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Information on EC 2.6.99.2 - pyridoxine 5'-phosphate synthase

for references in articles please use BRENDA:EC2.6.99.2

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IUBMB Comments

In Escherichia coli, the coenzyme pyridoxal 5′-phosphate is synthesized de novo by a pathway that involves EC 1.2.1.72 (erythrose-4-phosphate dehydrogenase), EC 1.1.1.290 (4-phosphoerythronate dehydrogenase), EC 2.6.1.52 (phosphoserine transaminase), EC 1.1.1.262 (4-hydroxythreonine-4-phosphate dehydrogenase), EC 2.6.99.2 (pyridoxine 5′-phosphate synthase) and EC 1.4.3.5 (with pyridoxine 5′-phosphate as substrate). 1-Deoxy-D-xylulose cannot replace 1-deoxy-D-xylulose 5-phosphate as a substrate .

The expected taxonomic range for this enzyme is: Bacteria, Archaea

Synonyms
pnp synthase, pyridoxine 5'-phosphate synthase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate = pyridoxine 5'-phosphate + phosphate + 2 H2O
show the reaction diagram
PATHWAY SOURCE
PATHWAYS
MetaCyc
pyridoxal 5'-phosphate biosynthesis I
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