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Information on EC 2.6.1.57 - aromatic-amino-acid transaminase and Organism(s) Saccharomyces cerevisiae and UniProt Accession P53090

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EC Tree
     2 Transferases
         2.6 Transferring nitrogenous groups
             2.6.1 Transaminases
                2.6.1.57 aromatic-amino-acid transaminase
IUBMB Comments
A pyridoxal-phosphate protein. L-Methionine can also act as donor, but more slowly; oxaloacetate can act as acceptor. Controlled proteolysis converts the enzyme into EC 2.6.1.1 aspartate transaminase.
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This record set is specific for:
Saccharomyces cerevisiae
UNIPROT: P53090
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Word Map
The taxonomic range for the selected organisms is: Saccharomyces cerevisiae
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
aromatic aminotransferase, aromatic amino acid aminotransferase, aroat, pdaroat, aromatic-amino-acid aminotransferase, yer152c, pdarat, aromatic aminotransferase ii, aromatic amino acid transaminase, caaro9p, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
aminotransferase, aromatic amino acid
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arom. amino acid transferase
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arom.-amino-acid transaminase
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aromatic amino acid aminotransferase
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aromatic amino acid transaminase
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aromatic aminotransferase
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aromatic aminotransferase II
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additional information
ARO9 is an aromatic aminotransferase II, that also belongs to a subfamily of enzymes within the aminotransferase subgroup I
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
amino group transfer
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SYSTEMATIC NAME
IUBMB Comments
aromatic-amino-acid:2-oxoglutarate aminotransferase
A pyridoxal-phosphate protein. L-Methionine can also act as donor, but more slowly; oxaloacetate can act as acceptor. Controlled proteolysis converts the enzyme into EC 2.6.1.1 aspartate transaminase.
CAS REGISTRY NUMBER
COMMENTARY hide
37332-38-0
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
additional information
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
additional information
?
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
mutation in Aro8 leads to substantial changes in the absolute and relative intracellular concentrations of amino acids. Deletion of Aro8 leads to de novo production of phenylethanol during growth on a glucose synthetic medium with ammonium as the sole nitrogen source. The mutation also stimulates phenylethanol production when combined with other mutations that deregulate aromatic amino acid biosynthesis
CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
ARO9 by hanging drop vapour diffusion method, X-ray diffraction structure determination and analysis at 2.6 A resolution
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
synthesis
deletion of the Aro8 gene stimulates phenylethanol production when combined with other mutations that deregulate aromatic amino acid biosynthesis, i.e. expression of phenylalanine and tyrosine feedback-insensitive DAHP synthase. The resulting engineered Saccharomyces cerevisiae strain produces more than 3 mM phenylethanol from glucose during growth on a simple synthetic medium
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Iraqui, I.; Vissers, S.; Cartiaux, M.; Urrestarazu, A.
Characterisation of Saccharomyces cerevisiae ARO8 and ARO9 genes encoding aromatic aminotransferases I and II reveals a new aminotransferase subfamily
Mol. Gen. Genet.
257
238-248
1998
Saccharomyces cerevisiae (P38840), Saccharomyces cerevisiae (P53090), Saccharomyces cerevisiae
Manually annotated by BRENDA team
Chen, H.; Huang, H.; Li, X.; Tong, S.; Niu, L.; Teng, M.
Crystallization and preliminary X-ray diffraction analysis of ARO9, an aromatic aminotransferase from Saccharomyces cerevisiae
Protein Pept. Lett.
16
450-453
2009
Saccharomyces cerevisiae (P38840), Saccharomyces cerevisiae
Manually annotated by BRENDA team
Romagnoli, G.; Knijnenburg, T.A.; Liti, G.; Louis, E.J.; Pronk, J.T.; Daran, J.M.
Deletion of the Saccharomyces cerevisiae ARO8 gene, encoding an aromatic amino acid transaminase, enhances phenylethanol production from glucose
Yeast
32
29-45
2015
Saccharomyces cerevisiae (P53090), Saccharomyces cerevisiae
Manually annotated by BRENDA team