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Information on EC 2.5.1.75 - tRNA dimethylallyltransferase
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EC Tree
2.5.1.75 tRNA dimethylallyltransferaseIUBMB Comments
Formerly known as tRNA isopentenyltransferase, but it is now known that prenyl diphosphate, rather than isopentenyl diphosphate, is the substrate.
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Word Map
- 2.5.1.75
-
prenylation
-
farnesylation
-
geranylgeranylated
-
isopentenylation
-
isoprenoids
-
geranyl
-
farnesyltransferase
-
ubiad1
-
geranylgeranyltransferase
-
isoprenylation
- isoprene
-
meroterpenoids
-
schnyder
-
neosartorya
-
polyprenyl
-
aspartate-rich
- ftase
- menaquinone-4
- undecaprenyl
- dimethylallyltryptophan
-
tryptophan-containing
- agriculture
- glyceollins
- medicine
- dmats
-
nonsterol
- biotechnology
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Reaction Schemes
+
adenine37 in tRNA
=
+
N6-dimethylallyladenine37 in tRNA
Synonyms
prenyltransferase, trit1, trna isopentenyltransferase, trna-ipt, dmatase, trna ipt, mhipt3, noipt2, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
DELTA2-isopentenyl pyrophosphate:transfer ribonucleic acid DELTA2-isopentenyltransferase
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-
-
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DELTA2-isopentenyl pyrophosphate:tRNA-DELTA2-isopentenyl transferase
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-
-
-
dimethylallyl (DELTA2-isopentenyl)diphosphate-tRNA transferase
dimethylallyl(D2-isopentenyl) diphosphate:tRNA transferase
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EC 2.5.1.8
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-
formerly
-
IPT
isopentenyltransferase
isopentenyltransferase, transfer ribonucleate
-
-
-
-
MiaA
Mod5
transfer ribonucleate isopentenyltransferase
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-
-
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TRIT1
dimethylallyl (DELTA2-isopentenyl)diphosphate-tRNA transferase
-
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
dimethylallyl diphosphate + adenine37 in tRNA = diphosphate + N6-dimethylallyladenine37 in tRNA
dimethylallyl diphosphate + adenine37 in tRNA = diphosphate + N6-dimethylallyladenine37 in tRNA
mechanism
-
dimethylallyl diphosphate + adenine37 in tRNA = diphosphate + N6-dimethylallyladenine37 in tRNA
ordered sequential mechanism for substrate binding
-
dimethylallyl diphosphate + adenine37 in tRNA = diphosphate + N6-dimethylallyladenine37 in tRNA
ordered substrate binding
dimethylallyl diphosphate + adenine37 in tRNA = diphosphate + N6-dimethylallyladenine37 in tRNA
-
-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
alkenyl group transfer
-
-
-
-
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PATHWAY SOURCE
PATHWAYS
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SYSTEMATIC NAME
IUBMB Comments
dimethylallyl-diphosphate: tRNA dimethylallyltransferase
Formerly known as tRNA isopentenyltransferase, but it is now known that prenyl diphosphate, rather than isopentenyl diphosphate, is the substrate.
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CAS REGISTRY NUMBER
COMMENTARY
37277-78-4
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
dimethylallyl diphosphate + A37 nucleoside
N6-(D2-isopentenyl)adenine + diphosphate
-
-
-
?
dimethylallyl diphosphate + adenine37 in tRNA
diphosphate + N6-dimethylallyladenine37 in tRNA
dimethylallyl diphosphate + adenine37 in tRNA([Ser]Sec)
diphosphate + N6-dimethylallyladenine37 in tRNA([Ser]Sec)
dimethylallyl diphosphate + adenine37 in tRNAPhe
diphosphate + N6-dimethylallyladenine37 in tRNAPhe
-
-
enzyme transfers the dimethylallyl moiety of dimethylallyl diphosphate to A37, located adjacent to the anticodon in undermodified tRNAPhe
-
?
dimethylallyl diphosphate + adenine37 in tRNATrp
diphosphate + N6-dimethylallyladenine37 in tRNATrp
dimethylallyl diphosphate + adenosine 37 in tRNA
N6-(dimethylallyl)adenosine37 in tRNA + diphosphate
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-
-
-
?
