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L-3-hydroxykynurenine + 2-oxoglutarate
xanthurenic acid + L-glutamate
-
-
?
L-kynurenine + 2-oxoadipate
kynurenic acid + 2-aminoadipate + H2O
91% of activity with 2-oxoglutarate
-
?
L-kynurenine + 2-oxobutyrate
kynurenic acid + 2-aminobutanoate + H2O
28% of activity with 2-oxoglutarate
-
?
L-kynurenine + 2-oxoglutarate
kynurenic acid + L-glutamate + H2O
enzyme has both kynurenine aminotransferase and alpha-aminoadipate aminotransferase activity
-
?
L-kynurenine + 4-methyl-2-oxovalerate
kynurenic acid + 2,4-dimethylvalerate + H2O
5.9% of activity with 2-oxoglutarate
-
?
L-kynurenine + phenylpyruvate
4-(2-aminophenyl)-2,4-dioxobutanoate + L-phenylalanine
43% of activity with 2-oxoglutarate
-
?
L-kynurenine + pyruvate
kynurenic acid + L-alanine + H2O
3% of activity with 2-oxoglutarate
-
?
3,5-diiodo-L-tyrosine + 2-oxoglutarate
3-(2,5-diiodo-4-hydroxyphenyl)-2-oxopropanoate + L-glutamate
-
slightly better than L-kynurenine
-
?
L-2-aminoheptane-1,7-dioate + 2-oxoglutarate
2-oxoheptane-1,7-dioate + L-glutamate
-
at 39.7% of the activity with 2-aminohexane-1,6-dioate
-
?
L-3-hydroxykynurenine + 2-oxoglutarate
xanthurenic acid + L-glutamate
L-4-chloro-kynurenine + 2-oxoglutarate
L-7-chloro-kynurenic acid + L-glutamate
-
-
-
?
L-5-chloro-kynurenine + 2-oxoglutarate
L-6-chloro-kynurenic acid + L-glutamate
-
-
-
?
L-histidine + 2-oxoglutarate
3-(1H-imidazol-4-yl)-2-oxopropanoate + L-glutamate
-
-
-
?
L-kynurenine + 2-oxobutyrate
kynurenic acid + 2-aminobutanoate + H2O
-
-
-
-
?
L-kynurenine + 2-oxoglutarate
kynurenic acid + L-glutamate + H2O
L-kynurenine + 2-oxohexanedioate
kynurenic acid + 2-aminohexanedioate + H2O
L-kynurenine + 2-oxoisohexanoate
kynurenic acid + 2-aminoisohexanoate + H2O
-
less effective than 2-oxoglutarate
-
?
L-kynurenine + glyoxylate
kynurenic acid + glycine + H2O
-
poor substrate
-
?
L-kynurenine + oxaloacetate
kynurenic acid + L-aspartate + H2O
L-kynurenine + pyruvate
kynurenic acid + L-alanine + H2O
L-methionine + 2-oxoglutarate
4-methylsulfanyl-2-oxobutanoate + glutamate
-
12% the rate of L-kynurenine
-
?
L-norleucine + 2-oxoglutarate
2-oxohexanoate + L-glutamate
-
at about 30% the rate of L-kynurenine
-
?
L-phenylalanine + 2-oxoglutarate
phenylpyruvate + L-glutamate
-
-
-
?
L-tryptophan + 2-oxoglutarate
3-indole-2-oxopropanoate + L-glutamate
L-tyrosine + 2-oxoglutarate
3-(4-hydroxyphenyl)-2-oxopropanoate + L-glutamate
additional information
?
-
L-3-hydroxykynurenine + 2-oxoglutarate
xanthurenic acid + L-glutamate
-
-
-
?
L-3-hydroxykynurenine + 2-oxoglutarate
xanthurenic acid + L-glutamate
-
-
-
?
L-3-hydroxykynurenine + 2-oxoglutarate
xanthurenic acid + L-glutamate
-
-
-
?
L-3-hydroxykynurenine + 2-oxoglutarate
xanthurenic acid + L-glutamate
-
-
-
ir
L-3-hydroxykynurenine + 2-oxoglutarate
xanthurenic acid + L-glutamate
-
no activity with D-isomer
-
?
L-3-hydroxykynurenine + 2-oxoglutarate
xanthurenic acid + L-glutamate
-
KAT I, no good substrate
-
?
