Disease on EC 2.5.1.6 - methionine adenosyltransferase

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DISEASE
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Adenocarcinoma
Polyamine and methionine adenosyltransferase 2A crosstalk in human colon and liver cancer.
adenosine kinase deficiency
Consensus recommendations for the diagnosis, treatment and follow-up of inherited methylation disorders.
Alzheimer Disease
APLP1 Is a Synaptic Cell Adhesion Molecule, Supporting Maintenance of Dendritic Spines and Basal Synaptic Transmission.
Influence of vitamin B12 on brain methionine adenosyltransferase activity in senile dementia of the Alzheimer's type.
Amyotrophic Lateral Sclerosis
Methionine adenosyltransferase activity in erythrocytes and spinal cord of patients with sporadic amyotrophic lateral sclerosis.
Aortic Aneurysm, Thoracic
MAT2A mutations predispose individuals to thoracic aortic aneurysms.
Aortic Diseases
MAT2A mutations predispose individuals to thoracic aortic aneurysms.
Asthma
Do family physicians choose self-assessment activities based on what they know or don't know?
Atherosclerosis
Elevated serum concentrations of soluble adhesion molecules in coronary artery disease and acute myocardial infarction.
Statin-associated muscle symptoms: impact on statin therapy-European Atherosclerosis Society Consensus Panel Statement on Assessment, Aetiology and Management.
[Severe hypercholesterolaemia--when to use the proprotein convertase subtilisin-kexin type 9 protease inhibitors (PCSK9 inhibitors)? Polish Society of Cardiology experts' group statement].
Brain Diseases
The role of methanethiol in the pathogenesis of hepatic encephalopathy.
Breast Neoplasms
Genetic Variants in CD44 and MAT1A Confer Susceptibility to Acute Skin Reaction in Breast Cancer Patients Undergoing Radiation Therapy.
Induction of methionine adenosyltransferase 2A in tamoxifen-resistant breast cancer cells.
Modulation of gene expression in human central nervous system tumors under methionine deprivation-induced stress.
Carcinogenesis
Chemopreventive N-(4-hydroxyphenyl)retinamide (fenretinide) targets deregulated NF-{kappa}B and Mat1A genes in the early stages of rat liver carcinogenesis.
Epigenetic regulation of methionine adenosyltransferase 1A; a role for microRNA-based treatment in liver cancer?
Expression of methionine adenosyltransferase 2A in renal cell carcinomas and potential mechanism for kidney carcinogenesis.
Forced expression of methionine adenosyltransferase 1A in human hepatoma cells suppresses in vivo tumorigenicity in mice.
GNL3 and SKA3 are novel prostate cancer metastasis susceptibility genes.
Methionine adenosyltransferases in cancers: Mechanisms of dysregulation and implications for therapy.
MicroRNAs regulate methionine adenosyltransferase 1A expression in hepatocellular carcinoma.
Role of epigenetic and miR-22 and miR-29b alterations in the downregulation of Mat1a and Mthfr genes in early preneoplastic livers in rats induced by 2-acetylaminofluorene.
THE X PROTEIN OF HEPATITIS B VIRUS INHIBITS APOPTOSIS IN HEPATOMA CELLS THROUGH ENHANCING THE METHIONINE ADENOSYLTRANSFERASE 2A GENE EXPRESSION AND REDUCING S-ADENOSYL-METHIONINE PRODUCTION.
Carcinoma
Expression of methionine adenosyltransferase 2A in renal cell carcinomas and potential mechanism for kidney carcinogenesis.
Inhibition of hepatocelluar carcinoma MAT2A and MAT2beta gene expressions by single and dual small interfering RNA.
Lentivirus mediated shRNA interference targeting MAT2B induces growth-inhibition and apoptosis in hepatocelluar carcinoma.
Carcinoma, Ehrlich Tumor
Translation in vitro and regulation of mouse liver S-adenosylmethionine synthetase messenger RNA.
Carcinoma, Hepatocellular
5-Aza-2<-deoxycytidine induces hepatoma cell apoptosis via enhancing methionine adenosyltransferase 1A expression and inducing S-adenosylmethionine production.
A novel mechanism of the M1-M2 methionine adenosyltransferase switch-mediated hepatocellular carcinoma metastasis.
Activation of LKB1-Akt pathway independent of phosphoinositide 3-kinase plays a critical role in the proliferation of hepatocellular carcinoma from nonalcoholic steatohepatitis.
CD133+ liver cancer stem cells from methionine adenosyl transferase 1A-deficient mice demonstrate resistance to transforming growth factor (TGF)-beta-induced apoptosis.
Changes in S-adenosylmethionine synthetase in human liver cancer: molecular characterization and significance.
Characterization of a full-length cDNA encoding human liver S-adenosylmethionine synthetase: tissue-specific gene expression and mRNA levels in hepatopathies.
Characterization of rat liver-specific methionine adenosyltransferase gene promoter. Role of distal upstream cis-acting elements in the regulation of the transcriptional activity.
