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EC Tree
IUBMB Comments This enzyme, characterized from animals, belongs to a family of aminotransferases some members of which can use other amino acceptors (cf. EC 2.6.1.7, kynurenine---oxoglutarate transaminase). The products, 4-(2-aminophenyl)-2,4-dioxobutanoate and 4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate, are converted to kynurenate and xanthurenate, respectively, by spontaneous reactions.
Word Map
2.6.1.63
xanthurenic
mosquito
aedes
aegypti
anopheles
gambiae
malaria
insecticides
transamination
transmission-blocking
pyridoxal
transaminases
plasmodium
larvicide
fever
detoxify
dengue
falciparum
oxadiazole
anopheline
5'-phosphate
1,2,4-oxadiazole
The enzyme appears in viruses and cellular organisms
Synonyms
3-HKT, 3-hydroxykynurenine transaminase, aminotransferase, kynurenine-glyoxylate,
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3-hydroxykynurenine transaminase
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aminotransferase, kynurenine-glyoxylate
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L-kynurenine + glyoxylate = 4-(2-aminophenyl)-2,4-dioxobutanoate + glycine
acts, more slowly, on L-phenylalanine, L-histidine and L-tyrosine
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amino group transfer
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L-kynurenine:glyoxylate aminotransferase (cyclizing)
This enzyme, characterized from animals, belongs to a family of aminotransferases some members of which can use other amino acceptors (cf. EC 2.6.1.7, kynurenine---oxoglutarate transaminase). The products, 4-(2-aminophenyl)-2,4-dioxobutanoate and 4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate, are converted to kynurenate and xanthurenate, respectively, by spontaneous reactions.
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3-hydroxykynurenine + glyoxylate
xanthurenic acid + glycine
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-
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?
5-hydroxytryptophan + glyoxylate
3-(5-hydroxyindole)-2-oxopropanoate + glycine
histidine + glyoxylate
3-(1H-imidazol-4-yl)-2-oxopropanoate + glycine
L-kynurenine + 2-oxoglutarate
4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate
L-kynurenine + 4-methylsulfanyl-2-oxobutanoate
4-(2-aminophenyl)-2,4-dioxobutanoate + L-methionine
L-kynurenine + glyoxylate
4-(2-aminophenyl)-2,4-dioxobutanoate + glycine
L-kynurenine + hydroxypyruvate
4-(2-aminophenyl)-2,4-dioxobutanoate + L-serine
L-kynurenine + pyruvate
4-(2-aminophenyl)-2,4-dioxobutanoate + L-alanine
phenylalanine + glyoxylate
phenylpyruvate + glycine
tryptophan + glyoxylate
3-indole-2-oxopropanoate + glycine
tyrosine + glyoxylate
3-(4-hydroxyphenyl)-2-oxopropanoate + glycine
5-hydroxytryptophan + glyoxylate
3-(5-hydroxyindole)-2-oxopropanoate + glycine
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-
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?
5-hydroxytryptophan + glyoxylate
3-(5-hydroxyindole)-2-oxopropanoate + glycine
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?
histidine + glyoxylate
3-(1H-imidazol-4-yl)-2-oxopropanoate + glycine
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?
histidine + glyoxylate
3-(1H-imidazol-4-yl)-2-oxopropanoate + glycine
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?
L-kynurenine + 2-oxoglutarate
4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate
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?
L-kynurenine + 2-oxoglutarate
4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate
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?
L-kynurenine + 4-methylsulfanyl-2-oxobutanoate
4-(2-aminophenyl)-2,4-dioxobutanoate + L-methionine
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?
L-kynurenine + 4-methylsulfanyl-2-oxobutanoate
4-(2-aminophenyl)-2,4-dioxobutanoate + L-methionine
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?
L-kynurenine + 4-methylsulfanyl-2-oxobutanoate
4-(2-aminophenyl)-2,4-dioxobutanoate + L-methionine
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?
L-kynurenine + glyoxylate
4-(2-aminophenyl)-2,4-dioxobutanoate + glycine
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?
L-kynurenine + glyoxylate
4-(2-aminophenyl)-2,4-dioxobutanoate + glycine
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?
L-kynurenine + glyoxylate
4-(2-aminophenyl)-2,4-dioxobutanoate + glycine
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glucagon inducible enzyme
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?
L-kynurenine + glyoxylate
4-(2-aminophenyl)-2,4-dioxobutanoate + glycine
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?
L-kynurenine + glyoxylate
4-(2-aminophenyl)-2,4-dioxobutanoate + glycine
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?
L-kynurenine + glyoxylate
4-(2-aminophenyl)-2,4-dioxobutanoate + glycine
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glucagon inducible enzyme
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?
L-kynurenine + glyoxylate
4-(2-aminophenyl)-2,4-dioxobutanoate + glycine
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-
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?
L-kynurenine + glyoxylate
4-(2-aminophenyl)-2,4-dioxobutanoate + glycine
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glucagon inducible enzyme
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?
L-kynurenine + glyoxylate
4-(2-aminophenyl)-2,4-dioxobutanoate + glycine
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-
-
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?
L-kynurenine + glyoxylate
4-(2-aminophenyl)-2,4-dioxobutanoate + glycine
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glucagon inducible enzyme
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?
