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Information on EC 2.5.1.61 - hydroxymethylbilane synthase

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IUBMB Comments
The enzyme works by stepwise addition of pyrrolylmethyl groups until a hexapyrrole is present at the active centre. The terminal tetrapyrrole is then hydrolysed to yield the product, leaving a cysteine-bound dipyrrole on which assembly continues. In the presence of a second enzyme, EC 4.2.1.75 uroporphyrinogen-III synthase, which is often called cosynthase, the product is cyclized to form uroporphyrinogen-III. If EC 4.2.1.75 is absent, the hydroxymethylbilane cyclizes spontaneously to form uroporphyrinogen I.
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Word Map
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
porphobilinogen deaminase, hmbs, pbg-d, uro-s, pbg deaminase, uroporphyrinogen i synthase, human porphobilinogen deaminase, uroporphyrinogen i synthetase, uroporphyrinogen synthase, human pbgd, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
4 porphobilinogen + H2O = hydroxymethylbilane + 4 NH3
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