L-kynurenine + 2-oxoglutarate
kynurenic acid + L-glutamate + H2O
-
-
-
?
L-kynurenine + 2-oxoglutarate
kynurenic acid + L-glutamate + H2O
-
-
-
?
L-kynurenine + 2-oxoglutarate
kynurenic acid + L-glutamate + H2O
-
-
-
?
L-kynurenine + 2-oxoglutarate
kynurenic acid + L-glutamate + H2O
-
-
-
?
L-kynurenine + 2-oxoglutarate
kynurenic acid + L-glutamate + H2O
-
-
-
?
L-kynurenine + 2-oxoglutarate
kynurenic acid + L-glutamate + H2O
-
-
-
?
L-kynurenine + 2-oxoglutarate
kynurenic acid + L-glutamate + H2O
-
-
-
?
L-kynurenine + 2-oxoglutarate
kynurenic acid + L-glutamate + H2O
-
-
-
-
?
L-kynurenine + 2-oxoglutarate
kynurenic acid + L-glutamate + H2O
-
broad specificity
-
?
L-kynurenine + 2-oxoglutarate
kynurenic acid + L-glutamate + H2O
-
best substrates
-
?
L-kynurenine + 2-oxoglutarate
kynurenic acid + L-glutamate + H2O
-
best substrates
-
ir
L-kynurenine + 2-oxoglutarate
kynurenic acid + L-glutamate + H2O
-
soluble kidney/brain kynurenine aminotransferase has both amino transferase and cysteine conjugate beta-lyase, i.e., glutamine transaminase K activities
-
?
L-kynurenine + 2-oxoglutarate
kynurenic acid + L-glutamate + H2O
-
KAT II shows equal activity with 2-oxoglutarate and pyruvate, KAT I shows lower activity with 2-oxoglutarate than with pyruvate, ratio of KAT I to KAT II in normal brain is approx. 1/4
-
?
L-kynurenine + 2-oxoglutarate
kynurenic acid + L-glutamate + H2O
enzyme has both kynurenine aminotransferase and glutamine transaminase K activity
-
?
L-kynurenine + 2-oxoglutarate
kynurenic acid + L-glutamate + H2O
-
isoenzyme 2, no activity with L-tyrosine, L-phenylalanine, L-tryptophan, 5-hydroxy-L-tryptophan and L-aspartate
-
?
L-kynurenine + 2-oxoglutarate
kynurenic acid + L-glutamate + H2O
-
inducible enzyme of tryptophan catabolism
-
-
?
L-kynurenine + 2-oxohexanedioate
kynurenic acid + 2-aminohexanedioate + H2O
-
-
-
?
L-kynurenine + 2-oxohexanedioate
kynurenic acid + 2-aminohexanedioate + H2O
-
-
-
?
L-kynurenine + oxaloacetate
kynurenic acid + L-aspartate + H2O
-
-
-
?
L-kynurenine + oxaloacetate
kynurenic acid + L-aspartate + H2O
-
less effective than 2-oxoglutarate
-
?
L-kynurenine + pyruvate
kynurenic acid + L-alanine + H2O
-
-
-
?
L-kynurenine + pyruvate
kynurenic acid + L-alanine + H2O
-
-
-
-
?
L-kynurenine + pyruvate
kynurenic acid + L-alanine + H2O
-
-
?
L-kynurenine + pyruvate
kynurenic acid + L-alanine + H2O
-
-
-
?
L-kynurenine + pyruvate
kynurenic acid + L-alanine + H2O
-
less effective than 2-oxoglutarate
-
?
L-kynurenine + pyruvate
kynurenic acid + L-alanine + H2O
-
less effective than 2-oxoglutarate
-
?
L-kynurenine + pyruvate
kynurenic acid + L-alanine + H2O
-
less effective than 2-oxoglutarate
-
?
L-kynurenine + pyruvate
kynurenic acid + L-alanine + H2O
-
less effective than 2-oxoglutarate
-
?
L-kynurenine + pyruvate
kynurenic acid + L-alanine + H2O
-
100fold higher maximal velocity than with 2-oxoglutarate
-
?
L-tryptophan + 2-oxoglutarate
3-indole-2-oxopropanoate + L-glutamate
-
poor substrate
-
?
