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EC Tree
IUBMB Comments Also acts on L-isoleucine and L-valine, and thereby differs from EC 2.6.1.6, leucine transaminase, which does not. It also differs from EC 2.6.1.66, valine---pyruvate transaminase.
The taxonomic range for the selected organisms is: Arabidopsis thaliana The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
bcat1, bcatm, branched-chain aminotransferase, bcatc, bcat2, branched-chain amino acid aminotransferase, branched chain aminotransferase, hbcat, hbcatm, branched-chain amino acid transaminase,
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branched-chain amino acid aminotransferase
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branched-chain amino acid-glutamate transaminase
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branched-chain aminotransferase
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branched-chain aminotransferase4
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glutamate-branched-chain amino acid transaminase
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L-branched chain amino acid aminotransferase
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amino group transfer
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-, -, -, -, -, -, -, -, -, -, -, -, -, -, -, -, -, -, -, -, -
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branched-chain-amino-acid:2-oxoglutarate aminotransferase
Also acts on L-isoleucine and L-valine, and thereby differs from EC 2.6.1.6, leucine transaminase, which does not. It also differs from EC 2.6.1.66, valine---pyruvate transaminase.
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2-oxoglutarate + L-isoleucine
L-glutamate + 3-methyl-2-oxopentanoate
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r
2-oxoglutarate + L-leucine
L-glutamate + 4-methyl-2-oxopentanoate
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r
3-methyl-2-oxobutanoate + L-glutamate
L-valine + 2-oxoglutarate
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r
4-methylthio-2-oxobutanoate + L-glutamate
L-methionine + 2-oxoglutarate
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r
L-2-aminobutanoate + 4-methylthio-2-oxo-butanoate
2-oxobutanoate + L-methionine
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r
L-glutamate + 3-methyl-2-oxopentanoate
2-oxoglutarate + L-isoleucine
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r
L-glutamate + 4-methyl-2-oxopentanoate
2-oxoglutarate + L-leucine
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r
L-homomethionine + 2-oxoglutarate
5-methylthio-2-oxopentanoate + L-glutamate
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?
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
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?
L-methionine + 2-oxobutanoate
4-methylthio-2-oxobutanoate + L-2-aminobutanoate
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r
L-methionine + 2-oxoglutarate
4-methylsulfanyl-2-oxobutanoate + L-glutamate
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?
L-methionine + 2-oxoglutarate
4-methylthio-2-oxobutanoate + L-glutamate
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r
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
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r
additional information
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additional information
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enzyme may influence methionine levels and play an important role in the metabolism of the nonprotein amino acid alpha-aminobutanoate
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additional information
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isoform Atbcat-1 is able to initiate degradation of all branched-chain amino acids
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additional information
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little or no activity is detected with L-isoleucine
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additional information
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no activity is observed with 6-methylthio-2-oxohexanoate, 3-methyl-2-oxopentanoate, or 3-methyl-2-oxobutyrate
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additional information
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enzyme may influence methionine levels and play an important role in the metabolism of the nonprotein amino acid alpha-aminobutanoate
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2.69
3-methyl-2-oxobutanoate
pH 8.3, 337°C
1.08
3-methyl-2-oxopentanoate
pH 8.3, 337°C
2.64
4-methyl-2-oxopentanoate
pH 8.3, 337°C
0.045
4-methylsulfanyl-2-oxobutanoate
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2.83
4-methylthio-2-oxobutanoate
pH 8.3, 337°C
3.27
L-isoleucine
pH 8.3, 337°C
4.41
L-valine
pH 8.3, 337°C
3.34
L-leucine
pH 8.3, 337°C
0.93
L-methionine
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6.58
L-methionine
pH 8.3, 337°C
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AtBCAT-4
SwissProt
brenda
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predominant expression of isoform Atbcat-1
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additional information
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isoforms Atbcat-1, Atbcat-3 are expressed in all tissues, isoforms Atbcat-4, Atbcat-6 mainly in tissues associated with transport function and meristematic tissues
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predominant expression of isoform Atbcat-1
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isoforms Atbcat-4, Atbcat-6
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isoform Atbcat-1
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isoforms Atbcat-2, Atbcat-3, Atbcat-5
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physiological function
mutant plants lacking the activities of isoforms bcat3, Bcat4, Bcat6 exhibit a clear macroscopic phenotype with smaller plants and abnormal leaf morphology. The triple mutant shows a dramatic reduction of Met-derived glucosinolate species down to 32 and 14% of wild-type levels in plant foliage and seeds, respectively, accompanied by a 46fold increase of free Met. 5?-Deoxy-5?-methylthioadenosine, an intermediate of the Met recycling pathway, accumulates to relative high amounts in the absence of the cytosolic Bcat4 and Bcat6
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BCAT4_ARATH
354
0
39019
Swiss-Prot
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S-protein agarose chromatography
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expressed in Escherichia coli
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Diebold, R.; Schuster, J.; Daeschner, K.; Binder, S.
The branched-chain amino acid transaminase gene family in Arabidopsis encodes plastid and mitochondrial proteins
Plant Physiol.
129
540-550
2002
Arabidopsis sp., Arabidopsis thaliana (Q93Y32), Arabidopsis thaliana (Q9FYA6), Arabidopsis thaliana (Q9LE06), Arabidopsis thaliana (Q9LPM9), Arabidopsis thaliana (Q9M401), Arabidopsis thaliana (Q9M439)
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Schuster, J.; Binder, S.
The mitochondrial branched-chain aminotransferase (AtBCAT-1) is capable to initiate degradation of leucine, isoleucine and valine in almost all tissues in Arabidopsis thaliana
Plant Mol. Biol.
57
241-254
2005
Arabidopsis thaliana
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Schuster, J.; Knill, T.; Reichelt, M.; Gershenzon, J.; Binder, S.
Branched-chain aminotransferase4 is part of the chain elongation pathway in the biosynthesis of methionine-derived glucosinolates in Arabidopsis
Plant Cell
18
2664-2679
2006
Arabidopsis thaliana
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Laechler, K.; Imhof, J.; Reichelt, M.; Gershenzon, J.; Binder, S.
The cytosolic branched-chain aminotransferases of Arabidopsis thaliana influence methionine supply, salvage and glucosinolate metabolism
Plant Mol. Biol.
88
119-131
2015
Arabidopsis thaliana (Q9LPM9), Arabidopsis thaliana
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