dimethylallyl diphosphate + adenosine 37 in tRNA-Phe
N6-(dimethylallyl)adenosine37 in tRNAPhe + diphosphate
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-
-
-
?
dimethylallyl diphosphate + adenosine 37 in tRNACys
N6-(dimethylallyl)adenosine37 in tRNACys + diphosphate
-
-
-
?
dimethylallyl diphosphate + adenosine 37 in tRNASer
N6-(dimethylallyl)adenosine37 in tRNASer + diphosphate
dimethylallyl diphosphate + adenosine 37 in tRNATrpCCA
N6-(dimethylallyl)adenosine37 in tRNATrpCCA + diphosphate
dimethylallyl diphosphate + adenosine 37 in tRNATyr
N6-(dimethylallyl)adenosine37 in tRNATyr + diphosphate
-
-
-
?
dimethylallyl diphosphate + adenosine 37 in tRNATyrGUA
N6-(dimethylallyl)adenosine37 in tRNATyrGUA + diphosphate
-
-
-
?
dimethylallyl diphosphate + adenosine37 in tRNATrpCCA
N6-(dimethylallyl)adenosine37 in tRNATrpCCA + diphosphate
-
-
-
?
dimethylallyl diphosphate + GCGGACUCAAAAUCCGC
diphosphate + GCGGACUCAAAAUCCGC containing 6-dimethylallyladenosine
-
chemically synthesized 17-base RNA oligoribonucleotide minihelix based on variations in the anticodon stem-loop of unmodified Escherichia coli tRNAPhe
-
-
?
dimethylallyl diphosphate + GGCCAUUGAAAAUGGCC
diphosphate + GGCCAUUGAAAAUGGCC containing 6-dimethylallyladenosine
-
chemically synthesized 17-base RNA oligoribonucleotide minihelix based on variations in the anticodon stem-loop of unmodified Escherichia coli tRNAPhe
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-
?
dimethylallyl diphosphate + GGGAAUUGAAAAUUCCC
diphosphate + GGCCAUUGAAAAUGGCC containing 6-dimethylallyladenosine
-
chemically synthesized 17-base RNA oligoribonucleotide minihelix based on variations in the anticodon stem-loop of unmodified Escherichia coli tRNAPhe
-
-
?
dimethylallyl diphosphate + GGGCAUUGAAAAUGCCC
diphosphate + GGGCAUUGAAAAUGCCC containing 6-dimethylallyladenosine
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chemically synthesized 17-base RNA oligoribonucleotide minihelix based on variations in the anticodon stem-loop of unmodified Escherichia coli tRNAPhe
-
-
?
dimethylallyl diphosphate + GGGGAUUGAAAAAGGGG
diphosphate + GGGGAUUGAAAAAGGGG containing 6-dimethylallyladenosine
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chemically synthesized 17-base RNA random coil oligoribonucleotide based on variations in the anticodon stem-loop of unmodified Escherichia coli tRNAPhe
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-
?
dimethylallyl diphosphate + GGGGAUUGAAAAUCCCC
diphosphate + GGGGAUUGAAAAAGGGG containing 6-dimethylallyladenosine
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chemically synthesized 17-base RNA oligoribonucleotide minihelix based on variations in the anticodon stem-loop of unmodified Escherichia coli tRNAPhe
-
-
?
dimethylallyl diphosphate + GGGGAUUGAAAGUCCCC
diphosphate + GGGGAUUGAAAGUCCCC containing 6-dimethylallyladenosine
-
chemically synthesized 17-base RNA oligoribonucleotide minihelix based on variations in the anticodon stem-loop of unmodified Escherichia coli tRNAPhe
-
-
?
dimethylallyl diphosphate + GGGGAUUGAGAAUCCCC
diphosphate + GGGGAUUGAGAAUCCCC containing 6-dimethylallyladenosine
-
chemically synthesized 17-base RNA oligoribonucleotide minihelix based on variations in the anticodon stem-loop of unmodified Escherichia coli tRNAPhe
-
-
?
