Information on EC 2.6.1.32 - valine-3-methyl-2-oxovalerate transaminase

for references in articles please use BRENDA:EC2.6.1.32
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The expected taxonomic range for this enzyme is: Bacteria, Eukaryota

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EC NUMBER
COMMENTARY hide
2.6.1.32
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RECOMMENDED NAME
GeneOntology No.
valine-3-methyl-2-oxovalerate transaminase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
L-valine + (S)-3-methyl-2-oxopentanoate = 3-methyl-2-oxobutanoate + L-isoleucine
show the reaction diagram
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
amino group transfer
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-
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SYSTEMATIC NAME
IUBMB Comments
L-valine:(S)-3-methyl-2-oxopentanoate aminotransferase
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CAS REGISTRY NUMBER
COMMENTARY hide
9023-14-7
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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C6UMN8, D2AFZ3
UniProt
Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
C6UMN8, D2AFZ3
an alanine auxotroph (mutated in yfdZ) is isolated from a prototrophic double mutant deficient in AvtA and YfbQ, a novel alanine aminotransferase, by chemical mutagenesis; Escherichia coli synthesizes L-alanine by means of three aminotransferases, YfbQ, YfdZ, and AvtA; level of yfdZ expression in minimal medium is higher than in rich medium; an alanine auxotroph (mutated in yfdZ) is isolated from a prototrophic double mutant deficient in AvtA and YfbQ by chemical mutagenesis; Escherichia coli synthesizes L-alanine by means of three aminotransferases, YfbQ, YfdZ, and AvtA; YfbQ contributes to most of the alanine aminotransferase activity in rich medium
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
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LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
L-valine + (S)-3-methyl-2-oxopentanoate
3-methyl-2-oxobutanoate + L-isoleucine
show the reaction diagram
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-
-
?
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
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Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
partial
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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
level of yfdZ expression in minimal medium is higher than in rich medium
C6UMN8, D2AFZ3
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LINKS TO OTHER DATABASES (specific for EC-Number 2.6.1.32)
ExplorEnz
ExPASy
KEGG
MetaCyc
SABIO-RK
NCBI: PubMed, Protein, Nucleotide, Structure, Genome, OMIM
IUBMB Enzyme Nomenclature
PROSITE Database of protein families and domains
InterPro (database of protein families, domains and functional sites)