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Information on EC - arginine-pyruvate transaminase

for references in articles please use BRENDA:EC2.6.1.84
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EC Tree
     2 Transferases
         2.6 Transferring nitrogenous groups
             2.6.1 Transaminases
       arginine-pyruvate transaminase
IUBMB Comments
A pyridoxal-phosphate protein. While L-arginine is the best substrate, the enzyme exhibits broad substrate specificity, with L-lysine, L-methionine, L-leucine, L-ornithine and L-glutamine also able to act as substrates, but more slowly. Pyruvate cannot be replaced by 2-oxoglutarate as amino-group acceptor. This is the first catalytic enzyme of the arginine transaminase pathway for L-arginine utilization in Pseudomonas aeruginosa. This pathway is only used when the major route of arginine catabolism, i.e. the arginine succinyltransferase pathway, is blocked.
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The enzyme appears in viruses and cellular organisms
arginine/lysine:pyruvate transaminase, arginine:pyruvate transaminase, aruF mutant, AruH, ATASE, L-arginine inducible arginine:pyruvate transaminase, L-arginine:pyruvate transaminase, more
L-arginine + pyruvate = 5-guanidino-2-oxopentanoate + L-alanine
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