dimethylallyl diphosphate + GGGGGUUGAAAACCCCC
diphosphate + GGGGGUUGAAAACCCCC containing 6-dimethylallyladenosine
-
chemically synthesized 17-base RNA oligoribonucleotide minihelix based on variations in the anticodon stem-loop of unmodified Escherichia coli tRNAPhe
-
-
?
dimethylallyl diphosphate + oligo-RNA
oligo-RNA containing N6-(dimethylallyl)adenosine + diphosphate
substrates are 17-nt or 19-nt synthetic oligo-RNAs representing anticondon stem-loops as minihelix analogs of tRNAs. Only the anticodon stem-loops with a predicted stem of 6 bp are efficiently modified
-
-
?
dimethylallyl diphosphate + seventeen-base RNA oligonucleotide
diphosphate + seventeen-base RNA oligonucleotide containing 6-dimethylallyladenosine
-
sequence 5'GCGGACUCAAAAUCCGC3', RNA oligonucleotide based on the unmodified stem-loop region of tRNAPhe
-
-
?
dimethylallyl diphosphate + tRNATrpCCA
tRNATrpCCA containing N6-(dimethylallyl)adenosine + diphosphate
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-
-
?
dimethylallyl diphosphate + adenine37 in tRNA
diphosphate + N6-dimethylallyladenine37 in tRNA
-
-
-
-
?
dimethylallyl diphosphate + adenine37 in tRNA
diphosphate + N6-dimethylallyladenine37 in tRNA
-
-
-
-
?
dimethylallyl diphosphate + adenine37 in tRNA
diphosphate + N6-dimethylallyladenine37 in tRNA
-
-
-
?
dimethylallyl diphosphate + adenine37 in tRNA
diphosphate + N6-dimethylallyladenine37 in tRNA
-
-
-
-
?
dimethylallyl diphosphate + adenine37 in tRNA
diphosphate + N6-dimethylallyladenine37 in tRNA
-
regulates global physiology by unknown mechanisms
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-
?
dimethylallyl diphosphate + adenine37 in tRNA
diphosphate + N6-dimethylallyladenine37 in tRNA
-
-
-
-
?
dimethylallyl diphosphate + adenine37 in tRNA
diphosphate + N6-dimethylallyladenine37 in tRNA
-
tRNA lacking the isopentenyl modification normally present in vivo
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?
dimethylallyl diphosphate + adenine37 in tRNA
diphosphate + N6-dimethylallyladenine37 in tRNA
-
specific for DELTA2-isopentenyl phosphate
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?
dimethylallyl diphosphate + adenine37 in tRNA
diphosphate + N6-dimethylallyladenine37 in tRNA
-
recognition mode of substrate, structural features of substrate tRNA
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-
?
dimethylallyl diphosphate + adenine37 in tRNA
diphosphate + N6-dimethylallyladenine37 in tRNA
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mycoplasma species (kid) tRNA
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?
dimethylallyl diphosphate + adenine37 in tRNA
diphosphate + N6-dimethylallyladenine37 in tRNA
-
no reaction with DELTA3-isopentenyl diphosphate
-
?
dimethylallyl diphosphate + adenine37 in tRNA
diphosphate + N6-dimethylallyladenine37 in tRNA
-
-
-
?
dimethylallyl diphosphate + adenine37 in tRNA
diphosphate + N6-dimethylallyladenine37 in tRNA
-
-
-
ir
dimethylallyl diphosphate + adenine37 in tRNA
diphosphate + N6-dimethylallyladenine37 in tRNA
-
-
-
?
dimethylallyl diphosphate + adenine37 in tRNA
diphosphate + N6-dimethylallyladenine37 in tRNA
-
-
-
ir
dimethylallyl diphosphate + adenine37 in tRNA
diphosphate + N6-dimethylallyladenine37 in tRNA
-
specific for DELTA2-isopentenyl phosphate
-
?
dimethylallyl diphosphate + adenine37 in tRNA
diphosphate + N6-dimethylallyladenine37 in tRNA
-
no reaction with DELTA3-isopentenyl diphosphate
-
?
