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Information on EC 2.7.1.1 - hexokinase
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2.7.1.1 hexokinaseIUBMB Comments
D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase.
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Word Map
- 2.7.1.1
- glucose-6-phosphate
-
phosphofructokinase
- glycogen
- fructose
- citrate
- adp
- erythrocyte
- malate
- phosphorylase
- pancreatic
- hypoxia
- islet
- pentose
- creatine
- mellitus
- 2-deoxyglucose
- aldolase
- hyperglycemia
- phosphoglucomutase
-
warburg
-
hypoxia-inducible
- 6-phosphogluconate
-
glut-1
-
voltage-dependent
-
vdacs
- streptozotocin
-
positron
- soleus
-
18f-fdg
- lateralis
- fructose-1,6-bisphosphatase
-
hypoglycemic
- invertase
- 2-deoxy-d-glucose
- fructokinase
-
gluconeogenic
-
insulin-stimulated
-
carboxykinase
- hexoses
-
vastus
-
glycogenolysis
- g6pase
- glycosomes
-
antihyperglycemic
-
phosphoglucose
-
18f-fluorodeoxyglucose
-
fdg-pet
- pharmacology
-
suvmax
- analysis
-
glutaminolysis
-
2,6-bisphosphate
- synthesis
- diagnostics
- industry
- medicine
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Reaction Schemes
Synonyms
hexokinase, hexokinase ii, hexokinase 2, hexokinase i, hk ii, hxk, liver glucokinase, hexokinase 1, hexokinase-2, hkdc1, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
ATP-D-hexose 6-phosphotransferase
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ATP-dependent hexokinase
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brain form hexokinase
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glucokinase
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glucose ATP phosphotransferase
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hexokinase (phosphorylating)
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hexokinase D
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hexokinase PI
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hexokinase PII
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hexokinase type IV
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hexokinase type IV glucokinase
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hexokinase, tumor isozyme
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HK
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HK4
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HXK
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kinase, hexo- (phosphorylating)
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muscle form hexokinase
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
phospho group transfer
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PATHWAY SOURCE
PATHWAYS
BRENDA
KEGG
Amino sugar and nucleotide sugar metabolism, Biosynthesis of secondary metabolites, Fructose and mannose metabolism, Galactose metabolism, Glycolysis / Gluconeogenesis, Microbial metabolism in diverse environments, Neomycin, kanamycin and gentamicin biosynthesis, Starch and sucrose metabolism, Streptomycin biosynthesis
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-, -, -, -, -, -, -, -, -, -, -, -, -, -, -, -
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SYSTEMATIC NAME
IUBMB Comments
ATP:D-hexose 6-phosphotransferase
D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase.
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CAS REGISTRY NUMBER
COMMENTARY
9001-51-8
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
additional information
?
-
the enzyme shows little catalytic capacity for galactose and fructose
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?
additional information
?
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-
the enzyme shows little catalytic capacity for galactose and fructose
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?
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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acidosis
Metabolism of totally ischemic excised dog heart. II. Interpretation of a computer model.
Acidosis
[Changes in the activity and isoenzymic spectrum of skeletal muscle and brain hexokinase under organism adaptation to intensive physical exercise.]
Acute Kidney Injury
Integrated Multiomics Reveals Glucose Use Reprogramming and Identifies a Novel Hexokinase in Alcoholic Hepatitis.
Acute Kidney Injury
Renal cortical hexokinase and pentose phosphate pathway activation through the EGFR/Akt signaling pathway in endotoxin-induced acute kidney injury.
Acute Kidney Injury
The effects of erdosteine on the activities of some metabolic enzymes during cisplatin-induced nephrotoxicity in rats.
Acute Lung Injury
Analysis of mRNA?lncRNA and mRNA?lncRNA-pathway co?expression networks based on WGCNA in developing pediatric sepsis.
Adenocarcinoma
Combination of arsenic trioxide and cisplatin synergistically inhibits both hexokinase activity and viability of Ehrlich ascites carcinoma cells.
Adenocarcinoma
Expressions of hypoxia-inducible factor-1? and hexokinase-II in gastric adenocarcinoma: the impact on prognosis and correlation to clinicopathologic features.
Adenocarcinoma
FDG-PET/CT imaging findings of hepatic tumors and tumor-like lesions based on molecular background.
Adenocarcinoma
High- and low-tumorigenic culture lines of rat uterine adenocarcinoma and their isozyme patterns of lactate dehydrogenase and hexokinase.
Adenocarcinoma
Inhibition of hexokinase-2 with targeted liposomal 3-bromopyruvate in an ovarian tumor spheroid model of aerobic glycolysis.
Adenocarcinoma
Long non-coding RNA HOTAIR promotes cancer cell energy metabolism in pancreatic adenocarcinoma by upregulating hexokinase-2.
Adenocarcinoma
Mitochondrial hexokinase from differentiated and undifferentiated HT29 colon cancer cells: effect of some metabolites on the bound/soluble equilibrium.
Adenocarcinoma
Modification of the hexokinase activity in the red blood cells of subjects with differentiated adenocarcinoma.
Adenocarcinoma
Relationship between erythrocyte hexokinase in cancer patients and red cell age.
Adenocarcinoma
Study on ATP-generating system and related hexokinase activity in mitochondria isolated from undifferentiated or differentiated HT29 adenocarcinoma cells.
Adenocarcinoma
[18F]2-fluoro-2-deoxy-D-glucose incorporation by AGS gastric adenocarcinoma cells in vitro during response to epirubicin, cisplatin and 5-fluorouracil.
Adenocarcinoma of Lung
HKDC1 promotes the tumorigenesis and glycolysis in lung adenocarcinoma via regulating AMPK/mTOR signaling pathway.
Adenoma
Determination and characterization of hexokinase in thyroid cancer and benign neoplasms.
Adenoma
[Catalytic properties and isoenzyme composition of hexokinase in thyroid gland normal and neoplastic tissue]
Adenoma, Islet Cell
Alloxan and ninhydrin inhibition of hexokinase from pancreatic islets and tumoural insulin-secreting cells.
adenosine deaminase deficiency
Ultra-performance liquid chromatography-tandem mass spectrometry-based multiplex enzyme assay for six enzymes associated with hereditary hemolytic anemia.
Adrenocortical Adenoma
Expression of Glucose Metabolism-Related Proteins in Adrenal Neoplasms.
Adrenocortical Carcinoma
Expression of Glucose Metabolism-Related Proteins in Adrenal Neoplasms.
Alkalosis
[Redox processes in the retina and tunic tissues of the rat eye in experimental alkalosis]
Altitude Sickness
Overexpression of genes associated with hypoxia in cattle adapted to Trans Himalayan region of Ladakh.
Alzheimer Disease
Activities of key glycolytic enzymes in the brains of patients with Alzheimer's disease.
Alzheimer Disease
Altered hexokinase activity in skin cultured fibroblasts and leukocytes from Alzheimer's disease patients.
Alzheimer Disease
Changes in Na+,K(+)-ATPase, Ca2(+)-ATPase and some soluble enzymes related to energy metabolism in brains of patients with Alzheimer's disease.
Alzheimer Disease
Decreased brain glucose metabolism in microvessels from patients with Alzheimer's disease.
Anaplasmosis
The effect of Anaplasma marginale on the glycolytic pathway in bovine erythrocytes.
Anemia
Downeast anemia (dea), a new mouse model of severe nonspherocytic hemolytic anemia caused by hexokinase (HK(1)) deficiency.
Anemia
Electrophoretic characterization and subcellular distribution of hexokinase isoenzymes in red blood cells of rabbits.
Anemia
Glucose 6-phosphate dehydrogenase, hexokinase activities and ATP levels as a function of cell density in thalassemia and iron deficiency anemia.
Anemia
The relationship between red cell aging and enzyme activities in experimental animals.
Anemia
[Activity of kidney tissue enzymes in phenylhydrazine anemia and post-transfusion polycythemia]
Anemia
[Atrio-digital dysplasia with anemia, erythrocyte hexokinase deficiency and chromosome anomalies]
Anemia
[Cytogenetic finding and etiology of Fanconi's anemia. A case of Fanconi's anemia without hexokinase deficiency]
Anemia
[Hexokinase isoenzymes in normal erythrocytes of adults and newborns and in various hyperregenerative anemias]
Anemia
[Leading criteria of reticulocyte maturation. 3. Behavior of hexokinase and glucokinase of red blood cells during a bleeding anemia of the rabbit]
Anemia, Aplastic
The pattern of reactivated fetal erythropoiesis in bone marrow disorders of childhood.
Anemia, Diamond-Blackfan
The pattern of reactivated fetal erythropoiesis in bone marrow disorders of childhood.
Anemia, Hemolytic
A nonsense variant in the Hexokinase 1 gene (HK1) causing severe non-spherocytic haemolytic anaemia: genetic analysis exemplifies ambiguity due to multiple Isoforms.
Anemia, Hemolytic
Age-related red cell enzymes in children with transient erythroblastopenia of childhood and with hemolytic anemia.
Anemia, Hemolytic
Allogeneic bone marrow transplantation for treatment of severe hemolytic anemia attributable to hexokinase deficiency.
Anemia, Hemolytic
Congenital nonspherocytic hemolytic anemia associated with an unusual erythrocyte hexokinase abnormality.
Anemia, Hemolytic
Congenital nonspherocytic hemolytic anemia with an unstable hexokinase variant.
Anemia, Hemolytic
Deficiencies of glycolytic enzymes as a possible cause of hemolytic anemia.
Anemia, Hemolytic
Downeast anemia (dea), a new mouse model of severe nonspherocytic hemolytic anemia caused by hexokinase (HK(1)) deficiency.
Anemia, Hemolytic
Generalized hexokinase deficiency in the blood cells of a patient with nonspherocytic hemolytic anemia.
Anemia, Hemolytic
Hereditary nonspherocytic hemolytic anemia due to a new hexokinase variant with reduced stability.
Anemia, Hemolytic
Hexokinase "New Hyde Park": a low activity erythrocyte isozyme in a Chinese kindred.
Anemia, Hemolytic
Hexokinase deficiency in erythrocytes: a new variant in 5 members of a Finnish family.
Anemia, Hemolytic
HK Utrecht: missense mutation in the active site of human hexokinase associated with hexokinase deficiency and severe nonspherocytic hemolytic anemia.
Anemia, Hemolytic
Homozygous intragenic deletion of type I hexokinase gene causes lethal hemolytic anemia of the affected fetus.
Anemia, Hemolytic
Human erythrocyte hexokinase deficiency. Characterization of a mutant enzyme with abnormal regulatory properties.
Anemia, Hemolytic
Intracellular free magnesium and phosphorylated metabolites in hexokinase- and pyruvate kinase-deficient red cells measured using 31P-NMR spectroscopy.
Anemia, Hemolytic
Non-spherocytic haemolytic anaemia in mother and son associated with hexokinase deficiency.
Anemia, Hemolytic
Normal and variant isoenzymes of human blood cell hexokinase and the isoenzyme patterns in hemolytic anemia.
Anemia, Hemolytic
Novel pathogenic variant c.2714C>A (p. Thr905Lys) in the HK1 gene causing severe haemolytic anaemia with developmental delay in an Indian family.
Anemia, Hemolytic
[Hereditary nonspherocytic hemolytic anemia caused by a deficiency in erythrocytic hexokinase associated with glycogenosis of muscles]
Anemia, Hemolytic, Congenital
Hereditary hemolytic anemia with hexokinase deficiency. Role of hexokinase in erythrocyte aging.
Anemia, Hemolytic, Congenital
Inhibitory effect of mannose on erythrocyte defense against oxidants.
Anemia, Hemolytic, Congenital Nonspherocytic
Congenital nonspherocytic hemolytic anemia associated with an unusual erythrocyte hexokinase abnormality.
Anemia, Hemolytic, Congenital Nonspherocytic
Congenital nonspherocytic hemolytic anemia with an unstable hexokinase variant.
Anemia, Hypochromic
A dual role of tobacco hexokinase 1 in primary metabolism and sugar sensing.
Anemia, Iron-Deficiency
Glucose 6-phosphate dehydrogenase, hexokinase activities and ATP levels as a function of cell density in thalassemia and iron deficiency anemia.
Arteriosclerosis
[Studies on arteriosclerosis and endangitis obliterans. VIII. Hexokinase and adenosine triphosphatase in skeletal muscles in peripheral vascular disorders.]
Arthritis, Rheumatoid
Hexokinase 2 as a novel selective metabolic target for rheumatoid arthritis.
Arthritis, Rheumatoid
Identification of new autoantigens for primary biliary cirrhosis using human proteome microarrays.
Arthritis, Rheumatoid
Increased hexokinase-2 as a novel biomarker for the diagnosis and correlating with disease severity in rheumatoid arthritis.
Astrocytoma
The membrane-bound hexokinase as a potential marker for malignancy in human gliomas.
Atherosclerosis
Regulation of glycolytic genes in human macrophages by oxysterols: a potential role for liver X receptors.
Atypical Squamous Cells of the Cervix
Protein degradation during yeast sporulation. Enzyme and cytochrome patterns.
Bile Duct Neoplasms
Analysis of the roles of glucose transporter 1 and hexokinase 2 in the metabolism of glucose by extrahepatic bile duct cancer cells.
Birth Injuries
[Hexokinase and aldolase activity in the healthy newborn, in asphyxia and in birth injuries]
Brain Diseases
Proton-dependent inhibition of yeast and brain hexokinases by aluminum in ATP preparations.
Brain Injuries
Hexokinase 2-dependent hyperglycolysis driving microglial activation contributes to ischemic brain injury.
Brain Neoplasms
Analyses of resected human brain metastases of breast cancer reveal the association between up-regulation of hexokinase 2 and poor prognosis.
Brain Neoplasms
Gliomas are driven by glycolysis: putative roles of hexokinase, oxidative phosphorylation and mitochondrial ultrastructure.
Brain Neoplasms
Hexokinase 2 (HK2), the tumor promoter in glioma, is downregulated by miR-218/Bmi1 pathway.
Brain Neoplasms
Hexokinase 2 is a key mediator of aerobic glycolysis and promotes tumor growth in human glioblastoma multiforme.
Brain Neoplasms
Homophilic anchorage of brain-hexokinase to mitochondria-porins revealed by specific-peptide antibody cross recognition.
Brain Neoplasms
Kinetic characterization of hexokinase isoenzymes from glioma cells: implications for FDG imaging of human brain tumors.
Brain Neoplasms
Potentiation of lonidamine and diazepam, two agents acting on mitochondria, in human glioblastoma treatment.
Breast Diseases
Glycolytic enzymes in breast cancer, benign breast disease and normal breast tissue.
Breast Neoplasms
17{beta}-Estradiol Augments 18F-FDG Uptake and Glycolysis of T47D Breast Cancer Cells via Membrane-Initiated Rapid PI3K-Akt Activation.
Breast Neoplasms
A novel miR-155/miR-143 cascade controls glycolysis by regulating hexokinase 2 in breast cancer cells.
Breast Neoplasms
Analyses of resected human brain metastases of breast cancer reveal the association between up-regulation of hexokinase 2 and poor prognosis.
Breast Neoplasms
Bisabolane Sesquiterpenoids from the Plant Endophytic Fungus Paraconiothyrium brasiliense.
Breast Neoplasms
Changes in 2-fluoro-2-deoxy-D-glucose incorporation, hexokinase activity and lactate production by breast cancer cells responding to treatment with the anti-HER-2 antibody trastuzumab.
Breast Neoplasms
Combination of arsenic trioxide and cisplatin synergistically inhibits both hexokinase activity and viability of Ehrlich ascites carcinoma cells.
Breast Neoplasms
Comparison of glycolytic enzyme and isoenzyme activity in breast cancers and dysplasia.
Breast Neoplasms
Correction: PIM2-mediated phosphorylation of hexokinase 2 is critical for tumor growth and paclitaxel resistance in breast cancer.
Breast Neoplasms
Direct inhibition of hexokinase activity by metformin at least partially impairs glucose metabolism and tumor growth in experimental breast cancer.
Breast Neoplasms
Dissection of signaling pathways in fourteen breast cancer cell lines using reverse-phase protein lysate microarray.
Breast Neoplasms
Down-regulation of RIP1 by 2-deoxy-D-glucose sensitizes breast cancer cells to TRAIL-induced apoptosis.
Breast Neoplasms
Effect of the antitumor drug lonidamine on glucose metabolism of adriamycin-sensitive and -resistant human breast cancer cells.
Breast Neoplasms
Effects of curcumin on cancer cell mitochondrial function and potential monitoring with 18F-FDG uptake.
Breast Neoplasms
Elevated Hexokinase II Expression Confers Acquired Resistance to 4-Hydroxytamoxifen in Breast Cancer Cells.
Breast Neoplasms
Gen-27, a newly synthesized flavonoid, inhibits glycolysis and induces cell apoptosis via suppression of hexokinase II in human breast cancer cells.
Breast Neoplasms
Glycolytic enzymes in breast cancer, benign breast disease and normal breast tissue.
Breast Neoplasms
Heterogeneity of glycolytic enzyme activity and isozyme composition of pyruvate kinase in breast cancer.
Breast Neoplasms
Hexokinase and phosphofructokinase activity and intracellular distribution correlate with aggressiveness and invasiveness of human breast carcinoma.
Breast Neoplasms
Hexokinase II in breast carcinoma: A potent prognostic factor associated with hypoxia-inducible factor-1? and Ki-67.
Breast Neoplasms
Hexokinase II inhibitor, 3-BrPA induced autophagy by stimulating ROS formation in human breast cancer cells.
Breast Neoplasms
Hexokinase II is a prognostic factor associated with HIF-1? and Ki-67 in breast carcinoma. Immunohistochemistry for hexokinase II in the invasive edge of breast carcinoma.See also Sato-Tadano, A., et al.
Breast Neoplasms
Hexokinase inhibition using D-Mannoheptulose enhances oncolytic newcastle disease virus-mediated killing of breast cancer cells.
Breast Neoplasms
HKDC1 promotes the tumorigenesis and glycolysis in lung adenocarcinoma via regulating AMPK/mTOR signaling pathway.
Breast Neoplasms
Impairment of HIF-1?-mediated metabolic adaption by NRF2-silencing in breast cancer cells.
Breast Neoplasms
Influence of resistance to 5-fluorouracil and tomudex on [18F]?FDG incorporation, glucose transport and hexokinase activity.
Breast Neoplasms
Inhibition of Lung Carcinoma A549 Cell Growth by Knockdown of Hexokinase 2 In Situ and In Vivo.
Breast Neoplasms
Kisspeptin 10 inhibits the Warburg effect in breast cancer through the Smad signaling pathway: both in vitro and in vivo.
Breast Neoplasms
Lipogenetic and glycolytic enzyme activities in carcinoma and nonmalignant diseases of the human breast.
Breast Neoplasms
Nanosized Tamoxifen-Porphyrin-Glucose [TPG] Conjugate: Novel Selective Anti-Breast-Cancer Agent, Synthesis and In Vitro Evaluations.
Breast Neoplasms
New challenges in integrated diagnosis by imaging and osteo-immunology in bone lesions.
Breast Neoplasms
Newcastle disease virus suppress glycolysis pathway and induce breast cancer cells death.
Breast Neoplasms
Oroxylin A induces dissociation of hexokinase II from the mitochondria and inhibits glycolysis by SIRT3-mediated deacetylation of cyclophilin D in breast carcinoma.
Breast Neoplasms
Overexpression of ErbB2 renders breast cancer cells susceptible to 3-BrPA through the increased dissociation of hexokinase II from mitochondrial outer membrane.
Breast Neoplasms
PGC1? Regulates Breast Tumor Growth and Metastasis by SREBP1-Mediated HKDC1 Expression.
Breast Neoplasms
PIM2-mediated phosphorylation of hexokinase 2 is critical for tumor growth and paclitaxel resistance in breast cancer.
Breast Neoplasms
Propranolol inhibits glucose metabolism and 18F-FDG uptake of breast cancer through posttranscriptional downregulation of hexokinase-2.
Breast Neoplasms
Response to trastuzumab by HER2 expressing breast tumour xenografts is accompanied by decreased Hexokinase II, glut1 and [18F]-FDG incorporation and changes in 31P-NMR-detectable phosphomonoesters.
Breast Neoplasms
Signal transducer and activator of transcription 3 promotes the Warburg effect possibly by inducing pyruvate kinase M2 phosphorylation in liver precancerous lesions.
Breast Neoplasms
Stunning and Its Effect on 3H-FDG Uptake and Key Gene Expression in Breast Cancer Cells Undergoing Chemotherapy.
Breast Neoplasms
The lipid metabolism gene FTO influences breast cancer cell energy metabolism via the PI3K/AKT signaling pathway.
Breast Neoplasms
Tissue-Specific Warburg Effect in Breast Cancer and Cancer-Associated Adipose Tissue-Relationship between AMPK and Glycolysis.
Breast Neoplasms
Tumor 18F-FDG incorporation is enhanced by attenuation of P53 function in breast cancer cells in vitro.
Breast Neoplasms
Uptake of 2-NBDG as a method to monitor therapy response in breast cancer cell lines.
Breast Neoplasms
WD-3 inhibits the proliferation of breast cancer cells by regulating the glycolytic pathway.
Breast Neoplasms
[F]fluoro-2-deoxy-d-glucose incorporation by mcf-7 breast tumour cells in vitro is modulated by treatment with tamoxifen, Doxorubicin, and docetaxel: relationship to chemotherapy-induced changes in ATP content, hexokinase activity, and glucose transport.
Breast Neoplasms
[Knockdown of hexokinase 2 (HK2) inhibits breast cancer cell proliferation and reduces their resistance to fluorouracil].
Burkitt Lymphoma
Hypoxia-Inducible Factor 1 and Dysregulated c-Myc Cooperatively Induce Vascular Endothelial Growth Factor and Metabolic Switches Hexokinase 2 and Pyruvate Dehydrogenase Kinase 1.
Carcinogenesis
AKT2 phosphorylation of hexokinase 2 at T473 promotes tumorigenesis and metastasis in colon cancer cells via NF-?B, HIF1?, MMP2, and MMP9 upregulation.
Carcinogenesis
An in situ study of bioenergetic properties of human colorectal cancer: the regulation of mitochondrial respiration and distribution of flux control among the components of ATP synthasome.
Carcinogenesis
c-Src phosphorylation and activation of hexokinase promotes tumorigenesis and metastasis.
Carcinogenesis
Corrigendum: Regulatory Role of Hexokinase 2 in Modulating Head and Neck Tumorigenesis.
Carcinogenesis
Differential association of STAT3 and HK-II expression in hepatitis B virus- and hepatitis C virus-related hepatocellular carcinoma.
Carcinogenesis
Evidence for heightened hexokinase II immunoexpression in hepatocyte dysplasia and hepatocellular carcinoma.
Carcinogenesis
Hexokinase 3 dysfunction promotes tumorigenesis and immune escape by upregulating monocyte/macrophage infiltration into the clear cell renal cell carcinoma microenvironment.
Carcinogenesis
HKDC1 promotes the tumorigenesis and glycolysis in lung adenocarcinoma via regulating AMPK/mTOR signaling pathway.
Carcinogenesis
Isozymic forms of some energy metabolism enzymes during oncovirus-induced cell transformation.
Carcinogenesis
Long noncoding RNA KCNQ1OT1 promotes colorectal carcinogenesis by enhancing aerobic glycolysis via hexokinase-2.
Carcinogenesis
Microcompartmentation of energy metabolism at the outer mitochondrial membrane: role in diabetes mellitus and other diseases.
Carcinogenesis
MiR-199a-5p is negatively associated with malignancies and regulates glycolysis and lactate production by targeting hexokinase 2 in liver cancer.
Carcinogenesis
Overexpression of Hexokinase 1 as a poor prognosticator in human colorectal cancer.
Carcinogenesis
PGC1? Regulates Breast Tumor Growth and Metastasis by SREBP1-Mediated HKDC1 Expression.
Carcinogenesis
SUMOylation controls the binding of hexokinase 2 to mitochondria and protects against prostate cancer tumorigenesis.
Carcinogenesis
The catalytic inactivation of the N-half of human hexokinase 2 and structural and biochemical characterization of its mitochondrial conformation.
Carcinogenesis
The miR-125a/HK2 axis regulates cancer cell energy metabolism reprogramming in hepatocellular carcinoma.
Carcinogenesis
[Activity and isoenzymatic spectrum of hexokinase and pyruvate kinase during carcinogenesis in the liver and in primary hepatoma]
Carcinogenesis
[Change in cell membrane permeability, and composition and properties of hexokinase during induced carcinogenesis]
Carcinogenesis
[CHANGES IN GLUCOKINASE AND HEXOKINASE CONTENT OF THE RAT LIVER AFTER FASTING, DURING CARCINOGENESIS AND IN PRIMARY AND TRANSPLANTED HEPATOMA.]
Carcinoma
CircCDKN2B-AS1 interacts with IMP3 to stabilize hexokinase 2 mRNA and facilitate cervical squamous cell carcinoma aerobic glycolysis progression.
Carcinoma
Clinical significance of serum lactate dehydrogenase, phosphohexose isomerase, aldolase and hexokinase in prostatic carcinoma.
