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Information on EC 2.6.1.97 - archaeosine synthase

for references in articles please use BRENDA:EC2.6.1.97

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IUBMB Comments

In Euryarchaeota the reaction is catalysed by ArcS [1,2]. In Crenarchaeota, which do not have an ArcS homologue, the reaction is catalysed either by a homologue of EC 6.3.4.20, 7-cyano-7-deazaguanine synthase that includes a glutaminase domain (cf. EC 3.5.1.2), or by a homologue of EC 1.7.1.13, preQ1 synthase . The enzyme from the Euryarchaeon Methanocaldococcus jannaschii can also use arginine and ammonium as amino donors.

The enzyme appears in viruses and cellular organisms
Reaction Schemes
+
7-cyano-7-carbaguanine15 in tRNA
+
=
+
archaeine15 in tRNA

Synonyms
archaeosine synthase, tgta2, quef-l, quef-like, lysine transferase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
L-glutamine + 7-cyano-7-carbaguanine15 in tRNA + H2O = L-glutamate + archaeine15 in tRNA
show the reaction diagram
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PATHWAY SOURCE
PATHWAYS
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Highest Expressing Human Cell Lines
Cell Line Links Gene Links