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EC Tree
IUBMB Comments The enzyme, found in bacteria, is part of a L-lysine degradation pathway. The enzyme is also active with other beta-amino compounds such as 3-amino-5-methylhexanoyl-CoA and 3-amino-3-phenylpropanoyl-CoA.
The enzyme appears in viruses and cellular organisms
Synonyms
3-aminobutyryl-CoA aminotransferase, acyl-CoA beta-transaminase,
KAT ,
more
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3-aminobutyryl-CoA aminotransferase
acyl-CoA beta-transaminase
3-aminobutyryl-CoA aminotransferase
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3-aminobutyryl-CoA aminotransferase
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acyl-CoA beta-transaminase
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acyl-CoA beta-transaminase
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acyl-CoA beta-transaminase
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KAT
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3-aminobutanoyl-CoA + 2-oxoglutarate = acetoacetyl-CoA + L-glutamate
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3-aminobutanoyl-CoA:2-oxoglutarate aminotransferase
The enzyme, found in bacteria, is part of a L-lysine degradation pathway. The enzyme is also active with other beta-amino compounds such as 3-amino-5-methylhexanoyl-CoA and 3-amino-3-phenylpropanoyl-CoA.
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(3S)-3-aminobutanoyl-CoA + 2-oxoglutarate
acetoacetyl-CoA + L-glutamate
(3S)-3-aminobutanoyl-CoA + pyruvate
acetoacetyl-CoA + L-alanine
S-[2-(acetylamino)ethyl] 3-amino-3-phenylpropanethioate + 2-oxoglutarate
S-[2-(acetylamino)ethyl] 3-oxo-3-phenylpropanethioate + L-glutamate
S-[2-(acetylamino)ethyl] 3-amino-5-methylhexanethioate + 2-oxoglutarate
S-[2-(acetylamino)ethyl] 3-oxo-5-methylhexanethioate + L-glutamate
S-[2-(acetylamino)ethyl] 3-aminobutanethioate + 2-oxoglutarate
S-[2-(acetylamino)ethyl] 3-oxobutanethioate + L-glutamate
(3S)-3-aminobutanoyl-CoA + 2-oxoglutarate
acetoacetyl-CoA + L-glutamate
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-
-
?
(3S)-3-aminobutanoyl-CoA + 2-oxoglutarate
acetoacetyl-CoA + L-glutamate
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-
-
?
(3S)-3-aminobutanoyl-CoA + pyruvate
acetoacetyl-CoA + L-alanine
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-
-
?
(3S)-3-aminobutanoyl-CoA + pyruvate
acetoacetyl-CoA + L-alanine
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-
-
?
S-[2-(acetylamino)ethyl] 3-amino-3-phenylpropanethioate + 2-oxoglutarate
S-[2-(acetylamino)ethyl] 3-oxo-3-phenylpropanethioate + L-glutamate
i.e. beta-phenylalanine-S-(N-acetylcysteamine), N-acetylcysteamine can serve as a CoA mimic for Kat
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-
?
S-[2-(acetylamino)ethyl] 3-amino-3-phenylpropanethioate + 2-oxoglutarate
S-[2-(acetylamino)ethyl] 3-oxo-3-phenylpropanethioate + L-glutamate
i.e. beta-phenylalanine-S-(N-acetylcysteamine), N-acetylcysteamine can serve as a CoA mimic for Kat
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-
?
S-[2-(acetylamino)ethyl] 3-amino-5-methylhexanethioate + 2-oxoglutarate
S-[2-(acetylamino)ethyl] 3-oxo-5-methylhexanethioate + L-glutamate
i.e. beta-homoleucine-S-(N-acetylcysteamine), N-acetylcysteamine can serve as a CoA mimic for Kat
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-
?
S-[2-(acetylamino)ethyl] 3-amino-5-methylhexanethioate + 2-oxoglutarate
S-[2-(acetylamino)ethyl] 3-oxo-5-methylhexanethioate + L-glutamate
i.e. beta-homoleucine-S-(N-acetylcysteamine), N-acetylcysteamine can serve as a CoA mimic for Kat
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?