Carcinoma
Combination of arsenic trioxide and cisplatin synergistically inhibits both hexokinase activity and viability of Ehrlich ascites carcinoma cells.
Carcinoma
Deregulation of Hexokinase II Is Associated with Glycolysis, Autophagy, and the Epithelial-Mesenchymal Transition in Tongue Squamous Cell Carcinoma under Hypoxia.
Carcinoma
Determination and characterization of hexokinase in thyroid cancer and benign neoplasms.
Carcinoma
Determination of hexokinase isoenzyme I and II composition by RT-PCR: increased hexokinase isoenzyme II in human renal cell carcinoma.
Carcinoma
Diagnostic and prognostic significance of serum phosphohexose isomerase, aldolase and hexokinase in carcinoma cervix.
Carcinoma
Differential glycolytic profile and Warburg effect in papillary thyroid carcinoma cell lines.
Carcinoma
Expression of type 2 hexokinase and mitochondria-related genes in gastric carcinoma tissues and cell lines.
Carcinoma
FDG-PET/CT imaging findings of hepatic tumors and tumor-like lesions based on molecular background.
Carcinoma
Glucose 6-phosphate-dependent binding of hexokinase to membranes of ascites tumor cells.
Carcinoma
Hexokinase 2 Depletion Confers Sensitization to Metformin and Inhibits Glycolysis in Lung Squamous Cell Carcinoma.
Carcinoma
Hexokinase 2 enhances the metastatic potential of tongue squamous cell carcinoma via the SOD2-H2O2 pathway.
Carcinoma
Hexokinase 2 overexpression promotes the proliferation and survival of laryngeal squamous cell carcinoma.
Carcinoma
Hexokinase 3 dysfunction promotes tumorigenesis and immune escape by upregulating monocyte/macrophage infiltration into the clear cell renal cell carcinoma microenvironment.
Carcinoma
Hexokinase II in breast carcinoma: A potent prognostic factor associated with hypoxia-inducible factor-1? and Ki-67.
Carcinoma
Hexokinase type II: a novel tumor-specific promoter for gene-targeted therapy differentially expressed and regulated in human cancer cells.
Carcinoma
Hexokinase-II expression in untreated oral squamous cell carcinoma: comparison with FDG PET imaging.
Carcinoma
Histochemical observations of hexokinase in leukoplakias and squamous cell carcinomas of oral cavity and maxillary sinus.
Carcinoma
HK2 is a radiation resistant and independent negative prognostic factor for patients with locally advanced cervical squamous cell carcinoma.
Carcinoma
Implication of KRT16, FAM129A and HKDC1 genes as ATF4 regulated components of the integrated stress response.
Carcinoma
Inhibition of Lung Carcinoma A549 Cell Growth by Knockdown of Hexokinase 2 In Situ and In Vivo.
Carcinoma
Interaction of cytotoxic antibiotic dactylarin with glycolytic thiol enzymes in Ehrlich ascites carcinoma cells.
Carcinoma
Isoenzyme shift from glucokinase to hexokinase is not an early but a late event in hepatocarcinogenesis.
Carcinoma
LncRNA loc285194 inhibits tumor growth of laryngeal squamous cell carcinoma cells by downregulating hexokinase 2.
Carcinoma
Long Term Prognostic Implications of Expression of Glucose Transporter-1 and Hexokinase II in Patients with Stage I Uterine Leiomyosarcoma.
Carcinoma
MicroRNA-143 suppresses oral squamous cell carcinoma cell growth, invasion and glucose metabolism through targeting hexokinase 2.
Carcinoma
miR-125a suppresses viability and glycolysis and induces apoptosis by targeting Hexokinase 2 in laryngeal squamous cell carcinoma.
Carcinoma
MiR-125b-5p suppressed the glycolysis of laryngeal squamous cell carcinoma by down-regulating hexokinase-2.
Carcinoma
On the mechanism of glycolysis stimulation by mitochondria from Guérin epithelioma.
Carcinoma
Physcion 8-O-?-glucopyranoside inhibits clear-cell renal cell carcinoma bydownregulating hexokinase II and inhibiting glycolysis.
Carcinoma
Prognostic significance of synergistic hexokinase-2 and beta2-adrenergic receptor expression in human hepatocelluar carcinoma after curative resection.
Carcinoma
Prognostic value of glycolysis markers in head and neck squamous cell carcinoma: a meta-analysis.
Carcinoma
Retraction notice to "physcion 8-O-?-glucopyranoside inhibits clear-cell renal cell carcinoma bydownregulating hexokinase II and inhibiting glycolysis" [Biomed. Pharmacother. 104 (2018) 28-35].
Carcinoma
Significance of serum phosphohexose isomerase, hexokinase and aldolase in carcinoma ovary.
Carcinoma
Strepantibins A-C: Hexokinase II Inhibitors from a Mud Dauber Wasp Associated Streptomyces sp.
Carcinoma
The Expression of Ubiquitous Mitochondrial Creatine Kinase Is Downregulated as Prostate Cancer Progression.
Carcinoma
The tumor-suppressive microRNA-143/145 cluster targets hexokinase-2 in renal cell carcinoma.
Carcinoma
Tumor grade, microvessel density, and activities of malate dehydrogenase, lactate dehydrogenase, and hexokinase in squamous cell carcinoma.
Carcinoma
Wortmannin influences hypoxia-inducible factor-1 alpha expression and glycolysis in esophageal carcinoma cells.
Carcinoma
[Cytochemical demonstration of the initial steps of glycolysis and hexokinase activity in Ehrlich carcinoma cells]
Carcinoma
[Inhibition of Sirolimus on the growth of pancreatic carcinoma and its effect on the expression of glucose transporter and hexokinase ?].
Carcinoma
[Maximum activity and substrate affinity of hexokinase in homogenates and in intact Ehrlich ascites carcinoma cells]
Carcinoma, Ehrlich Tumor
A variant of hexokinase isoenzymes detected in ascites tumor cells.
Carcinoma, Ehrlich Tumor
Bioflavonoid regulation of ATPase and hexokinase activity in Ehrlich ascites cell mitochondria.
Carcinoma, Ehrlich Tumor
Effect of lonidamine on the energy metabolism of Ehrlich ascites tumor cells.
Carcinoma, Ehrlich Tumor
Inhibition of hexokinase and protein kinase activities of tumor cells by a chloromethyl ketone derivative of lactic acid.
Carcinoma, Ehrlich Tumor
Studies on the mode of action of RC4, a new anti-cancer agent containing ethyleneimino ring. I. Effects of RC4 and allied agents on glycolysis, respiration, hexokinase and phosphatase of Ehrlich ascites tumor cells and on choline-esterase of human blood.
Carcinoma, Ehrlich Tumor
The effect of glucosone on the proliferation and energy metabolism of in vitro grown Ehrlich ascites tumor cells.
Carcinoma, Ehrlich Tumor
[Studies on the soluble and particular hexokinase in Ehrlich ascites tumor cells]
Carcinoma, Hepatocellular
3-Bromopyruvic acid, a hexokinase II inhibitor, is an effective antitumor agent on the hepatoma cells : in vitro and in vivo findings.
Carcinoma, Hepatocellular
A case of minimal deviation hepatoma in man with elevated liver-type pyruvate kinase isozyme.
Carcinoma, Hepatocellular
A hexokinase isoenzyme switch in human liver cancer cells promotes lipogenesis and enhances innate immunity.
Carcinoma, Hepatocellular
Aberrant expression of the glycolytic enzymes aldolase B and type II hexokinase in hepatocellular carcinoma are predictive markers for advanced stage, early recurrence and poor prognosis.
Carcinoma, Hepatocellular
Adenylate kinase is a source of ATP for tumor mitochondrial hexokinase.
Carcinoma, Hepatocellular
Alteration of enzyme function of the type II hexokinase C-terminal half on replacements of restricted regions by corresponding regions of glucokinase.
Carcinoma, Hepatocellular
Altered metabolic states do not change the intracellular distribution of hexokinase in Zajdela hepatoma ascites cells.
Carcinoma, Hepatocellular
Amentoflavone suppresses hepatocellular carcinoma by repressing hexokinase 2 expression through inhibiting JAK2/STAT3 signaling.
Carcinoma, Hepatocellular
An unusual high-Km hexokinase is expressed in the mhAT3F hepatoma cell line.
Carcinoma, Hepatocellular
Androgen Receptor Stimulates Hexokinase 2 and Induces Glycolysis by PKA/CREB Signaling in Hepatocellular Carcinoma.
Carcinoma, Hepatocellular
Apoptosis-inducing antitumor efficacy of hexokinase II inhibitor in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Astragalin Reduces Hexokinase 2 through Increasing miR-125b to Inhibit the Proliferation of Hepatocellular Carcinoma Cells in Vitro and in Vivo.
Carcinoma, Hepatocellular
Author Correction: Hexokinase-2 depletion inhibits glycolysis and induces oxidative phosphorylation in hepatocellular carcinoma and sensitizes to metformin.
Carcinoma, Hepatocellular
By blocking hexokinase-2 phosphorylation, limonin suppresses tumor glycolysis and induces cell apoptosis in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Carbonic anhydrase-IX inhibition enhances the efficacy of hexokinase II inhibitor for hepatocellular carcinoma in a murine model.
Carcinoma, Hepatocellular
Caveolin enhances hepatocellular carcinoma cell metabolism, migration, and invasion in vitro via a hexokinase 2-dependent mechanism.
Carcinoma, Hepatocellular
Changes in hexokinase properties during transformation and subsequent proliferation of liver cells.
Carcinoma, Hepatocellular
Characteristics of mitochondria isolated by rate zonal centrifugation from normal liver and Novikoff hepatomas.
Carcinoma, Hepatocellular
Choline kinase alpha and hexokinase-2 protein expression in hepatocellular carcinoma: association with survival.
Carcinoma, Hepatocellular
Chrysin inhibited tumor glycolysis and induced apoptosis in hepatocellular carcinoma by targeting hexokinase-2.
Carcinoma, Hepatocellular
Clinical implication of glucose transport and metabolism evaluated by 18F-FDG PET in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Clinicopathological presentation of varying 18F-FDG uptake and expression of glucose transporter 1 and hexokinase II in cases of hepatocellular carcinoma and cholangiocellular carcinoma.
Carcinoma, Hepatocellular
Detection of a progression-linked DNA restriction fragment in rat hepatoma cells probed with a hexokinase cDNA.
Carcinoma, Hepatocellular
Determining and understanding the control of glycolysis in fast-growth tumor cells. Flux control by an over-expressed but strongly product-inhibited hexokinase.
Carcinoma, Hepatocellular
Differential association of STAT3 and HK-II expression in hepatitis B virus- and hepatitis C virus-related hepatocellular carcinoma.
Carcinoma, Hepatocellular
Effect of growth in vivo and in vitro on phenotype of hexokinase isozymes in hepatoma cells.
Carcinoma, Hepatocellular
Effect of Plumbagin on some glucose metabolising enzymes studied in rats in experimental hepatoma.
Carcinoma, Hepatocellular
Enhancement of hexokinase II inhibitor-induced apoptosis in hepatocellular carcinoma cells via augmenting ER stress and anti-angiogenesis by protein disulfide isomerase inhibition.
Carcinoma, Hepatocellular
Evaluation of the role of hexokinase type II in cellular proliferation and apoptosis using human hepatocellular carcinoma cell lines.
Carcinoma, Hepatocellular
Evidence for heightened hexokinase II immunoexpression in hepatocyte dysplasia and hepatocellular carcinoma.
Carcinoma, Hepatocellular
Evidence for multiple genes coding for the isozymes of hexokinase in the highly glycolytic AS-30D rat hepatoma.
Carcinoma, Hepatocellular
Evidence that transcription of the hexokinase gene is increased in a rapidly growing rat hepatoma.
Carcinoma, Hepatocellular
Functional significance of mitochondrial bound hexokinase in tumor cell metabolism. Evidence for preferential phosphorylation of glucose by intramitochondrially generated ATP.
Carcinoma, Hepatocellular
Glucose catabolism in cancer cells. Isolation, sequence, and activity of the promoter for type II hexokinase.
Carcinoma, Hepatocellular
Glucose catabolism in cancer cells. The type II hexokinase promoter contains functionally active response elements for the tumor suppressor p53.
Carcinoma, Hepatocellular
Glucose catabolism in cancer cells: amplification of the gene encoding type II hexokinase.
Carcinoma, Hepatocellular
Glucose catabolism in cancer cells: identification and characterization of a marked activation response of the type II hexokinase gene to hypoxic conditions.
Carcinoma, Hepatocellular
Glucose catabolism in cancer cells: regulation of the Type II hexokinase promoter by glucose and cyclic AMP.
Carcinoma, Hepatocellular
Glucose metabolism in cancer. Evidence that demethylation events play a role in activating type II hexokinase gene expression.
Carcinoma, Hepatocellular
Glucose phosphorylation in tumor cells. Cloning, sequencing, and overexpression in active form of a full-length cDNA encoding a mitochondrial bindable form of hexokinase.
Carcinoma, Hepatocellular
Glucose utilization by tumor cells: a post-translational modification of mitochondrial hexokinase may play a regulatory role.
Carcinoma, Hepatocellular
Glycolysis inhibitor 2-deoxy-D-glucose suppresses carcinogen-induced rat hepatocarcinogenesis by restricting cancer cell metabolism.
Carcinoma, Hepatocellular
Hepatic glycogen synthesis in the absence of glucokinase: the case of embryonic liver.
Carcinoma, Hepatocellular
Hexokinase activity and glycolytic capacity of plasma membranes of hepatomas.
Carcinoma, Hepatocellular
Hexokinase and glucose-6-phosphatase activity in woodchuck model of hepatitis virus-induced hepatocellular carcinoma.
Carcinoma, Hepatocellular
Hexokinase II and VEGF expression in liver tumors: correlation with hypoxia-inducible factor 1 alpha and its significance.
Carcinoma, Hepatocellular
Hexokinase receptor complex in hepatoma mitochondria: evidence from N,N'-dicyclohexylcarbodiimide-labeling studies for the involvement of the pore-forming protein VDAC.
Carcinoma, Hepatocellular
Hexokinase receptors: preferential enzyme binding in normal cells to nonmitochondrial sites and in transformed cells to mitochondrial sites.
Carcinoma, Hepatocellular
Hexokinase-2 bound to mitochondria: cancer's stygian link to the "Warburg Effect" and a pivotal target for effective therapy.
Carcinoma, Hepatocellular
Hexokinase-2 depletion inhibits glycolysis and induces oxidative phosphorylation in hepatocellular carcinoma and sensitizes to metformin.
Carcinoma, Hepatocellular
Hexokinase-II Inhibition Synergistically Augments the Anti-tumor Efficacy of Sorafenib in Hepatocellular Carcinoma.
Carcinoma, Hepatocellular
High aerobic glycolysis of rat hepatoma cells in culture: role of mitochondrial hexokinase.
Carcinoma, Hepatocellular
Hypoxia stimulates proliferation of human hepatoma cells through the induction of hexokinase II expression.
Carcinoma, Hepatocellular
Identification of upstream stimulatory factor as transcriptional activator of the liver promoter of the glucokinase gene.
Carcinoma, Hepatocellular
Inhibition of hypoxia-inducible carbonic anhydrase-IX enhances hexokinase II inhibitor-induced hepatocellular carcinoma cell apoptosis.
Carcinoma, Hepatocellular
Inihibition of Glycolysis by Using a Micro/Nano-Lipid Bromopyruvic Chitosan Carrier as a Promising Tool to Improve Treatment of Hepatocellular Carcinoma.
Carcinoma, Hepatocellular
Liver glycogen synthase but not the muscle isoform differentiates between glucose 6-phosphate produced by glucokinase or hexokinase.
Carcinoma, Hepatocellular
LL95 monoclonal antibody mimics functional effects of ZP3 on mouse sperm: evidence that the antigen recognized is not hexokinase.
Carcinoma, Hepatocellular
MicroRNA-34a inhibit hepatocellular carcinoma progression by repressing hexokinase-1.
Carcinoma, Hepatocellular
Mitochondrial hexokinase of rat hepatoma cells in culture: solubilization and kinetic properties.
Carcinoma, Hepatocellular
Modulating effect of Semecarpus anacardium Linn. nut extract on glucose metabolizing enzymes in aflatoxin B1-induced experimental hepatocellular carcinoma.
Carcinoma, Hepatocellular
Modulatory Role of Shorea robusta Bark on Glucose-metabolizing Enzymes in Diethylnitrosamine Induced Hepatocellular Carcinoma in Rats.
Carcinoma, Hepatocellular
Nucleotide sequence of the 5'-flanking region of the rat type II hexokinase gene.
Carcinoma, Hepatocellular
Overexpression of microRNA-125b sensitizes human hepatocellular carcinoma cells to 5-fluorouracil through inhibition of glycolysis by targeting hexokinase II.
Carcinoma, Hepatocellular
p95, the major phosphotyrosine-containing protein in mouse spermatozoa, is a hexokinase with unique properties.
Carcinoma, Hepatocellular
Profiles of carbohydrate-metabolizing enzymes in human hepatocellular carcinomas and preneoplastic livers.
Carcinoma, Hepatocellular
Prognostic significance of synergistic hexokinase-2 and beta2-adrenergic receptor expression in human hepatocelluar carcinoma after curative resection.
Carcinoma, Hepatocellular
Purification and characterization of a bindable form of mitochondrial bound hexokinase from the highly glycolytic AS-30D rat hepatoma cell line.
Carcinoma, Hepatocellular
Reduced survival of patients with hepatocellular carcinoma expressing hexokinase II.
Carcinoma, Hepatocellular
Remarkably enhanced expression of the type II hexokinase in rat hepatoma cell line AH130.
Carcinoma, Hepatocellular
Retraction notice to "Amentoflavone suppresses hepatocellular carcinoma by repressing hexokinase 2 expression through inhibiting JAK2/STAT3 signaling" [Biomed Pharmacother. 107 (2018) 243-253].
Carcinoma, Hepatocellular
RRAD inhibits aerobic glycolysis, invasion, and migration and is associated with poor prognosis in hepatocellular carcinoma.
Carcinoma, Hepatocellular
STAT3 regulates glycolysis via targeting hexokinase 2 in hepatocellular carcinoma cells.
Carcinoma, Hepatocellular
Strepantibins A-C: Hexokinase II Inhibitors from a Mud Dauber Wasp Associated Streptomyces sp.
Carcinoma, Hepatocellular
Studies on particle-bound hexokinase in rat ascites hepatoma cells.
Carcinoma, Hepatocellular
Synthesis and targeting of hexokinase to mitochondria in hepatoma cells.
Carcinoma, Hepatocellular
Targets of 3-Bromopyruvate, a New, Energy Depleting, Anticancer Agent.
Carcinoma, Hepatocellular
The antitumor effect and hepatotoxicity of a hexokinase II inhibitor 3-bromopyruvate: in vivo investigation of intraarterial administration in a rabbit VX2 hepatoma model.
Carcinoma, Hepatocellular
The EGFR-P38 MAPK axis up-regulates PD-L1 through miR-675-5p and down-regulates HLA-ABC via hexokinase-2 in hepatocellular carcinoma cells.
Carcinoma, Hepatocellular
The HGF-MET axis coordinates liver cancer metabolism and autophagy for chemotherapeutic resistance.
Carcinoma, Hepatocellular
Unique hexokinase messenger ribonucleic acids lacking the porin-binding domain are developmentally expressed in mouse spermatogenic cells.
Carcinoma, Hepatocellular
[Activity and isoenzymatic spectrum of hexokinase and pyruvate kinase during carcinogenesis in the liver and in primary hepatoma]
Carcinoma, Hepatocellular
[Activity of enzymes of glycolysis and gluconeogenesis in primary hepatomas induced by diethylnitrosamine]
Carcinoma, Hepatocellular
[Activity of soluble and bound hexokinase in transplantable hepatomas of different degrees of malignancy, and in normal and regenerating mouse livers]
Carcinoma, Hepatocellular
[Activity of the key glycolysis and respiration enzymes in the rat liver in chemical carcinogenesis]
Carcinoma, Hepatocellular
[Biochemical characteristics determining the rates of tumour growth in the organism]
Carcinoma, Hepatocellular
[Biochemical features of the liver of high and low cancer mouse strains and primary spontaneous hepatomas]
Carcinoma, Hepatocellular
[Carbohydrate metabolism enzymatic activity and its alteration under the influence of thyroid hormone during tumor growth]
Carcinoma, Hepatocellular
[CHANGES IN GLUCOKINASE AND HEXOKINASE CONTENT OF THE RAT LIVER AFTER FASTING, DURING CARCINOGENESIS AND IN PRIMARY AND TRANSPLANTED HEPATOMA.]
Carcinoma, Hepatocellular
[Characteristics of hexosephosphate transformation regulation in Zajdela hepatoma and the liver of tumor-bearing rats]
Carcinoma, Hepatocellular
[Differences in activity and intracellular localization of hexokinase between normal liver and hepatomas in the rat]
Carcinoma, Hepatocellular
[Noradrenaline and glycogen content and the activity of several enzymes of carbohydrate metabolism in normal, embryonic, and partly denervated livers and in hepatomas of the rat]
Carcinoma, Hepatocellular
[Some characteristics of isoenzymic spectrum of hexokinase and glucose levels in hepatomas and liver of the host]
Carcinoma, Hepatocellular
[Subcellular distribution of hexokinase in hepatoma and its electrophoretic properties]
Carcinoma, Hepatocellular
[THE HEXOKINASE ACTIVITY IN HOMOGENATES OF NORMAL, REGENERATING AND PRECANCEROUS RAT LIVER AND IN PRIMARY AND TRANSPLANTED HEPATOMA.]
Carcinoma, Hepatocellular
[THE HEXOKINASE ACTIVITY IN THE MITOCHONDRIA OF THE PRECANCEROUS RAT LIVER AND TRANSPLANTED DIETHYLNITROSAMINE HEPATOMA.]
Carcinoma, Hepatocellular
[The role of hexokinase 2 in the metastasis of hepatocellular carcinoma cells].
Carcinoma, Non-Small-Cell Lung
Jolkinolide B inhibits glycolysis by downregulating hexokinase 2 expression through inactivating the Akt/mTOR pathway in non-small cell lung cancer cells.
Carcinoma, Non-Small-Cell Lung
miR-206 regulates non-small cell lung cancer cell aerobic glycolysis by targeting hexokinase 2.
Carcinoma, Non-Small-Cell Lung
Octamer transcription factor-1 induces the Warburg effect via up-regulation of hexokinase 2 in non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Oroxylin A sensitizes non-small cell lung cancer cells to anoikis via glucose-deprivation-like mechanisms: c-Src and hexokinase II.
Carcinoma, Non-Small-Cell Lung
Relationship between (18)F-FDG uptake on PET and various biologic molecular markers in benign pulmonary lesion: comparison with primary lung cancer.
Carcinoma, Ovarian Epithelial
Association of overexpression of hexokinase II with chemoresistance in epithelial ovarian cancer.
Carcinoma, Ovarian Epithelial
Euxanthone inhibits glycolysis and triggers mitochondria-mediated apoptosis by targeting hexokinase 2 in epithelial ovarian cancer.
Carcinoma, Ovarian Epithelial
p53 Promotes chemoresponsiveness by regulating hexokinase II gene transcription and metabolic reprogramming in epithelial ovarian cancer.
Carcinoma, Pancreatic Ductal
The combination of the expression of hexokinase 2 and pyruvate kinase M2 is a prognostic marker in patients with pancreatic cancer.
Carcinoma, Papillary
Determination and characterization of hexokinase in thyroid cancer and benign neoplasms.
Carcinoma, Renal Cell
Determination of hexokinase isoenzyme I and II composition by RT-PCR: increased hexokinase isoenzyme II in human renal cell carcinoma.
Carcinoma, Renal Cell
Hexokinase 3 dysfunction promotes tumorigenesis and immune escape by upregulating monocyte/macrophage infiltration into the clear cell renal cell carcinoma microenvironment.
Carcinoma, Renal Cell
Physcion 8-O-?-glucopyranoside inhibits clear-cell renal cell carcinoma bydownregulating hexokinase II and inhibiting glycolysis.
Carcinoma, Renal Cell
Retraction notice to "physcion 8-O-?-glucopyranoside inhibits clear-cell renal cell carcinoma bydownregulating hexokinase II and inhibiting glycolysis" [Biomed. Pharmacother. 104 (2018) 28-35].
Carcinoma, Renal Cell
The tumor-suppressive microRNA-143/145 cluster targets hexokinase-2 in renal cell carcinoma.
Carcinoma, Squamous Cell
CircCDKN2B-AS1 interacts with IMP3 to stabilize hexokinase 2 mRNA and facilitate cervical squamous cell carcinoma aerobic glycolysis progression.
Carcinoma, Squamous Cell
Deregulation of Hexokinase II Is Associated with Glycolysis, Autophagy, and the Epithelial-Mesenchymal Transition in Tongue Squamous Cell Carcinoma under Hypoxia.
Carcinoma, Squamous Cell
FDG-PET/CT imaging findings of hepatic tumors and tumor-like lesions based on molecular background.
