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Information on EC 2.6.1.42 - branched-chain-amino-acid transaminase and Organism(s) Mus musculus and UniProt Accession O35855

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EC Tree
     2 Transferases
         2.6 Transferring nitrogenous groups
             2.6.1 Transaminases
                2.6.1.42 branched-chain-amino-acid transaminase
IUBMB Comments
Also acts on L-isoleucine and L-valine, and thereby differs from EC 2.6.1.6, leucine transaminase, which does not. It also differs from EC 2.6.1.66, valine---pyruvate transaminase.
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This record set is specific for:
Mus musculus
UNIPROT: O35855
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Word Map
The taxonomic range for the selected organisms is: Mus musculus
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
bcat1, bcatm, branched-chain aminotransferase, bcatc, bcat2, branched-chain amino acid aminotransferase, branched chain aminotransferase, hbcat, hbcatm, branched-chain amino acid transaminase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
BcaT
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branched-chain amino acid aminotransferase
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-
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branched-chain amino acid-glutamate transaminase
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branched-chain aminotransferase
glutamate-branched-chain amino acid transaminase
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L-branched chain amino acid aminotransferase
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transaminase B
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
amino group transfer
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-
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-
SYSTEMATIC NAME
IUBMB Comments
branched-chain-amino-acid:2-oxoglutarate aminotransferase
Also acts on L-isoleucine and L-valine, and thereby differs from EC 2.6.1.6, leucine transaminase, which does not. It also differs from EC 2.6.1.66, valine---pyruvate transaminase.
CAS REGISTRY NUMBER
COMMENTARY hide
9054-65-3
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + L-glutamate
show the reaction diagram
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-
-
-
?
L-valine + 2-oxoglutarate
3-methyl-2-oxobutanoate + L-glutamate
show the reaction diagram
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-
?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
pyridoxal 5'-phosphate
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2-((4-chloro-2,6-difluorobenzyl)amino)-7-oxo-5-propyl-4,7-dihydropyrazolo[1,5-a]-pyrimidine-3-carbonitrile
oral administration of the compound significantly raises the circulating levels of the branched-chain amino acids leucine, isoleucine, and valine. Compound demonstrates a good dose response, with leucine increasing from 473 microM (basal level) to 1.2 mM in 100 mg/kg treated mice
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
UniProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
BCAT2_MOUSE
393
0
44127
Swiss-Prot
Mitochondrion (Reliability: 4)
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Castellano, S.; Casarosa, S.; Sweatt, A.J.; Hutson, S.M.; Bozzi, Y.
Expression of cytosolic branched chain aminotransferase (BCATc) mRNA in the developing mouse brain
Gene Expr. Patterns
7
485-490
2007
Mus musculus
Manually annotated by BRENDA team
Bertrand, S.M.; Ancellin, N.; Beaufils, B.; Bingham, R.P.; Borthwick, J.A.; Boullay, A.B.; Boursier, E.; Carter, P.S.; Chung, C.W.; Churcher, I.; Dodic, N.; Fouchet, M.H.; Fournier, C.; Francis, P.L.; Gummer, L.A.; Herry, K.; Hobbs, A.; Hobbs, C.I.; Homes, P.; Jamieson, C.; Nicodeme, E.; Pickett, S.D.; Reid, I.
The discovery of in vivo active mitochondrial branched-chain aminotransferase (BCATm) inhibitors by hybridizing fragment and HTS hits
J. Med. Chem.
58
7140-7163
2015
Mus musculus (O35855)
Manually annotated by BRENDA team