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IUBMB CommentsThis enzyme, characterized from animals, belongs to a family of aminotransferases some members of which can use other amino acceptors (cf. EC 2.6.1.7, kynurenine---oxoglutarate transaminase). The products, 4-(2-aminophenyl)-2,4-dioxobutanoate and 4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate, are converted to kynurenate and xanthurenate, respectively, by spontaneous reactions.
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3-hydroxykynurenine + glyoxylate
xanthurenic acid + glycine
-
-
-
-
?
5-hydroxytryptophan + glyoxylate
3-(5-hydroxyindole)-2-oxopropanoate + glycine
histidine + glyoxylate
3-(1H-imidazol-4-yl)-2-oxopropanoate + glycine
L-kynurenine + 2-oxoglutarate
4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate
L-kynurenine + 4-methylsulfanyl-2-oxobutanoate
4-(2-aminophenyl)-2,4-dioxobutanoate + L-methionine
L-kynurenine + glyoxylate
4-(2-aminophenyl)-2,4-dioxobutanoate + glycine
L-kynurenine + hydroxypyruvate
4-(2-aminophenyl)-2,4-dioxobutanoate + L-serine
L-kynurenine + pyruvate
4-(2-aminophenyl)-2,4-dioxobutanoate + L-alanine
phenylalanine + glyoxylate
phenylpyruvate + glycine
tryptophan + glyoxylate
3-indole-2-oxopropanoate + glycine
tyrosine + glyoxylate
3-(4-hydroxyphenyl)-2-oxopropanoate + glycine
5-hydroxytryptophan + glyoxylate
3-(5-hydroxyindole)-2-oxopropanoate + glycine
-
-
-
-
?
5-hydroxytryptophan + glyoxylate
3-(5-hydroxyindole)-2-oxopropanoate + glycine
-
-
-
-
?
histidine + glyoxylate
3-(1H-imidazol-4-yl)-2-oxopropanoate + glycine
-
-
-
-
?
histidine + glyoxylate
3-(1H-imidazol-4-yl)-2-oxopropanoate + glycine
-
-
-
-
?
L-kynurenine + 2-oxoglutarate
4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate
-
-
-
-
?
L-kynurenine + 2-oxoglutarate
4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate
-
-
-
-
?
L-kynurenine + 4-methylsulfanyl-2-oxobutanoate
4-(2-aminophenyl)-2,4-dioxobutanoate + L-methionine
-
-
-
-
?
L-kynurenine + 4-methylsulfanyl-2-oxobutanoate
4-(2-aminophenyl)-2,4-dioxobutanoate + L-methionine
-
-
-
-
?
L-kynurenine + 4-methylsulfanyl-2-oxobutanoate
4-(2-aminophenyl)-2,4-dioxobutanoate + L-methionine
-
-
-
-
?
L-kynurenine + glyoxylate
4-(2-aminophenyl)-2,4-dioxobutanoate + glycine
-
-
-
?
L-kynurenine + glyoxylate
4-(2-aminophenyl)-2,4-dioxobutanoate + glycine
-
-
-
-
?
L-kynurenine + glyoxylate
4-(2-aminophenyl)-2,4-dioxobutanoate + glycine
-
glucagon inducible enzyme
-
-
?
L-kynurenine + glyoxylate
4-(2-aminophenyl)-2,4-dioxobutanoate + glycine
-
-
-
?
L-kynurenine + glyoxylate
4-(2-aminophenyl)-2,4-dioxobutanoate + glycine
-
-
-
-
?
L-kynurenine + glyoxylate
4-(2-aminophenyl)-2,4-dioxobutanoate + glycine
-
glucagon inducible enzyme
-
-
?
L-kynurenine + glyoxylate
4-(2-aminophenyl)-2,4-dioxobutanoate + glycine
-
-
-
?
L-kynurenine + glyoxylate
4-(2-aminophenyl)-2,4-dioxobutanoate + glycine
-
glucagon inducible enzyme
-
-
?
L-kynurenine + glyoxylate
4-(2-aminophenyl)-2,4-dioxobutanoate + glycine
-
-
-
-
?
L-kynurenine + glyoxylate
4-(2-aminophenyl)-2,4-dioxobutanoate + glycine
-
glucagon inducible enzyme
-
-
?
