, H.; Akesson, B.
Properties of microsomal and soluble diacylglycerol kinase in rat liver
Eur. J. Biochem.
85
225-232
1978
Rattus norvegicus
brenda
Walsh, J.P.; Bell, R.M.
sn-1,2-Diacylglycerol kinase of Escherichia coli. Mixed micellar analysis of the phospholipid cofactor requirement and divalent cation dependence
J. Biol. Chem.
261
6239-6247
1986
Rattus norvegicus
brenda
Hee-Cheong, M.; Fletcher, T.; Kryski, S.K.; Severson, D.L.
Diacylglycerol lipase and kinase activities in rat brain microvessels
Biochim. Biophys. Acta
883
59-68
1985
Rattus norvegicus
-
brenda
Goto, K.; Kondo, H.
Heterogeneity of diacylglycerol kinase in terms of molecular structure, biochemical characteristics and gene expression localization in the brain
J. Lipid Mediat. Cell Signal.
14
251-257
1996
Rattus norvegicus
brenda
Tabellini, G.; Bortul, R.; Santi, S.; Riccio, M.; Baldini, G.; Cappellini, A.; Billi, A.M.; Berezney, R.; Ruggeri, A.; Cocco, L.; Martelli, A.M.
Diacylglycerol kinase-theta is localized in the speckle domains of the nucleus
Exp. Cell Res.
287
143-154
2003
Homo sapiens, Rattus norvegicus
brenda
Sakane, F.; Kanoh, H.
Molecules in focus: diacylglycerol kinase
Int. J. Biochem. Cell Biol.
29
1139-1143
1997
Homo sapiens, Mesocricetus auratus, Rattus norvegicus, Sus scrofa
brenda
Yamada, K.; Sakane, F.; Matsushima, N.; Kanoh, H.
EF-hand motifs of alpha, beta and gamma isoforms of diacylglycerol kinase bind calcium with different affinities and conformational changes
Biochem. J.
321
59-64
1997
Homo sapiens, Rattus norvegicus, Sus scrofa, Sus scrofa DGKalpha
brenda
Katagiri, Y.; Ito, T.; Saino-Saito, S.; Hozumi, Y.; Suwabe, A.; Otake, K.; Sata, M.; Kondo, H.; Sakane, F.; Kanoh, H.; Kubota, I.; Goto, K.
Expression and localization of diacylglycerol kinase isozymes and enzymatic features in rat lung
Am. J. Physiol.
288
L1171-1178
2005
Rattus norvegicus
brenda
Adachi, N.; Oyasu, M.; Taniguchi, T.; Yamaguchi, Y.; Takenaka, R.; Shirai, Y.; Saito, N.
Immunocytochemical localization of a neuron-specific diacylglycerol kinase beta and gamma in the developing rat brain
Mol. Brain Res.
139
288-299
2005
Rattus norvegicus
brenda
Clarke, C.J.; Ohanian, V.; Ohanian, J.
Norepinephrine and endothelin activate diacylglycerol kinases in caveolae/rafts of rat mesenteric arteries: agonist-specific role of PI3-kinase
Am. J. Physiol. Heart Circ. Physiol.
292
H2248-H2256
2007
Rattus norvegicus
brenda
Sasaki, H.; Hozumi, Y.; Hasegawa, H.; Ito, T.; Takagi, M.; Ogino, T.; Watanabe, M.; Goto, K.
gene expression and localization of diacylglycerol kinase isozymes in the rat spinal cord and dorsal root ganglia
Cell Tissue Res.
326
35-42
2006
Rattus norvegicus, Rattus norvegicus (O08560)
brenda
Evangelisti, C.; Bortul, R.; Fala, F.; Tabellini, G.; Goto, K.; Martelli, A.M.
Nuclear diacylglycerol kinases: emerging downstream regulators in cell signalling networks
Histol. Histopathol.
22
573-579
2007
Chlorocebus aethiops, Cricetulus griseus, Homo sapiens, Mus musculus, Rattus norvegicus
brenda
Takeishi, Y.; Goto, K.; Endoh, M.
Role of siacylglycerol kinase in cellular regulatory processes: a new regulator for cardiomyocyte hypertrophy
Pharmacol. Ther.
115
352-359
2007
Rattus norvegicus
brenda
Song, J.; Li, J.; Mourot, J.M.; Evers, B.M.; Chung, D.H.
Diacylglycerol kinase regulation of protein kinase D during oxidative stress-induced intestinal cell injury
Biochem. Biophys. Res. Commun.