dimethylallyl diphosphate + adenine37 in tRNA
diphosphate + N6-dimethylallyladenine37 in tRNA
-
no reaction with homologous native tRNA or homologous, permanganate-treated tRNA (permanganate specifically cleaves the DELTA2-isopentenyl groups of tRNA leaving adenosine residues)
-
?
dimethylallyl diphosphate + adenine37 in tRNA
diphosphate + N6-dimethylallyladenine37 in tRNA
-
the enzyme from both yeast and rat liver catalyzes a significant incorporation of DELTA2-isopentenyl groups into untreated E. coli B tRNA
-
?
dimethylallyl diphosphate + adenine37 in tRNA
diphosphate + N6-dimethylallyladenine37 in tRNA
-
biosynthesis of N6-(DELTA2-isopentenyl)adenosine which several species of tRNA contain adjacent to the 3'-end of the anticodon
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-
?
dimethylallyl diphosphate + adenine37 in tRNA
diphosphate + N6-dimethylallyladenine37 in tRNA
-
-
-
?
dimethylallyl diphosphate + adenine37 in tRNA
diphosphate + N6-dimethylallyladenine37 in tRNA
-
-
-
?
dimethylallyl diphosphate + adenine37 in tRNA
diphosphate + N6-dimethylallyladenine37 in tRNA
-
-
-
?
dimethylallyl diphosphate + adenine37 in tRNA
diphosphate + N6-dimethylallyladenine37 in tRNA
-
no reaction with DELTA3-isopentenyl diphosphate
-
-
?
dimethylallyl diphosphate + adenine37 in tRNA([Ser]Sec)
diphosphate + N6-dimethylallyladenine37 in tRNA([Ser]Sec)
-
-
-
?
dimethylallyl diphosphate + adenine37 in tRNA([Ser]Sec)
diphosphate + N6-dimethylallyladenine37 in tRNA([Ser]Sec)
tRNA[Ser]Sec modification assay with [14C]DMAPP and in vitro transcribed tRNA[Ser]Sec. Incubation of in vitro transcribed tRNA[Ser]Sec with recombinant Trit1 transfers [14C]dimethylallyl diphosphate to tRNA[Ser]Sec reveals that 37A>G tRNA[Ser]Sec is resistant to isopentenylation by Trit1
-
-
?
dimethylallyl diphosphate + adenine37 in tRNATrp
diphosphate + N6-dimethylallyladenine37 in tRNATrp
isopentenylaion of the A37 within the ACSLTrp sequence, detailed spectrometrical reaction analysis, overview
-
-
?
dimethylallyl diphosphate + adenine37 in tRNATrp
diphosphate + N6-dimethylallyladenine37 in tRNATrp
isopentenylaion of the A37 within the ACSLTrp sequence, detailed spectrometrical reaction analysis, overview
-
-
?
dimethylallyl diphosphate + adenosine 37 in tRNASer
N6-(dimethylallyl)adenosine37 in tRNASer + diphosphate
-
-
-
?
dimethylallyl diphosphate + adenosine 37 in tRNASer
N6-(dimethylallyl)adenosine37 in tRNASer + diphosphate
-
-
-
?
dimethylallyl diphosphate + adenosine 37 in tRNATrpCCA
N6-(dimethylallyl)adenosine37 in tRNATrpCCA + diphosphate
-
-
-
?
dimethylallyl diphosphate + adenosine 37 in tRNATrpCCA
N6-(dimethylallyl)adenosine37 in tRNATrpCCA + diphosphate
-
-
-
?
additional information
?
-
-
enzyme does not bind dimethylallyl diphosphate in absence of tRNA
-
-
?
additional information
?
-
-
The A36-A37-A38 motif, which is completely conserved in tRNAs modified by the enzyme, is important for modification. A helix-loop structure is essential for recognition
-
-
?
additional information
?
-
enzyme recognizes the tRNA substrate through indirect sequence readout. The targeted nucleotide A37 flips out from the anticodon loop of tRNA and flips into a channel in DMATase, where it meets its reaction partner dimethylallyl diphosphate, which enters the channel from the opposite end. Structural changes accompanying the transfer reaction result in disengagement of DMATase-tRNA interaction near the reaction center
-
-
?
additional information
?