L-tryptophan + 2-oxoglutarate
3-indole-2-oxopropanoate + L-glutamate
-
16% the rate of L-kynurenine
-
?
L-tyrosine + 2-oxoglutarate
3-(4-hydroxyphenyl)-2-oxopropanoate + L-glutamate
-
-
-
?
L-tyrosine + 2-oxoglutarate
3-(4-hydroxyphenyl)-2-oxopropanoate + L-glutamate
-
-
-
?
additional information
?
-
-
does not use D-kynurenine as substrate
-
-
?
additional information
?
-
-
KAT I is most active with large neutral/aromatic/sulfur-containing amino acids, including L-glutamine, L-phenylalanine, L-leucine, L-kynurenine, L-tryptophan, L-methionine, L-tyrosine, L-histidine, L-cysteine, aminobutyrate, S-(1,1,2,2-tetrafluoroethyl)-L-cysteine, and S-(1,2-dichlorovinyl)-L-cysteine. The enzyme has detectable activity with Se-methylselenocysteine, 5-S-cysteinyldopamine, 5-S-cysteinyl-DOPA, L-asparagine, glycine, L-alanine, L-arginine, L-serine, and L-lysine. KAT I can use many 2-oxo acids as its amino group acceptors: 2-oxoglutarate, 2-oxocaproic acid, phenylpyruvate, 2-oxo-4-methylthiobutyrate, mercaptopyruvate, indol-3-ylpyruvate, 2-oxovalerate, 2-oxoleucine, 2-oxobutyrate, p-hydroxyphenylpyruvate, 2-oxoadipate, glyoxylate, oxaloacetate, 2-oxovaline, 2-oxoisoleucine, and pyruvate. All of them demonstrate the capacity to act as amino group acceptors, but 2-oxoglutarate, 2-oxoisoleucine, indol-3-ylpyruvate, 2-oxoadipate, and 2-oxovaline have very low activity. Although the activity of KAT I using oxaloacetate, phenylpyruvate, or pyruvate as an amino group acceptor is detectable, the specific activity with these three 2-oxo acids is so low that they are unlikely to be physiological co-substrates for human KAT I
-
-
?
additional information
?
-
-
KAT II is efficient in catalyzing the transamination of aminoadipate, L-kynurenine, L-methionine, and L-glutamate, and is less efficient in catalyzing L-tyrosine, L-phenylalanine, L-tryptophan, L-leucine, 3-hydroxykynurenine, L-glutamine, L-alanine, and aminobutyrate. KAT II is efficient in catalyzing the transamination of 2-oxoglutarate, 2-oxocaproic acid, phenylpyruvate, and 2-oxo-4-methylthiobutyrate, and less efficient in catalyzing mercaptopyruvate, indol-3-ylpyruvate, 2-oxovalerate, 2-oxoleucine, 2-oxobutyrate, p-hydroxyphenylpyruvate, 2-oxoadipate, glyoxylate, oxaloacetate, 2-oxovaline, 2-oxoisoleucine, and pyruvate (in order of decreasing catalytic efficiency)
-
-
?
additional information
?
-
-
KAT III shows activity towards L-phenylalanine, L-kynurenine, L-tryptophan, 3-hydroxykynurenine, L-tyrosine, and L-histidine, L-methionine and L-cysteine, L-glutamine, L-asparagine, L-serine, L-alanine, aminobutyrate, and L-lysine. Glyoxylate, 2-oxocaproic acid, phenylpyruvate, 2-oxobutyrate, 2-oxo-4-methylthiobutyrate, 2-oxovalerate, indol-3-ylpyruvate, p-hydroxyphenylpyruvate, mercaptopyruvate, and oxaloacetate are good amino group acceptors for KAT III and pyruvate, phenylpyruvate, while 2-oxoglutarate are poor co-substrates for the enzyme
-
-
?
additional information
?
-
-
KAT IV shows high transamination activity towards L-glutamate, L-aspartate, L-phenylalanine, L-tyrosine, and L-cysteine, and detectable activity towards L-tryptophan, 3-hydroxykynurenine, L-methionine, L-kynurenine, and L-asparagine. It can use 2-oxoglutarate, phenylpyruvate, 2-oxo-4-methylthiobutyrate, indol-3-ylpyruvate, hydroxyphenylpyruvate, mercaptopyruvate, 2-oxocaproic acid, oxaloacetate, 2-oxobutyrate, pyruvate, and glyoxylate as amino group acceptors. It also shows detectable activity towards other co-substrates, including 2-oxovalerate, 2-oxoleucine, 2-oxoadipate, 2-oxovaline, and 2-oxoisoleucine
-
-
?