375
200-204
2008
Rattus norvegicus
brenda
Chibalin, A.V.; Leng, Y.; Vieira, E.; Krook, A.; Bjoernholm, M.; Long, Y.C.; Kotova, O.; Zhong, Z.; Sakane, F.; Steiler, T.; Nylen, C.; Wang, J.; Laakso, M.; Topham, M.K.; Gilbert, M.; Wallberg-Henriksson, H.; Zierath, J.R.
Downregulation of diacylglycerol kinase delta contributes to hyperglycemia-induced insulin resistance
Cell
132
375-386
2008
Mus musculus, Rattus norvegicus, Homo sapiens (Q16760), Homo sapiens
brenda
Kobayashi, N.; Hozumi, Y.; Ito, T.; Hosoya, T.; Kondo, H.; Goto, K.
Differential subcellular targeting and activity-dependent subcellular localization of diacylglycerol kinase isozymes in transfected cells
Eur. J. Cell Biol.
86
433-444
2007
Rattus norvegicus, Rattus norvegicus (O08560), Rattus norvegicus (P49621), Rattus norvegicus (P51556)
brenda
Miele, C.; Paturzo, F.; Teperino, R.; Sakane, F.; Fiory, F.; Oriente, F.; Ungaro, P.; Valentino, R.; Beguinot, F.; Formisano, P.
Glucose regulates diacylglycerol intracellular levels and protein kinase C activity by modulating diacylglycerol kinase subcellular localization
J. Biol. Chem.
282
31835-31843
2007
Rattus norvegicus
brenda
Hozumi, Y.; Watanabe, M.; Otani, K.; Goto, K.
Diacylglycerol kinase beta promotes dendritic outgrowth and spine maturation in developing hippocampal neurons
BMC Neurosci.
10
99
2009
Rattus norvegicus (P49621)
brenda
Nakano, T.; Hozumi, Y.; Goto, K.; Wakabayashi, I.
Localization of diacylglycerol kinase epsilon on stress fibers in vascular smooth muscle cells
Cell Tissue Res.
337
167-175
2009
Rattus norvegicus
brenda
Hozumi, Y.; Fukaya, M.; Adachi, N.; Saito, N.; Otani, K.; Kondo, H.; Watanabe, M.; Goto, K.
Diacylglycerol kinase beta accumulates on the perisynaptic site of medium spiny neurons in the striatum
Eur. J. Neurosci.
28
2409-2422
2008
Rattus norvegicus (P49621)
brenda
Hozumi, Y.; Watanabe, M.; Goto, K.
Signaling cascade of diacylglycerol kinase beta in the pituitary intermediate lobe: Dopamine D2 receptor/phospholipase Cbeta4/diacylglycerol kinase beta/protein kinase Calpha
J. Histochem. Cytochem.
58
119-129
2010
Rattus norvegicus
brenda
Kim, K.; Yang, J.; Kim, E.
Diacylglycerol kinases in the regulation of dendritic spines
J. Neurochem.
112
577-587
2010
Rattus norvegicus (O08560), Mus musculus (Q80UP3)
brenda
Nakano, T.; Iseki, K.; Hozumi, Y.; Kawamae, K.; Wakabayashi, I.; Goto, K.
Brain trauma induces expression of diacylglycerol kinase zeta in microglia
Neurosci. Lett.
461
110-115
2009
Rattus norvegicus (O08560)
brenda
Sato, Y.; Murakami, C.; Yamaki, A.; Mizuno, S.; Sakai, H.; Sakane, F.
Distinct 1-monoacylglycerol and 2-monoacylglycerol kinase activities of diacylglycerol kinase isozymes
Biochim. Biophys. Acta
1864
1170-1176
2016
Homo sapiens (O75912), Homo sapiens (P49619), Homo sapiens (P52429), Homo sapiens (P52824), Homo sapiens (Q13574), Homo sapiens (Q16760), Homo sapiens (Q5KSL6), Homo sapiens (Q86XP1), Sus scrofa (P20192), Rattus norvegicus (P68403)
brenda
Natalini, P.M.; Zulian, S.E.; Ilincheta de Boschero, M.G.; Giusto, N.M.
Diacylglycerol kinase epsilon in bovine and rat photoreceptor cells. Light-dependent distribution in photoreceptor cells
Exp. Eye Res.
112
139-150
2013
Bos taurus, Rattus norvegicus, Rattus norvegicus Wistar
brenda
Hozumi, Y.; Nakano, T.; Tanaka, T.; Goto, K.
Localization of diacylglycerol kinase zeta in rat pancreatic islet cells under normal and streptozotocin-induced stress conditions
Arch. Histol. Cytol.
76
23-33
2016
Rattus norvegicus (O08560)
-
brenda