L-kynurenine + hydroxypyruvate
4-(2-aminophenyl)-2,4-dioxobutanoate + L-serine
-
-
-
-
?
L-kynurenine + hydroxypyruvate
4-(2-aminophenyl)-2,4-dioxobutanoate + L-serine
-
-
-
-
?
L-kynurenine + hydroxypyruvate
4-(2-aminophenyl)-2,4-dioxobutanoate + L-serine
-
-
-
-
?
L-kynurenine + pyruvate
4-(2-aminophenyl)-2,4-dioxobutanoate + L-alanine
-
-
-
-
?
L-kynurenine + pyruvate
4-(2-aminophenyl)-2,4-dioxobutanoate + L-alanine
-
-
-
-
?
L-kynurenine + pyruvate
4-(2-aminophenyl)-2,4-dioxobutanoate + L-alanine
-
-
-
-
?
phenylalanine + glyoxylate
phenylpyruvate + glycine
-
-
-
-
?
phenylalanine + glyoxylate
phenylpyruvate + glycine
-
-
-
-
?
phenylalanine + glyoxylate
phenylpyruvate + glycine
-
-
-
-
?
tryptophan + glyoxylate
3-indole-2-oxopropanoate + glycine
-
-
-
-
?
tryptophan + glyoxylate
3-indole-2-oxopropanoate + glycine
-
-
-
-
?
tyrosine + glyoxylate
3-(4-hydroxyphenyl)-2-oxopropanoate + glycine
-
-
-
-
?
tyrosine + glyoxylate
3-(4-hydroxyphenyl)-2-oxopropanoate + glycine
-
-
-
-
?
tyrosine + glyoxylate
3-(4-hydroxyphenyl)-2-oxopropanoate + glycine
-
-
-
-
?
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3-hydroxykynurenine + glyoxylate
xanthurenic acid + glycine
-
-
-
-
?
L-kynurenine + glyoxylate
4-(2-aminophenyl)-2,4-dioxobutanoate + glycine
L-kynurenine + glyoxylate
4-(2-aminophenyl)-2,4-dioxobutanoate + glycine
-
glucagon inducible enzyme
-
-
?
L-kynurenine + glyoxylate
4-(2-aminophenyl)-2,4-dioxobutanoate + glycine
-
glucagon inducible enzyme
-
-
?
L-kynurenine + glyoxylate
4-(2-aminophenyl)-2,4-dioxobutanoate + glycine
-
glucagon inducible enzyme
-
-
?
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-20°C, in 50 mM potassium phosphate buffer, pH 7.5, 0.2 mM pyridoxal 5-phosphate, 5 mM 2-mercaptoethanol, 20% glycerol, at least 4 weeks
-
-20°C, in 50 mM potassium phosphate buffer, pH 7.5, 0.2 mM pyridoxal 5-phosphate, 5 mM 2-mercaptoethanol, 20% glycerol, at least 7 weeks
-
0-4°C, in 50 mM potassium phosphate buffer, pH 7.5, 0.2 mM pyridoxal 5-phosphate, 5 mM 2-mercaptoethanol, 20% glycerol, 2 weeks
-
0-4°C, in 50 mM potassium phosphate buffer, pH 7.5, 0.2 mM pyridoxal phosphate, 5 mM mercaptoethanol, 20% glycerol, 3 weeks
-
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Harada, I.; Noguchi, T.; Kido, R.
Purification and characterization of aromatic-amino-acid-glyoxylate aminotransferase from monkey and rat liver
Hoppe-Seyler's Z. Physiol. Chem.
359
481-488
1978
Macaca fuscata, Rattus norvegicus, Rattus norvegicus Donryu
brenda
Harada, I.
Glucagon inducible kynurenine aminotransferase
Wakayama Igaku
31
61-68
1980
Macaca fuscata, Rattus norvegicus, Rattus norvegicus Donryu
-
brenda
Canavesi, R.; Miggiano, R.; Stella, M.; Galli, U.; Rossi, F.; Rizzi, M.; Del Grosso, E.
Study of Anopheles gambiae 3-hydroxykynurenine transaminase activity and inhibition by LC-MS/MS method
J. Pharm. Biomed. Anal.
173
154-161
2019
Anopheles gambiae
brenda
2.6.1.63 kynurenine-glyoxylate transaminase
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