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(3S)-3-amino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one
-
i.e. PF-04859989, selective inhibitor
(S)-(4)-(ethylsulfonyl)benzoylalanine
-
no inhibition of the human enzyme
(S)-4-ethylsulfonylbenzoylalanine
-
specific inhibitor of KAT II
(S)-9-(4-aminopiperazine-1-yl)-8-fluoro-3-methyl-6-oxo-2,3,5,6-tetrahydro-4H-1-oxa-3a-azaphenalene-5-carboxylic acid
-
BFF 122, KAT II activity is totally blocked at 0.01 mM, 43% inhibition of KAT II at 0.001 mM, 26% inhibition of KAT I at 1 mM
2-oxoglutarate
-
substrate inhibition
4-carboxy-3-hydroxyphenylglycine
-
inhibition of brain KAT II
4-chloromercuribenzoate
-
-
alpha-aminoadipate
-
strong inhibition of KAT II
amino-2,3-dihydro-5-methyl-3-oxo-4-isoxazolepropionic acid
-
inhibitory in whole cells
aminooxyacetic acid
-
inhibitory in whole cells
anthranilate
-
weak inhibition
Dicarboxylic acids
-
C-2 to C-10
dimethylglutaric acid
-
-
EGTA
-
strong inhibition at pH 6.8 and Ca2+ concentrations below 0.5 mM
glutamate
-
weak inhibition
hydroxylamine
-
complete inhibition
Isonicotinic acid hydrazide
-
anti-tuberculosis drug, enzyme is inhibited in animals fed with a diet containing isonicotinic acid hydrazide and by injection of the drug
KCN
-
complete inhibition
Kynurenate
-
weak inhibition
L-2-amino-4-phosphonobutyric acid
-
inhibition of brain KAT II
L-aspartate
-
0.72 mM, 50% inhibition of brain KAT I, 0.073 mM, 50% inhibition of brain KAT II
L-cysteate
-
5.38 mM, 50% inhibition of brain KAT I, 1.55 mM, 50% inhibition of brain KAT II
L-cysteine sulfinate
-
0.002 mM, 50% inhibition of brain KAT II
L-glutamate
-
1.3 mM, 50% inhibition of brain KAT I, 0.79 mM, 50% inhibition of brain KAT II
L-Homocysteate
-
5.0 mM, 50% inhibition of brain KAT I, 2.1 mM, 50% inhibition of brain KAT II
L-Homocysteine sulfinate
-
1.59 mM, 50% inhibition of brain KAT II
L-kynurenine
-
substrate inhibition above 6 mM
L-leucine
-
inhibitory in whole cells
L-phenylalanine
-
strong inhibition of KAT I
L-serine-O-phosphate
-
inhibition of brain KAT II
N-omega-nitro-L-arginine
-
-
nicotinate
-
weak inhibition
quinolinic acid
-
strong inhibition at pH 6.8 and Ca2+ concentrations below 0.5 mM
S-dichlorovinyl-L-cysteine
Sulfate or phosphate esters of steroids
-
-
-
trans-pyrrolidine-2,4-dicarboxylate
-
inhibition of brain KAT II
xanthurenate
-
weak inhibition
3-hydroxykynurenine
-
2 mM, 50% inhibition of KAT I activity
3-hydroxykynurenine
-
0.6 mM, 54% inhibition of KAT I, 88% inhibition of KAT II
adipate
-
-
adipate
-
strong inhibition
glutamine
-
strong inhibition of KAT I, phenylpyruvate, 2-oxo-4-methiolbutyrate or 2-oxo-isocaproate protect
glutamine
-
strong inhibition of KAT I
Hg2+
-
-
L-cysteine
-
inhibition of KAT I
L-cysteine
-
inhibitory in whole cells
L-tryptophan
-
strong inhibition of KAT I
L-tryptophan
-
inhibitory in whole cells
quisqualate
-
0.52 mM, 50% inhibition of KAT II, 2 mM, 80% inhibition
quisqualate
-
inhibition of brain KAT II
S-dichlorovinyl-L-cysteine
-
strong inhibition of KAT I
S-dichlorovinyl-L-cysteine
-
2 mM, 90% inhibition of KAT I and KAT II
additional information
-
not inhibited by antibodies against 2-aminoadipate transaminase
-
additional information
-
not inhibited by aspartate, tyrosine, phenylalanine
-
additional information
-