S-[2-(acetylamino)ethyl] 3-aminobutanethioate + 2-oxoglutarate
S-[2-(acetylamino)ethyl] 3-oxobutanethioate + L-glutamate
i.e. 3-aminobutanoyl-S-(N-acetylcysteamine), N-acetylcysteamine can serve as a CoA mimic for Kat
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-
?
S-[2-(acetylamino)ethyl] 3-aminobutanethioate + 2-oxoglutarate
S-[2-(acetylamino)ethyl] 3-oxobutanethioate + L-glutamate
i.e. 3-aminobutanoyl-S-(N-acetylcysteamine), N-acetylcysteamine can serve as a CoA mimic for Kat
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?
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(3S)-3-aminobutanoyl-CoA + 2-oxoglutarate
acetoacetyl-CoA + L-glutamate
(3S)-3-aminobutanoyl-CoA + pyruvate
acetoacetyl-CoA + L-alanine
(3S)-3-aminobutanoyl-CoA + 2-oxoglutarate
acetoacetyl-CoA + L-glutamate
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?
(3S)-3-aminobutanoyl-CoA + 2-oxoglutarate
acetoacetyl-CoA + L-glutamate
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?
(3S)-3-aminobutanoyl-CoA + pyruvate
acetoacetyl-CoA + L-alanine
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?
(3S)-3-aminobutanoyl-CoA + pyruvate
acetoacetyl-CoA + L-alanine
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?
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0.0043
(3S)-3-aminobutanoyl-CoA
pH 8.1, 28°C
2.9
2-oxoglutarate
pH 8.1, 28°C
20.1
pyruvate
pH 8.1, 28°C
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1.8
(3S)-3-aminobutanoyl-CoA
pH 8.1, 28°C
1.8
2-oxoglutarate
pH 8.1, 28°C
0.4
pyruvate
pH 8.1, 28°C
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420
(3S)-3-aminobutanoyl-CoA
pH 8.1, 28°C
0.62
2-oxoglutarate
pH 8.1, 28°C
0.02
pyruvate
pH 8.1, 28°C
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10
20% of maximum activity
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33
complete loss of activity above
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UniProt
brenda
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UniProt
brenda
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physiological function
gene product Kat may participate in an alternative pathway of lysine fermentation
physiological function
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gene product Kat may participate in an alternative pathway of lysine fermentation
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KAT_CLOAI
Cloacimonas acidaminovorans (strain Evry)
414
0
46481
Swiss-Prot
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A0A644WSD8_9ZZZZ
431
0
48332
TrEMBL
Mitochondrion (Reliability: 5 )
A0A2Z4AS04_9BACT
452
0
49233
TrEMBL
-
A0A7U9NLS9_9FIRM
443
0
49475
TrEMBL
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A0A7U9XEU2_9FIRM
443
0
49380
TrEMBL
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A0A644TUS9_9ZZZZ
430
0
47649
TrEMBL
other Location (Reliability: 4 )
A0A7C8HWT8_9DELT
433
0
47314
TrEMBL
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A0A7U9WR64_9FIRM
433
0
47824
TrEMBL
-
A0A7K0DG84_9NOCA
445
0
47545
TrEMBL
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A0A7U9SWQ2_9FIRM
440
0
49162
TrEMBL
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A0A645CXU4_9ZZZZ
192
0
21178
TrEMBL
other Location (Reliability: 2 )
A0A645D9R6_9ZZZZ
204
0
22722
TrEMBL
other Location (Reliability: 4 )
A0A2Z4AMQ5_9BACT
449
0
49334
TrEMBL
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dimer
2 * 46481, calculated
dimer
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2 * 46481, calculated
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Perret, A.; Lechaplais, C.; Tricot, S.; Perchat, N.; Vergne, C.; Pelle, C.; Bastard, K.; Kreimeyer, A.; Vallenet, D.; Zaparucha, A.; Weissenbach, J.; Salanoubat, M.
A novel acyl-CoA beta-transaminase characterized from a metagenome
PLoS ONE
6
e22918
2011
Candidatus Cloacimonas acidaminovorans (B0VH76), Candidatus Cloacimonas acidaminovorans Evry (B0VH76)
brenda
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