L-kynurenine + hydroxypyruvate
4-(2-aminophenyl)-2,4-dioxobutanoate + L-serine
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?
L-kynurenine + hydroxypyruvate
4-(2-aminophenyl)-2,4-dioxobutanoate + L-serine
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?
L-kynurenine + hydroxypyruvate
4-(2-aminophenyl)-2,4-dioxobutanoate + L-serine
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?
L-kynurenine + pyruvate
4-(2-aminophenyl)-2,4-dioxobutanoate + L-alanine
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?
L-kynurenine + pyruvate
4-(2-aminophenyl)-2,4-dioxobutanoate + L-alanine
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?
L-kynurenine + pyruvate
4-(2-aminophenyl)-2,4-dioxobutanoate + L-alanine
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?
phenylalanine + glyoxylate
phenylpyruvate + glycine
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?
phenylalanine + glyoxylate
phenylpyruvate + glycine
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?
phenylalanine + glyoxylate
phenylpyruvate + glycine
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?
tryptophan + glyoxylate
3-indole-2-oxopropanoate + glycine
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?
tryptophan + glyoxylate
3-indole-2-oxopropanoate + glycine
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?
tyrosine + glyoxylate
3-(4-hydroxyphenyl)-2-oxopropanoate + glycine
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?
tyrosine + glyoxylate
3-(4-hydroxyphenyl)-2-oxopropanoate + glycine
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?
tyrosine + glyoxylate
3-(4-hydroxyphenyl)-2-oxopropanoate + glycine
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?
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3-hydroxykynurenine + glyoxylate
xanthurenic acid + glycine
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?
L-kynurenine + glyoxylate
4-(2-aminophenyl)-2,4-dioxobutanoate + glycine
L-kynurenine + glyoxylate
4-(2-aminophenyl)-2,4-dioxobutanoate + glycine
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glucagon inducible enzyme
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?
L-kynurenine + glyoxylate
4-(2-aminophenyl)-2,4-dioxobutanoate + glycine
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glucagon inducible enzyme
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?
L-kynurenine + glyoxylate
4-(2-aminophenyl)-2,4-dioxobutanoate + glycine
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glucagon inducible enzyme
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?
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pyridoxal 5'-phosphate
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pyridoxal 5'-phosphate
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requirement, tightly bound
pyridoxal 5'-phosphate
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requirement, tightly bound
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hydroxylamine
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Isonicotinic hydrazide
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Isonicotinic hydrazide
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KCN
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Semicarbazide
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Dengue
The enzyme 3-hydroxykynurenine transaminase as potential target for 1,2,4-oxadiazoles with larvicide activity against the dengue vector Aedes aegypti.
Malaria
Characterization of the 3-HKT gene in important malaria vectors in India, viz: Anopheles culicifacies and Anopheles stephensi (Diptera: Culicidae).
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0.4
glyoxylate
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1.2
L-kynurenine
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8 - 8.5
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additional information
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pI: 8.0
additional information
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pI: 8.0
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37
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assay at
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brenda
Donryu strain
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brenda
Donryu strain
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brenda
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brenda
Blyth monkey
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brenda
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brenda
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brenda
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brenda
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brenda
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brenda
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brenda
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40000
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2 * 40000, SDS-PAGE
40000
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2 * 40000, SDS-PAGE
80000
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gel filtration
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dimer
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2 * 40000, SDS-PAGE
dimer
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2 * 40000, SDS-PAGE
dimer
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2 * 40000, SDS-PAGE
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-20°C, in 50 mM potassium phosphate buffer, pH 7.5, 0.2 mM pyridoxal 5’-phosphate, 5 mM 2-mercaptoethanol, 20% glycerol, at least 4 weeks
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-20°C, in 50 mM potassium phosphate buffer, pH 7.5, 0.2 mM pyridoxal 5’-phosphate, 5 mM 2-mercaptoethanol, 20% glycerol, at least 7 weeks
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0-4°C, in 50 mM potassium phosphate buffer, pH 7.5, 0.2 mM pyridoxal 5’-phosphate, 5 mM 2-mercaptoethanol, 20% glycerol, 2 weeks
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0-4°C, in 50 mM potassium phosphate buffer, pH 7.5, 0.2 mM pyridoxal phosphate, 5 mM mercaptoethanol, 20% glycerol, 3 weeks
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Harada, I.; Noguchi, T.; Kido, R.
Purification and characterization of aromatic-amino-acid-glyoxylate aminotransferase from monkey and rat liver
Hoppe-Seyler's Z. Physiol. Chem.
359
481-488
1978
Macaca fuscata, Rattus norvegicus, Rattus norvegicus Donryu
brenda
Harada, I.
Glucagon inducible kynurenine aminotransferase
Wakayama Igaku
31
61-68
1980
Macaca fuscata, Rattus norvegicus, Rattus norvegicus Donryu
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brenda
Canavesi, R.; Miggiano, R.; Stella, M.; Galli, U.; Rossi, F.; Rizzi, M.; Del Grosso, E.
Study of Anopheles gambiae 3-hydroxykynurenine transaminase activity and inhibition by LC-MS/MS method
J. Pharm. Biomed. Anal.
173
154-161
2019
Anopheles gambiae
brenda
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2.6.1.63 kynurenine-glyoxylate transaminase
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