Carcinoma, Squamous Cell
Hexokinase 2 Depletion Confers Sensitization to Metformin and Inhibits Glycolysis in Lung Squamous Cell Carcinoma.
Carcinoma, Squamous Cell
Hexokinase 2 enhances the metastatic potential of tongue squamous cell carcinoma via the SOD2-H2O2 pathway.
Carcinoma, Squamous Cell
Histochemical observations of hexokinase in leukoplakias and squamous cell carcinomas of oral cavity and maxillary sinus.
Carcinoma, Squamous Cell
HK2 is a radiation resistant and independent negative prognostic factor for patients with locally advanced cervical squamous cell carcinoma.
Carcinoma, Squamous Cell
Prognostic value of glycolysis markers in head and neck squamous cell carcinoma: a meta-analysis.
Carcinoma, Squamous Cell
Tumor grade, microvessel density, and activities of malate dehydrogenase, lactate dehydrogenase, and hexokinase in squamous cell carcinoma.
Cardiomegaly
Effects of beta 1- and beta 1 + beta 2-antagonists on training-induced myocardial hypertrophy and enzyme adaptation.
Cardiomegaly
Hexokinase II knockdown results in exaggerated cardiac hypertrophy via increased ROS production.
Cardiomyopathies
Enhanced glycolytic metabolism contributes to cardiac dysfunction in polymicrobial sepsis.
Cataract
Levels of expression of hexokinase, aldose reductase and sorbitol dehydrogenase genes in lens of mouse and rat.
Cataract
Mechanism of "hypoglycemic" cataract formation in the rat lens. I. The role of hexokinase instability.
Cataract
Mechanism of "hypoglycemic" cataract formation in the rat lens. II. Further studies on the role of hexokinase instability.
Cataract
[Study of the hexokinase activity of the crystallinelens in rabbits made diabetic by dithizone and the problem of diabetic cataract.]
Cell Transformation, Neoplastic
Differences in expression and intracellular distribution of hexokinase isoenzymes in rat liver cells of different transformation stages.
Chagas Disease
A Mechanistic Probe into the Dual Inhibition of T. cruzi Glucokinase and Hexokinase in Chagas Disease Treatment - A Stone Killing Two Birds?
Chagas Disease
Bisphosphonates as inhibitors of Trypanosoma cruzi hexokinase: kinetic and metabolic studies.
Chagas Disease
Comparative study of enzymes in testes and ovaries from adult Dipetalogaster maximus (Uhler) and triatoma infestans (Klug) (Hemiptera: Reduviidae). correlation with fine structural organization.
Chagas Disease
Specific chemotherapy of Chagas disease: Relevance, current limitations and new approaches.
Chagas Disease
Structure-based approach to the identification of a novel group of selective glucosamine analogue inhibitors of Trypanosoma cruzi glucokinase.
Cholangiocarcinoma
Clinicopathological presentation of varying 18F-FDG uptake and expression of glucose transporter 1 and hexokinase II in cases of hepatocellular carcinoma and cholangiocellular carcinoma.
Cholangiocarcinoma
Different glucose uptake and glycolytic mechanisms between hepatocellular carcinoma and intrahepatic mass-forming cholangiocarcinoma with increased (18)F-FDG uptake.
Cholangiocarcinoma
Expression of glucose transporters and hexokinase II in cholangiocellular carcinoma compared using [18F]-2-fluro-2-deoxy-D-glucose positron emission tomography.
Cholangitis
Novel Anti-Hexokinase 1 Antibodies Are Associated With Poor Prognosis in Patients With Primary Biliary Cholangitis.
Cholestasis
[Activity of carbohydrate metabolism enzyme activity in normal and pathologic parodontal tissues]
Chondroblastoma
False positive (18)F-FDG PET in an ischial chondroblastoma; an analysis of glucose transporter 1 and hexokinase II expression.
Chordoma
The nature of cytoplasmic vacuoles in chordoma cells. A correlative enzyme and electron microscopic histochemical study.
Choriocarcinoma
Enzymes of normal and malignant trophoblast: phosphoglucose isomerase, phosphoglucomutase, hexokinase, lactate dehydrogenase, and alkaline phosphatase.
Clonorchiasis
Advanced enzymology, expression profile and immune response of Clonorchis sinensis hexokinase show its application potential for prevention and control of clonorchiasis.
Colonic Neoplasms
A combination of inhibitors of glycolysis, glutaminolysis and de novo fatty acid synthesis decrease the expression of chemokines in human colon cancer cells.
Colonic Neoplasms
AKT2 phosphorylation of hexokinase 2 at T473 promotes tumorigenesis and metastasis in colon cancer cells via NF-?B, HIF1?, MMP2, and MMP9 upregulation.
Colonic Neoplasms
Downregulation of the hexokinase II gene sensitizes human colon cancer cells to 5-fluorouracil.
Colonic Neoplasms
Interleukin-22 promotes aerobic glycolysis associated with tumor progression via targeting hexokinase-2 in human colon cancer cells.
Colonic Neoplasms
LncRNA-DANCR Interferes With miR-125b-5p/HK2 Axis to Desensitize Colon Cancer Cells to Cisplatin vis Activating Anaerobic Glycolysis.
Colonic Neoplasms
Mechanisms related to [18F]fluorodeoxyglucose uptake of human colon cancers transplanted in nude mice.
Colonic Neoplasms
Metabolic reprogramming in colon cancer reversed by DHTS through regulating PTEN/AKT/HIF1? mediated signal pathway.
Colonic Neoplasms
MicroRNA-98 Suppress Warburg Effect by Targeting HK2 in Colon Cancer Cells.
Colonic Neoplasms
Mitochondrial hexokinase from differentiated and undifferentiated HT29 colon cancer cells: effect of some metabolites on the bound/soluble equilibrium.
Colonic Neoplasms
PHLPP regulates hexokinase 2-dependent glucose metabolism in colon cancer cells.
Colonic Neoplasms
Regulation of mitochondrial hexokinase in cultured HT 29 human cancer cells. An ultrastructural and biochemical study.
Colonic Neoplasms
Silencing hexokinase II gene sensitizes human colon cancer cells to 5-fluorouracil.
Colonic Neoplasms
Stable RNA interference of hexokinase II gene inhibits human colon cancer LoVo cell growth in vitro and in vivo.
Colonic Neoplasms
Study on ATP-generating system and related hexokinase activity in mitochondria isolated from undifferentiated or differentiated HT29 adenocarcinoma cells.
Colonic Neoplasms
[Expression of hexokinase-II gene in human colon cancer cells and the therapeutic significance of inhibition thereof]
Colorectal Neoplasms
Colorectal tumor cells treated with 5-FU, oxaliplatin, irinotecan, and cetuximab exhibit changes in 18F-FDG incorporation corresponding to hexokinase activity and glucose transport.
Colorectal Neoplasms
Combined evaluation of hexokinase 2 and phosphorylated pyruvate dehydrogenase-E1? in invasive front lesions of colorectal tumors predicts cancer metabolism and patient prognosis.
Colorectal Neoplasms
Curcumin inhibits aerobic glycolysis and induces mitochondrial-mediated apoptosis through hexokinase II in human colorectal cancer cells in vitro.
Colorectal Neoplasms
Dioscin Inhibited Glycolysis and Induced Cell Apoptosis in Colorectal Cancer via Promoting c-myc Ubiquitination and Subsequent Hexokinase-2 Suppression.
Colorectal Neoplasms
Effect of HK2, PKM2 and LDHA on Cetuximab efficacy in metastatic colorectal cancer.
Colorectal Neoplasms
Effect of lentivirus-mediated shRNA inactivation of HK1, HK2, and HK3 genes in colorectal cancer and melanoma cells.
Colorectal Neoplasms
Hexokinase 2 in colorectal cancer: a potent prognostic factor associated with glycolysis, proliferation and migration.
Colorectal Neoplasms
Long Non-Coding RNA C1QTNF1 Antisense RNA 1 Upregulates Hexokinase 2 by Sponging microRNA-484 to Promote the Malignancy of Colorectal Cancer.
Colorectal Neoplasms
MicroRNA-513a-3p regulates colorectal cancer cell metabolism via targeting hexokinase 2.
Colorectal Neoplasms
Overexpression of Hexokinase 1 as a poor prognosticator in human colorectal cancer.
Colorectal Neoplasms
Penfluridol triggers mitochondrial-mediated apoptosis and suppresses glycolysis in colorectal cancer cells through down-regulating hexokinase-2.
Colorectal Neoplasms
Targeting hexokinase 2 increases the sensitivity of oxaliplatin by Twist1 in colorectal cancer.
Colorectal Neoplasms
The Circadian Clock Regulates Metabolic Phenotype Rewiring Via HKDC1 and Modulates Tumor Progression and Drug Response in Colorectal Cancer.
Colorectal Neoplasms
The combined effect of dichloroacetate and 3-bromopyruvate on glucose metabolism in colorectal cancer cell line, HT-29; the mitochondrial pathway apoptosis.
Colorectal Neoplasms
The effect of 3-bromopyruvate on human colorectal cancer cells is dependent on glucose concentration but not hexokinase II expression.
Colorectal Neoplasms
[Evaluation of Gene Expression of Hexokinases in Colorectal Cancer with the Use of Bioinformatics Methods].
Congenital Hyperinsulinism
Congenital Hyperinsulinism Caused by Hexokinase I Expression or Glucokinase-Activating Mutation in a Subset of ?-Cells.
Coronary Artery Disease
Molecular and Biochemical Parameters Related to Plasma Mannose Levels in Coronary Artery Disease Among Nondiabetic Patients.
Coronary Occlusion
Alterations in brain hexokinase activity associated with heart failure in rats.
COVID-19
Mitochondrial induced T cell apoptosis and aberrant myeloid metabolic programs define distinct immune cell subsets during acute and recovered SARS-CoV-2 infection.
Craniopharyngioma
Subtype-dependent difference of glucose transporter 1 and hexokinase II expression in craniopharyngioma: an immunohistochemical study.
Cystic Fibrosis
Increased activity of four glycolytic enzymes in cultured fibroblasts from cystic fibrosis patients.
Cysts
Isoenzyme and molecular characterization of Entamoeba histolytica and Entamoeba dispar isolates from symptomatic and asymptomatic subjects.
Cysts
Some glucose metabolic enzymes in various fractions of sarcocysts of Sarcocystis fusiformis of buffalo (Bubalus bubalis).
Dehydration
A novel method for determining rate constants for dehydration of aldehyde hydrates.
Dehydration
Changes in leaf hexokinase activity and metabolite levels in response to drying in the desiccation-tolerant species Sporobolus stapfianus and Xerophyta viscosa.
Dehydration
Regional alterations in hexokinase activity within rat brain during dehydration and rehydration.
Dehydration
Volumetric and spectroscopic characterizations of glucose-hexokinase association.
Diabetes Insipidus
Increased hexokinase activity in forebrain of water-deprived and diabetes insipidus rats.
Diabetes Mellitus
Activation of hexokinase by mild insulin dependent diabetes mellitus in rat erythrocytes.
Diabetes Mellitus
Alterations in brain hexokinase activity associated with streptozotocin-induced diabetes mellitus in the rat.
Diabetes Mellitus
Comparison of Accu Chek Inform II point-of-care test blood glucose meter with Hexokinase Plasma method for a diabetes mellitus population during surgery under general anesthesia.
Diabetes Mellitus
Diabetes Modulates MicroRNAs 29b-3p, 29c-3p, 199a-5p and 532-3p Expression in Muscle: Possible Role in GLUT4 and HK2 Repression.
Diabetes Mellitus
Functional consequences of naturally occurring variants of human hexokinase II.
Diabetes Mellitus
Microcompartmentation of energy metabolism at the outer mitochondrial membrane: role in diabetes mellitus and other diseases.
Diabetes Mellitus
Myocardial dysfunction in diabetic rats: influence of beta-adrenoceptor blockade (propranolol).
Diabetes Mellitus
[Activity of isoenzymes of hexokinase in erythrocytes of children with diabetes mellitus]
Diabetes Mellitus
[Dynamics of erythrocyte hexokinase activity during glucose tolerance test in children with hereditary diabetes mellitus]
Diabetes Mellitus, Experimental
Changes in the activity of enzymes, participating in glycogen metabolism of alloxan diabetic rats.
Diabetes Mellitus, Experimental
THE REGULATION OF HEXOKINASE AND PHOSPHOFRUCTOKINASE ACTIVITY IN HEART MUSCLE. EFFECTS OF ALLOXAN DIABETES, GROWTH HORMONE, CORTISOL, AND ANOXIA.
Diabetes Mellitus, Experimental
[Activity of hexokinase and glucose-6-phosphate dehydrogenase in hemopoietic cells of the bone marrow in normal rabbits and after hydrocortisone administration during starvation and alloxan diabetes]
Diabetes Mellitus, Experimental
[Effect of trihydroxyoctadecadiene acids from Bryonia alba L. on the activity of glycogen metabolism enzymes in alloxan diabetes]
Diabetes Mellitus, Experimental
[Hexokinase activity of cardiac muscle in animals with alloxan diabetes]
Diabetes Mellitus, Experimental
[Ultrastructural manifestations of early metabolic disorders in the myocardium of dogs with alloxan diabetes]
Diabetes Mellitus, Type 1
The accuracy of the FreeStyle Navigator continuous glucose monitoring system in children with type 1 diabetes.
Diabetes Mellitus, Type 1
[CARBOHYDRATE METABOLISM IN TYPE 1 DIABETIC RATS UNDER THE CONDITIONS OF THE KIDNEY BEAN PODS AQUEOUS EXTRACT APPLICATION].
Diabetes Mellitus, Type 2
A novel (TA)n polymorphism in the hexokinase II gene: application to noninsulin-dependent diabetes mellitus in the Pima Indians.
Diabetes Mellitus, Type 2
A rare splice site mutation in the gene encoding glucokinase/hexokinase 4 in a patient with MODY type 2.
Diabetes Mellitus, Type 2
Altered glycolytic and oxidative capacities of skeletal muscle contribute to insulin resistance in NIDDM.
Diabetes Mellitus, Type 2
Amino acid substitutions in hexokinase II among patients with NIDDM.
Diabetes Mellitus, Type 2
Analysis of the hexokinase II gene in subjects with insulin resistance and NIDDM and detection of a Gln142-->His substitution.
Diabetes Mellitus, Type 2
Assessing the potential of glucokinase activators in diabetes therapy.
Diabetes Mellitus, Type 2
Exercise increases hexokinase II mRNA, but not activity in obesity and type 2 diabetes.
Diabetes Mellitus, Type 2
Hexokinase II-deficient mice. Prenatal death of homozygotes without disturbances in glucose tolerance in heterozygotes.
Diabetes Mellitus, Type 2
Human hexokinase II gene: exon-intron organization, mutation screening in NIDDM, and its relationship to muscle hexokinase activity.
Diabetes Mellitus, Type 2
Human hexokinase II: localization of the polymorphic gene to chromosome 2.
Diabetes Mellitus, Type 2
Identification of four amino acid substitutions in hexokinase II and studies of relationships to NIDDM, glucose effectiveness, and insulin sensitivity.
Diabetes Mellitus, Type 2
Impaired activity and gene expression of hexokinase II in muscle from non-insulin-dependent diabetes mellitus patients.
Diabetes Mellitus, Type 2
Impaired insulin-induced site-specific phosphorylation of TBC1 domain family, member 4 (TBC1D4) in skeletal muscle of type 2 diabetes patients is restored by endurance exercise-training.
Diabetes Mellitus, Type 2
Insulin-induced hexokinase II expression is reduced in obesity and NIDDM.
Diabetes Mellitus, Type 2
Overexpression of hexokinase 2 reduces mitochondrial calcium overload in coronary endothelial cells of type 2 diabetic mice.
Diabetes Mellitus, Type 2
Polymorphisms of the human hexokinase II gene: lack of association with NIDDM and insulin resistance.
Diabetes Mellitus, Type 2
Primary pancreatic beta-cell secretory defect caused by mutations in glucokinase gene in kindreds of maturity onset diabetes of the young.
Diabetes Mellitus, Type 2
Promoter variation in the liver glucokinase is a risk factor for non-insulin-dependent diabetes mellitus.
Diabetes Mellitus, Type 2
Quercetin modulates hyperglycemia by improving the pancreatic antioxidant status and enzymes activities linked with glucose metabolism in type 2 diabetes model of rats: In silico studies of molecular interaction of quercetin with hexokinase and catalase.
Diabetes Mellitus, Type 2
Reduced expression of hexokinase II in insulin-resistant diabetes.
Diabetes Mellitus, Type 2
Regulation of skeletal muscle hexokinase II by insulin in nondiabetic and NIDDM subjects.
Diabetes Mellitus, Type 2
Search for a third susceptibility gene for maturity-onset diabetes of the young. Studies with eleven candidate genes.
Diabetes Mellitus, Type 2
The human hexokinase II gene promoter: functional characterization and detection of variants among patients with NIDDM.
Diabetes Mellitus, Type 2
Type 2 diabetes differentially affects the substrate saturation kinetic attributes of erythrocyte hexokinase and phosphofructokinase.
Diabetes Mellitus, Type 2
Use of a reflectance photometer as a diabetes mellitus screening tool under field conditions.
Diabetes Mellitus, Type 2
[Swiss journey through the clinical and genetic characteristics of diabetes in young patients]
Diabetes, Gestational
Hexokinase Domain Containing 1 (HKDC1) Gene Variants and their Association with Gestational Diabetes Mellitus in a South Indian Population.
Diabetes, Gestational
Replication of previous genome-wide association studies of HKDC1, BACE2, SLC16A11 and TMEM163 SNPs in a gestational diabetes mellitus case-control sample from Han Chinese population.
Diabetes, Gestational
The impact of differences in plasma glucose between glucose oxidase and hexokinase methods on estimated gestational diabetes mellitus prevalence.
Diabetic Nephropathies
High glucose induces type 1 hexokinase gene expression in isolated glomeruli of diabetic rats and in mesangial cells.
Diabetic Retinopathy
Light activation of the insulin receptor regulates mitochondrial hexokinase. A possible mechanism of retinal neuroprotection.
Diabetic Retinopathy
MicroRNA-384-3p inhibits retinal neovascularization through targeting hexokinase 2 in mice with diabetic retinopathy.
Dysentery, Amebic
[Distribution of zymodemes of Entamoeba histolytica from different areas of China]
Encephalomyelitis, Autoimmune, Experimental
[Hexokinase and lactate dehydrogenase activity and isoenzymatic makeup of the soluble fraction of dissimilarly functioning rabbit muscles normally and in experimental allergic encephalomyelitis]
Endometrial Neoplasms
Knockdown of long non-coding RNA small nucleolar RNA host gene 9 or hexokinase 2 both suppress endometrial cancer cell proliferation and glycolysis.
Endometrial Neoplasms
Therapeutic potential of riboflavin, niacin and ascorbic Acid on carbohydrate metabolizing enzymes in secondary endometrial carcinoma bearing rats.
Ependymoma
[Histochemical demonstration of glial enzyme activity. II. Reagent and neoplastic glia]
Epilepsy
Kinetic properties of hexokinase in resected temporal lobes of patients with drug-resistant epilepsy.
Esophageal Neoplasms
Hexokinase isoenzymes in the diagnosis of gastric and esophageal neoplasms.
Esophageal Neoplasms
Relationship between glucose transporter, hexokinase and FDG-PET in esophageal cancer.
Esophageal Neoplasms
[Analysis of glucose metabolism in patients with esophageal cancer by PET: estimation of hexokinase activity in the tumor and usefulness for clinical assessment using 18F-fluorodeoxyglucose]
Essential Hypertension
Nucleotide(-258) G-to-A transition variant of the liver glucokinase gene is associated with essential hypertension.
Fanconi Anemia
[Cytogenetic finding and etiology of Fanconi's anemia. A case of Fanconi's anemia without hexokinase deficiency]
Fibroadenoma
Relative value of oestrogen receptor assay, lactoferrin content, and glucose-6-phosphate dehydrogenase activity as prognostic indicators in primary breast cancer.
Fibrocystic Breast Disease
Comparison of glycolytic enzyme and isoenzyme activity in breast cancers and dysplasia.
Foot-and-Mouth Disease
Hexokinase activity as marker to assess time of harvest of foot-and-mouth disease virus in BHK(21) Cl(13) cell cultures.
Giant Cell Tumor of Bone
Overexpression of hexokinase-2 in giant cell tumor of bone is associated with false positive in bone tumor on FDG-PET/CT.
Giant Cell Tumors
Overexpression of hexokinase-2 in giant cell tumor of bone is associated with false positive in bone tumor on FDG-PET/CT.
Glioblastoma
Developmental profile and regulation of the glycolytic enzyme hexokinase 2 in normal brain and glioblastoma multiforme.
Glioblastoma
Hexokinase 2 is a key mediator of aerobic glycolysis and promotes tumor growth in human glioblastoma multiforme.
Glioblastoma
High glycolysis in gliomas despite low hexokinase transcription and activity correlated to chromosome 10 loss.
Glioblastoma
HOTAIR/miR-125 axis-mediated Hexokinase 2 expression promotes chemoresistance in human glioblastoma.
Glioblastoma
Ketoconazole and Posaconazole Selectively Target HK2-expressing Glioblastoma Cells.
Glioblastoma
miR-143 inhibits glycolysis and depletes stemness of glioblastoma stem-like cells.
Glioblastoma
Potentiation of lonidamine and diazepam, two agents acting on mitochondria, in human glioblastoma treatment.
Glioblastoma
Selective induction of cancer cell death by VDAC1-based peptides and their potential use in cancer therapy.
Glioblastoma
Targeting hexokinase 2 enhances response to radio-chemotherapy in glioblastoma.
Glioblastoma
Xanthohumol suppresses glioblastoma via modulation of Hexokinase 2 -mediated glycolysis.
Glioblastoma
[Targeting the gene of glucose metabolism for the treatment of advanced gliomas]
Glioma
Activities of glycolytic enzymes in rapidly proliferating and differentiated C6 glioma cells.
Glioma
Connexin 30 mediated rewiring of glucose metabolism in rat C6 xenograft and grades of glioma.
Glioma
Determination of the deoxyglucose and glucose phosphorylation ratio and the lumped constant in rat brain and a transplantable rat glioma.
Glioma
Developmental profile and regulation of the glycolytic enzyme hexokinase 2 in normal brain and glioblastoma multiforme.
Glioma
Effect of Naringenin on metabolic markers, lipid profile and expression of GFAP in C6 glioma cells implanted rat's brain.
Glioma
Enzymes of glucose metabolism in cultured human gliomas: neoplasia is accompanied by altered hexokinase, phosphofructokinase, and glucose-6-phosphate dehydrogenase levels.
Glioma
Gliomas are driven by glycolysis: putative roles of hexokinase, oxidative phosphorylation and mitochondrial ultrastructure.
Glioma
Glycolytic profile in normal brain tissue and gliomas determined by a micro-method analysis.
Glioma
Gomisin J inhibits the glioma progression by inducing apoptosis and reducing HKII-regulated glycolysis.
Glioma
Hexokinase 2 (HK2), the tumor promoter in glioma, is downregulated by miR-218/Bmi1 pathway.
Glioma
Hexokinase 2 and nuclear factor erythroid 2-related factor 2 transcriptionally coactivate xanthine oxidoreductase expression in stressed glioma cells.
Glioma
High expression of ALDH1A3 might independently influence poor progression-free and overall survival in patients with glioma via maintaining glucose uptake and lactate production.
Glioma
High glycolysis in gliomas despite low hexokinase transcription and activity correlated to chromosome 10 loss.
Glioma
HIV-1 Envelope Protein gp120 Promotes Proliferation and the Activation of Glycolysis in Glioma Cell.
Glioma
Intracellular pH governs the subcellular distribution of hexokinase in a glioma cell line.
Glioma
Kinetic characterization of hexokinase isoenzymes from glioma cells: implications for FDG imaging of human brain tumors.
Glioma
Light-induced photoactivation of hypericin affects the energy metabolism of human glioma cells by inhibiting hexokinase bound to mitochondria.
Glioma
LncRNA ZFAS1/miR-1271-5p/HK2 Promotes Glioma Development Through Regulating Proliferation, Migration, Invasion and Apoptosis.
Glioma
Metabolic remodeling precedes mitochondrial outer membrane permeabilization in human glioma xenograft cells.
Glioma
No relationship between 18F-fluorodeoxyglucose positron emission tomography and expression of Glut-1 and -3 and hexokinase I and II in high-grade glioma.
Glioma
Nodal regulates energy metabolism in glioma cells by inducing expression of hypoxia-inducible factor 1?.
Glioma
PERK silence inhibits glioma cell growth under low glucose stress by blockage of p-AKT and subsequent HK2's mitochondria translocation.
Glioma
Phosphorylation of pyruvate kinase and glycolytic metabolism in three human glioma cell lines.
Glioma
Rapamycin inhibits human glioma cell proliferation through down-regulating mammalian target of rapamycin pathway and up-regulating microRNA-143.
Glioma
Targeting HLA-F suppresses the proliferation of glioma cells via a reduction in hexokinase 2-dependent glycolysis.
Glioma
The increase in gap junctional communication decreases the rate of glucose uptake in C6 glioma cells by releasing hexokinase from mitochondria.