not inhibited by oxaloacetic acid, 3-methylglutaric acid
-
additional information
-
not inhibited by L-3-hydroxykynurenine at higher concentrations
-
additional information
-
not inhibited by glycerol, DTT, up to 10%, tryptophan, 3-hydroxyanthranilate, picolinate, NAD+, NADH, NADP+, NADPH, serotonin, tryptamine, 5-hydroxytryptophan, indole-3-acetate, organic acids of tricarboxylic acid cycle, glyoxylate, pyruvate, glutamine, Mg2+, Ca2+, Mn2+, monovalent cations
-
additional information
-
not inhibited by quinolinate
-
additional information
-
not inhibited by quinolinate
-
additional information
-
brain KAT I is not inhibited by L-cysteine sulfinate and L-homocysteine sulfinate
-
additional information
-
not inhibited by 2-aminoadipate
-
additional information
-
brain KAT I is not inhibited by quiqualate, 4-carboxy-3-hydroxyphenylglycine, L-2-amino-4-phosphonobutyric acid, L-serine-O-phosphate, and trans-pyrrolidine-2,4-dicarboxylate
-
additional information
-
not inhibited by EGTA
-
additional information
-
KAT I is not inhibited by quisqualate
-
additional information
-
no influence on kynurenic acid synthesis: K+, 4-aminopyridine, N-methyl-D-aspartate
-
additional information
-
KAT is not inhibited by UPF 648
-
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Alberati-Giani, D.; Malherbe, P.; Khler, C.; Lang, G.; Kiefer, V.; Lahm, H.W.; Cesura, A.M.
Cloning and characterization of a soluble kynurenine aminotransferase from rat brain: identity with kidney cysteine conjugate beta-lyase
J. Neurochem.
64
1448-1455
1995
Rattus norvegicus
brenda
Cesura, A.M.; Alberati-Giani, D.; Buchli, R.; Broger, C.; Kohler, C.; Vilbois, F.; Lahm, H.W.; Heitz, M.P.; Malherbe, P.
Molecular characterization of kynurenine pathway enzymes: 3-Hydroxyanthranilic-acid dioxygenase and kynurenine aminotransferase
Adv. Exp. Med. Biol.
398
477-483
1996
Rattus norvegicus
brenda
Mason, M.
Kynurenine transaminase of rat kidney: a study of coenzyme dissociation
J. Biol. Chem.
227
61-68
1957
Rattus norvegicus
brenda
Tobes, M.C.
Kynurenine-oxoglutarate aminotransferase from rat kidney
Methods Enzymol.
142
217-224
1987
Rattus norvegicus
brenda
De Antoni, A.; Costa, C.; Allegri, G.
Studies on the kynurenine adminotransferase activity in rat liver and kidney
Hoppe-Seyler's Z. Physiol. Chem.
357
1707-1712
1976
Rattus norvegicus
brenda
Noguchi, T.; Minatogawa, Y.; Okuno, E.; Nakatani, M.; Morimoto, M.; Kido, R.
Purification and characterization of kynurenine-2-oxoglutarate aminotransferase from the liver, brain and small intestine of rats
Biochem. J.
151
399-406
1975
Rattus norvegicus, Rattus norvegicus Donryu
brenda
Nakatani, M.; Morimoto, M.; Noguchi, T.; Kido, R.
Subcellular distribution and properties of kynurenine transaminase in rat liver
Biochem. J.
143
303-310
1974
Rattus norvegicus, Rattus norvegicus Donryu
brenda
Mason, M.
Effects of calcium ions and quinolinic acid on rat kidney mitochondrial kynurenine aminotransferase
Biochem. Biophys. Res. Commun.
60
64-69
1974
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
brenda
Kido, R.; Noguchi, T.
Subcellular distribution and properties of rat liver kynurenine transaminase
Acta Vitaminol. Enzymol.
29
307-309
1975
Rattus norvegicus
brenda
Hartline, R.A.
Kynurenine aminotransferase from kidney supernatant
Methods Enzymol.