-
-
enzyme recognizes the tRNA substrate through indirect sequence readout. The targeted nucleotide A37 flips out from the anticodon loop of tRNA and flips into a channel in DMATase, where it meets its reaction partner dimethylallyl diphosphate, which enters the channel from the opposite end. Structural changes accompanying the transfer reaction result in disengagement of DMATase-tRNA interaction near the reaction center
-
-
?
additional information
?
-
the minimal substrate for bacterial MiaA is the anticodon stem loop (ACSL) of targeted tRNA molecules
-
-
?
additional information
?
-
the minimal substrate for bacterial MiaA is the anticodon stem loop (ACSL) of targeted tRNA molecules
-
-
?
additional information
?
-
anticondon stem-loops with substitutions as in Ser-G36, Ser-G37, and Ser-G36,G38 greatly diminish activity, and Ser-C38 and Ser-U38 are not modified, while Ser-G38 is a substrate
-
-
?
additional information
?
-
-
anticondon stem-loops with substitutions as in Ser-G36, Ser-G37, and Ser-G36,G38 greatly diminish activity, and Ser-C38 and Ser-U38 are not modified, while Ser-G38 is a substrate
-
-
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
dimethylallyl diphosphate + adenine37 in tRNA
diphosphate + N6-dimethylallyladenine37 in tRNA
dimethylallyl diphosphate + adenine37 in tRNA([Ser]Sec)
diphosphate + N6-dimethylallyladenine37 in tRNA([Ser]Sec)
-
-
-
?
dimethylallyl diphosphate + tRNATrpCCA
tRNATrpCCA containing N6-(dimethylallyl)adenosine + diphosphate
-
-
-
?
dimethylallyl diphosphate + adenine37 in tRNA
diphosphate + N6-dimethylallyladenine37 in tRNA
-
regulates global physiology by unknown mechanisms
-
-
?
dimethylallyl diphosphate + adenine37 in tRNA
diphosphate + N6-dimethylallyladenine37 in tRNA
-
-
-
ir
dimethylallyl diphosphate + adenine37 in tRNA
diphosphate + N6-dimethylallyladenine37 in tRNA
-
biosynthesis of N6-(DELTA2-isopentenyl)adenosine which several species of tRNA contain adjacent to the 3'-end of the anticodon
-
-
?
dimethylallyl diphosphate + adenine37 in tRNA
diphosphate + N6-dimethylallyladenine37 in tRNA
-
-
-
?
dimethylallyl diphosphate + adenine37 in tRNA
diphosphate + N6-dimethylallyladenine37 in tRNA
-
-
-
?
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Mg2+
Mn2+
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Adenocarcinoma of Lung
Ethnic differences in frequencies of gene polymorphisms in the MYCL1 region and modulation of lung cancer patients' survival.
African Swine Fever
The African swine fever virus prenyltransferase is an integral membrane trans-geranylgeranyl-diphosphate synthase.
Arthritis, Rheumatoid
Protein isoprenylation regulates secretion of matrix metalloproteinase 1 from rheumatoid synovial fibroblasts: effects of statins and farnesyl and geranylgeranyl transferase inhibitors.
Cardiomegaly
UBIAD1 expression is associated with cardiac hypertrophy in spontaneously hypertensive rats.
Cardiovascular Diseases
Depletion of ubiA prenyltransferase domain containing 1 expression promotes angiotensin II?induced hypertrophic response in AC16 human myocardial cells via modulating the expression levels of coenzyme Q10 and endothelial nitric oxide synthase.
Choroideremia
Dual chemical probes enable quantitative system-wide analysis of protein prenylation and prenylation dynamics.
Corneal Dystrophies, Hereditary
A Mouse Model of Schnyder Corneal Dystrophy with the N100S Point Mutation.
Corneal Dystrophies, Hereditary
A mutation in the UBIAD1 gene in a Han Chinese family with Schnyder corneal dystrophy.
Corneal Dystrophies, Hereditary
In Vivo Laser Confocal Microscopy Findings and Mutational Analysis for Schnyder's Crystalline Corneal Dystrophy.