Glioma
TNF? driven HIF-1?-hexokinase II axis regulates MHC-I cluster stability through actin cytoskeleton.
Glioma
XBP1 silencing decreases glioma cell viability and glycolysis possibly by inhibiting HK2 expression.
Gliosarcoma
Mechanism of action of lonidamine in the 9L brain tumor model involves inhibition of lactate efflux and intracellular acidification.
Glucose Intolerance
Control of liver glucokinase activity: A potential new target for incretin hormones?
Glucose Intolerance
Hexokinase isoenzymes in normal and cirrhotic human liver: suppression of glucokinase in cirrhosis.
Glucose Intolerance
Ingestion of a moderate high-sucrose diet results in glucose intolerance with reduced liver glucokinase activity and impaired glucagon-like peptide-1 secretion.
glucose-6-phosphate dehydrogenase (nadp+) deficiency
A simple screening procedure for adenylate kinase, hexokinase and glucose-6-phosphate dehydrogenase deficiencies.
glucose-6-phosphate dehydrogenase (nadp+) deficiency
Red cell enzyme deficiencies in the tribal population groups of the Bastar District, Madhya Pradesh, India.
glucose-6-phosphate dehydrogenase (nadp+) deficiency
Role of hexokinase in the regulation of erythrocyte hexose monophosphate pathway under oxidative stress.
Glucosephosphate Dehydrogenase Deficiency
A simple screening procedure for adenylate kinase, hexokinase and glucose-6-phosphate dehydrogenase deficiencies.
Glucosephosphate Dehydrogenase Deficiency
Red cell enzyme deficiencies in the tribal population groups of the Bastar District, Madhya Pradesh, India.
Glucosephosphate Dehydrogenase Deficiency
Role of hexokinase in the regulation of erythrocyte hexose monophosphate pathway under oxidative stress.
Glycogen Storage Disease
[Hereditary nonspherocytic hemolytic anemia caused by a deficiency in erythrocytic hexokinase associated with glycogenosis of muscles]
Glycosuria
Accuracy and influence of ascorbic acid on glucose-test with urine dip sticks in prenatal care.
Granuloma
Insulin-like effect of sulfhydryl inhibitor on hexokinase isoenzyme of rat granuloma tissue in vitro and the opposite effect of sulfhydryl compound.
Graves Disease
Metabolism of glucose and glutamine in lymphocytes from Graves' hyperthyroid patients: influence of methimazole treatment.
Hamartoma
mTOR and HIF-1alpha-mediated tumor metabolism in an LKB1 mouse model of Peutz-Jeghers syndrome.
Heart Failure
Acute detachment of hexokinase II from mitochondria modestly increases oxygen consumption of the intact mouse heart.
Heart Failure
Alterations in brain hexokinase activity associated with heart failure in rats.
Heart Failure
Metabolic markers of myocardium insulin resistance in dogs with heart failure.
Hemoglobinopathies
Erythrocyte hexokinase isoenzyme patterns in hereditary hemoglobinopathies.
Hepatitis
Hexokinase and glucose-6-phosphatase activity in woodchuck model of hepatitis virus-induced hepatocellular carcinoma.
Hepatitis
Reduced survival of patients with hepatocellular carcinoma expressing hexokinase II.
Hepatitis
[Phosphoglucomutase and hexokinase activities of various organs (liver, brain, kidney, myocardium) in the course of experimental MHV-3 hepatitis virus.]
Hepatitis B
Identification of new autoantigens for primary biliary cirrhosis using human proteome microarrays.
Hepatitis C
Activity of hexokinase is increased by its interaction with hepatitis C virus protein NS5A.
Hepatitis C
Identification of new autoantigens for primary biliary cirrhosis using human proteome microarrays.
Hepatitis, Alcoholic
Integrated Multiomics Reveals Glucose Use Reprogramming and Identifies a Novel Hexokinase in Alcoholic Hepatitis.
Hepatitis, Autoimmune
Identification of new autoantigens for primary biliary cirrhosis using human proteome microarrays.
Hepatitis, Chronic
Profiles of carbohydrate-metabolizing enzymes in human hepatocellular carcinomas and preneoplastic livers.
Hepatoblastoma
Mutant CTNNB1 and histological heterogeneity define metabolic subtypes of hepatoblastoma.
Hereditary Sensory and Motor Neuropathy
A mutation in an alternative untranslated exon of hexokinase 1 associated with Hereditary Motor and Sensory Neuropathy - Russe (HMSNR).
Herpes Simplex
Hexokinase II gene transfer protects against neurodegeneration in the rotenone and MPTP mouse models of Parkinson's disease.
hexokinase deficiency
Allogeneic bone marrow transplantation for treatment of severe hemolytic anemia attributable to hexokinase deficiency.
hexokinase deficiency
Downeast anemia (dea), a new mouse model of severe nonspherocytic hemolytic anemia caused by hexokinase (HK(1)) deficiency.
hexokinase deficiency
First mutation in the red blood cell-specific promoter of hexokinase combined with a novel missense mutation causes hexokinase deficiency and mild chronic hemolysis.
hexokinase deficiency
Frequency of glucose-6-phosphate dehydrogenase, pyruvate kinase and hexokinase deficiency in the Saudi population.
hexokinase deficiency
Generalized hexokinase deficiency in the blood cells of a patient with nonspherocytic hemolytic anemia.
hexokinase deficiency
Glucose metabolism in fibroblasts from patients with erythrocyte hexokinase deficiency.
hexokinase deficiency
Hemolytic anemia and hexokinase deficiency associated with malformations.
hexokinase deficiency
Hereditary hemolytic anemia with hexokinase deficiency. Role of hexokinase in erythrocyte aging.
hexokinase deficiency
Hereditary nonspherocytic hemolytic anemia due to a new hexokinase variant with reduced stability.
hexokinase deficiency
Hexokinase "New Hyde Park": a low activity erythrocyte isozyme in a Chinese kindred.
hexokinase deficiency
Hexokinase deficiency anemia with dental and other anomalies: report of case.
hexokinase deficiency
Hexokinase deficiency in erythrocytes: a new variant in 5 members of a Finnish family.
hexokinase deficiency
Hexokinase II-deficient mice. Prenatal death of homozygotes without disturbances in glucose tolerance in heterozygotes.
hexokinase deficiency
HK Utrecht: missense mutation in the active site of human hexokinase associated with hexokinase deficiency and severe nonspherocytic hemolytic anemia.
hexokinase deficiency
Human erythrocyte hexokinase deficiency. Characterization of a mutant enzyme with abnormal regulatory properties.
hexokinase deficiency
Human erythrocyte hexokinase deficiency: a new variant with abnormal kinetic properties.
hexokinase deficiency
Human red blood cell loading with hexokinase-inactivating antibodies. An in vitro model for enzyme deficiencies.
hexokinase deficiency
Intracellular free magnesium and phosphorylated metabolites in hexokinase- and pyruvate kinase-deficient red cells measured using 31P-NMR spectroscopy.
hexokinase deficiency
Molecular characterization of six new cases of red blood cell hexokinase deficiency yields four novel mutations in HK1.
hexokinase deficiency
Non-spherocytic haemolytic anaemia in mother and son associated with hexokinase deficiency.
hexokinase deficiency
Novel pathogenic variant c.2714C>A (p. Thr905Lys) in the HK1 gene causing severe haemolytic anaemia with developmental delay in an Indian family.
hexokinase deficiency
Platelet functions and energy metabolism in a patient with hexokinase deficiency.
hexokinase deficiency
Proteomic and functional consequences of hexokinase deficiency in glucose-repressible Kluyveromyces lactis.
hexokinase deficiency
Red blood cell loading with hexokinase and hexokinase-inactivating antibodies. A new strategy for studying the role of enzymes in red cell metabolism and removal.
hexokinase deficiency
Role of hexokinase in the regulation of erythrocyte hexose monophosphate pathway under oxidative stress.
hexokinase deficiency
Role of hexokinase in the regulation of glucose metabolism in human erythrocytes.
hexokinase deficiency
[Atrio-digital dysplasia with anemia, erythrocyte hexokinase deficiency and chromosome anomalies]
hexokinase deficiency
[Cytogenetic finding and etiology of Fanconi's anemia. A case of Fanconi's anemia without hexokinase deficiency]
hexokinase deficiency
[Hexokinase deficiency in blood cells in a group of kin with familial panmyelopathy (Fanconi type)]
hexokinase deficiency
[Hexokinase deficiency of erythrocytes. Familial study of a case of primary isolated deficiency and ancassociated case with glucose-6 phosphate dehydrogenase deficiency]
Hodgkin Disease
Relationship between FDG uptake and expressions of glucose transporter type 1, type 3, and hexokinase-II in Reed-Sternberg cells of Hodgkin lymphoma.
Hookworm Infections
Biochemical and histopathological alterations in golden hamster during infection with Ancylostoma ceylanicum.
Hyperglycemia
A glucokinase-like enzyme carries out glucose phosphorylation in capillaries of normal and spontaneously hyperglycemic rabbits.
Hyperglycemia
Antihyperglycemic and antilipidperoxidative effects ofTephrosia purpurea seed extract in streptozotocin induced diabetic rats.
Hyperglycemia
Characterization of the gene expression profile of heterozygous liver-specific glucokinase knockout mice at a young age.
Hyperglycemia
Differential regulation of glucokinase activity in pancreatic islets and liver of the rat.
Hyperglycemia
Effects of tephrosia purpurea aqueous seed extract on blood glucose and antioxidant enzyme activities in streptozotocin induced diabetic rats.
Hyperglycemia
Energy substrate metabolism and mitochondrial oxidative stress in cardiac ischemia/reperfusion injury.
Hyperglycemia
Glucagon-like peptide-1 decreases intracerebral glucose content by activating hexokinase and changing glucose clearance during hyperglycemia.
Hyperglycemia
Glucokinase expression is regulated by glucose through O-GlcNAc glycosylation.
Hyperglycemia
Glucosamine-induced inhibition of liver glucokinase impairs the ability of hyperglycemia to suppress endogenous glucose production.
Hyperglycemia
Glucose catabolic gene mRNA levels in skeletal muscle exhibit non-coordinate expression in hyperglycemic mice.
Hyperglycemia
Hexokinase-2 Glycolytic Overload in Diabetes and Ischemia-Reperfusion Injury.
Hyperglycemia
In vitro inhibition of human erythrocyte hexokinase by various hyperglycemic drugs.
Hyperglycemia
Increased hexokinase activity in fetuses of rats developed under maternal hyperglycemia.
Hyperglycemia
Kinetic behaviour of liver glucokinase in diabetes. II. Possible role of non-enzymatic protein glycation.
Hyperglycemia
Neonatal seizures in monkeys and rabbits: brain glucose depletion in the face of normoglycemia, prevention by glucose loads.
Hyperglycemia
Potential use of aldose reductase inhibitors to prevent diabetic complications.
Hyperglycemia
Quercetin modulates hyperglycemia by improving the pancreatic antioxidant status and enzymes activities linked with glucose metabolism in type 2 diabetes model of rats: In silico studies of molecular interaction of quercetin with hexokinase and catalase.
Hyperglycemia
Rabbit lens and retina phosphorylate glucose through a glucokinase-like enzyme: study in normal and spontaneously hyperglycemic animals.
Hyperglycemia
Reduction of Glut1 in the Neural Retina But Not the RPE Alleviates Polyol Accumulation and Normalizes Early Characteristics of Diabetic Retinopathy.
Hyperglycemia
Statistical comparison of blood glucose as determined by several test-strip procedures and by a hexokinase procedure.
Hyperglycemia
The effects of hyperinsulinemia and hyperglycemia on GLUT4 and hexokinase II mRNA and protein in rat skeletal muscle and adipose tissue.
Hyperglycemia
Transgenic overexpression of hexokinase II in skeletal muscle does not increase glucose disposal in wild-type or Glut1-overexpressing mice.
Hyperglycemia
Upregulated hexokinase activity in isolated islets from diabetic 90% pancreatectomized rats.
Hyperglycemia
[Peculiarities of carbohydrate metabolism in rabbits following prolonged immunization with viral antigens]
Hyperinsulinism
beta-cell stimulus - secretion coupling defects in rodent models of obesity.
Hyperinsulinism
Control of liver glucokinase activity: A potential new target for incretin hormones?
Hyperinsulinism
Differential regulation of glucokinase activity in pancreatic islets and liver of the rat.
Hyperinsulinism
Overexpression of hexokinase II increases insulinand exercise-stimulated muscle glucose uptake in vivo.
Hyperinsulinism
Phosphorylation barriers to skeletal and cardiac muscle glucose uptakes in high-fat fed mice: studies in mice with a 50% reduction of hexokinase II.
Hyperinsulinism
Physiological hyperinsulinemia impairs insulin-stimulated glycogen synthase activity and glycogen synthesis.
Hyperinsulinism
Regulation of hexokinase II and glycogen synthase mRNA, protein, and activity in human muscle.
Hyperinsulinism
The effects of hyperinsulinemia and hyperglycemia on GLUT4 and hexokinase II mRNA and protein in rat skeletal muscle and adipose tissue.
Hyperlipoproteinemias
Adaptation of red cell enzymes and intermediates in metabolic disorders.
Hypersensitivity
Changes induced by sucrose administration on glucose metabolism in pancreatic islets in normal hamsters.
Hypersensitivity
Upregulated hexokinase activity in isolated islets from diabetic 90% pancreatectomized rats.
Hypertension
Increased in vivo mitochondrial oxygenation with right ventricular failure induced by pulmonary arterial hypertension: mitochondrial inhibition as driver of cardiac failure?
Hypertension
Metabolic alterations in discrete regions of the rat brain during development of spontaneous hypertension.
Hypertension
miR-125a-5p inhibits glycolysis by targeting hexokinase-II to improve pulmonary arterial hypertension.
Hyperthyroidism
Changes in hexokinase and glucose-6-phosphate dehydrogenase in red cells during hypo and hyperthyroidism.
Hyperthyroidism
Effect of hypo- and hyperthyroidism on hexokinase in the developing cerebellum of the rat.
Hyperthyroidism
Effect of hypo- and hyperthyroidism on the function and metabolism of macrophages in rats.
Hyperthyroidism
Effect of thyroid hormones on the glycolytic enzyme activity in brain areas of the rat.
Hyperthyroidism
Effects of hyperthyroidism on glucose, glutamine and ketone-body metabolism in the gut of the rat.
Hyperthyroidism
Increased acylphosphatase levels in erythrocytes from hyperthyroid patients.
Hyperthyroidism
Investigation of red blood cell carbonic anhydrase, glucose 6-phosphate dehydrogenase, hexokinase enzyme activities, and zinc concentration in patients with hyperthyroid diseases.
Hyperthyroidism
Specific effect of thyroid hormone on testicular enzymes involved in carbohydrate metabolism. II. Hyperthyroidism.
Hyperthyroidism
The effects of insulin on transport and metabolism of glucose in skeletal muscle from hyperthyroid and hypothyroid rats.
Hyperthyroidism
[Intraerythrocytic enzyme activities in euthyroid subjects and hyperthyroid patients before treatment and following stabilization of metabolism using radioiodine therapy]
Hypertriglyceridemia
Control of liver glucokinase activity: A potential new target for incretin hormones?
Hypertrophy, Left Ventricular
Left ventricular enzyme activities of the energy-supplying metabolism in Goldblatt-II rats.
Hypoglycemia
Changes in hexokinase isoenzymes in regions of rat brain during insulin-induced hypoglycemia.
Hypoglycemia
Changes in muscle mRNAs for hexokinase, phosphofructokinase-1 and glycogen synthase in acute and persistent hypoglycemia induced by tolbutamide in chickens.
Hypoglycemia
Clinical utility and accuracy of a blood glucose meter for the detection of neonatal hypoglycemia.
Hypoglycemia
Computational prediction and experimental validation of the activator function of C2-?-D-glucopyranosyl-1,3,6,7-tetrahydroxyxanthone on pancreatic and hepatic hexokinase.
Hypoglycemia
Differential regulation of glucokinase activity in pancreatic islets and liver of the rat.
Hypoglycemia
Effect of diabetes and insulin-induced hypoglycemia on hexokinase and glucose-6-phosphate dehydrogenase in red blood cells.
Hypoglycemia
False paraprotein-induced hypoglycemia in the measurement of glucose by the hexokinase method.
Hypoglycemia
How accurate is glucose analysis in the presence of multiple interfering substances in the neonate? (glucose analysis and interfering substances).
Hypoglycemia
Modeling cancer glycolysis under hypoglycemia, and the role played by the differential expression of glycolytic isoforms.
Hypoglycemia
Statistical comparison of blood glucose as determined by several test-strip procedures and by a hexokinase procedure.
Hypoglycemia
SUMOylation of Pancreatic Glucokinase Regulates Its Cellular Stability and Activity.
Hypokinesia
[Glycogen level and activity of carbohydrate metabolism enzymes in the liver of rats during the readaptation period after a 20-day hypokinesia]
Hypothyroidism
Effect of hypo- and hyperthyroidism on hexokinase in the developing cerebellum of the rat.
Hypothyroidism
Effect of primary congenital hypothyroidism upon expression of genes mediating murine brain glucose uptake.
Hypothyroidism
Synaptic and Non-Synaptic Mitochondria in Hippocampus of Adult Rats Differ in Their Sensitivity to Hypothyroidism.
Hypothyroidism
The effects of insulin on transport and metabolism of glucose in skeletal muscle from hyperthyroid and hypothyroid rats.
Infections
A Mechanistic Probe into the Dual Inhibition of T. cruzi Glucokinase and Hexokinase in Chagas Disease Treatment - A Stone Killing Two Birds?
Infections
ARGONAUTE 2 increases rice susceptibility to rice black-streaked dwarf virus infection by epigenetically regulating HEXOKINASE 1 expression.
Infections
cAMP Receptor Protein of Salmonella enterica Serovar Typhimurium Modulate Glycolysis in Macrophages to Induce Cell Apoptosis.
Infections
Cyclin-Dependent Kinases 8 and 19 Regulate Host Cell Metabolism during Dengue Virus Serotype 2 Infection.
Infections
Effects of Salmonella enterica serovar typhimurium sseK1 on macrophage inflammation-related cytokines and glycolysis.
Infections
Hexokinase 2 controls cellular stress response through localization of an RNA-binding protein.
Infections
Human metapneumovirus infection of airway epithelial cells is associated with changes in core metabolic pathways.
Infections
Lonidamine potentiates the oncolytic efficiency of M1 virus independent of hexokinase 2 but via inhibition of antiviral immunity.
Infections
Plasmodium vivax and human hexokinases share similar active sites but display distinct quaternary architectures.
Infections
Regulation of autophagy, glucose uptake, and glycolysis under dengue virus infection.
Infections
Susceptibility of Biomphalaria alexandrina to infection with Schistosoma mansoni: correlation with the activity of certain glycolytic enzymes.
Infections
Upregulation of Glucose Uptake and Hexokinase Activity of Primary Human CD4+ T Cells in Response to Infection with HIV-1.
Infections
[Difference in the inactivation of hexokinase activity in wheat leaves following infection with Puccinia graminis tritici]
Infertility
Quality and safety of parenteral nutrition for newborn and preterm infants as an on-ward preparation.
Infertility, Male
Deficiency of rice hexokinase HXK5 impairs synthesis and utilization of starch in pollen grains and causes male sterility.
Infertility, Male
Pentatricopeptide-repeat family protein RF6 functions with hexokinase 6 to rescue rice cytoplasmic male sterility.
Insulin Resistance
Acyl-CoA inhibition of hexokinase in rat and human skeletal muscle is a potential mechanism of lipid-induced insulin resistance.
Insulin Resistance
Age-related hyperinsulinemia leads to insulin resistance in neurons and cell-cycle-induced senescence.
Insulin Resistance
Allosteric regulation of glycogen synthase and hexokinase by glucosamine-6-phosphate during glucosamine-induced insulin resistance in skeletal muscle and heart.
Insulin Resistance
Analysis of the hexokinase II gene in subjects with insulin resistance and NIDDM and detection of a Gln142-->His substitution.
Insulin Resistance
Chebulagic acid attenuates HFD/Streptozotocin induced impaired glucose metabolism and insulin resistance via up regulations of PPAR ? and GLUT 4 in type 2 diabetic rats.
Insulin Resistance
Comparative effects of single-mode vs. duration-matched concurrent exercise training on body composition, low-grade inflammation, and glucose regulation in sedentary, overweight, middle-aged men.
Insulin Resistance
Defect of an early event of glucose metabolism in skeletal muscle of the male Otsuka Long-Evans Tokushima Fatty (OLETF) rat, a non-insulin-dependent diabetes mellitus (NIDDM) model.
Insulin Resistance
Diabetes Modulates MicroRNAs 29b-3p, 29c-3p, 199a-5p and 532-3p Expression in Muscle: Possible Role in GLUT4 and HK2 Repression.
Insulin Resistance
Dietary energy source and physical conditioning affect insulin sensitivity and skeletal muscle glucose metabolism in horses.
Insulin Resistance
Differential regulation of metabolic genes in skeletal muscle during starvation and refeeding in humans.
Insulin Resistance
Effects of glucocorticoid excess on the sensitivity of glucose transport and metabolism to insulin in rat skeletal muscle.
Insulin Resistance
Effects of menopause and high-intensity training on insulin sensitivity and muscle metabolism.
Insulin Resistance
Effects of short-term training on insulin sensitivity and skeletal muscle glucose metabolism in standardbred horses.
Insulin Resistance
Endotoxin-induced alterations in glucose transport in isolated adipocytes.
Insulin Resistance
Functional consequences of naturally occurring variants of human hexokinase II.
Insulin Resistance
GLUT4 and Glycogen Synthase Are Key Players in Bed Rest-Induced Insulin Resistance.
Insulin Resistance
Hepatic hexokinase domain containing 1 (HKDC1) improves whole body glucose tolerance and insulin sensitivity in pregnant mice.
Insulin Resistance
Hexokinase II activity and messenger ribonucleic acid abundance in adipose tissue and skeletal muscle during pregnancy and lactation in rats.
Insulin Resistance
Hypoglycemic effects and modulation of gut microbiota of diabetic mice by saponin from Polygonatum sibiricum.
Insulin Resistance
Identification of four amino acid substitutions in hexokinase II and studies of relationships to NIDDM, glucose effectiveness, and insulin sensitivity.
Insulin Resistance
Impaired glucose metabolism and exercise capacity with muscle-specific glycogen synthase 1 (gys1) deletion in adult mice.
Insulin Resistance
Impaired insulin-induced site-specific phosphorylation of TBC1 domain family, member 4 (TBC1D4) in skeletal muscle of type 2 diabetes patients is restored by endurance exercise-training.
Insulin Resistance
Insulin sensitivity in growth hormone (GH)-deficient adults and effect of GH replacement therapy.
Insulin Resistance
Insulin-induced hexokinase II expression is reduced in obesity and NIDDM.
Insulin Resistance
Interaction of physical activity and diet: implications for insulin-glucose dynamics.
Insulin Resistance
Linkage analysis of 19 candidate regions for insulin resistance in familial NIDDM.
Insulin Resistance
Metabolic and molecular changes associated with the increased skeletal muscle insulin action 24-48?h after exercise in young and old humans.
Insulin Resistance
Mitigating Perspectives of Asiatic acid in the Renal derangements of Streptozotocin-Nicotinamide induced Diabetic Rats.
Insulin Resistance
Molecular and Metabolic Markers of Fructose Induced Hepatic Insulin Resistance in Developing and Adult Rats are Distinct and Aegle marmelos is an Effective Modulator.
Insulin Resistance
Muscle fiber composition and capillarization in relation to metabolic alterations in hypertensive men.
Insulin Resistance
Overexpression of PGC-1? improves insulin sensitivity and mitochondrial function in 3T3-L1 adipocytes.
Insulin Resistance
Pathogenesis of skeletal muscle insulin resistance in type 2 diabetes mellitus.
Insulin Resistance
Polymorphisms of the human hexokinase II gene: lack of association with NIDDM and insulin resistance.
Insulin Resistance
Regulation of liver glucokinase activity in rats with fructose-induced insulin resistance and impaired glucose and lipid metabolism.
Insulin Resistance
Studies of the impact of a liver glucokinase promoter variant on glucose tolerance and insulin sensitivity index.
Insulin Resistance
The insulin resistance is reversed by exogenous 3,5,3'triiodothyronine in type 2 diabetic Goto-Kakizaki rats by an inflammatory-independent pathway.
Insulin Resistance
The Role of Hexokinase Domain Containing Protein-1 in Glucose Regulation During Pregnancy.
Insulin Resistance
Transgenic overexpression of hexokinase II in skeletal muscle does not increase glucose disposal in wild-type or Glut1-overexpressing mice.
Insulinoma
Evaluation of the expression of hexokinase 1, glucokinase, and insulin by canine insulinoma cells maintained in short-term culture.
Insulinoma
Hexokinase isoenzymes of RIN-m5F insulinoma cells. Expression of glucokinase gene in insulin-producing cells.
Insulinoma
Porin proteins in mitochondria from rat pancreatic islet cells and white adipocytes: identification and regulation of hexokinase binding by the sulfonylurea glimepiride.
