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Information on EC - O-phospho-L-seryl-tRNA:Cys-tRNA synthase

for references in articles please use BRENDA:EC2.5.1.73
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IUBMB Comments
In organisms like Archaeoglobus fulgidus lacking EC (cysteine---tRNA ligase) for the direct Cys-tRNACys formation, Cys-tRNACys is produced by an indirect pathway, in which EC (O-phosphoseryl-tRNA ligase) ligates O-phosphoserine to tRNACys, and EC converts the produced O-phospho-L-seryl-tRNACys to Cys-tRNACys. The SepRS/SepCysS pathway is the sole route for cysteine biosynthesis in the organism . Methanosarcina mazei can use both pathways, the direct route using EC (cysteine---tRNA ligase) and the indirect pathway with EC (O-phosphoseryl-tRNA ligase) and EC .
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Word Map
  • acid-inducible
  • helicase
  • dsrnas
  • rig-i-mediated
  • rig-i-like
  • gene-i
  • 5'-triphosphate
  • toll-like
  • differentiation-associated
  • pamps
  • trim25
  • sendai
  • ifn-beta
  • pathogen-associated
  • k63-linked
  • rig-i-dependent
  • pattern-recognition
  • cys-trnacys
  • ifn-stimulated
  • polyi:c
  • blunt-ended
  • negative-stranded
  • ifn-mediated
  • rna-sensing
  • triphosphorylated
  • panhandle
  • nonself
  • 5'-triphosphorylated
  • cardif
  • paramyxoviruses
The expected taxonomic range for this enzyme is: Archaea, Bacteria
sepcyss, sep-trna:cys-trna synthase, sep-trna-cys-trna synthase, more
O-phospho-L-seryl-tRNACys + sulfide = L-cysteinyl-tRNACys + phosphate
show the reaction diagram
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