Information on EC 2.6.1.74 - cephalosporin-C transaminase

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The expected taxonomic range for this enzyme is: Bacillus licheniformis

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EC NUMBER
COMMENTARY hide
2.6.1.74
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RECOMMENDED NAME
GeneOntology No.
cephalosporin-C transaminase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(7R)-7-(5-carboxy-5-oxopentanoyl)aminocephalosporinate + D-glutamate = cephalosporin C + 2-oxoglutarate
show the reaction diagram
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-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
amino group transfer
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-
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Penicillin and cephalosporin biosynthesis
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Biosynthesis of antibiotics
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-
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SYSTEMATIC NAME
IUBMB Comments
cephalosporin-C:2-oxoglutarate aminotransferase
A number of D-amino acids, including D-alanine, D-aspartate and D-methionine can also act as amino-group donors. Although this enzyme acts on several free D-amino acids, it differs from EC 2.6.1.21, D-alanine transaminase, in that it can use cephalosporin C as an amino donor.
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CAS REGISTRY NUMBER
COMMENTARY hide
122096-91-7
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
ATCC 9945
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Manually annotated by BRENDA team
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
cephalosporin C + 2-oxoglutarate
7-(5-carboxy-5-oxopentanoyl)aminocephalosporinate + D-glutamate
show the reaction diagram
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i.e. alpha-ketoadipyl-7-aminocephalosporanic acid + D-Glu
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D-Ala-D-Ala + 2-oxoadipate
? + 2-aminoadipate
show the reaction diagram
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-
-
-
?
D-alanine + 2-oxoadipate
pyruvate + 2-aminoadipate
show the reaction diagram
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-
-
-
?
D-alanine + 2-oxoglutarate
pyruvate + L-glutamate
show the reaction diagram
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-
-
-
?
D-aspartate + 2-oxoadipate
oxaloacetate + 2-aminoadipate
show the reaction diagram
-
-
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-
?
D-cystine + 2-oxoadipate
? + 2-aminoadipate
show the reaction diagram
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-
-
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?
D-glutamate + 2-oxoadipate
2-oxoglutarate + 2-aminoadipate
show the reaction diagram
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-
-
-
?
D-leucine + 2-oxoadipate
4-methyl-2-oxopentanoate + 2-aminoadipate
show the reaction diagram
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-
-
-
?
D-methionine + 2-oxoadipate
4-methylsulfanyl-2-oxobutanoate + 2-aminoadipate
show the reaction diagram
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-
-
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?
D-serine + 2-oxoadipate
3-hydroxy-2-oxopropanoate + 2-aminoadipate
show the reaction diagram
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-
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?
D-tryptophan + 2-oxoadipate
3-indole-2-oxopropanoate + 2-aminoadipate
show the reaction diagram
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-
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?
D-valine + 2-oxoadipate
3-methyl-2-oxobutanoate + 2-aminoadipate
show the reaction diagram
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-
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?
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
30000
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gel filtration
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STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
-20�C, 2 years, stable
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Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
ATCC 9945, partial
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LINKS TO OTHER DATABASES (specific for EC-Number 2.6.1.74)
ExplorEnz
ExPASy
KEGG
MetaCyc
SABIO-RK
NCBI: PubMed, Protein, Nucleotide, Structure, Genome, OMIM
IUBMB Enzyme Nomenclature
PROSITE Database of protein families and domains
InterPro (database of protein families, domains and functional sites)