Intervertebral Disc Degeneration
HIF1A Alleviates compression-induced apoptosis of nucleus pulposus derived stem cells via upregulating autophagy.
Intracranial Embolism
Naftidrofuryl oxalate improves impaired brain glucose metabolism after microsphere-induced cerebral embolism in rats.
Iron Deficiencies
Iron deficiency attenuates protein synthesis stimulated by branched-chain amino acids and insulin in myotubes.
Irritable Bowel Syndrome
Isoenzyme and molecular characterization of Entamoeba histolytica and Entamoeba dispar isolates from symptomatic and asymptomatic subjects.
Ischemic Stroke
Succinate-induced neuronal mitochondrial fission and hexokinase II malfunction in ischemic stroke: Therapeutical effects of kaempferol.
Keratosis
A Hexokinase 2 Modulator for Field-Directed Treatment of Experimental Actinic Keratoses.
Ketosis
Effect of prenatally-induced and postnatally-maintained ketosis on beta-hydroxybutyrate dehydrogenase and hexokinase levels in the developing rat brain.
Ketosis
Renal enzymes during experimental diabetes mellitus in the rat. Role of insulin, carbohydrate metabolism, and ketoacidosis.
Klatskin Tumor
PKM2 regulates neural invasion of and predicts poor prognosis for human hilar cholangiocarcinoma.
Laryngeal Neoplasms
INPP4B-mediated tumor resistance is associated with modulation of glucose metabolism via hexokinase 2 regulation in laryngeal cancer cells.
Leiomyoma
Activity of glycolytic enzymes and glucose-6-phosphate dehydrogenase in smooth muscle proliferation.
Leiomyosarcoma
Activity of glycolytic enzymes and glucose-6-phosphate dehydrogenase in smooth muscle proliferation.
Leiomyosarcoma
Long Term Prognostic Implications of Expression of Glucose Transporter-1 and Hexokinase II in Patients with Stage I Uterine Leiomyosarcoma.
Leishmaniasis
Expression of Hexokinase in the Proteome Profile of Leishmania major and Crithidia
Leishmaniasis, Cutaneous
Development of Assays Using Hexokinase and Phosphoglucomutase Gene Sequences That Distinguish Strains of Leishmania tropica from Different Zymodemes and Microsatellite Clusters and Their Application to Palestinian Foci of Cutaneous Leishmaniasis.
Leukemia
2-Deoxy-D-glucose Restore Glucocorticoid Sensitivity in Acute Lymphoblastic Leukemia via Modification of N-Linked Glycosylation in an Oxygen Tension-Independent Manner.
Leukemia
ITD mutation in FLT3 tyrosine kinase promotes Warburg effect and renders therapeutic sensitivity to glycolytic inhibition.
Leukemia
Methyl Jasmonate: Putative Mechanisms of Action on Cancer Cells Cycle, Metabolism, and Apoptosis.
Leukemia
Selective induction of cancer cell death by VDAC1-based peptides and their potential use in cancer therapy.
Leukemia
Suppression of Glut1 and Glucose Metabolism by Decreased Akt/mTORC1 Signaling Drives T Cell Impairment in B Cell Leukemia.
Leukemia, B-Cell
Suppression of Glut1 and Glucose Metabolism by Decreased Akt/mTORC1 Signaling Drives T Cell Impairment in B Cell Leukemia.
Leukemia, Lymphocytic, Chronic, B-Cell
Isozyme distribution of hexokinase, phosphofructokinase and pyruvate kinase in lymphocytes from patients with chronic lymphocytic leukemia.
Leukemia, Lymphoid
Anomeric specificity of hexokinase in rat, human, and murine tumor cells.
Leukemia, Lymphoid
Antitumor agents. XXXV: Effects of brusatol, bruceoside A, and bruceantin on P-388 lymphocytic leukemia cell respiration.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Overexpression of miR-202 re-sensitizes imatinib resistant chronic myeloid leukemia cells through targeting Hexokinase 2 (HK2).
Leukemia, Myeloid
Matrine Promotes Human Myeloid Leukemia Cells Apoptosis Through Warburg Effect Mediated by Hexokinase 2.
Leukoplakia
Histochemical observations of hexokinase in leukoplakias and squamous cell carcinomas of oral cavity and maxillary sinus.
Liver Cirrhosis
Hexokinase isoenzymes in normal and cirrhotic human liver: suppression of glucokinase in cirrhosis.
Liver Cirrhosis
Profiles of carbohydrate-metabolizing enzymes in human hepatocellular carcinomas and preneoplastic livers.
Liver Cirrhosis, Biliary
Anti-kelch-like 12 and anti-hexokinase 1: novel autoantibodies in primary biliary cirrhosis.
Liver Cirrhosis, Biliary
Hexokinase isoenzymes in normal and cirrhotic human liver: suppression of glucokinase in cirrhosis.
Liver Cirrhosis, Biliary
Novel Anti-Hexokinase 1 Antibodies Are Associated With Poor Prognosis in Patients With Primary Biliary Cholangitis.
Liver Diseases
Hexokinase isoenzymes in normal and cirrhotic human liver: suppression of glucokinase in cirrhosis.
Liver Diseases, Alcoholic
Hexokinase isoenzymes in normal and cirrhotic human liver: suppression of glucokinase in cirrhosis.
Liver Neoplasms
A hexokinase isoenzyme switch in human liver cancer cells promotes lipogenesis and enhances innate immunity.
Liver Neoplasms
Glucose catabolism in the rabbit VX2 tumor model for liver cancer: characterization and targeting hexokinase.
Liver Neoplasms
Hexokinase II and VEGF expression in liver tumors: correlation with hypoxia-inducible factor 1 alpha and its significance.
Liver Neoplasms
HKDC1 promotes the tumorigenesis and glycolysis in lung adenocarcinoma via regulating AMPK/mTOR signaling pathway.
Liver Neoplasms
MiR-199a-5p is negatively associated with malignancies and regulates glycolysis and lactate production by targeting hexokinase 2 in liver cancer.
Liver Neoplasms
miR-885-5p Negatively Regulates Warburg Effect by Silencing Hexokinase 2 in Liver Cancer.
Liver Neoplasms
The combination of the glycolysis inhibitor 2-DG and sorafenib can be effective against sorafenib-tolerant persister cancer cells.
Liver Neoplasms
[Mechanism of the anticancer action of selenium--influence on glycolysis and its key enzyme]
Liver Neoplasms, Experimental
Absence of hexokinase activity in plasma membranes of Morris hepatoma 5123 t.c.
Liver Neoplasms, Experimental
Amino acid sequence homology between yeast hexokinases and rat hexokinase C.
Liver Neoplasms, Experimental
Hexokinase isoenzymes from the Novikoff hepatoma. Purification, kinetic and structural characterization, with emphasis on hexokinase C.
Liver Neoplasms, Experimental
Hexokinase isozyme patterns of experimental hepatomas of rats.
Liver Neoplasms, Experimental
Microheterogeneity of cytosolic and membrane-bound hexokinase II in Morris hepatoma 3924A.
Liver Neoplasms, Experimental
Presence of fast moving type IV hexokinase isozyme in Morris hepatoma.
Lung Neoplasms
A causal link from ALK to hexokinase II overexpression and hyperactive glycolysis in EML4-ALK-positive lung cancer.
Lung Neoplasms
Aerosolized 3-bromopyruvate inhibits lung tumorigenesis without causing liver toxicity.
Lung Neoplasms
Differentiation of histological subtypes in lung cancer with 18F-FDG-PET 3-point imaging and kinetic analysis.
Lung Neoplasms
Down-regulation of miR-214 inhibits proliferation and glycolysis in non-small-cell lung cancer cells via down-regulating the expression of hexokinase 2 and pyruvate kinase isozyme M2.
Lung Neoplasms
Hexokinase 2 discerns a novel circulating tumor cell population associated with poor prognosis in lung cancer patients.
Lung Neoplasms
Inhibition of glycolytic enzyme hexokinase II (HK2) suppresses lung tumor growth.
Lung Neoplasms
Jolkinolide B inhibits glycolysis by downregulating hexokinase 2 expression through inactivating the Akt/mTOR pathway in non-small cell lung cancer cells.
Lung Neoplasms
miR-206 regulates non-small cell lung cancer cell aerobic glycolysis by targeting hexokinase 2.
Lung Neoplasms
New challenges in integrated diagnosis by imaging and osteo-immunology in bone lesions.
Lung Neoplasms
Octamer transcription factor-1 induces the Warburg effect via up-regulation of hexokinase 2 in non-small cell lung cancer.
Lung Neoplasms
Oroxylin A sensitizes non-small cell lung cancer cells to anoikis via glucose-deprivation-like mechanisms: c-Src and hexokinase II.
Lung Neoplasms
Programmed cell death ligand-1-mediated enhancement of hexokinase 2 expression is inversely related to T-cell effector gene expression in non-small-cell lung cancer.
Lung Neoplasms
Radiogenomic Analysis Demonstrates Associations between (18)F-Fluoro-2-Deoxyglucose PET, Prognosis, and Epithelial-Mesenchymal Transition in Non-Small Cell Lung Cancer.
Lung Neoplasms
Relationship between (18)F-FDG uptake on PET and various biologic molecular markers in benign pulmonary lesion: comparison with primary lung cancer.
Lung Neoplasms
S100A4 alters metabolism and promotes invasion of lung cancer cells by up-regulating mitochondrial complex I protein NDUFS2.
Lung Neoplasms
SILAC Quantitative Proteomics and Biochemical Analyses Reveal a Novel Molecular Mechanism by Which ADAM12S Promotes the Proliferation, Migration, and Invasion of Small Cell Lung Cancer Cells through Upregulating Hexokinase 1.
Lung Neoplasms
[Prognostic significance of the hexokinase test in patients with lung cancer]
Lymphoma
Expression of hypoxia-inducible factor 1?, glucose transporter 1, and hexokinase 2 in primary central nervous system lymphoma and the correlation with the biological behaviors.
Lymphoma
Expressions of glucose transporter Types 1 and 3 and hexokinase-II in diffuse large B-cell lymphoma and other B-cell non-Hodgkin's lymphomas.
Lymphoma
Glycolytic enzyme hexokinase II is a putative therapeutic target in B-cell malignant lymphoma.
Lymphoma
HKDC1 C-terminal based peptides inhibit extranodal natural killer/T-cell lymphoma by modulation of mitochondrial function and EBV suppression.
Lymphoma
HKDC1 promotes the tumorigenesis and glycolysis in lung adenocarcinoma via regulating AMPK/mTOR signaling pathway.
Lymphoma
Icaritin inhibits glioblastoma cell viability and glycolysis by blocking the IL-6/Stat3 pathway.
Lymphoma
Lysophosphatidic acid promotes survival of T lymphoma cells by altering apoptosis and glucose metabolism.
Lymphoma, B-Cell
3-Bromopyruvate inhibits human gastric cancer tumor growth in nude mice via the inhibition of glycolysis.
Lymphoma, B-Cell
Evidence of altered depression and dementia-related proteins in the brains of young rats after ovariectomy.
Lymphoma, B-Cell
Expressions of glucose transporter Types 1 and 3 and hexokinase-II in diffuse large B-cell lymphoma and other B-cell non-Hodgkin's lymphomas.
Lymphoma, B-Cell
Voltage-Dependent Anion Channel 1 As an Emerging Drug Target for Novel Anti-Cancer Therapeutics.
Lymphoma, Large B-Cell, Diffuse
Expressions of glucose transporter Types 1 and 3 and hexokinase-II in diffuse large B-cell lymphoma and other B-cell non-Hodgkin's lymphomas.
Lymphoma, Non-Hodgkin
A comparison of the effect of glucocorticoids on glucose uptake and hexokinase activity in lymphosarcoma P1798.
Malaria
Purification and characterisation of the hexokinase of Plasmodium berghei, a murine malaria parasite.
Malnutrition
Beta-cell secretory dysfunction in the pathogenesis of low birth weight-associated diabetes: a murine model.
Malnutrition
Evidence for liver energy metabolism programming in offspring subjected to intrauterine undernutrition during midgestation.
Malnutrition
Maternal undernutrition induces the expression of hypoxia-related genes in the fetal brain.
Medulloblastoma
Pyruvate Kinase Inhibits Proliferation during Postnatal Cerebellar Neurogenesis and Suppresses Medulloblastoma Formation.
Melanoma
Automated in vivo screen in zebrafish identifies Clotrimazole as targeting a metabolic vulnerability in a melanoma model.
Melanoma
Biologic correlation between glucose transporters, hexokinase-II, Ki-67 and FDG uptake in malignant melanoma.
Melanoma
Effect of lentivirus-mediated shRNA inactivation of HK1, HK2, and HK3 genes in colorectal cancer and melanoma cells.
Melanoma
Factors influencing [F-18] 2-fluoro-2-deoxy-D-glucose (F-18 FDG) uptake in melanoma cells: the role of proliferation rate, viability, glucose transporter expression and hexokinase activity.
Melanoma
Long Noncoding RNA CCAT1 Functions as a Competing Endogenous RNA to Upregulate ITGA9 by Sponging MiR-296-3p in Melanoma.
Melanoma
Variability in glucose transporter-1 levels and hexokinase activity in human melanoma.
Melanoma, Experimental
Clotrimazole and bifonazole detach hexokinase from mitochondria of melanoma cells.
Melanoma, Experimental
Lithium detaches hexokinase from mitochondria and inhibits proliferation of B16 melanoma cells.
Metabolic Diseases
An HPLC method for the determination of adenosine diphosphate: An important marker of hexokinase activity in metabolic diseases.
Metabolic Diseases
Structure and function of human xylulokinase, an enzyme with important roles in carbohydrate metabolism.
Multiple Myeloma
Hypoxia-inducible hexokinase-2 enhances anti-apoptotic function via activating autophagy in multiple myeloma.
Multiple Myeloma
Low expression of hexokinase-2 is associated with false-negative FDG-positron emission tomography in multiple myeloma.
Multiple Myeloma
Low hexokinase-2 expression-associated false-negative 18F-FDG PET/CT as a potential prognostic predictor in patients with multiple myeloma.
Multiple Myeloma
New challenges in integrated diagnosis by imaging and osteo-immunology in bone lesions.
Muscular Dystrophies
The increase in hexokinase activity in hereditary avian muscular dystrophy.
Myocardial Infarction
Enhanced activity and subcellular redistribution of myocardial hexokinase after acute myocardial infarction.
Myocardial Infarction
Inhibition of carnitine synthesis modulates protein contents of the cardiac sarcoplasmic reticulum Ca2+-ATPase and hexokinase type I in rat hearts with myocardial infarction.
Myocardial Ischemia
sDR5-Fc inhibits macrophage M1 polarization by blocking the glycolysis.
Myocardial Ischemia
[Diagnostic value of determining hexokinase activity of leukocytes in ischemic heart disease]
Myocarditis
[Glycolysis and hexokinase activity in the subcellular fraction of the rabbit myocardium in adrenalinic myocarditis]
Myotonia
Changes of hexokinase in the enzyme activity pattern of muscle in human myotonia congenita and in experimental myotonia of the rat.
Myotonia Congenita
Changes of hexokinase in the enzyme activity pattern of muscle in human myotonia congenita and in experimental myotonia of the rat.
Myotonic Dystrophy
Correlation between decreased myocardial glucose phosphorylation and the DNA mutation size in myotonic dystrophy.
Myotonic Dystrophy
Myotonic dystrophy protein kinase (DMPK) prevents ROS-induced cell death by assembling a hexokinase II-Src complex on the mitochondrial surface.
Nasopharyngeal Carcinoma
hsa-miR-9-5p Down-Regulates HK2 and Confers Radiosensitivity to Nasopharyngeal Carcinoma.
Nasopharyngeal Carcinoma
Long-term prognostic implications and therapeutic target role of hexokinase II in patients with nasopharyngeal carcinoma.
Neoplasm Metastasis
AKT2 phosphorylation of hexokinase 2 at T473 promotes tumorigenesis and metastasis in colon cancer cells via NF-?B, HIF1?, MMP2, and MMP9 upregulation.
Neoplasm Metastasis
c-Src phosphorylation and activation of hexokinase promotes tumorigenesis and metastasis.
Neoplasm Metastasis
Heterogeneity of glycolytic enzyme activity and isozyme composition of pyruvate kinase in breast cancer.
Neoplasm Metastasis
Hexokinase 2 enhances the metastatic potential of tongue squamous cell carcinoma via the SOD2-H2O2 pathway.
Neoplasm Metastasis
Hexokinase 2 promotes tumor growth and metastasis by regulating lactate production in pancreatic cancer.
Neoplasm Metastasis
Hexokinase II-Derived Cell-Penetrating Peptide Mediates Delivery of MicroRNA Mimic for Cancer-Selective Cytotoxicity.
Neoplasm Metastasis
Hexokinase II: cancer's double-edged sword acting as both facilitator and gatekeeper of malignancy when bound to mitochondria.
Neoplasm Metastasis
Identification of novel alternative splicing isoform biomarkers and their association with overall survival in colorectal cancer.
Neoplasm Metastasis
PGC1? Regulates Breast Tumor Growth and Metastasis by SREBP1-Mediated HKDC1 Expression.
Neoplasm Metastasis
Reciprocal immunohistochemical expression of sodium/iodide symporter and hexokinase I in primary thyroid tumors with synchronous cervical metastasis.
Neoplasm Metastasis
S100A4 alters metabolism and promotes invasion of lung cancer cells by up-regulating mitochondrial complex I protein NDUFS2.
Neoplasm Metastasis
Taurine upregulated gene 1 functions as a master regulator to coordinate glycolysis and metastasis in hepatocellular carcinoma.
Neoplasm Metastasis
[Diagnostic and prognostic significance of biochemical indicators in colorectal neoplasms]
Neoplasm Metastasis
[The role of hexokinase 2 in the metastasis of hepatocellular carcinoma cells].
Neoplasms
(18)F-FDG uptake on PET in primary mediastinal non-thymic neoplasm: A clinicopathological study.
Neoplasms
(18)FDG PET for grading malignancy in thymic epithelial tumors: Significant differences in (18)FDG uptake and expression of glucose transporter-1 and hexokinase II between low and high-risk tumors: Preliminary study.
Neoplasms
18F-FDG-PET of musculoskeletal tumors: a correlation with the expression of glucose transporter 1 and hexokinase II.
Neoplasms
2-Deoxy-D-glucose Restore Glucocorticoid Sensitivity in Acute Lymphoblastic Leukemia via Modification of N-Linked Glycosylation in an Oxygen Tension-Independent Manner.
Neoplasms
2-[18F]-2-deoxy-D-glucose (FDG) uptake in human tumor cells is related to the expression of GLUT-1 and hexokinase II.
Neoplasms
3-bromopyruvate (3BP) a fast acting, promising, powerful, specific, and effective "small molecule" anti-cancer agent taken from labside to bedside: introduction to a special issue.
Neoplasms
3-Bromopyruvate as a potent anticancer therapy in honor and memory of the late Professor André Goffeau.
Neoplasms
3-Bromopyruvate attenuates experimental pulmonary hypertension via inhibition of glycolysis.
Neoplasms
3-bromopyruvate enhanced daunorubicin-induced cytotoxicity involved in monocarboxylate transporter 1 in breast cancer cells.
Neoplasms
3-Bromopyruvate induces apoptosis in breast cancer cells by downregulating Mcl-1 through the PI3K/Akt signaling pathway.
Neoplasms
3-Bromopyruvic acid, a hexokinase II inhibitor, is an effective antitumor agent on the hepatoma cells : in vitro and in vivo findings.
Neoplasms
6-phosphogluconate dehydrogenase, glucose-6-phosphate dehydrogenase, glucose-6-phosphate isomerase, and hexokinase activity ratios in some human tumor cytosols.
Neoplasms
A Hexokinase 2 Modulator for Field-Directed Treatment of Experimental Actinic Keratoses.
Neoplasms
A lentiviral sponge for miRNA-21 diminishes aerobic glycolysis in bladder cancer T24 cells via the PTEN/PI3K/AKT/mTOR axis.
Neoplasms
A pan-cancer analysis of molecular characteristics and oncogenic role of hexokinase family genes in human tumors.
Neoplasms
A precision therapeutic strategy for hexokinase 1-null, hexokinase 2-positive cancers.
Neoplasms
A recent application of fluoro-18-deoxyglucose positron emission tomography, treatment monitoring with a mammalian target of rapamycin inhibitor: an example of a patient with a desmoplastic small round cell tumor.
Neoplasms
A tumor agnostic therapeutic strategy for Hexokinase 1 Null/Hexokinase 2 positive cancers.
Neoplasms
Aberrant glycolytic metabolism of cancer cells: a remarkable coordination of genetic, transcriptional, post-translational, and mutational events that lead to a critical role for type II hexokinase.
Neoplasms
Activity of glycolytic enzymes and glucose-6-phosphate dehydrogenase in lipoblastic and neurogenic proliferations.
Neoplasms
Activity of glycolytic enzymes and glucose-6-phosphate dehydrogenase in smooth muscle proliferation.
Neoplasms
Adaptations of energy metabolism during cerebellar neurogenesis are co-opted in medulloblastoma.
Neoplasms
Adenine Nucleotide Translocase 2 as an Enzyme Related to [18F] FDG Accumulation in Various Cancers.
Neoplasms
Aegle marmelos differentially affects hepatic markers of glycolysis, insulin signalling pathway, hypoxia, and inflammation in HepG2 cells grown in fructose versus glucose-rich environment.
Neoplasms
Aerosolized 3-bromopyruvate inhibits lung tumorigenesis without causing liver toxicity.
Neoplasms
Akt inhibition promotes hexokinase 2 redistribution and glucose uptake in cancer cells.
Neoplasms
Alloxan and ninhydrin inhibition of hexokinase from pancreatic islets and tumoural insulin-secreting cells.
Neoplasms
Alterations in glucose metabolism proteins responsible for the Warburg effect in esophageal squamous cell carcinoma.
Neoplasms
An HK2 Antisense Oligonucleotide Induces Synthetic Lethality in HK1-HK2+ Multiple Myeloma.
Neoplasms
An HPLC method for the determination of adenosine diphosphate: An important marker of hexokinase activity in metabolic diseases.
Neoplasms
Analysis of the Effects of Hexokinase 2 Detachment From Mitochondria-Associated Membranes with the Highly Selective Peptide HK2pep.
Neoplasms
Analysis of the roles of glucose transporter 1 and hexokinase 2 in the metabolism of glucose by extrahepatic bile duct cancer cells.
Neoplasms
Androgen deprivation leads to increased carbohydrate metabolism and hexokinase 2-mediated survival in Pten/Tp53-deficient prostate cancer.
Neoplasms
Androgen Receptor Stimulates Hexokinase 2 and Induces Glycolysis by PKA/CREB Signaling in Hepatocellular Carcinoma.
Neoplasms
Anti PD-1 treatment increases [18F]FDG uptake by cancer cells in a mouse B16F10 melanoma model.
Neoplasms
Apoptosis-inducing antitumor efficacy of hexokinase II inhibitor in hepatocellular carcinoma.
Neoplasms
Ascites tumor mitochondrial hexokinase II. Effect of binding on kinetic properties.
Neoplasms
ATG12 deficiency leads to tumor cell oncosis owing to diminished mitochondrial biogenesis and reduced cellular bioenergetics.
Neoplasms
Benserazide, a dopadecarboxylase inhibitor, suppresses tumor growth by targeting hexokinase 2.
Neoplasms
Biochemical alterations in 7,12-dimethylbenz[a]anthracene-induced mammary tumors from rats subjected to caloric restriction.
Neoplasms
Bioflavonoid regulation of ATPase and hexokinase activity in Ehrlich ascites cell mitochondria.
Neoplasms
Biologic correlates of (18)fluorodeoxyglucose uptake in human breast cancer measured by positron emission tomography.
Neoplasms
Biologic correlates of intratumoral heterogeneity in 18F-FDG distribution with regional expression of glucose transporters and hexokinase-II in experimental tumor.
Neoplasms
Bis(3,5-diiodo-2,4,6-trihydroxyphenyl)squaraine: A novel candidate in photodynamic therapy for skin cancer models in vivo.
Neoplasms
By blocking hexokinase-2 phosphorylation, limonin suppresses tumor glycolysis and induces cell apoptosis in hepatocellular carcinoma.
Neoplasms
By reducing hexokinase 2, resveratrol induces apoptosis in HCC cells addicted to aerobic glycolysis and inhibits tumor growth in mice.
Neoplasms
c-Myc targeted regulators of cell metabolism in a transgenic mouse model of papillary lung adenocarcinoma.
Neoplasms
Carpesium abrotanoides (L.) Root as a Potential Source of Natural Anticancer Compounds: Targeting Glucose Metabolism and PKM2/HIF-1? Axis of Breast Cancer Cells.
Neoplasms
Casiopeina II-gly and bromo-pyruvate inhibition of tumor hexokinase, glycolysis, and oxidative phosphorylation.
Neoplasms
Cerulenin-induced apoptosis is mediated by disrupting the interaction between AIF and hexokinase II.
Neoplasms
Characterization of hexokinase isoenzyme types I and II in ascites tumor cells by an interaction with mitochondrial membrane.
