We're sorry, but BRENDA doesn't work properly without JavaScript. Please make sure you have JavaScript enabled in your browser settings.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
IUBMB Comments The enzyme participates in an L -lysine biosynthesis pathway in certain species of archaea and bacteria.
Synonyms lysJ , [LysW]-aminoadipate semialdehyde transaminase,
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
[LysW]-aminoadipate semialdehyde transaminase
-
lysJ
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
an [amino group carrier protein]-C-terminal-gamma-(L-lysyl)-L-glutamate + 2-oxoglutarate = an [amino group carrier protein]-C-terminal-N-(1-carboxy-5-oxopentan-1-yl)-L-glutamine + L-glutamate
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
MetaCyc
L-lysine biosynthesis V
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
2-oxoglutarate:[amino group carrier protein]-C-terminal-gamma-(L-lysyl)-L-glutamate aminotransferase
The enzyme participates in an L-lysine biosynthesis pathway in certain species of archaea and bacteria.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
N2-acetyl-L-lysine + 2-oxoglutarate
N2-acetyl-L-aminoadipate semialdehyde + L-glutamate
Substrates: ping-pong bi-bi mechanism
?
N2-acetyl-L-ornithine + 2-oxoglutarate
(2R)-2-acetamido-5-oxopentanoic acid + L-glutamate
Substrates: -
?
[carrier protein LysW]-C-terminal-N-(1-carboxy-5-oxopentan-1-yl)-L-glutamine + L-glutamate
[carrier protein LysW]-C-terminal-gamma-(L-lysyl)-L-glutamate + 2-oxoglutarate
Substrates: -
?
[LysW]-aminoadipate 6-semialdehyde + L-glutamate
?
Substrates: -
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
10
N2-acetyl-L-lysine
pH 8.9, 45°C
0.8
N2-Acetyl-L-ornithine
pH 8.9, 45°C
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
0.8
N2-acetyl-L-lysine
pH 8.9, 45°C
1
N2-Acetyl-L-ornithine
pH 8.9, 45°C
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
0.0786
N2-acetyl-L-lysine
pH 8.9, 45°C
1.266
N2-Acetyl-L-ornithine
pH 8.9, 45°C
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
-
UniProt
brenda
Highest Expressing Human Cell Lines
Filter by:
Cell Line Links
Gene Links
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
physiological function
for the conversion of alpha-aminoadipate to lysine, the amino group of alpha-aminoadipate is modified by attachment to the gamma-carboxyl group of the C-terminal Glu54 of a small protein, LysW. The side chain of alpha-aminoadipate is converted to the lysyl side chain while still attached to LysW, and lysine is subsequently liberated from the LysW-lysine fusion
physiological function
gene product is essential for lysine biosynthesis in Thermus thermophilus
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
dimer
2 * 43000, SDS-PAGE, 2 * 43503, calculated from sequence
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
expression in Escherichia coli
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Horie, A.; Tomita, T.; Saiki, A.; Kono, H.; Taka, H.; Mineki, R.; Fujimura, T.; Nishiyama, C.; Kuzuyama, T.; Nishiyama, M.
Discovery of proteinaceous N-modification in lysine biosynthesis of Thermus thermophilus
Nat. Chem. Biol.
5
673-679
2009
Thermus thermophilus (Q93R93)
brenda
Miyazaki, J.; Kobashi, N.; Nishiyama, M.; Yamane, H.
Functional and evolutionary relationship between arginine biosynthesis and prokaryotic lysine biosynthesis through alpha-aminoadipate
J. Bacteriol.
183
5067-5073
2001
Thermus thermophilus (Q93R93)
brenda
html completed
show
top
