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Information on EC 2.5.1.94 - adenosyl-chloride synthase

for references in articles please use BRENDA:EC2.5.1.94
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IUBMB Comments
This enzyme, isolated from the marine bacterium Salinispora tropica, catalyses an early step in the pathway leading to biosynthesis of the proteosome inhibitor salinosporamide A. The enzyme is very similar to EC 2.5.1.63, adenosyl-fluoride synthase, but does not accept fluoride.
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Word Map
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
5'-chloro-5'-deoxyadenosine synthase, AclH, chlorinase, S-adenosyl-L-methionine-dependent chlorinase, SalL, SAM-dependent chlorinase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
S-adenosyl-L-methionine + chloride = 5-deoxy-5-chloroadenosine + L-methionine
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PATHWAY SOURCE
PATHWAYS
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