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Information on EC 2.6.1.114 - 8-demethyl-8-aminoriboflavin-5'-phosphate synthase

for references in articles please use BRENDA:EC2.6.1.114
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IUBMB Comments
The enzyme, characterized from the bacterium Streptomyces davawensis, has the activities of an oxidoreductase, a decarboxylase, and an aminotransferase. Its combined actions result in the replacement of a methyl substituent of one of the aromatic rings of FMN by an amino group, a step in the biosynthetic pathway of roseoflavin. The reaction requires thiamine for completion.
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The expected taxonomic range for this enzyme is: Streptomyces davaonensis
Synonyms
8-amino-flavin synthase, 8-demethyl-8-aminoriboflavin-5’-phosphate synthase, AFP synthase, BN159_7989, rosB, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
8-demethyl-8-formylriboflavin 5'-phosphate + H2O + acceptor = 8-carboxy-8-demethylriboflavin 5'-phosphate + reduced acceptor
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(1b)
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FMN + O2 = 8-demethyl-8-formylriboflavin 5'-phosphate + H2O
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(1a)
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L-glutamate + 8-carboxy-8-demethylriboflavin 5'-phosphate + H2O + 2 acceptor = 2-oxoglutarate + 8-amino-8-demethylriboflavin 5'-phosphate + CO2 + 2 reduced acceptor
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(1c)
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L-glutamate + FMN + O2 + H2O + 3 acceptor = 2-oxoglutarate + 8-amino-8-demethylriboflavin 5'-phosphate + CO2 + 3 reduced acceptor
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overall reaction
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