Corneal Dystrophies, Hereditary
Long-Term Outcome After Penetrating Keratoplasty in a Pedigree With the G177E Mutation in the UBIAD1 Gene for Schnyder Corneal Dystrophy.
Corneal Dystrophies, Hereditary
Mutations in the UBIAD1 gene, encoding a potential prenyltransferase, are causal for Schnyder crystalline corneal dystrophy.
Corneal Dystrophies, Hereditary
Phenotype-genotype correlation in patients with schnyder corneal dystrophy.
Corneal Dystrophies, Hereditary
Schnyder Corneal Dystrophy-Associated UBIAD1 is Defective in MK-4 Synthesis and Resists Autophagy-Mediated Degradation.
Corneal Dystrophies, Hereditary
Structure of a membrane-embedded prenyltransferase homologous to UBIAD1.
Corneal Dystrophies, Hereditary
UBIAD1 mutation alters a mitochondrial prenyltransferase to cause Schnyder corneal dystrophy.
creatine kinase deficiency
Manipulation of cytokinin level in the ergot fungus Claviceps purpurea emphasizes its contribution to virulence.
Epilepsies, Myoclonic
Noninvasive diagnosis of TRIT1-related mitochondrial disorder by measuring i6 A37 and ms2 i6 A37 modifications in tRNAs from blood and urine samples.
Epilepsy
Matchmaking facilitates the diagnosis of an autosomal-recessive mitochondrial disease caused by biallelic mutation of the tRNA isopentenyltransferase (TRIT1) gene.
Genetic Diseases, Inborn
Structure of a membrane-embedded prenyltransferase homologous to UBIAD1.
Hepatitis C
Prenyltransferase Inhibitors: Treating Human Ailments from Cancer to Parasitic Infections.
Hypercholesterolemia
The tumor suppressor TERE1 (UBIAD1) prenyltransferase regulates the elevated cholesterol phenotype in castration resistant prostate cancer by controlling a program of ligand dependent SXR target genes.
Infections
Further investigations of race:cultivar-specific induction of enzymes related to phytoalexin biosynthesis in soybean roots following infection with Phytophthora megasperma f.sp. glycinea.
Ischemic Stroke
Effect of Coenzyme Q10 on Expression of UbiAd1 Gene in Rat Model of Local Cerebral Ischemia.
Leukemia, Myeloid, Acute
Is there a future for prenyltransferase inhibitors in cancer therapy?
Lung Neoplasms
Ethnic differences in frequencies of gene polymorphisms in the MYCL1 region and modulation of lung cancer patients' survival.
Lung Neoplasms
Gene Amplification-Associated Overexpression of the Selenoprotein tRNA Enzyme TRIT1 Confers Sensitivity to Arsenic Trioxide in Small-Cell Lung Cancer.
Lung Neoplasms
Identification and functional characterization of the candidate tumor suppressor gene TRIT1 in human lung cancer.
Lymphatic Metastasis
Association of polymorphisms and haplotype in the region of TRIT1, MYCL1 and MFSD2A with the risk and clinicopathological features of gastric cancer in a southeast Chinese population.
Malaria
Global proteomic analysis of prenylated proteins in Plasmodium falciparum using an alkyne-modified isoprenoid analogue.
Melanoma
Antimelanoma CTL recognizes peptides derived from an ORF transcribed from the antisense strand of the 3' untranslated region of TRIT1.
Microcephaly
Matchmaking facilitates the diagnosis of an autosomal-recessive mitochondrial disease caused by biallelic mutation of the tRNA isopentenyltransferase (TRIT1) gene.
Mitochondrial Diseases
Matchmaking facilitates the diagnosis of an autosomal-recessive mitochondrial disease caused by biallelic mutation of the tRNA isopentenyltransferase (TRIT1) gene.
Mitochondrial Diseases
Noninvasive diagnosis of TRIT1-related mitochondrial disorder by measuring i6 A37 and ms2 i6 A37 modifications in tRNAs from blood and urine samples.
Mitochondrial Diseases
The first Korean cases of combined oxidative phosphorylation deficiency 35 with two novel TRIT1 mutations in two siblings confirmed by clinical and molecular investigation.