113
664-672
1985
Rattus norvegicus
brenda
Mawal, M.R.; Mukhopadhyay, A.; Deshmukh, D.R.
Purification and properties of kynurenine aminotransferase from rat kidney
Biochem. J.
279
595-599
1991
Rattus norvegicus
-
brenda
Mawal, M.R.; Deshmukh, D.R.
alpha-Aminoadipate and kynurenine aminotransferase activities from rat kidney. Evidence for separate identity
J. Biol. Chem.
266
2573-2575
1991
Rattus norvegicus
brenda
Takeuchi, F.; Otsuka, H.; Shibata, Y.
Purification, characterization and identification of rat liver mitochondrial kynurenine aminotransferase with alpha-aminoadipate aminotransferase
Biochim. Biophys. Acta
743
323-330
1983
Rattus norvegicus
brenda
Buchli, R.; Alberati-Giani, D.; Malherbe, P.; Kohler, C.; Broger, C.; Cesura, A.M.
Cloning and functional expression of a soluble form of kynurenine/alpha-aminoadipate aminotransferase from rat kidney
J. Biol. Chem.
270
29330-29335
1995
Rattus norvegicus (Q64602)
brenda
Malherbe, P.; Alberati-Giani, D.; Koehler, C.; Cesura, A.M.
Identification of a mitochondrial form of kynurenine aminotransferase/glutamine transaminase K from rat brain
FEBS Lett.
367
141-144
1995
Rattus norvegicus (Q08415)
brenda
Varasi, M.; Della Torre, A.; Heidempergher, F.; Pevarello, P.; Speciale, C.; Guidetti, P.; Wells, D.R.; Schwarcz, R.
Derivatives of kynurenine as inhibitors of rat brain kynurenine aminotransferase
Eur. J. Med. Chem.
31
11-21
1996
Rattus norvegicus
-
brenda
Shibata, K.; Marugami, M.; Kondo, T.
In vivo inhibition of kynurenine aminotransferase activity by isonicotinic acid hydrazide in rats
Biosci. Biotechnol. Biochem.
60
874-876
1996
Rattus norvegicus
brenda
Okuno, E.; Nishikawa, T.; Nakamura, M.
Kynurenine aminotransferases in the rat. Localization and characterization
Adv. Exp. Med. Biol.
398
455-464
1996
Rattus norvegicus
brenda
Guidetti, P.; Okuno, E.; Schwarcz, R.
Characterization of rat brain kynurenine aminotransferases I and II
J. Neurosci. Res.
50
457-465
1997
Rattus norvegicus
brenda
Knyihar-Csillik, E.; Okuno, E.; Vecsei, L.
Effects of in vivo sodium azide administration on the immunohistochemical localization of kynurenine aminotransferase in the rat brain
Neuroscience
94
269-277
1999
Rattus norvegicus
brenda
Battaglia, G.; Rassoulpour, A.; Wu, H.Q.; Hodgkins, P.S.; Kiss, C.; Nicoletti, F.; Schwarcz, R.
Some metabotropic glutamate receptor ligands reduce kynurenate synthesis in rats by intracellular inhibition of kynurenine aminotransferase II
J. Neurochem.
75
2051-2060
2000
Rattus norvegicus
brenda
Kwok, J.B.J.; Kapoor, R.; Gotoda, T.; Iwamoto, Y.; Iizuka, Y.; Yamada, N.; Isaacs, K.E.; Kushwaha, V.V.; Church, W.B.; Schofield, P.R.; Kapoor, V.
A Missense Mutation in Kynurenine Aminotransferase-1 in Spontaneously Hypertensive Rats
J. Biol. Chem.
277
35779-35782
2002
Rattus norvegicus (Q08415)
brenda
Csillik, A.; Knyihar, E.; Okuno, E.; Krisztin-Peva, B.; Csillik, B.; Vecsei, L.
Effect of 3-nitropropionic acid on kynurenine aminotransferase in the rat brain
Exp. Neurol.
177
233-241
2002
Rattus norvegicus
brenda
Kocki, T.; Luchowski, P.; Luchowska, E.; Wielosz, M.; Turski, W.A.; Urbanska, E.M.
L-cysteine sulphinate, endogenous sulphur-containing amino acid, inhibits rat brain kynurenic acid production via selective interference with kynurenine aminotransferase II
Neurosci. Lett.