Neoplasms
Choline kinase alpha and hexokinase-2 protein expression in hepatocellular carcinoma: association with survival.
Neoplasms
Chrysin inhibited tumor glycolysis and induced apoptosis in hepatocellular carcinoma by targeting hexokinase-2.
Neoplasms
Cleavage of hexokinase II to two domains by trypsin without significant change in catalytic activity.
Neoplasms
Clinicopathologic Features and Molecular Characteristics of Glucose Metabolism Contributing to ¹?F-fluorodeoxyglucose Uptake in Gastrointestinal Stromal Tumors.
Neoplasms
Clinicopathological presentation of varying 18F-FDG uptake and expression of glucose transporter 1 and hexokinase II in cases of hepatocellular carcinoma and cholangiocellular carcinoma.
Neoplasms
Clotrimazole and bifonazole detach hexokinase from mitochondria of melanoma cells.
Neoplasms
Co-targeting hexokinase 2-mediated Warburg effect and ULK1-dependent autophagy suppresses tumor growth of PTEN- and TP53-deficiency-driven castration-resistant prostate cancer.
Neoplasms
Combination of arsenic trioxide and cisplatin synergistically inhibits both hexokinase activity and viability of Ehrlich ascites carcinoma cells.
Neoplasms
Combinatorial regulation of neuroblastoma tumor progression by N-Myc and hypoxia inducible factor (HIF)-1{alpha}.
Neoplasms
Combined evaluation of hexokinase 2 and phosphorylated pyruvate dehydrogenase-E1? in invasive front lesions of colorectal tumors predicts cancer metabolism and patient prognosis.
Neoplasms
Comparative effects of single-mode vs. duration-matched concurrent exercise training on body composition, low-grade inflammation, and glucose regulation in sedentary, overweight, middle-aged men.
Neoplasms
Complete amino acid sequence of the type II isozyme of rat hexokinase, deduced from the cloned cDNA: comparison with a hexokinase from novikoff ascites tumor.
Neoplasms
Conserved features of cancer cells define their sensitivity to HAMLET-induced death; c-Myc and glycolysis.
Neoplasms
Correction: PIM2-mediated phosphorylation of hexokinase 2 is critical for tumor growth and paclitaxel resistance in breast cancer.
Neoplasms
Correlation between biological marker expression and F-fluorodeoxyglucose uptake in cervical cancer measured by positron emission tomography.
Neoplasms
Correlation of metabolism/hypoxia markers and fluorodeoxyglucose uptake in oral squamous cell carcinomas.
Neoplasms
D-amino acid oxidase gene therapy sensitizes glioma cells to the antiglycolytic effect of 3-bromopyruvate.
Neoplasms
D-Amino acid oxidase-induced oxidative stress, 3-bromopyruvate and citrate inhibit angiogenesis, exhibiting potent anticancer effects.
Neoplasms
Degradation of HK2 by chaperone-mediated autophagy promotes metabolic catastrophe and cell death.
Neoplasms
Deregulation of energetic metabolism in the clear cell renal cell carcinoma: A multiple pathway analysis based on microarray profiling.
Neoplasms
Deregulation of Hexokinase II Is Associated with Glycolysis, Autophagy, and the Epithelial-Mesenchymal Transition in Tongue Squamous Cell Carcinoma under Hypoxia.
Neoplasms
Determination and characterization of hexokinase in thyroid cancer and benign neoplasms.
Neoplasms
Determining and understanding the control of glycolysis in fast-growth tumor cells. Flux control by an over-expressed but strongly product-inhibited hexokinase.
Neoplasms
Development of artificial chimerical gene regulatory elements specific for cancer gene therapy.
Neoplasms
Diclofenac impairs the proliferation and glucose metabolism of triple-negative breast cancer cells by targeting the c-Myc pathway.
Neoplasms
Differences in expression and intracellular distribution of hexokinase isoenzymes in rat liver cells of different transformation stages.
Neoplasms
Different glucose uptake and glycolytic mechanisms between hepatocellular carcinoma and intrahepatic mass-forming cholangiocarcinoma with increased (18)F-FDG uptake.
Neoplasms
Differential association of STAT3 and HK-II expression in hepatitis B virus- and hepatitis C virus-related hepatocellular carcinoma.
Neoplasms
Differential Expression of Glycolysis-Related Proteins in Follicular Neoplasms versus Hürthle Cell Neoplasms: A Retrospective Analysis.
Neoplasms
Differential regulation of glucokinase activity in pancreatic islets and liver of the rat.
Neoplasms
Dioscin Inhibited Glycolysis and Induced Cell Apoptosis in Colorectal Cancer via Promoting c-myc Ubiquitination and Subsequent Hexokinase-2 Suppression.
Neoplasms
Direct inhibition of hexokinase activity by metformin at least partially impairs glucose metabolism and tumor growth in experimental breast cancer.
Neoplasms
Dual-time-point FDG-PET/CT Imaging of Temporal Bone Chondroblastoma: A Report of Two Cases.
Neoplasms
Early evaluation of the effects of chemotherapy with longitudinal FDG small-animal PET in human testicular cancer xenografts: early flare response does not reflect refractory disease.
Neoplasms
Effect of HK2, PKM2 and LDHA on Cetuximab efficacy in metastatic colorectal cancer.
Neoplasms
Effect of N6-(delta2-isopentenyl)adenosine treatment in vivo on hexokinase activity of mouse L 1210 cells.
Neoplasms
Effect of nutrient intake on intramuscular glucose metabolism during the early growth stage in cross-bred steers (Japanese Black male?×?Holstein female).
Neoplasms
Effects of various dietary fatty acids on enzyme activities of carbohydrate and glutamine metabolism and the metabolic response of lymphocytes and macrophages during Walker-256 ascites cell tumour growth in rats.
Neoplasms
Efficacy of 2-halogen substituted D-glucose analogs in blocking glycolysis and killing "hypoxic tumor cells".
Neoplasms
Efficacy of Terminalia arjuna (Roxb.) on N-nitrosodiethylamine induced hepatocellular carcinoma in rats.
Neoplasms
Efflux of adenine nucleotides in mitochondria from rat tumor cells of varying growth rates.
Neoplasms
Energy metabolism of tumor cells. Requirement for a form of hexokinase with a propensity for mitochondrial binding.
Neoplasms
Enhanced antitumor effects of follicle-stimulating hormone receptor-mediated hexokinase-2 depletion on ovarian cancer mediated by a shift in glucose metabolism.
Neoplasms
Enhancement of hexokinase II inhibitor-induced apoptosis in hepatocellular carcinoma cells via augmenting ER stress and anti-angiogenesis by protein disulfide isomerase inhibition.
Neoplasms
Enzyme pathology and the histologic categorization of human lung tumors: the continuum of quantitative biochemical indices of neoplasticity.
Neoplasms
Enzymes of glucose metabolism in carcinoma of the cervix and endometrium of the human uterus.
Neoplasms
Enzymes of glucose metabolism in cultured human gliomas: neoplasia is accompanied by altered hexokinase, phosphofructokinase, and glucose-6-phosphate dehydrogenase levels.
Neoplasms
Erratum to: Inhibition of glycolytic enzyme hexokinase II (HK2) suppresses lung tumor growth.
Neoplasms
Establishment of a [18F]-FDG-PET/MRI Imaging Protocol for Gastric Cancer PDX as a Preclinical Research Tool.
Neoplasms
Evaluation of efficacy of a new MEK inhibitor, RO4987655, in human tumor xenografts by [(18)F] FDG-PET imaging combined with proteomic approaches.
Neoplasms
Evaluation of experimental liver tumors using fluorine-18-2-fluoro-2-deoxy-D-glucose PET.
Neoplasms
Evaluation of Glucose Uptake in Normal and Cancer Cell Lines by Positron Emission Tomography.
Neoplasms
Evaluation of liver tumors using fluorine-18-fluorodeoxyglucose PET: characterization of tumor and assessment of effect of treatment.
Neoplasms
Evaluation of the antiproliferative activity of 106 marine microbial metabolites against human lung cancer cells and potential antiproliferative mechanism of purpuride G.
Neoplasms
Evaluation of the role of hexokinase type II in cellular proliferation and apoptosis using human hepatocellular carcinoma cell lines.
Neoplasms
Evidence that does not support PKM2-catalyzed reaction as a rate-limiting step in cancer cell glycolysis.
Neoplasms
Evidence that transcription of the hexokinase gene is increased in a rapidly growing rat hepatoma.
Neoplasms
Exosomal Circ-MEMO1 Promotes the Progression and Aerobic Glycolysis of Non-small Cell Lung Cancer Through Targeting MiR-101-3p/KRAS Axis.
Neoplasms
Expression of glucose transporter isoforms (GLUT1, GLUT2) and activities of hexokinase, pyruvate kinase, and malic enzyme in preneoplastic and neoplastic rat renal basophilic cell lesions.
Neoplasms
Expression of glucose transporter-1, hexokinase-II, proliferating cell nuclear antigen and survival of patients with pancreatic cancer.
Neoplasms
Expression of hexokinase 2 in epithelial ovarian tumors and its clinical significance in serous ovarian cancer.
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Expression of hexokinases and glucose transporters in treated and untreated oesophageal adenocarcinoma.
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Expression of two type II-like tumor hexokinase RNA transcripts in cancer cell lines.
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FDG PET imaging of Ela1-myc mice reveals major biological differences between pancreatic acinar and ductal tumours.
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FDG-PET for evaluating the antitumor effect of intraarterial 3-bromopyruvate administration in a rabbit VX2 liver tumor model.
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FDG-PET/CT imaging findings of hepatic tumors and tumor-like lesions based on molecular background.
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Fenbendazole acts as a moderate microtubule destabilizing agent and causes cancer cell death by modulating multiple cellular pathways.
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Fructose 1,6-Bisphosphatase 1 Expression Reduces 18F-FDG Uptake in Clear Cell Renal Cell Carcinoma.
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Fubp1 supports the lactate-Akt-mTOR axis through the upregulation of Hk1 and Hk2.
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Functional significance of mitochondrial bound hexokinase in tumor cell metabolism. Evidence for preferential phosphorylation of glucose by intramitochondrially generated ATP.
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Gamma-linolenic acid alters the composition of mitochondrial membrane subfractions, decreases outer mitochondrial membrane binding of hexokinase and alters carnitine palmitoyltransferase I properties in the Walker 256 rat tumour.
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Gene expression patterns and tumor uptake of 18F-FDG, 18F-FLT, and 18F-FEC in PET/MRI of an orthotopic mouse xenotransplantation model of pancreatic cancer.
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Glucose 6-phosphate-dependent binding of hexokinase to membranes of ascites tumor cells.
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Glucose and Lactate Transport in Pancreatic Cancer: Glycolytic Metabolism Revisited.
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Glucose catabolism in cancer cells. Isolation, sequence, and activity of the promoter for type II hexokinase.
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Glucose catabolism in cancer cells. The type II hexokinase promoter contains functionally active response elements for the tumor suppressor p53.
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Glucose catabolism in cancer cells: amplification of the gene encoding type II hexokinase.
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Glucose catabolism in cancer cells: identification and characterization of a marked activation response of the type II hexokinase gene to hypoxic conditions.
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Glucose catabolism in cancer cells: regulation of the Type II hexokinase promoter by glucose and cyclic AMP.
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Glucose catabolism in the rabbit VX2 tumor model for liver cancer: characterization and targeting hexokinase.
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Glucose metabolism in cancer. Evidence that demethylation events play a role in activating type II hexokinase gene expression.
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Glucose metabolism in cancer: importance of transcription factor-DNA interactions within a short segment of the proximal region og the type II hexokinase promoter.
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Glucose phosphorylation in tumor cells. Cloning, sequencing, and overexpression in active form of a full-length cDNA encoding a mitochondrial bindable form of hexokinase.
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Glucose transporter protein-independent tumor cell accumulation of fluorine-18-AFDG, a lipophilic fluorine-18-FDG analog.
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Glucose utilization by tumor cells: a post-translational modification of mitochondrial hexokinase may play a regulatory role.
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Glucose utilization by tumor cells: the enzyme hexokinase autophosphorylates both its N- and C-terminal halves.
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Glucose-6-phosphatase Expression-Mediated [18F]FDG Efflux in Murine Inflammation and Cancer Models.
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Growth condition-dependent synchronized changes in transcript levels of type II hexokinase and type 1 glucose transporter in tumor cells.
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Hepatic glucose-6-phosphatase-? deficiency leads to metabolic reprogramming in glycogen storage disease type Ia.
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Heterogeneity of glycolytic enzyme activity and isozyme composition of pyruvate kinase in breast cancer.
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Hexokinase 2 (HK2), the tumor promoter in glioma, is downregulated by miR-218/Bmi1 pathway.
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Hexokinase 2 dimerization and interaction with voltage-dependent anion channel promoted resistance to cell apoptosis induced by gemcitabine in pancreatic cancer.
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Hexokinase 2 discerns a novel circulating tumor cell population associated with poor prognosis in lung cancer patients.
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Hexokinase 2 displacement from mitochondria-associated membranes prompts Ca2+ -dependent death of cancer cells.
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Hexokinase 2 enhances the metastatic potential of tongue squamous cell carcinoma via the SOD2-H2O2 pathway.
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Hexokinase 2 is a key mediator of aerobic glycolysis and promotes tumor growth in human glioblastoma multiforme.
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Hexokinase 2 is required for tumor initiation and maintenance and its systemic deletion is therapeutic in mouse models of cancer.
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Hexokinase 2 is targetable for HK1 negative, HK2 positive tumors from a wide variety of tissues of origin.
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Hexokinase 2 Promotes Cell Growth and Tumor Formation Through the Raf/MEK/ERK Signaling Pathway in Cervical Cancer.
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Hexokinase 2 promotes tumor growth and metastasis by regulating lactate production in pancreatic cancer.
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Hexokinase 2 regulates G1/S checkpoint through CDK2 in cancer-associated fibroblasts.
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Hexokinase activity in tumorigenic and nontumorigenic cell cultures derived from mouse ascites tumor cells.
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Hexokinase and phosphofructokinase activity and intracellular distribution correlate with aggressiveness and invasiveness of human breast carcinoma.
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Hexokinase II and VEGF expression in liver tumors: correlation with hypoxia-inducible factor 1 alpha and its significance.
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Hexokinase II detachment from the mitochondria potentiates cisplatin induced cytotoxicity through a caspase-2 dependent mechanism.
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Hexokinase II inhibition by 3-bromopyruvate sensitizes myeloid leukemic cells K-562 to anti-leukemic drug, daunorubicin.
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Hexokinase II inhibitor, 3-BrPA induced autophagy by stimulating ROS formation in human breast cancer cells.
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Hexokinase II promotes the Warburg effect by phosphorylating alpha subunit of pyruvate dehydrogenase.
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Hexokinase II-Derived Cell-Penetrating Peptide Mediates Delivery of MicroRNA Mimic for Cancer-Selective Cytotoxicity.
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Hexokinase II-derived cell-penetrating peptide targets mitochondria and triggers apoptosis in cancer cells.
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Hexokinase II: cancer's double-edged sword acting as both facilitator and gatekeeper of malignancy when bound to mitochondria.
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Hexokinase inhibition after the addition of glucose to Ehrlich-Lettré ascites tumor cells under aerobiosis.
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Hexokinase inhibition using D-Mannoheptulose enhances oncolytic newcastle disease virus-mediated killing of breast cancer cells.
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Hexokinase isoenzymes from anaplastic and differentiated medullary thyroid carcinoma in the rat.
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Hexokinase isozymes in human neoplastic and fetal tissues: the existence of hexokinase II in malignant tumors and in placenta.
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Hexokinase receptor complex in hepatoma mitochondria: evidence from N,N'-dicyclohexylcarbodiimide-labeling studies for the involvement of the pore-forming protein VDAC.
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Hexokinase receptors: preferential enzyme binding in normal cells to nonmitochondrial sites and in transformed cells to mitochondrial sites.
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Hexokinase type II: a novel tumor-specific promoter for gene-targeted therapy differentially expressed and regulated in human cancer cells.
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Hexokinase-2 bound to mitochondria: cancer's stygian link to the "Warburg Effect" and a pivotal target for effective therapy.
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Hexokinase-I protection against apoptotic cell death is mediated via interaction with the voltage-dependent anion channel-1: mapping the site of binding.
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Hexokinase-mitochondrial interactions regulate glucose metabolism differentially in adult and neonatal cardiac myocytes.
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Hexokinase: the direct link between mitochondrial and glycolytic reactions in rapidly growing cancer cells.
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HIF-1alpha Modulates Energy Metabolism in Cancer Cells by Inducing Over-expression of Specific Glycolytic Isoforms.
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HIF-1alpha modulates energy metabolism in cancer cells by inducing over-expression of specific glycolytic isoforms.
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High expression of hexokinase domain containing 1 is associated with poor prognosis and aggressive phenotype in hepatocarcinoma.
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High Km glucose-phosphorylating (glucokinase) activities in a range of tumor cell lines and inhibition of rates of tumor growth by the specific enzyme inhibitor mannoheptulose.
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HKDC1 C-terminal based peptides inhibit extranodal natural killer/T-cell lymphoma by modulation of mitochondrial function and EBV suppression.
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HKDC1 promotes the tumorigenesis and glycolysis in lung adenocarcinoma via regulating AMPK/mTOR signaling pathway.
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HNF4A-AS1/hnRNPU/CTCF axis as a therapeutic target for aerobic glycolysis and neuroblastoma progression.
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Homeostatic derangement in the CBA rodent host during the growth of the CaNT tumor.
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HOTAIR/miR-125 axis-mediated Hexokinase 2 expression promotes chemoresistance in human glioblastoma.
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Human steroid sulfatase enhances aerobic glycolysis through induction of HIF1? and glycolytic enzymes.
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Identification of a Mitochondrial-Binding Site on the Amino-Terminal End of Hexokinase II.
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Identification of a mitochondrial-binding site on the N-terminal end of hexokinase II.
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Identification of plant-based hexokinase 2 inhibitors: combined molecular docking and dynamics simulation studies.
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Identification of regulatory properties of metabolic networks by graph theoretical modeling.
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Identity, release, and binding of mitochondrial-bound hexokinases in mammary glands and adenocarcinomas of lactating mice.
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Immune effects of glycolysis or oxidative phosphorylation metabolic pathway in protecting against bacterial infection.
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Immunochemical analysis of the membrane proteins of rat liver and Zajdela hepatoma mitochondria.
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Implication of KRT16, FAM129A and HKDC1 genes as ATF4 regulated components of the integrated stress response.
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Importance of determinations of serum hexokinase, aldolase, and lactate dehydrogenase activities, and of the lactate/pyruvate-quotient in the diagnosis of malignant tumors.
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In self-defence: hexokinase promotes voltage-dependent anion channel closure and prevents mitochondria-mediated apoptotic cell death.
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In silico construction of HK2-VDAC1 complex and investigating the HK2 binding-induced molecular gating mechanism of VDAC1.
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In vivo assessment of glucose metabolism in hepatocellular carcinoma with FDG-PET.
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Inferring therapeutic targets from heterogeneous data: HKDC1 is a novel potential therapeutic target for cancer.
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Influence of insulin on estrogen-induced responses in the r3230ac mammary carcinoma.
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Influence of resistance to 5-fluorouracil and tomudex on [18F]?FDG incorporation, glucose transport and hexokinase activity.
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Influence of thiopental on intracellular distribution of hexokinase activity in various tumor cells.
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Inhibition of Glycolysis and Glutaminolysis: An Emerging Drug Discovery Approach to Combat Cancer.
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Inhibition of Glycolysis in Prostate Cancer Chemoprevention by Phenethyl Isothiocyanate.
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Inhibition of glycolytic enzyme hexokinase II (HK2) suppresses lung tumor growth.
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Inhibition of hexokinase and protein kinase activities of tumor cells by a chloromethyl ketone derivative of lactic acid.
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Inhibition of hexokinase-2 with targeted liposomal 3-bromopyruvate in an ovarian tumor spheroid model of aerobic glycolysis.
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Inhibition of Non-flux-Controlling Enzymes Deters Cancer Glycolysis by Accumulation of Regulatory Metabolites of Controlling Steps.
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Inhibitory action of the antitumor agent lonidamine on mitochondrial respiration of Trypanosoma cruzi and T. brucei.
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Inihibition of Glycolysis by Using a Micro/Nano-Lipid Bromopyruvic Chitosan Carrier as a Promising Tool to Improve Treatment of Hepatocellular Carcinoma.
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INPP4B-mediated tumor resistance is associated with modulation of glucose metabolism via hexokinase 2 regulation in laryngeal cancer cells.
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Insulin and hypoxia-inducible factor-1 cooperate in pancreatic cancer cells to increase cell viability.
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Insulin, growth factors, and cancer cell energy metabolism: an hypothesis on oncogene action.
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Insulin-like growth factor I induces tumor hexokinase RNA expression in cancer cells.
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Interleukin-22 promotes aerobic glycolysis associated with tumor progression via targeting hexokinase-2 in human colon cancer cells.
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Intracellular localization and properties of particulate hexokinase in the Novikoff ascites tumor. Evidence for an outer mitochondrial membrane location.
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Intracellular pH governs the subcellular distribution of hexokinase in a glioma cell line.
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Ischemic preconditioning, insulin, and morphine all cause hexokinase redistribution.
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Isoenzyme pattern and subcellular localization of hexokinases in human breast cancer and nonpathological breast tissue.
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Isoenzymes of hexokinase, 6-phosphogluconate dehydrogenase, phosphoglucomutase and lactate dehydrogenase in uterine cancer.
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Jiedu Sangen decoction inhibits chemoresistance to 5-fluorouracil of colorectal cancer cells by suppressing glycolysis via PI3K/AKT/HIF-1? signaling pathway.
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Kaempferol inhibits cell proliferation and glycolysis in esophagus squamous cell carcinoma via targeting EGFR signaling pathway.
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Kinetic analysis of glucose metabolism by FDG-PET versus proliferation index of Ki-67 in meningiomas--comparison with gliomas.
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Kinetic and proteomic analyses of S-nitrosoglutathione-treated hexokinase A: consequences for cancer energy metabolism.
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Kinetic characterization of hexokinase isoenzymes from glioma cells: implications for FDG imaging of human brain tumors.
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L-type amino acid transporter 1 (LAT1) expression in malignant pleural mesothelioma.
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Latent Membrane Protein 1 Promotes Tumorigenesis Through Upregulation of PGC1? Signaling Pathway.
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Lectin PCL inhibits the Warburg effect of PC3 cells by combining with EGFR and inhibiting HK2.
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Licochalcone A suppresses hexokinase 2-mediated tumor glycolysis in gastric cancer via downregulation of the Akt signaling pathway.
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Linked Hexokinase and Glucose-6-Phosphatase Activities Reflect Grade of Ovarian Malignancy.
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Linker residues regulate the activity and stability of hexokinase 2, a promising anticancer target.
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Lithium detaches hexokinase from mitochondria and inhibits proliferation of B16 melanoma cells.
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LncRNA loc285194 inhibits tumor growth of laryngeal squamous cell carcinoma cells by downregulating hexokinase 2.
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Local toxicity of hepatic arterial infusion of hexokinase II inhibitor, 3-bromopyruvate: In vivo investigation in normal rabbit model.
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Long Non-Coding RNA C1QTNF1 Antisense RNA 1 Upregulates Hexokinase 2 by Sponging microRNA-484 to Promote the Malignancy of Colorectal Cancer.
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Long non-coding RNA HOTAIR promotes cancer cell energy metabolism in pancreatic adenocarcinoma by upregulating hexokinase-2.
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Long noncoding RNA MALAT1 mediates stem cell-like properties in human colorectal cancer cells by regulating miR-20b-5p/Oct4 axis.
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Long Term Prognostic Implications of Expression of Glucose Transporter-1 and Hexokinase II in Patients with Stage I Uterine Leiomyosarcoma.
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Low expression of hexokinase-2 is associated with false-negative FDG-positron emission tomography in multiple myeloma.
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Luteolin-7-O-?-d-Glucoside Inhibits Cellular Energy Production Interacting with HEK2 in Keratinocytes.
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Mechanism of action of lonidamine in the 9L brain tumor model involves inhibition of lactate efflux and intracellular acidification.
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Mechanisms related to [18F]fluorodeoxyglucose uptake of human colon cancers transplanted in nude mice.
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Metabolic characteristics distinguishing intrahepatic cholangiocarcinoma: a negative pilot study of (18)F-fluorocholine PET/CT clarified by transcriptomic analysis.
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Metabolic control analysis indicates a change of strategy in the treatment of cancer.
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Metabolic Imaging Detects Low Levels of Glycolytic Activity That Vary with Levels of c-Myc Expression in Patient-Derived Xenograft Models of Glioblastoma.
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Metabolic orchestration between cancer cells and tumor microenvironment as a co-evolutionary source of chemoresistance in ovarian cancer: a therapeutic implication.
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Metabolic reprogramming in colon cancer reversed by DHTS through regulating PTEN/AKT/HIF1? mediated signal pathway.
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METABOLISM OF ASCITES TUMOR CELLS. II. INHIBITION OF RESPIRATION BY GLYCOLYZABLE AND NONGLYCOLYZABLE SUGARS PHOSPHORYLATED BY HEXOKINASE.
