Information on EC 2.6.1.63 - kynurenine-glyoxylate transaminase

for references in articles please use BRENDA:EC2.6.1.63
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The enzyme appears in viruses and cellular organisms

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EC NUMBER
COMMENTARY hide
2.6.1.63
-
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RECOMMENDED NAME
GeneOntology No.
kynurenine-glyoxylate transaminase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
L-kynurenine + glyoxylate = 4-(2-aminophenyl)-2,4-dioxobutanoate + glycine
show the reaction diagram
acts, more slowly, on L-phenylalanine, L-histidine and L-tyrosine
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-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
amino group transfer
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-
-
-
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SYSTEMATIC NAME
IUBMB Comments
L-kynurenine:glyoxylate aminotransferase (cyclizing)
Acts, more slowly, on L-phenylalanine, L-histidine and L-tyrosine.
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CAS REGISTRY NUMBER
COMMENTARY hide
74506-33-5
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
Donryu strain
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-
Manually annotated by BRENDA team
Donryu strain
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-
Manually annotated by BRENDA team
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
5-hydroxytryptophan + glyoxylate
3-(5-hydroxyindole)-2-oxopropanoate + glycine
show the reaction diagram
histidine + glyoxylate
3-(1H-imidazol-4-yl)-2-oxopropanoate + glycine
show the reaction diagram
L-kynurenine + 2-oxoglutarate
4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate
show the reaction diagram
L-kynurenine + 4-methylsulfanyl-2-oxobutanoate
4-(2-aminophenyl)-2,4-dioxobutanoate + L-methionine
show the reaction diagram
L-kynurenine + glyoxylate
4-(2-aminophenyl)-2,4-dioxobutanoate + glycine
show the reaction diagram
L-kynurenine + hydroxypyruvate
4-(2-aminophenyl)-2,4-dioxobutanoate + L-serine
show the reaction diagram
L-kynurenine + pyruvate
4-(2-aminophenyl)-2,4-dioxobutanoate + L-alanine
show the reaction diagram
phenylalanine + glyoxylate
phenylpyruvate + glycine
show the reaction diagram
tryptophan + glyoxylate
3-indole-2-oxopropanoate + glycine
show the reaction diagram
tyrosine + glyoxylate
3-(4-hydroxyphenyl)-2-oxopropanoate + glycine
show the reaction diagram
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
L-kynurenine + glyoxylate
4-(2-aminophenyl)-2,4-dioxobutanoate + glycine
show the reaction diagram
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
pyridoxal 5'-phosphate
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INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
hydroxylamine
Isonicotinic hydrazide
Semicarbazide
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.4 - 0.5
glyoxylate
1.2 - 1.5
L-kynurenine
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
8 - 8.5
additional information
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TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
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LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
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SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
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TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
70
-
t1/2: 25 min
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STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
-20°C, in 50 mM potassium phosphate buffer, pH 7.5, 0.2 mM pyridoxal 5’-phosphate, 5 mM 2-mercaptoethanol, 20% glycerol, at least 4 weeks
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-20°C, in 50 mM potassium phosphate buffer, pH 7.5, 0.2 mM pyridoxal 5’-phosphate, 5 mM 2-mercaptoethanol, 20% glycerol, at least 7 weeks
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0-4°C, in 50 mM potassium phosphate buffer, pH 7.5, 0.2 mM pyridoxal 5’-phosphate, 5 mM 2-mercaptoethanol, 20% glycerol, 2 weeks
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0-4°C, in 50 mM potassium phosphate buffer, pH 7.5, 0.2 mM pyridoxal phosphate, 5 mM mercaptoethanol, 20% glycerol, 3 weeks
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Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
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LINKS TO OTHER DATABASES (specific for EC-Number 2.6.1.63)
ExplorEnz
ExPASy
KEGG
MetaCyc
SABIO-RK
NCBI: PubMed, Protein, Nucleotide, Structure, Genome, OMIM
IUBMB Enzyme Nomenclature
PROSITE Database of protein families and domains
InterPro (database of protein families, domains and functional sites)