Chemotherapeutic potential of methionine analogue inhibitors of tumor-derived methionine adenosyltransferases.
Deregulation of methionine metabolism as determinant of progression and prognosis of hepatocellular carcinoma.
Differential effects of dimethylsulfoxide on S-adenosylmethionine synthetase from rat liver and hepatoma.
Differential expression of methionine adenosyltransferase genes influences the rate of growth of human hepatocellular carcinoma cells.
Effect of hepatocyte growth factor on methionine adenosyltransferase genes and growth is cell density-dependent in HepG2 cells.
Epigenetic regulation of methionine adenosyltransferase 1A; a role for microRNA-based treatment in liver cancer?
Expansion of liver cancer stem cells during aging in methionine adenosyltransferase 1A-deficient mice.
Expression of non-hepatic-type S-adenosylmethionine synthetase isozyme in rat hepatomas induced by 3'-methyl-4-dimethylaminoazobenzene.
Expression pattern, regulation, and functions of methionine adenosyltransferase 2beta splicing variants in hepatoma cells.
Forced expression of methionine adenosyltransferase 1A in human hepatoma cells suppresses in vivo tumorigenicity in mice.
Glucocorticoid regulation of hepatic S-adenosylmethionine synthetase gene expression.
Histological expression of methionine adenosyl transferase (MAT) 2A as a post-surgical prognostic surrogate in patients with hepatocellular carcinoma.
Hybrid immobilization of galactosyl lactose and cellobiose on a gold substrate to modulate biological responses.
Hypermethylation-repressed methionine adenosyltransferase 1A as a potential biomarker for hepatocellular carcinoma.
Hypoxia induces genomic DNA demethylation through the activation of HIF-1{alpha} and transcriptional up-regulation of MAT2A in hepatoma cells.
Impaired liver regeneration in mice lacking methionine adenosyltransferase 1A.
Induction of human methionine adenosyltransferase 2A expression by tumor necrosis factor alpha. Role of NF-kappa B and AP-1.
Inhibition of human methionine adenosyltransferase 1A transcription by coding region methylation.
Liver cell proliferation requires methionine adenosyltransferase 2A mRNA up-regulation.
Liver-specific deletion of prohibitin 1 results in spontaneous liver injury, fibrosis, and hepatocellular carcinoma in mice.
Liver-specific methionine adenosyltransferase MAT1A gene expression is associated with a specific pattern of promoter methylation and histone acetylation: implications for MAT1A silencing during transformation.
Methionine adenosyltransferase II beta subunit gene expression provides a proliferative advantage in human hepatoma.
Methionine adenosyltransferases in cancers: Mechanisms of dysregulation and implications for therapy.
MicroRNA-203 impacts on the growth, aggressiveness and prognosis of hepatocellular carcinoma by targeting MAT2A and MAT2B genes.
MicroRNA-21-3p, a Berberine-Induced miRNA, Directly Down-Regulates Human Methionine Adenosyltransferases 2A and 2B and Inhibits Hepatoma Cell Growth.
MicroRNAs regulate methionine adenosyltransferase 1A expression in hepatocellular carcinoma.
NADP+ binding to the regulatory subunit of methionine adenosyltransferase II increases intersubunit binding affinity in the hetero-trimer.
Pleiotropic effects of methionine adenosyltransferases deregulation as determinants of liver cancer progression and prognosis.
Proteome analysis of human hepatocellular carcinoma tissues by two-dimensional difference gel electrophoresis and mass spectrometry.
Proteomic analysis of human hepatoma cells expressing methionine adenosyltransferase I/III Characterization of DDX3X as a target of S-adenosylmethionine.
Reduced mRNA abundance of the main enzymes involved in methionine metabolism in human liver cirrhosis and hepatocellular carcinoma.
Role of methionine adenosyltransferase and S-adenosylmethionine in alcohol-associated liver cancer.
Role of promoter methylation in increased methionine adenosyltransferase 2A expression in human liver cancer.
S-Adenosylmethionine in cell growth, apoptosis and liver cancer.
S-adenosylmethionine in liver health, injury, and cancer.
S-adenosylmethionine stabilizes cystathionine beta-synthase and modulates redox capacity.
S-adenosylmethionine synthetase activity in some normal rat tissues and transplantable hepatomas.
S-Adenosylmethionine synthetase isozyme patterns from rat hepatoma induced by N-2-fluorenylacetamide.
Separation of different forms of S-adenosylmethionine synthetase by fast protein liquid chromatography.
Silencing MAT2A gene by RNA interference inhibited cell growth and induced apoptosis in human hepatoma cells.
Silencing of human methionine adenosyltransferase 1A expression by methylation of the coding region.
SNHG6 Acts as a Genome-Wide Hypomethylation Trigger via Coupling of miR-1297-Mediated S-Adenosylmethionine-Dependent Positive Feedback Loops.