Neoplasm Metastasis
Association of polymorphisms and haplotype in the region of TRIT1, MYCL1 and MFSD2A with the risk and clinicopathological features of gastric cancer in a southeast Chinese population.
Neoplasms
Antimelanoma CTL recognizes peptides derived from an ORF transcribed from the antisense strand of the 3' untranslated region of TRIT1.
Neoplasms
Association of polymorphisms and haplotype in the region of TRIT1, MYCL1 and MFSD2A with the risk and clinicopathological features of gastric cancer in a southeast Chinese population.
Neoplasms
Breast cancer cell targeting by prenylation inhibitors elucidated in living animals with a bioluminescence reporter.
Neoplasms
Circulating essential metals and lung cancer: Risk assessment and potential molecular effects.
Neoplasms
Direct evidence for the contribution of activated N-ras and K-ras oncogenes to increased intrinsic radiation resistance in human tumor cell lines.
Neoplasms
Evaluation of prenylated peptides for use in cellular imaging and biochemical analysis.
Neoplasms
Gene Amplification-Associated Overexpression of the Selenoprotein tRNA Enzyme TRIT1 Confers Sensitivity to Arsenic Trioxide in Small-Cell Lung Cancer.
Neoplasms
Human cells have a limited set of tRNA anticodon loop substrates of the tRNA isopentenyltransferase TRIT1 tumor suppressor.
Neoplasms
Identification and functional characterization of the candidate tumor suppressor gene TRIT1 in human lung cancer.
Neoplasms
Inhibiting Ras prenylation increases the radiosensitivity of human tumor cell lines with activating mutations of ras oncogenes.
Neoplasms
Inhibitors of farnesyltransferase and geranylgeranyltransferase-I for antitumor therapy: substrate-based design, conformational constraint and biological activity.
Neoplasms
Molecular targets for altering radiosensitivity: lessons from Ras as a pre-clinical and clinical model.
Neoplasms
Pancreatic cancer cell radiation survival and prenyltransferase inhibition: the role of K-Ras.
Neoplasms
Plasticity and diversity of tRNA anticodon determinants of substrate recognition by eukaryotic A37 isopentenyltransferases.
Neoplasms
Prenyltransferase Inhibitors: Treating Human Ailments from Cancer to Parasitic Infections.
Neoplasms
The cytoplasmic and nuclear populations of the eukaryote tRNA-isopentenyl transferase have distinct functions with implications in human cancer.
Neoplasms
The Role of Geranylgeranyltransferase I-Mediated Protein Prenylation in the Brain.
Neoplasms
The tumor suppressor TERE1 (UBIAD1) prenyltransferase regulates the elevated cholesterol phenotype in castration resistant prostate cancer by controlling a program of ligand dependent SXR target genes.
Pancreatic Neoplasms
Pancreatic cancer cell radiation survival and prenyltransferase inhibition: the role of K-Ras.
Parasitic Diseases
Prenyltransferase Inhibitors: Treating Human Ailments from Cancer to Parasitic Infections.
Parasitic Diseases
Protein prenylation: enzymes, therapeutics, and biotechnology applications.
Progeria
Prenyltransferase Inhibitors: Treating Human Ailments from Cancer to Parasitic Infections.
Prostatic Neoplasms
The tumor suppressor TERE1 (UBIAD1) prenyltransferase regulates the elevated cholesterol phenotype in castration resistant prostate cancer by controlling a program of ligand dependent SXR target genes.
Seizures
Noninvasive diagnosis of TRIT1-related mitochondrial disorder by measuring i6 A37 and ms2 i6 A37 modifications in tRNAs from blood and urine samples.
Stomach Neoplasms
Association of polymorphisms and haplotype in the region of TRIT1, MYCL1 and MFSD2A with the risk and clinicopathological features of gastric cancer in a southeast Chinese population.
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
additional information
additional information
-
KM of substrates and tRNA from various species
-
additional information
additional information
-
KM for tRNA substrates is around 3 nM
-
additional information
additional information
Michaelis-Menten steady-state kinetics
-
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TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE