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EC unknown
Synonyms
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dTDP-4-amino-4,6-dideoxy-alpha-D-glucopyranose + 2-oxoglutarate = dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose + L-glutamate
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dTDP-4-amino-4,6-dideoxy-alpha-D-glucopyranose:2-oxoglutarate aminotransferase
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dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose + L-glutamate
dTDP-4-amino-4,6-dideoxy-alpha-D-glucopyranose + 2-oxoglutarate
dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose + L-glutamate
dTDP-4-amino-4,6-dideoxy-alpha-D-glucopyranose + 2-oxoglutarate
Substrates: the enzyme is involved in biosynthesis of desosamine
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dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose + L-glutamate
dTDP-4-amino-4,6-dideoxy-alpha-D-glucopyranose + 2-oxoglutarate
Substrates: the two active sites of the enzyme are located in clefts at the subunit/subunit interface. Electron density corresponding to the bound product demonstrates a covalent bond between the amino group of the product and C-4' of the pyridoxal 5'-phosphate cofactor
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dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose + L-glutamate
dTDP-4-amino-4,6-dideoxy-alpha-D-glucopyranose + 2-oxoglutarate
Substrates: the enzyme is involved in biosynthesis of desosamine
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pyridoxal 5'-phosphate
a pyridoxal-phosphate protein
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UniProt
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Highest Expressing Human Cell Lines
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Q9ZGH0_STRVZ
415
0
44292
TrEMBL
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dimer
each subunit of the dimeric enzyme contains 12 alpha-helices and 14 alpha-strands
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hanging drop method of vapor diffusion. The structure of DesI is solved in complex with its product, dTDP-4-amino-4,6-dideoxyglucose, to a nominal resolution of 2.1 A. Each subunit of the dimeric enzyme contains 12 alpha-helices and 14 alpha-strands. Crystals belong to the space group P2(1)2(1)2(1) with unit cell dimensions of 59.5 A, 66.8 A, 242.0 A and one dimer per asymmetric unit. Crystal dimensions are typically 1 mm * 0.6 mm * 0.2 mm
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Burgie, E.S.; Holden, H.M.
Molecular architecture of DesI: a key enzyme in the biosynthesis of desosamine
Biochemistry
46
8999-9006
2007
Streptomyces venezuelae (Q9ZGH0)
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