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Information on EC 2.6.1.2 - alanine transaminase and Organism(s) Arabidopsis thaliana and UniProt Accession F4I7I0

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EC Tree
     2 Transferases
         2.6 Transferring nitrogenous groups
             2.6.1 Transaminases
                2.6.1.2 alanine transaminase
IUBMB Comments
A pyridoxal-phosphate protein. 2-Aminobutanoate can act slowly instead of alanine.
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This record set is specific for:
Arabidopsis thaliana
UNIPROT: F4I7I0
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The taxonomic range for the selected organisms is: Arabidopsis thaliana
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Synonyms
alanine aminotransferase, alanine transaminase, alat, pyruvate transaminase, glutamic-pyruvic transaminase, glutamate-pyruvate transaminase, alanine-aminotransferase, alaat, l-alanine aminotransferase, c-aat, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
alanine aminotransferase
-
alanine aminotransferase
-
-
-
-
alanine-alpha-ketoglutarate aminotransferase
-
-
-
-
alanine-pyruvate aminotransferase
-
-
-
-
ALT
-
-
-
-
aminotransferase, alanine
-
-
-
-
beta-alanine aminotransferase
-
-
-
-
glutamic acid-pyruvic acid transaminase
-
-
-
-
glutamic-alanine transaminase
-
-
-
-
glutamic-pyruvic aminotransferase
-
-
-
-
glutamic-pyruvic transaminase
-
-
-
-
GPT
-
-
-
-
L-alanine aminotransferase
-
-
-
-
L-alanine transaminase
-
-
-
-
L-alanine-alpha-ketoglutarate aminotransferase
-
-
-
-
pyruvate transaminase
-
-
-
-
pyruvate-alanine aminotransferase
-
-
-
-
pyruvate-glutamate transaminase
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
amino group transfer
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
L-alanine:2-oxoglutarate aminotransferase
A pyridoxal-phosphate protein. 2-Aminobutanoate can act slowly instead of alanine.
CAS REGISTRY NUMBER
COMMENTARY hide
9000-86-6
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
L-alanine + 2-oxoglutarate
pyruvate + L-glutamate
show the reaction diagram
pyruvate + L-glutamate
L-alanine + 2-oxoglutarate
show the reaction diagram
-
-
-
?
L-alanine + 2-oxoglutarate
pyruvate + L-glutamate
show the reaction diagram
-
-
-
?
pyruvate + L-glutamate
L-alanine + 2-oxoglutarate
show the reaction diagram
-
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
L-alanine + 2-oxoglutarate
pyruvate + L-glutamate
show the reaction diagram
-
-
-
r
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.1
2-oxoglutarate
pH 8.0, 20°C
2.4
L-alanine
pH 8.0, 20°C
2.5
L-glutamate
pH 8.0, 20°C
0.1
pyruvate
pH 8.0, 20°C
1
2-oxoglutarate
pH 8.0, 20°C
10.4
L-alanine
pH 8.0, 20°C
4.9
L-glutamate
pH 8.0, 20°C
5.1
pyruvate
pH 8.0, 20°C
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
ALAT1_ARATH
543
0
59821
Swiss-Prot
Mitochondrion (Reliability: 5)
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expression in Escherichia coli
expression in Escherichia coli
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
the enzyme expression is induced under oxygen stress
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
McAllister, C.H.; Facette, M.; Holt, A.; Good, A.G.
Analysis of the enzymatic properties of a broad family of alanine aminotransferases
PLoS ONE
8
e55032
2013
Medicago truncatula, Arabidopsis thaliana (F4I7I0), Arabidopsis thaliana (Q9LDV4), Saccharomyces cerevisiae (P52893), Hordeum vulgare (P52894), Mus musculus (Q8QZR5), Pyrococcus furiosus (Q9P9M8)
Manually annotated by BRENDA team
Diab, H.; Limami, A.
Reconfiguration of N metabolism upon hypoxia stress and recovery Roles of alanine aminotransferase (AlaAt) and glutamate dehydrogenase (GDH)
Plants (Basel)
5
345-367
2016
Glycine max, Lotus japonicus, Medicago truncatula, Arabidopsis thaliana (F4I7I0)
Manually annotated by BRENDA team