346
97-100
2003
Rattus norvegicus
brenda
Mosca, M.; Croci, C.; Mostardini, M.; Breton, J.; Malyszko, J.; Avanzi, N.; Toma, S.; Benatti, L.; Gatti, S.
Tissue expression and translational control of rat kynurenine aminotransferase/glutamine transaminase K mRNAs
Biochim. Biophys. Acta
1628
1-10
2003
Homo sapiens, Rattus norvegicus (Q08415)
brenda
Wejksza, K.; Rzeski, W.; Okuno, E.; Kandefer-Szerszen, M.; Albrecht, J.; Turski, W.A.
Demonstration of kynurenine aminotransferases I and II and characterization of kynurenic acid synthesis in oligodendrocyte cell line (OLN-93)
Neurochem. Res.
30
963-968
2005
Rattus norvegicus
brenda
Knyihar-Csillik, E.; Chadaide, Z.; Mihaly, A.; Krisztin-Peva, B.; Fenyo, R.; Vecsei, L.
Effect of 6-hydroxydopamine treatment on kynurenine aminotransferase-I (KAT-I) immunoreactivity of neurons and glial cells in the rat substantia nigra
Acta Neuropathol.
112
127-137
2006
Rattus norvegicus (Q08415)
brenda
Yu, P.; Li, Z.; Zhang, L.; Tagle, D.A.; Cai, T.
Characterization of kynurenine aminotransferase III, a novel member of a phylogenetically conserved KAT family
Gene
365
111-118
2006
Rattus norvegicus (Q58FK9), Homo sapiens (Q6YP21), Homo sapiens, Mus musculus (Q71RI9), Mus musculus
brenda
Rzeski, W.; Kocki, T.; Dybel, A.; Wejksza, K.; Zdzisinska, B.; Kandefer-Szerszen, M.; Turski, W.A.; Okuno, E.; Albrecht, J.
Demonstration of kynurenine aminotransferases I and II and characterization of kynurenic acid synthesis in cultured cerebral cortical neurons
J. Neurosci. Res.
80
677-682
2005
Rattus norvegicus (Q08415), Rattus norvegicus (Q64602)
brenda
Rozsa, E.; Robotka, H.; Nagy, D.; Farkas, T.; Sas, K.; Vecsei, L.; Toldi, J.
The pentylenetetrazole-induced activity in the hippocampus can be inhibited by the conversion of L-kynurenine to kynurenic acid: an in vitro study
Brain Res. Bull.
76
474-479
2008
Rattus norvegicus
brenda
Han, Q.; Cai, T.; Tagle, D.A.; Li, J.
Structure, expression, and function of kynurenine aminotransferases in human and rodent brains
Cell. Mol. Life Sci.
67
353-368
2010
Homo sapiens, Mus musculus, Rattus norvegicus
brenda
Fukushima, T.; Sone, Y.; Mitsuhashi, S.; Tomiya, M.; Toyooka, T.
Alteration of kynurenic acid concentration in rat plasma following optically pure kynurenine administration: a comparative study between enantiomers
Chirality
21
468-472
2009
Rattus norvegicus
brenda
Rossi, F.; Schwarcz, R.; Rizzi, M.
Curiosity to kill the KAT (kynurenine aminotransferase): structural insights into brain kynurenic acid synthesis
Curr. Opin. Struct. Biol.
18
748-755
2008
Homo sapiens, Rattus norvegicus
brenda
Amori, L.; Guidetti, P.; Pellicciari, R.; Kajii, Y.; Schwarcz, R.
On the relationship between the two branches of the kynurenine pathway in the rat brain in vivo
J. Neurochem.
109
316-325
2009
Rattus norvegicus
brenda
Casazza, V.; Rossi, F.; Rizzi, M.
Biochemical and structural investigations on kynurenine aminotransferase II: an example of conformation-driven species-specific inhibition?
Curr. Top. Med. Chem.
11
148-157
2011
Homo sapiens, Rattus norvegicus
brenda
Linderholm, K.R.; Alm, M.T.; Larsson, M.K.; Olsson, S.K.; Goiny, M.; Hajos, M.; Erhardt, S.; Engberg, G.
Inhibition of kynurenine aminotransferase II reduces activity of midbrain dopamine neurons
Neuropharmacology
102
42-47
2016
Rattus norvegicus
brenda