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EC Tree
IUBMB Comments D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase.
The taxonomic range for the selected organisms is: Nicotiana tabacum The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Synonyms
hexokinase, hexokinase ii, hexokinase 2, hexokinase i, hk ii, hxk, liver glucokinase, hexokinase 1, hexokinase-2, hkdc1,
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ATP-D-hexose 6-phosphotransferase
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ATP-dependent hexokinase
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brain form hexokinase
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glucose ATP phosphotransferase
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hexokinase (phosphorylating)
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hexokinase type IV
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hexokinase type IV glucokinase
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hexokinase, tumor isozyme
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kinase, hexo- (phosphorylating)
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muscle form hexokinase
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additional information
enzyme is a type A hexokinase
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phospho group transfer
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-, -, -, -, -, -, -, -, -, -, -, -, -, -, -, -
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ATP:D-hexose 6-phosphotransferase
D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase.
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ATP + D-fructose
ADP + D-fructose 6-phosphate
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?
ATP + D-glucose
ADP + D-glucose 6-phosphate
ATP + D-mannose
ADP + D-mannose 6-phosphate
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?
ATP + D-fructose
ADP + D-fructose 6-phosphate
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?
ATP + D-glucose
ADP + D-glucose 6-phosphate
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?
ATP + D-glucose
ADP + D-glucose 6-phosphate
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?
ATP + D-glucose
ADP + D-glucose 6-phosphate
isozyme hexokinase 2 plays a role in starch and secondary metabolism in starch sheath, xylem parenchyma, guard cells, and root tips
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ATP + D-fructose
ADP + D-fructose 6-phosphate
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?
ATP + D-glucose
ADP + D-glucose 6-phosphate
isozyme hexokinase 2 plays a role in starch and secondary metabolism in starch sheath, xylem parenchyma, guard cells, and root tips
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?
ATP + D-mannose
ADP + D-mannose 6-phosphate
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?
ATP + D-fructose
ADP + D-fructose 6-phosphate
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?
ATP + D-glucose
ADP + D-glucose 6-phosphate
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?
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additional information
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increased activity of the cytosolic and non-cytosolic isozymes induced by tobacco mosaic virus TMV
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0.025
D-fructose
pH 8.4, 30°C, recombinant isozyme hexokinase 2
0.06
D-glucose
pH 8.4, 30°C, recombinant isozyme hexokinase 2
0.149
D-mannose
pH 8.4, 30°C, recombinant isozyme hexokinase 2
additional information
additional information
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additional information
additional information
kinetics of isozyme hexokinase 2
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additional information
additional information
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kinetics of isozyme hexokinase 2
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0.114
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healthy leaves, soluble glucokinase activity
0.199
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TMV-infected leaves, soluble glucokinase activity
0.574
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healthy leaves, particulate glucokinase activity
0.609
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healthy leaves, soluble fructokinase activity
0.693
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TMV-infected leaves, particulate glucokinase activity
0.892
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TMV-infected leaves, total glucokinase activity
1.297
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healthy leaves, total fructokinase activity
0.688
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healthy leaves, particulate fructokinase activity
0.688
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healthy leaves, total glucokinase activity
additional information
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additional information
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isozyme hexokinase 2
SwissProt
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vascular starch sheath
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xylem
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parenchym
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changes in the cytosolic and non-cytosolic isozyme complexes induced by tobacco mosaic virus infection
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hexokinase 2, enzyme contains a putative cleavable chloroplast transit peptide of 30 amino acids
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2 soluble isozymes, increased activity of the cytosolic and non-cytosolic isozymes induced by tobacco mosaic virus infection
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1 particulate isozyme, increased activity of the cytosolic and non-cytosolic isozymes induced by tobacco mosaic virus infection
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malfunction
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after silencing NtHXK1 using RNAi plants show stunted growth and leaf chlorosis
malfunction
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overexpression of NtHXK1 results in elevated glucose phosphorylation activity in leaf extracts or chloroplasts. NtHXK1 is able to complement the glucose-insensitive Arabidopsis mutant gin2-1 suggesting that NtHXK1 can take over glucose sensing functions
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HXK2_TOBAC
499
0
53997
Swiss-Prot
Chloroplast (Reliability: 3 )
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54000
x * 54000, about, amino acid sequence calculation
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?
x * 54000, about, amino acid sequence calculation
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additional information
construction of transgenic tobacco plants overexpressing isozyme hexokinase 2 via Agrobacterium tumefaciens infection system
additional information
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construction of transgenic tobacco plants overexpressing isozyme hexokinase 2 via Agrobacterium tumefaciens infection system
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partially, subcellular fractionation by anion exchange chromatography of isozymes from healthy and TMV-infected leaves
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isozyme hexokinase 2, promotor isolation and analysis, in vitro transcription and translation, and import of intact precursor proteins, native or fused to GFP, into stroma of chloroplasts of spinach or pea, expression in transgenic tobacco plants via Agrobacterium tumefaciens infection system
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Sindelar, L.; Sindelarova, M.
Hexokinases of tobacco leaves: Changes in the cytosolic and non-cytosolic isozyme complexes induced by tobacco mosaic virus infection
Biol. Plant.
47
413-419
2003
Nicotiana tabacum
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brenda
Giese, J.O.; Herbers, K.; Hoffmann, M.; Klosgen, R.B.; Sonnewald, U.
Isolation and functional characterization of a novel plastidic hexokinase from Nicotiana tabacum
FEBS Lett.
579
827-831
2005
Nicotiana tabacum (Q6Q8A5), Nicotiana tabacum
brenda
Kim, Y.; Heinzel, N.; Giese, J.; Koeber, J.; Melzer, M.; Rutten, T.; Von Wiren, N.; Sonnewald, U.; Hajirezaei, M.
A dual role of tobacco hexokinase 1 in primary metabolism and sugar sensing
Plant Cell Environ.
36
1311-1327
2013
Nicotiana tabacum
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