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Information on EC 2.7.1.105 - 6-phosphofructo-2-kinase
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2.7.1.105 6-phosphofructo-2-kinaseIUBMB Comments
Not identical with EC 2.7.1.11 6-phosphofructokinase. The enzyme co-purifies with EC 3.1.3.46 fructose-2,6-bisphosphate 2-phosphatase.
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Word Map
- 2.7.1.105
- 2,6-bisphosphate
- fructose-2,6-bisphosphate
- pfkfb3
- 6-phosphofructo-1-kinase
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camp-dependent
- phosphofructokinase-1
- mgatp
- phosphoenzyme
- medicine
- sn-glycerol
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cyclic-amp-dependent
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fru-6-p
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3-3hglucose
- fbpase-2
- pharmacology
- diagnostics
- drug development
The expected taxonomic range for this enzyme is: Eukaryota, Archaea, Bacteria
Synonyms
6-phosphofructo-2-kinase, phosphofructokinase 2, phosphofructokinase-2, upfk-2, inducible 6-phosphofructo-2-kinase, fructose 6-phosphate 2-kinase, ipfk2, tpfk-2, phosphofructokinase-2/fructose bisphosphatase-2, 6-phosphofructose 2-kinase, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase
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6-phosphofructose 2-kinase
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ATP:D-fructose-6-phosphate 2-phosphotransferase
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fructose 6-phosphate 2-kinase
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kinase, 6-phosphofructo-2-(phosphorylating)
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phosphofructokinase 2
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
phospho group transfer
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SYSTEMATIC NAME
IUBMB Comments
ATP:beta-D-fructose-6-phosphate 2-phosphotransferase
Not identical with EC 2.7.1.11 6-phosphofructokinase. The enzyme co-purifies with EC 3.1.3.46 fructose-2,6-bisphosphate 2-phosphatase.
CAS REGISTRY NUMBER
COMMENTARY
78689-77-7
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
expressed at high abundance in both hypothalami and clonal hypothalamic neurons. In response to re-feeding, isoform PFKFB3 mRNA levels are increased by 10fold in mouse hypothalami
expressed at high abundance in both hypothalami and clonal hypothalamic neurons
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
physiological function
knockdown of isoform PFKFB3/iPFK2 in N-43/5 neurons causes a decrease in rates of glycolysis, which is accompanied by increased AMP-activated protein kinase phosphorylation, increased agouti-related protein mRNA levels and decreased cocaine-amphetamine-related transcript mRNA levels. Overexpression of PFKFB3/iPFK2 in N-43/5 neurons causes an increase in glycolysis, which is accompanied by decreased AMP-activated protein kinase phosphorylation and decreased agouti-related protein mRNA levels and increased cocaine-amphetamine-related transcript mRNA levels
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). EXPRESSION
ORGANISM
UNIPROT
LITERATURE
upon re-feeding, isoform PFKFB3 mRNA levels are increased by 10fold in mouse hypothalami
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ORGANISM (UNIPROT)
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Release 2023.1 (January 2023)
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