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Methyl Jasmonate: Putative Mechanisms of Action on Cancer Cells Cycle, Metabolism, and Apoptosis.
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MicroRNA-143 (miR-143) regulates cancer glycolysis via targeting hexokinase 2 gene.
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MicroRNA-143 acts as a tumor suppressor by targeting hexokinase 2 in human prostate cancer.
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Mild Alkalization Acutely Triggers the Warburg Effect by Enhancing Hexokinase Activity via Voltage-Dependent Anion Channel Binding.
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MiR-125b-5p suppressed the glycolysis of laryngeal squamous cell carcinoma by down-regulating hexokinase-2.
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miR-139-5p inhibits aerobic glycolysis, cell proliferation, migration, and invasion in hepatocellular carcinoma via a reciprocal regulatory interaction with ETS1.
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MiR-199a-5p is negatively associated with malignancies and regulates glycolysis and lactate production by targeting hexokinase 2 in liver cancer.
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MiR-216a-5p/Hexokinase 2 axis regulates uveal melanoma growth through modulation of Warburg effect.
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Mitochondria, hexokinase and pyruvate kinase isozymes in the aerobic glycolysis of tumor cells.
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Mitochondria-acting hexokinase II peptides carried by short-length carbon nanotubes with increased cellular uptake, endosomal evasion, and enhanced bioactivity against cancer cells.
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Mitochondrial bound type II hexokinase: a key player in the growth and survival of many cancers and an ideal prospect for therapeutic intervention.
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Mitochondrial hexokinase of rat hepatoma cells in culture: solubilization and kinetic properties.
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Mitochondrial membrane-bound hexokinase of ascites tumor cells. Functional implications of lysine residues studied by modification with imidoesters.
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Mitochondrial VDAC1: Function in Cell Life and Death and a Target for Cancer Therapy.
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Mitochondrial voltage-dependent anion channels (VDACs) as novel pharmacological targets for anti-cancer agents.
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Molecular characteristics in papillary thyroid cancers (PTCs) with no 131I uptake.
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Molecular model of hexokinase binding to the outer mitochondrial membrane porin (VDAC1): Implication for the design of new cancer therapies.
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Monitoring Response to Radiotherapy in Human Squamous Cell Cancer Bearing Nude Mice: Comparison of 2'-deoxy-2'-[(18)F]fluoro-D: -glucose (FDG) and 3'-[ (18)F]fluoro-3'-deoxythymidine (FLT).
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Natural product triptolide induces GSDME-mediated pyroptosis in head and neck cancer through suppressing mitochondrial hexokinase-??.
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Neuroendocrine differentiation of LNCaP cells suggests: VDAC in the cell membrane is involved in the extrinsic apoptotic pathway.
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New Amino Acid Schiff Bases as Anticancer Agents via Potential Mitochondrial Complex I-Associated Hexokinase Inhibition and Targeting AMP-Protein Kinases/mTOR Signaling Pathway.
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New challenges in integrated diagnosis by imaging and osteo-immunology in bone lesions.
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Non-proteolytic ubiquitination of Hexokinase 2 by HectH9 controls tumor metabolism and cancer stem cell expansion.
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Novel selective hexokinase 2 inhibitor Benitrobenrazide blocks cancer cells growth by targeting glycolysis.
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Overexpression of hexokinase-2 in giant cell tumor of bone is associated with false positive in bone tumor on FDG-PET/CT.
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Overexpression of metabolic markers HK1 and PKM2 contributes to lymphatic metastasis and adverse prognosis in Chinese gastric cancer.
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Overexpression of METTL3 associated with the metabolic status on 18F-FDG PET/CT in patients with Esophageal Carcinoma.
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p53 Promotes chemoresponsiveness by regulating hexokinase II gene transcription and metabolic reprogramming in epithelial ovarian cancer.
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PET imaging of tumor glycolysis downstream of hexokinase through noninvasive measurement of pyruvate kinase M2.
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PGC1? Promotes Cisplatin Resistance in Ovarian Cancer by Regulating the HSP70/HK2/VDAC1 Signaling Pathway.
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PGC1? Regulates Breast Tumor Growth and Metastasis by SREBP1-Mediated HKDC1 Expression.
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pH in human tumor xenografts and transplanted rat tumors: effect of insulin, inorganic phosphate, and m-iodobenzylguanidine.
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Physicochemical properties and isoenzyme composition of hexokinase from normal and malignant human tissues.
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PI3K/Akt signaling mediated Hexokinase-2 expression inhibits cell apoptosis and promotes tumor growth in pediatric osteosarcoma.
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PIM2-mediated phosphorylation of hexokinase 2 is critical for tumor growth and paclitaxel resistance in breast cancer.
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PKM2 regulates neural invasion of and predicts poor prognosis for human hilar cholangiocarcinoma.
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Poor prognosis of hexokinase 2 overexpression in solid tumors of digestive system: a meta-analysis.
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Porin interaction with hexokinase and glycerol kinase: metabolic microcompartmentation at the outer mitochondrial membrane.
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Profiles of carbohydrate-metabolizing enzymes in human hepatocellular carcinomas and preneoplastic livers.
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Prognostic predictive value of 18F-fluorodeoxyglucose positron emission tomography for patients with pancreatic cancer.
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Prognostic Significance and Related Mechanisms of Hexokinase 1 in Ovarian Cancer.
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Prognostic Significance of 18F-FDG PET/CT Metabolic Parameters and Tumor Galectin-1 Expression in Patients With Surgically Resected Lung Adenocarcinoma.
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Prognostic Significance of the Metabolic Marker Hexokinase-2 in Various Solid Tumors: A Meta-Analysis.
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Purification and characterization of a bindable form of mitochondrial bound hexokinase from the highly glycolytic AS-30D rat hepatoma cell line.
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Quantitative determinations of the steady state transcript levels of hexokinase isozymes and glucose transporter isoforms in normal rat tissues and the malignant tumor cell line AH130.
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Quantitative Proteomics Analysis Revealed the Potential Role of lncRNA Ftx in Promoting Gastric Cancer Progression.
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Re-programming tumour cell metabolism to treat cancer: no lone target for lonidamine.
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Recent chemotherapy reduces the sensitivity of [18F]fluorodeoxyglucose positron emission tomography in the detection of colorectal metastases.
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Recent studies on lonidamine, the lead compound of the antispermatogenic indazol-carboxylic acids.
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Recently elucidated energy catabolism pathways provide opportunities for novel treatments in hepatocellular carcinoma.
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Reciprocal immunohistochemical expression of sodium/iodide symporter and hexokinase I in primary thyroid tumors with synchronous cervical metastasis.
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Reduced survival of patients with hepatocellular carcinoma expressing hexokinase II.
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Regulation of HK2 expression through alterations in CpG methylation of the HK2 promoter during progression of hepatocellular carcinoma.
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Regulation of mitochondrial hexokinase in cultured HT 29 human cancer cells. An ultrastructural and biochemical study.
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Regulation of respiration in muscle cells in vivo by VDAC through interaction with the cytoskeleton and MtCK within Mitochondrial Interactosome.
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Relationship between (18)F-FDG uptake on PET and various biologic molecular markers in benign pulmonary lesion: comparison with primary lung cancer.
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Relationship between (18)F-FDG uptake on positron emission tomography and molecular biology in malignant pleural mesothelioma.
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Relationship between retention index in dual-phase (18)F-FDG PET, and hexokinase-II and glucose transporter-1 expression in pancreatic cancer.
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Relative value of oestrogen receptor assay, lactoferrin content, and glucose-6-phosphate dehydrogenase activity as prognostic indicators in primary breast cancer.
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Remarkably enhanced expression of the type II hexokinase in rat hepatoma cell line AH130.
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Role of mitochondria-associated hexokinase II in cancer cell death induced by 3-bromopyruvate.
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Role of reactive oxygen species-mediated mitochondrial dysregulation in 3-bromopyruvate induced cell death in hepatoma cells : ROS-mediated cell death by 3-BrPA.
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S100A4 alters metabolism and promotes invasion of lung cancer cells by up-regulating mitochondrial complex I protein NDUFS2.
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Safety and outcome of treatment of metastatic melanoma using 3-bromopyruvate: a concise literature review and case study.
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Selective induction of cancer cell death by VDAC1-based peptides and their potential use in cancer therapy.
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Significance of serum phosphohexose isomerase, hexokinase and aldolase in carcinoma ovary.
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Single Nucleotide Polymorphisms in MIR143 Contribute to Protection Against Non-Hodgkin Lymphoma (NHL) in Caucasian Populations.
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Stable RNA interference of hexokinase II gene inhibits human colon cancer LoVo cell growth in vitro and in vivo.
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Steady state transcript levels of the type II hexokinase and type 1 glucose transporter in human tumor cell lines.
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Structure/function relationships in hexokinase. Site-directed mutational analyses and characterization of overexpressed fragments implicate different functions for the N- and C-terminal halves of the enzyme.
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Studies on the mode of action of RC4, a new anti-cancer agent containing ethyleneimino ring. I. Effects of RC4 and allied agents on glycolysis, respiration, hexokinase and phosphatase of Ehrlich ascites tumor cells and on choline-esterase of human blood.
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Study on ATP-generating system and related hexokinase activity in mitochondria isolated from undifferentiated or differentiated HT29 adenocarcinoma cells.
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Succinate aggravates NAFLD progression to liver cancer on the onset of obesity: An in silico model.
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SUMOylation controls the binding of hexokinase 2 to mitochondria and protects against prostate cancer tumorigenesis.
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Suppression of apoptosis by cyclophilin D via stabilization of hexokinase II mitochondrial binding in cancer cells.
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Synergism of ursolic acid derivative US597 with 2-deoxy-D-glucose to preferentially induce tumor cell death by dual-targeting of apoptosis and glycolysis.
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Synergistic Effect of 3-Bromopyruvate in Combination with Rapamycin Impacted Neuroblastoma Metabolism by Inhibiting Autophagy.
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Synthesis of novel methyl jasmonate derivatives and evaluation of their biological activity in various cancer cell lines.
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Synthesis of radioiodinated 1-deoxy-nojirimycin derivatives: novel glucose analogs.
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Systematic identification of arsenic-binding proteins reveals that hexokinase-2 is inhibited by arsenic.
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Tanshinone IIA inhibits oral squamous cell carcinoma via reducing Akt-c-Myc signaling-mediated aerobic glycolysis.
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Targeting glucose and glutamine metabolism combined with radiation therapy in non-small cell lung cancer.
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Targeting hexokinase 2 inhibition promotes radiosensitization in HPV16 E7-induced cervical cancer and suppresses tumor growth.
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Targeting Hexokinase II to mitochondria to modulate energy metabolism and reduce ischemia-reperfusion injury in heart.
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Targeting metabolic plasticity in glioma stem cells in vitro and in vivo through specific inhibition of c-Src by TAT-Cx43266-283.
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The catalytic inactivation of the N-half of human hexokinase 2 and structural and biochemical characterization of its mitochondrial conformation.
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The Circadian Clock Regulates Metabolic Phenotype Rewiring Via HKDC1 and Modulates Tumor Progression and Drug Response in Colorectal Cancer.
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The combination of the expression of hexokinase 2 and pyruvate kinase M2 is a prognostic marker in patients with pancreatic cancer.
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The complexity of mitochondrial outer membrane permeability and VDAC regulation by associated proteins.
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The decrease of glycolytic enzyme hexokinase 1 accelerates tumor malignancy via deregulating energy metabolism but sensitizes cancer cells to 2-deoxyglucose inhibition.
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The effect of 3-bromopyruvate on human colorectal cancer cells is dependent on glucose concentration but not hexokinase II expression.
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The effect of glucosone on the proliferation and energy metabolism of in vitro grown Ehrlich ascites tumor cells.
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The effect of lymphoma and other neoplasms on hepatic and plasma enzymes of the host rat.
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The energy blocker inside the power house: Mitochondria targeted delivery of 3-bromopyruvate.
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The HGF-MET axis coordinates liver cancer metabolism and autophagy for chemotherapeutic resistance.
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The HK2 Dependent "Warburg Effect" and Mitochondrial Oxidative Phosphorylation in Cancer: Targets for Effective Therapy with 3-Bromopyruvate.
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The importance of glucose transport activity as the rate-limiting step of 2-deoxyglucose uptake in tumor cells in vitro.
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The insulin-like growth factor-system in a patient with diffuse large B-cell non-Hodgkin's lymphoma and lactic acidosis.
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The interaction among glucose transport, hexokinase, and glucose-6-phosphatase with respect to 3H-2-deoxyglucose retention in murine tumor models.
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The membrane-bound hexokinase as a potential marker for malignancy in human gliomas.
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The miR-125a/HK2 axis regulates cancer cell energy metabolism reprogramming in hepatocellular carcinoma.
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The Natural Product ?-Escin Targets Cancer and Stromal Cells of the Tumor Microenvironment to Inhibit Ovarian Cancer Metastasis.
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The progress and development of GLUT1 inhibitors targeting cancer energy metabolism.
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The role of hexokinase in cardioprotection - mechanism and potential for translation.
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The role of mitochondrial hexokinase binding in the abnormal energy metabolism of tumor cell lines.
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The role of phosphometabolites in cell proliferation, energy metabolism, and tumor therapy.
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The tumor-suppressive microRNA-143/145 cluster targets hexokinase-2 in renal cell carcinoma.
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The voltage dependent anion channel affects mitochondrial cholesterol distribution and function.
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Therapeutic effect of tamoxifen and energy-modulating vitamins on carbohydrate-metabolizing enzymes in breast cancer.
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Therapeutic efficacy and safety of paclitaxel/lonidamine loaded EGFR-targeted nanoparticles for the treatment of multi-drug resistant cancer.
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Transcriptional targeting of virus-mediated gene transfer by the human hexokinase II promoter.
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Transient isolation of the hexokinase reaction from the glycolytic sequence on initiation of glycolysis in ascites tumor cells.
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Tristetraprolin-mediated hexokinase 2 expression regulation contributes glycolysis in cancer cells.
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Tumor cells switch to mitochondrial oxidative phosphorylation under radiation via mTOR-mediated hexokinase II inhibition--a Warburg-reversing effect.
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Tumor dynamics in response to antiangiogenic therapy with oral metronomic topotecan and pazopanib in neuroblastoma xenografts.
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Tumor grade, microvessel density, and activities of malate dehydrogenase, lactate dehydrogenase, and hexokinase in squamous cell carcinoma.
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Up-regulation of hexokinase II contributes to rituximab-chemotherapy resistance and is a clinically relevant target for therapeutic development.
Neoplasms
Up-regulation of hexokinaseII in myeloma cells: targeting myeloma cells with 3-bromopyruvate.
Neoplasms
Upregulation of hypoxia-inducible factor-1alpha mRNA and its clinical significance in non-small cell lung cancer.
Neoplasms
Using positron emission tomography with [(18)F]FDG to predict tumor behavior in experimental colorectal cancer.
Neoplasms
Variability in glucose transporter-1 levels and hexokinase activity in human melanoma.
Neoplasms
VDAC1-based peptides: novel pro-apoptotic agents and potential therapeutics for B-cell chronic lymphocytic leukemia.
Neoplasms
Voltage dependent anion channels (VDACs): a brief introduction with a focus on the outer mitochondrial compartment's roles together with hexokinase-2 in the "Warburg effect" in cancer.
Neoplasms
Voltage-dependent anion channel (VDAC) as mitochondrial governator--thinking outside the box.
Neoplasms
Voltage-Dependent Anion Channel 1 As an Emerging Drug Target for Novel Anti-Cancer Therapeutics.
Neoplasms
Voltage-dependent anion channel 1-based peptides interact with hexokinase to prevent its anti-apoptotic activity.
Neoplasms
Walker 256 tumour growth causes marked changes of glutamine metabolism in rat small intestine.
Neoplasms
Warburg effect increases steady-state ROS condition in cancer cells through decreasing their antioxidant capacities (Anticancer effects of 3-bromopyruvate through antagonizing Warburg effect).
Neoplasms
Warburg, me and Hexokinase 2: Multiple discoveries of key molecular events underlying one of cancers' most common phenotypes, the "Warburg Effect", i.e., elevated glycolysis in the presence of oxygen.
Neoplasms
Who controls the ATP supply in cancer cells? Biochemistry lessons to understand cancer energy metabolism.
Neoplasms
Xanthohumol inhibits colorectal cancer cells via downregulation of Hexokinases II-mediated glycolysis.
Neoplasms
[18F]FDG uptake and PCNA, Glut-1, and Hexokinase-II expressions in cancers and inflammatory lesions of the lung.
Neoplasms
[18F]fluorodeoxyglucose uptake in recurrent thyroid cancer is related to hexokinase i expression in the primary tumor.
Neoplasms
[Activity of soluble and bound hexokinase in transplantable hepatomas of different degrees of malignancy, and in normal and regenerating mouse livers]
Neoplasms
[Activity of the key glycolysis and respiration enzymes in the rat liver in chemical carcinogenesis]
Neoplasms
[Analysis of glucose metabolism in patients with esophageal cancer by PET: estimation of hexokinase activity in the tumor and usefulness for clinical assessment using 18F-fluorodeoxyglucose]
Neoplasms
[Analysis of hexokinase isoenzymes in the differential diagnosis of malignant and benign tumors]
Neoplasms
[Biochemical features of the liver of high and low cancer mouse strains and primary spontaneous hepatomas]
Neoplasms
[Brain metabolism of sarcoma 45-bearing rats undergoing radiation and the effect of hyperthermia on the tumor]
Neoplasms
[Can fluorodeoxyglucose-positron emission tomography evaluate the functional differentiation of hepatocellular carcinoma]
Neoplasms
[Carbohydrate metabolism enzymatic activity and its alteration under the influence of thyroid hormone during tumor growth]
Neoplasms
[Carbohydrate metabolism in the kidneys of rats with dimethylnitrosamine-induced tumors]
Neoplasms
[Catalytic properties and isoenzyme composition of hexokinase in thyroid gland normal and neoplastic tissue]
Neoplasms
[Cooperation of membrane proteins and cytosolic proteins in metabolic regulation--involvement of binding of hexokinase to mitochondria in regulation of glucose metabolism and association and complex formation between membrane proteins and cytosolic proteins in regulation of active oxygen production]
Neoplasms
[CORRELATIONS BETWEEN THE BLOOD SERUM HEXOKINASE ACTIVITY AND MALIGNANT TUMORS IN MAN.]
Neoplasms
[Diagnostic and prognostic significance of biochemical indicators in colorectal neoplasms]
Neoplasms
[Effects of stromal cells derived from the normal prostate on the glycolysis of prostate cancer cells].
Neoplasms
[Effects of Tramadol on Insulin Resistance during Cesarean Section Complicated with Gestational Diabetes Mellitus].
Neoplasms
[Estrogen dependence of mammary gland tumors: the mechanisms of the disorder and the evaluation criteria]
Neoplasms
[Hemocirculation and metabolism in intraventricular tumors: kinetic analysis of glucose metabolism]
Neoplasms
[Hexokinase activity in erythrocytes, liver and brain of normal rats, roentgen irradiated rats and rats with Guerin tumor and chronic hypoxia induced with potassium cyanide (KCN)]
Neoplasms
[Hexokinase test for determining precancerous diseases and cancer of the rectum and large intestine]
Neoplasms
[Histochemical demonstration of glial enzyme activity. II. Reagent and neoplastic glia]
Neoplasms
[Identification and characterization of hexokinase isozyme predominantly expressed in malignant tumor cells]
Neoplasms
[Identification of hexokinase synthesizing polyribosomes in human normal and tumor tissues]
Neoplasms
[Inhibition of Sirolimus on the growth of pancreatic carcinoma and its effect on the expression of glucose transporter and hexokinase ?].
Neoplasms
[On the use and clinical importance of the hexokinase test in diagnosis of cancer of the cervix uteri]
Neoplasms
[Physico-chemical and kinetic properties of hexokinase isoenzymes from human normal and tumor tissues]
Neoplasms
[Sensitivity of hexokinase and glucokinase to hormonal action during hepatocarcinogenesis]
Neoplasms
[STUDIES ON THE PHYSIOLOGICAL FUNCTIONS OF THE MITOCHONDRIAL BOUND HEXOKINASE OF ASCITES TUMOR CELLS.]
Neoplasms
[Subcellular distribution of hexokinase in hepatoma and its electrophoretic properties]
Neoplasms
[Subcellular localization, isoenzyme spectrum and properties of hexokinase from sarcoma M-1]
Neoplasms
[The precipitin test for cancer, serum hexokinase and polarography for recognition of malignant tumors]
Neoplasms
[Theoretical premises and methodology for studying hexokinase for the purpose of diagnosing malignant neoplasms]
Neoplastic Cells, Circulating
Hexokinase 2 discerns a novel circulating tumor cell population associated with poor prognosis in lung cancer patients.
Neuritis
[Activity and isoenzymatic makeup of the hexokinase of rapid and slow muscles in the rabbit normally and the experimental allergic polyneuritis]
Neuritis
[Hexokinase and dehydrogenases of the pentose pathway in the skeletal muscles of rabbits with experimental allergic polyneuritis]
Neuritis
[Neural regulation of the activity of energy metabolism enzymes in differently functioning rabbit skeletal muscles]
Neuritis, Autoimmune, Experimental
[Neural regulation of the activity of energy metabolism enzymes in differently functioning rabbit skeletal muscles]
Neuroblastoma
Barbiturates suppress glucose utilization by inhibition of hexokinase in neuroblastoma cells.
Neuroblastoma
Combinatorial regulation of neuroblastoma tumor progression by N-Myc and hypoxia inducible factor (HIF)-1{alpha}.
Neuroblastoma
Effect of methohexital on the relationship between hexokinase distribution and energy metabolism in neuroblastoma cells.
Neuroblastoma
Effect of oxygen and glucose availability on the glycolytic rate in neuroblastoma cells under different conditions of culture.
Neuroblastoma
Solubilization of hexokinase activity by an effect of thiopental on the mitochondrial membrane.
Neuroblastoma
The regulation of apoptosis by the downstream regulatory element antagonistic modulator/potassium channel interacting Protein 3 (DREAM/KChIP3) through interactions with hexokinase I.
Neuroendocrine Tumors
FDG-PET/CT imaging findings of hepatic tumors and tumor-like lesions based on molecular background.
Neuroendocrine Tumors
Gene Expression of Glucose Transporter 1 (GLUT1), Hexokinase 1 and Hexokinase 2 in Gastroenteropancreatic Neuroendocrine Tumors: Correlation with F-18-fluorodeoxyglucose Positron Emission Tomography and Cellular Proliferation.
Neuroinflammatory Diseases
Hexokinase 2-dependent hyperglycolysis driving microglial activation contributes to ischemic brain injury.
Newcastle Disease
Hexokinase inhibition using D-Mannoheptulose enhances oncolytic newcastle disease virus-mediated killing of breast cancer cells.
Non-alcoholic Fatty Liver Disease
Hepatic HKDC1 Expression Contributes to Liver Metabolism.
Obesity
Cardiac Transcriptome Analysis Reveals Nr4a1 Mediated Glucose Metabolism Dysregulation in Response to High-Fat Diet.
Obesity
Changes in pancreatic islet glucokinase and hexokinase activities with increasing age, obesity, and the onset of diabetes.
Obesity
Exercise increases hexokinase II mRNA, but not activity in obesity and type 2 diabetes.
Obesity
Green tea polyphenol extract in vivo attenuates inflammatory features of neutrophils from obese rats.
Obesity, Abdominal
Insulin sensitivity in growth hormone (GH)-deficient adults and effect of GH replacement therapy.
Optic Atrophy
Impact of Hypoxic Exercise Recovery on Skeletal Muscle Glycogen and Gene Expression.
Osteoarthritis
Increased hexokinase-2 as a novel biomarker for the diagnosis and correlating with disease severity in rheumatoid arthritis.
Osteosarcoma
LncRNA-SARCC sensitizes osteosarcoma to cisplatin through the miR-143-mediated glycolysis inhibition by targeting Hexokinase 2.
Osteosarcoma
miR?185 regulates the growth of osteosarcoma cells via targeting Hexokinase 2.
Osteosarcoma
PI3K/Akt signaling mediated Hexokinase-2 expression inhibits cell apoptosis and promotes tumor growth in pediatric osteosarcoma.
Ovarian Neoplasms
Ciglitazone enhances ovarian cancer cell death via inhibition of glucose transporter-1.
Ovarian Neoplasms
Enhanced antitumor effects of follicle-stimulating hormone receptor-mediated hexokinase-2 depletion on ovarian cancer mediated by a shift in glucose metabolism.
Ovarian Neoplasms
Expression of hexokinase 2 in epithelial ovarian tumors and its clinical significance in serous ovarian cancer.
Ovarian Neoplasms
Ginsenoside 20(S)?Rg3 inhibits the Warburg effect through STAT3 pathways in ovarian cancer cells.
Ovarian Neoplasms
Hexokinase 2 confers resistance to cisplatin in ovarian cancer cells by enhancing cisplatin-induced autophagy.
Ovarian Neoplasms
Hexokinase 2 Regulates Ovarian Cancer Cell Migration, Invasion and Stemness via FAK/ERK1/2/MMP9/NANOG/SOX9 Signaling Cascades.
