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Information on EC 2.6.1.77 - taurine-pyruvate aminotransferase

for references in articles please use BRENDA:EC2.6.1.77

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IUBMB Comments

The enzyme from the bacterium Bilophila wadsworthia requires pyridoxal 5′-phosphate as a cofactor, and catalyses a reversible reaction that starts an anaerobic taurine degradation pathway. β-Alanine is also a significant amino group donor. The enzyme from the bacterium Pseudomonas denitrificans PD1222 can also use hypotaurine, producing 2-sulfinoacetaldehyde, which spontaneously hydrolyses to sulfite and acetaldehyde. Unlike, EC 2.6.1.55, taurine—2-oxoglutarate transaminase, 2-oxoglutarate cannot serve as an acceptor for the amino group.

The expected taxonomic range for this enzyme is: Bacteria, Archaea

Synonyms
taurine:pyruvate aminotransferase, taurine-pyruvate aminotransferase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
taurine + pyruvate = L-alanine + 2-sulfoacetaldehyde
show the reaction diagram
PATHWAY SOURCE
PATHWAYS
MetaCyc
hypotaurine degradation, taurine degradation I