Ovarian Neoplasms
Inhibition of Lung Carcinoma A549 Cell Growth by Knockdown of Hexokinase 2 In Situ and In Vivo.
Ovarian Neoplasms
Linked Hexokinase and Glucose-6-Phosphatase Activities Reflect Grade of Ovarian Malignancy.
Ovarian Neoplasms
Lysophosphatidic Acid Up-Regulates Hexokinase II and Glycolysis to Promote Proliferation of Ovarian Cancer Cells.
Ovarian Neoplasms
Metabolic orchestration between cancer cells and tumor microenvironment as a co-evolutionary source of chemoresistance in ovarian cancer: a therapeutic implication.
Ovarian Neoplasms
miR-603 targeted hexokinase-2 to inhibit the malignancy of ovarian cancer cells.
Ovarian Neoplasms
Prognostic Significance and Related Mechanisms of Hexokinase 1 in Ovarian Cancer.
Pancreatic Neoplasms
Activated Pancreatic Stellate Cells Enhance the Warburg Effect to Cause the Malignant Development in Chronic Pancreatitis.
Pancreatic Neoplasms
BAG3 directly stabilizes Hexokinase 2 mRNA and promotes aerobic glycolysis in pancreatic cancer cells.
Pancreatic Neoplasms
Drp1 Promotes KRas-Driven Metabolic Changes to Drive Pancreatic Tumor Growth.
Pancreatic Neoplasms
Expression of glucose transporter-1, hexokinase-II, proliferating cell nuclear antigen and survival of patients with pancreatic cancer.
Pancreatic Neoplasms
Glycolytic enzyme inhibitors affect pancreatic cancer survival by modulating its signaling and energetics.
Pancreatic Neoplasms
Hexokinase 2 dimerization and interaction with voltage-dependent anion channel promoted resistance to cell apoptosis induced by gemcitabine in pancreatic cancer.
Pancreatic Neoplasms
Hexokinase 2 promotes tumor growth and metastasis by regulating lactate production in pancreatic cancer.
Pancreatic Neoplasms
Identification of genes differentially induced by hypoxia in pancreatic cancer cells.
Pancreatic Neoplasms
Ikarugamycin inhibits pancreatic cancer cell glycolysis by targeting hexokinase 2.
Pancreatic Neoplasms
MicroRNA-202 suppresses glycolysis of pancreatic cancer by targeting hexokinase 2.
Pancreatic Neoplasms
MIR210HG regulates glycolysis, cell proliferation, and metastasis of pancreatic cancer cells through miR-125b-5p/HK2/PKM2 axis.
Pancreatic Neoplasms
Non-invasive MRI tumor imaging and synergistic anticancer effect of HSP90 inhibitor and glycolysis inhibitor in RIP1-Tag2 transgenic pancreatic tumor model.
Pancreatic Neoplasms
Relationship between retention index in dual-phase (18)F-FDG PET, and hexokinase-II and glucose transporter-1 expression in pancreatic cancer.
Pancreatic Neoplasms
Synergistic Antipancreatic Tumor Effect by Simultaneously Targeting Hypoxic Cancer Cells With HSP90 Inhibitor and Glycolysis Inhibitor.
Pancreatic Neoplasms
Synergistic up-regulation of Hexokinase-2, glucose transporters and angiogenic factors in pancreatic cancer cells by glucose deprivation and hypoxia.
Papilloma
A Case of Intraductal Papilloma of the Breast With High 18F-FDG Uptake on PET/CT.
Paralysis
Effects of growth medium, electrical stimulation and paralysis on various enzyme activities in cultured rat muscle cells. Comparison with activities in rat muscles in vivo.
Parasitemia
Malarial parasite hexokinase and hexokinase-dependent glutathione reduction in the Plasmodium falciparum-infected human erythrocyte.
Parkinson Disease
?-Synuclein fibrillation products trigger the release of hexokinase I from mitochondria: Protection by curcumin, and possible role in pathogenesis of Parkinson's disease.
Parkinson Disease
Hexokinase II gene transfer protects against neurodegeneration in the rotenone and MPTP mouse models of Parkinson's disease.
Periapical Periodontitis
iTRAQ-based quantitative analysis of alveolar bone resorption in rats with experimental periodontitis.
Periodontal Diseases
Glycolytic overload-driven dysfunction of periodontal ligament fibroblasts in high glucose concentration, corrected by glyoxalase 1 inducer.
Plague
[Use of hexokinase and creatine kinase systems for measurement of oxidative phosphorylation in the plague microbe]
Pneumonia
[Hexokinase and phosphofructokinase activity in acute pneumonia in children in the 1st year of life]
Pre-Eclampsia
Alterations in antioxidant system, mitochondrial biogenesis and autophagy in preeclamptic myometrium.
Pre-Eclampsia
Preeclampsia inactivates glucose-6-phosphate dehydrogenase and impairs the redox status of erythrocytes and fetal endothelial cells.
Primary Myelofibrosis
Blood leucocyte enzymes. II. Activities at 8-9 a.m. in cells of normal subjects, chronic lymphatic leukaemia and chronic myeloid leukaemia patients.
Prostatic Hyperplasia
Lonidamine: basic science and rationale for treatment of prostatic proliferative disorders.
Prostatic Neoplasms
Androgen deprivation leads to increased carbohydrate metabolism and hexokinase 2-mediated survival in Pten/Tp53-deficient prostate cancer.
Prostatic Neoplasms
Androgen stimulates glycolysis for de novo lipid synthesis by increasing the activities of hexokinase 2 and 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 in prostate cancer cells.
Prostatic Neoplasms
Co-targeting hexokinase 2-mediated Warburg effect and ULK1-dependent autophagy suppresses tumor growth of PTEN- and TP53-deficiency-driven castration-resistant prostate cancer.
Prostatic Neoplasms
Hexokinase 2-mediated Warburg effect is required for PTEN- and p53-deficiency-driven prostate cancer growth.
Prostatic Neoplasms
Lectin PCL inhibits the Warburg effect of PC3 cells by combining with EGFR and inhibiting HK2.
Prostatic Neoplasms
MicroRNA-143 acts as a tumor suppressor by targeting hexokinase 2 in human prostate cancer.
Prostatic Neoplasms
New challenges in integrated diagnosis by imaging and osteo-immunology in bone lesions.
Prostatic Neoplasms
SUMOylation controls the binding of hexokinase 2 to mitochondria and protects against prostate cancer tumorigenesis.
Prostatic Neoplasms
Targeting prostate cancer cell metabolism: impact of hexokinase and CPT-1 enzymes.
Prostatic Neoplasms
Zinc and p53 disrupt mitochondrial binding of HK2 by phosphorylating VDAC1.
Psoriasis
[The skin activity of hexokinase, glucokinase and phosphofructokinase in psoriasis patients]
Pulmonary Arterial Hypertension
Increased in vivo mitochondrial oxygenation with right ventricular failure induced by pulmonary arterial hypertension: mitochondrial inhibition as driver of cardiac failure?
Pulmonary Arterial Hypertension
miR-125a-5p inhibits glycolysis by targeting hexokinase-II to improve pulmonary arterial hypertension.
Pulmonary Disease, Chronic Obstructive
Metabolic enzymatic activities in the diaphragm of normal men and patients with moderate chronic obstructive pulmonary disease.
Pulmonary Disease, Chronic Obstructive
Metabolic enzymatic activities in the intercostal and serratus muscles and in the latissimus dorsi of middle-aged normal men and patients with moderate obstructive pulmonary disease.
Pulmonary Disease, Chronic Obstructive
Organization of metabolic pathways in vastus lateralis of patients with chronic obstructive pulmonary disease.
Pulmonary Edema
Maternal nicotine exposure during pregnancy and lactation: I. Effect on glycolysis in the lungs of the offspring.
pyruvate kinase deficiency
Deficiencies of glycolytic enzymes as a possible cause of hemolytic anemia.
pyruvate kinase deficiency
Intracellular free magnesium and phosphorylated metabolites in hexokinase- and pyruvate kinase-deficient red cells measured using 31P-NMR spectroscopy.
Rectal Neoplasms
[Hexokinase test for determining precancerous diseases and cancer of the rectum and large intestine]
Renal Insufficiency, Chronic
Melatonin Protects Chronic Kidney Disease Mesenchymal Stem/Stromal Cells against Accumulation of Methylglyoxal via Modulation of Hexokinase-2 Expression.
Renal Insufficiency, Chronic
[Effect of hemodialysis on erythrocyte acetylcholinesterase and adenosine triphosphatase activity in chronic renal insufficiency]
Reperfusion Injury
Hexokinase II and reperfusion injury: TAT-HK2 peptide impairs vascular function in Langendorff-perfused rat hearts.
Reperfusion Injury
Hexokinase II dissociation alone cannot account for changes in heart mitochondrial function, morphology and sensitivity to permeability transition pore opening following ischemia.
Reperfusion Injury
Hexokinase-2 Glycolytic Overload in Diabetes and Ischemia-Reperfusion Injury.
Reperfusion Injury
Hydroxysafflor yellow A cardioprotection in ischemia-reperfusion (I/R) injury mainly via Akt/hexokinase II independent of ERK/GSK-3? pathway.
Reperfusion Injury
Targeting Hexokinase II to mitochondria to modulate energy metabolism and reduce ischemia-reperfusion injury in heart.
Reperfusion Injury
The role of hexokinase in cardioprotection - mechanism and potential for translation.
Retinal Degeneration
Neurochemical studies on the inherited retinal degeneration of the rat. 3. Hexokinase, phosphofructokinase and atpase in the developing retina.
Retinal Degeneration
Whole exome sequencing revealed HKDC1 as a candidate gene associated with autosomal-recessive retinitis pigmentosa.
Retinal Neovascularization
MicroRNA-384-3p inhibits retinal neovascularization through targeting hexokinase 2 in mice with diabetic retinopathy.
Retinitis Pigmentosa
A dominant mutation in hexokinase 1 (HK1) causes retinitis pigmentosa.
Retinitis Pigmentosa
Hexokinase 1 and retinitis pigmentosa: insights into the retina and the molecule.
Retinitis Pigmentosa
Light activation of the insulin receptor regulates mitochondrial hexokinase. A possible mechanism of retinal neuroprotection.
Retinitis Pigmentosa
Whole exome sequencing revealed HKDC1 as a candidate gene associated with autosomal-recessive retinitis pigmentosa.
Retinoblastoma
Characterization of some glycolytic enzymes from human retina and retinoblastoma.
Retinoblastoma
Structure, regulation, and biological functions of TIGAR and its role in diseases.
Rheumatic Fever
[Spectrum of hexokinase isoenzymes in the serum of patients with active rheumatic fever depending upon the clinical variant of disease]
Sarcoma
Classical NF-?B Metabolically Reprograms Sarcoma Cells Through Regulation of Hexokinase 2.
Sarcoma
Enzyme changes induced in normal and malignant tissues with chemical agents. IV. Effect of alpha-peltatin on glucose utilization by sarcoma 37 and on the adenosinetriphosphatase, hexokinase, aldolase, and pyridine nucleotide levels of sarcoma 37.
Sarcoma
FDG-PET/CT imaging findings of hepatic tumors and tumor-like lesions based on molecular background.
Sarcoma
[Brain metabolism of sarcoma 45-bearing rats undergoing radiation and the effect of hyperthermia on the tumor]
Sarcoma
[Hexokinase, aspartate and alanine aminotransferase activity in transplanted rat sarcomas]
Sarcoma
[Subcellular localization, isoenzyme spectrum and properties of hexokinase from sarcoma M-1]
Sarcoma 37
Enzyme changes induced in normal and malignant tissues with chemical agents. IV. Effect of alpha-peltatin on glucose utilization by sarcoma 37 and on the adenosinetriphosphatase, hexokinase, aldolase, and pyridine nucleotide levels of sarcoma 37.
Sarcoma, Avian
Inhibition of hexokinase and protein kinase activities of tumor cells by a chloromethyl ketone derivative of lactic acid.
Sarcoma, Avian
Metabolism of 2-[18F]fluoro-2-deoxyglucose in tumor-bearing rats: chromatographic and enzymatic studies.
Sarcoma, Avian
Transport and phosphorylation of hexoses in normal and Rous sarcoma virus-transformed chick embryo fibroblasts.
Scleroderma, Systemic
Identification of new autoantigens for primary biliary cirrhosis using human proteome microarrays.
Seizures
Neonatal seizures in monkeys and rabbits: brain glucose depletion in the face of normoglycemia, prevention by glucose loads.
Sepsis
Enhanced glycolytic metabolism contributes to cardiac dysfunction in polymicrobial sepsis.
Sepsis
MAPK interacting serine/threonine kinase 1 (MKNK1), one target gene of miR-223-3p, correlates with neutrophils in sepsis based on bioinformatic analysis.
Sleep Deprivation
Rapid eye movement sleep-deprivation-induced changes in glucose metabolic enzymes in rat brain.
Small Cell Lung Carcinoma
SILAC Quantitative Proteomics and Biochemical Analyses Reveal a Novel Molecular Mechanism by Which ADAM12S Promotes the Proliferation, Migration, and Invasion of Small Cell Lung Cancer Cells through Upregulating Hexokinase 1.
Squamous Cell Carcinoma of Head and Neck
Hexokinase 2 overexpression promotes the proliferation and survival of laryngeal squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
Hexokinase-II expression in untreated oral squamous cell carcinoma: comparison with FDG PET imaging.
Squamous Cell Carcinoma of Head and Neck
HPV-associated differential regulation of tumor metabolism in oropharyngeal head and neck cancer.
Squamous Cell Carcinoma of Head and Neck
LncRNA loc285194 inhibits tumor growth of laryngeal squamous cell carcinoma cells by downregulating hexokinase 2.
Squamous Cell Carcinoma of Head and Neck
MicroRNA-143 suppresses oral squamous cell carcinoma cell growth, invasion and glucose metabolism through targeting hexokinase 2.
Squamous Cell Carcinoma of Head and Neck
miR-125a suppresses viability and glycolysis and induces apoptosis by targeting Hexokinase 2 in laryngeal squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
MiR-125b-5p suppressed the glycolysis of laryngeal squamous cell carcinoma by down-regulating hexokinase-2.
Squamous Cell Carcinoma of Head and Neck
Prognostic value of glycolysis markers in head and neck squamous cell carcinoma: a meta-analysis.
Starvation
Age-dependent glycolysis and gluconeogenesis enzyme activities in starved-refed rats.
Starvation
Differential regulation of metabolic genes in skeletal muscle during starvation and refeeding in humans.
Starvation
Divergent targets of glycolysis and oxidative phosphorylation result in additive effects of metformin and starvation in colon and breast cancer.
Starvation
dMyc expression in the fat body affects DILP2 release and increases the expression of the fat desaturase Desat1 resulting in organismal growth.
Starvation
Effects of glucose refeeding and glibenclamide treatment on glucokinase and GLUT2 gene expression in pancreatic B-cells and liver from rats.
Starvation
Effects of phorbol, dexamethasone and starvation on 3-O-methyl-D-glucose transport by rat thymocytes. Modulation of transport by altered trans effects.
Starvation
Endoplasmic Reticulum Stress Sensor IRE1? Enhances IL-23 Expression by Human Dendritic Cells.
Starvation
Glucose dehydrogenase, glucose-6-phosphate dehydrogenase and hexokinase in liver of rainbow trout (Salmo gairdneri). Effects of starvation and temperature variations.
Starvation
In situ activities of hexokinase and fructokinase in relation to phosphorylation status of root meristem cells of Vicia faba during reactivation from sugar starvation
Starvation
In situ activities of hexokinase and fructokinase in relation to phosphorylation status of root meristem cells of Vicia faba during reactivation from sugar starvation.
Starvation
Insulin and glucagon family peptides in relation to activities of hepatic hexokinase and other enzymes in fed and starved Atlantic salmon (Salmo salar) and cod (Gadus morhua).
Starvation
Metabolism of glucose, glutamine, long-chain fatty acids and ketone bodies by lungs of the rat.
Starvation
Protein metabolism during nutrient deprivation and refeeding of neonatal heart cells.
Starvation
Sucrose transport is inhibited by okadaic acid during regeneration of sugar-starved Vicia faba root meristem cells.
Starvation
Testing biochemistry revisited: how in vivo metabolism can be understood from in vitro enzyme kinetics.
Starvation
[Activity of hexokinase and glucose-6-phosphate dehydrogenase in hemopoietic cells of the bone marrow in normal rabbits and after hydrocortisone administration during starvation and alloxan diabetes]
Starvation
[Activity, hexokinase isoenzyme spectrum and various factors of their regulation in liver and skeletal muscles of young piglets]
Stomach Neoplasms
3-Bromopyruvate and sodium citrate induce apoptosis in human gastric cancer cell line MGC-803 by inhibiting glycolysis and promoting mitochondria-regulated apoptosis pathway.
Stomach Neoplasms
Expression of pyruvate dehydrogenase kinase-1 in gastric cancer as a potential therapeutic target.
Stomach Neoplasms
Helicobacter pylori CagA Protein Attenuates 5-Fu Sensitivity of Gastric Cancer Cells Through Upregulating Cellular Glucose Metabolism.
Stomach Neoplasms
Licochalcone A suppresses hexokinase 2-mediated tumor glycolysis in gastric cancer via downregulation of the Akt signaling pathway.
Stomach Neoplasms
MicroRNA-181b inhibits glycolysis in gastric cancer cells via targeting hexokinase 2 gene.
Stomach Neoplasms
Physicochemical properties and isoenzyme composition of hexokinase from normal and malignant human tissues.
Stomach Neoplasms
Quantitative Proteomics Analysis Revealed the Potential Role of lncRNA Ftx in Promoting Gastric Cancer Progression.
Stomach Neoplasms
SALL4 promotes gastric cancer progression via hexokinase II mediated glycolysis.
Stomach Neoplasms
[Clinical significance of determining hexokinase, lactate dehydrogenase and its isoenzymes in stomach cancer]
Stomach Neoplasms
[Hexokinase and lactate dehydrogenase activity, lactic and pyruvic acid content of erythrocytes and acid-base equilibrium in stomach cancer patients after radical operations]
Stomach Ulcer
[Assessment of the findings of fibrogastroscopy with gastrobiopsy and determination of hexokinase activity in the serum and gastric juice of stomach ulcer patients]
Thalassemia
Glucose 6-phosphate dehydrogenase, hexokinase activities and ATP levels as a function of cell density in thalassemia and iron deficiency anemia.
Thrombosis
Human coronary thrombus formation is associated with degree of plaque disruption and expression of tissue factor and hexokinase II.
Thymoma
Expression of cardiac insulin signalling genes and proteins in rats fed a high-sucrose diet: effect of bilberry anthocyanin extract.
Thyroid Carcinoma, Anaplastic
Combined RNA interference of hexokinase II and (131)I-sodium iodide symporter gene therapy for anaplastic thyroid carcinoma.
Thyroid Carcinoma, Anaplastic
Glycolytic inhibition with 3-bromopyruvate suppresses tumor growth and improves survival in a murine model of anaplastic thyroid cancer.
Thyroid Carcinoma, Anaplastic
Hexokinase isoenzymes from anaplastic and differentiated medullary thyroid carcinoma in the rat.
Thyroid Diseases
[Diagnostic value of the determination of serum hexokinase activity in thyroid cancer and autoimmune thyroiditis]
Thyroid Neoplasms
Determination and characterization of hexokinase in thyroid cancer and benign neoplasms.
Thyroid Neoplasms
Hexokinase isoenzymes from anaplastic and differentiated medullary thyroid carcinoma in the rat.
Thyroid Neoplasms
Relationship between biological marker expression and fluorine-18 fluorodeoxyglucose uptake in incidentally detected thyroid cancer.
Thyroid Neoplasms
[18F]fluorodeoxyglucose uptake in recurrent thyroid cancer is related to hexokinase i expression in the primary tumor.
Thyroid Neoplasms
[Catalytic properties and isoenzyme composition of hexokinase in thyroid gland normal and neoplastic tissue]
Thyroid Neoplasms
[Diagnostic value of the determination of serum hexokinase activity in thyroid cancer and autoimmune thyroiditis]
Thyroid Nodule
Hexokinase III, cyclin A and galectin-3 are overexpressed in malignant follicular thyroid nodules.
Thyroiditis, Autoimmune
[Diagnostic value of the determination of serum hexokinase activity in thyroid cancer and autoimmune thyroiditis]
Triple Negative Breast Neoplasms
Direct inhibition of hexokinase activity by metformin at least partially impairs glucose metabolism and tumor growth in experimental breast cancer.
Trypanosomiasis, African
A target-based high throughput screen yields Trypanosoma brucei hexokinase small molecule inhibitors with antiparasitic activity.
Uremia
[The physiopathologic bases of the neurotoxicity of phosphorus chelating agents containing soluble aluminum salts in patients with renal insufficiency]
Urinary Bladder Neoplasms
A lentiviral sponge for miRNA-21 diminishes aerobic glycolysis in bladder cancer T24 cells via the PTEN/PI3K/AKT/mTOR axis.
Urinary Bladder Neoplasms
Long non-coding RNA UCA1 promotes glycolysis by upregulating hexokinase 2 through the mTOR-STAT3/microRNA143 pathway.
Urinary Bladder Neoplasms
Proteomic analysis of bladder cancer by iTRAQ after Bifidobacterium infantis-mediated HSV-TK/GCV suicide gene treatment.
Urinary Bladder Neoplasms
Single-Cell Sequencing-Enabled Hexokinase 2 Assay for Noninvasive Bladder Cancer Diagnosis and Screening by Detecting Rare Malignant Cells in Urine.
Uterine Cervical Neoplasms
Correlation Between FDG Uptake by PET/CT and the Expressions of Glucose Transporter Type 1 and Hexokinase II in Cervical Cancer.
Uterine Cervical Neoplasms
Hexokinase 2 Promotes Cell Growth and Tumor Formation Through the Raf/MEK/ERK Signaling Pathway in Cervical Cancer.
Uterine Cervical Neoplasms
Targeting hexokinase 2 inhibition promotes radiosensitization in HPV16 E7-induced cervical cancer and suppresses tumor growth.
Uterine Cervical Neoplasms
[On the use and clinical importance of the hexokinase test in diagnosis of cancer of the cervix uteri]
Uterine Neoplasms
Isoenzymes of hexokinase, 6-phosphogluconate dehydrogenase, phosphoglucomutase and lactate dehydrogenase in uterine cancer.
Virus Diseases
ARGONAUTE 2 increases rice susceptibility to rice black-streaked dwarf virus infection by epigenetically regulating HEXOKINASE 1 expression.
Virus Diseases
Differential association of STAT3 and HK-II expression in hepatitis B virus- and hepatitis C virus-related hepatocellular carcinoma.
Virus Diseases
Hexokinase activity as marker to assess time of harvest of foot-and-mouth disease virus in BHK(21) Cl(13) cell cultures.
Virus Diseases
Hexokinase II may be dispensable for CD4 T cell responses against a virus infection.
Virus Diseases
Mitochondrial induced T cell apoptosis and aberrant myeloid metabolic programs define distinct immune cell subsets during acute and recovered SARS-CoV-2 infection.
Virus Diseases
Reduced survival of patients with hepatocellular carcinoma expressing hexokinase II.
Virus Diseases
[Biochemical study of experimental West Nile virus infections; behavior of succinodehydrogenase, asparticketoglutaric transaminase, adenylpyrophosphatase, rhodanese and hexokinase activity in the brain and liver.]
Virus Diseases
[Hexokinase activity of the brain and myocardium in experimental encephalomyocardial virus infection.]
Vitamin K Deficiency
[Kinetic characteristics of creatine kinase and hexokinase from rat skeletal muscles during dietary deficit of vitamin K and administration of pelentane]
Vitamin K Deficiency
[Skeletal muscle phosphorylase and hexokinase activity in vitamin K deficiency and the effect of several 6-hydroxychromane derivatives on changes in hexokinase activity]
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). Q5SLJ4_THET8
Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)
302
0
31479
TrEMBL
-
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PDB
SCOP
CATH
UNIPROT
ORGANISM
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SUBUNIT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
homotetramer
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CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
crystal structure of the enzyme is determined at a resolution of 2.02 A, with Rcryst and Rfree values of 18.1% and 22.6%, respectively
the crystal structure of the enzyme is determined at a resolution of 2.02 A
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TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
90
90
circular dichroism measurements indicates that the enzyme is structurally stable at 90°C
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PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Nakamura, T.; Kashima, Y.; Mine, S.; Oku, T.; Uegaki, K.
Characterization and crystal structure of the thermophilic ROK hexokinase from Thermus thermophilus
J. Biosci. Bioeng.
114
150-154
2012
Thermus thermophilus (Q5SLJ4), Thermus thermophilus
brenda
Nakamura, T.; Kashima, Y.; Mine, S.; Oku, T.; Uegaki, K.
Characterization and crystal structure of the thermophilic ROK hexokinase from Thermus thermophilus
J. Biosci. Bioeng.
114
150-154
2012
Thermus thermophilus (Q5SLJ4), Thermus thermophilus, Thermus thermophilus DSM 579 (Q5SLJ4)
brenda
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Release 2023.1 (January 2023)
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