Structure and function study of the complex that synthesizes S-adenosylmethionine.
The Oncogene PDRG1 Is an Interaction Target of Methionine Adenosyltransferases.
The role of c-Myb and Sp1 in the up-regulation of methionine adenosyltransferase 2A gene expression in human hepatocellular carcinoma.
THE X PROTEIN OF HEPATITIS B VIRUS INHIBITS APOPTOSIS IN HEPATOMA CELLS THROUGH ENHANCING THE METHIONINE ADENOSYLTRANSFERASE 2A GENE EXPRESSION AND REDUCING S-ADENOSYL-METHIONINE PRODUCTION.
Theoretical mechanisms for synthesis of carcinogen-induced embryonic proteins: XXIV. Repeated embryonic genes in liver.
Thyroid hormone receptor-mediated regulation of the methionine adenosyltransferase 1 gene is associated with cell invasion in hepatoma cell lines.
Carcinoma, Renal Cell
Expression of methionine adenosyltransferase 2A in renal cell carcinomas and potential mechanism for kidney carcinogenesis.
Cardiovascular Diseases
MAT1A variants are associated with hypertension, stroke, and markers of DNA damage and are modulated by plasma vitamin B-6 and folate.
New concepts in the management of dyslipidaemiaa.
Practical aspects in the management of statin-associated muscle symptoms (SAMS).
Stress-induced activation of the sympathetic nervous system.
Cholangiocarcinoma
Deregulated methionine adenosyltransferase ?1, c-myc and maf proteins interplay promotes cholangiocarcinoma growth in mice and humans.
Methionine adenosyltransferases in cancers: Mechanisms of dysregulation and implications for therapy.
Cholestasis
Deregulated methionine adenosyltransferase ?1, c-myc and maf proteins interplay promotes cholangiocarcinoma growth in mice and humans.
Cholestasis, Intrahepatic
[Screening for amino acid metabolic disorders of newborns in Zhejiang province:prevalence, outcome and follow-up].
Citrullinemia
[Screening for amino acid metabolic disorders of newborns in Zhejiang province:prevalence, outcome and follow-up].
Clubfoot
Effects of botulinum toxin-A on gait velocity, step length, and base of support of patients with dynamic equinovarus foot.
Colonic Neoplasms
Expression of methionine adenosyltransferase 2A in renal cell carcinomas and potential mechanism for kidney carcinogenesis.
Fluorinated N,N-Dialkylaminostilbenes Repress Colon Cancer by Targeting Methionine S-Adenosyltransferase 2A.
Insulin-like growth factor 1 activates methionine adenosyltransferase 2A transcription by multiple pathways in human colon cancer cells.
Methionine adenosyltransferase 2B-GIT1 complex serves as a scaffold to regulate Ras/Raf/MEK1/2 activity in human liver and colon cancer cells.
Methionine adenosyltransferase 2B-GIT1 interplay activates MEK1-ERK1/2 to induce growth in human liver and colon cancer.
Methionine adenosyltransferase ?2 sumoylation positively regulate Bcl-2 expression in human colon and liver cancer cells.
Polyamine and methionine adenosyltransferase 2A crosstalk in human colon and liver cancer.
Role of methionine adenosyltransferase 2A and S-adenosylmethionine in mitogen-induced growth of human colon cancer cells.
Colorectal Neoplasms
Correlation between the expression of methionine adenosyltransferase and the stages of human colorectal carcinoma.
Cullin 3 targets methionine adenosyltransferase II? for ubiquitylation-mediated degradation and regulates colorectal cancer cell proliferation.
Fluorinated N,N-Dialkylaminostilbenes Repress Colon Cancer by Targeting Methionine S-Adenosyltransferase 2A.
Congenital Abnormalities
Constitutive overexpression of cystathionine gamma-synthase in Arabidopsis leads to accumulation of soluble methionine and S-methylmethionine.
Coronary Disease
Elevated serum concentrations of soluble adhesion molecules in coronary artery disease and acute myocardial infarction.
cystathionine beta-synthase deficiency
Clinical and metabolic findings in patients with methionine adenosyltransferase I/III deficiency detected by newborn screening.
Glycine N -methyltransferase deficiency: a new patient with a novel mutation.
Newborn screening for homocystinurias: recent recommendations versus current practice.
Newborn screening for homocystinurias: Recent recommendations versus current practice.
cystathionine gamma-synthase deficiency
Cystathionine-synthase-deficient patients do not use the transamination pathway of methionine to reduce hypermethioninemia and homocystinemia.
Cysts
Nucleotide sequence and developmental expression of Acanthamoeba S-adenosylmethionine synthetase gene.
Dehydration
4-Mercaptophenylboronic acid SAMs on gold: comparison with SAMs derived from thiophenol, 4-mercaptophenol, and 4-mercaptobenzoic acid.
A gene expression analysis of syncytia laser microdissected from the roots of the Glycine max (soybean) genotype PI 548402 (Peking) undergoing a resistant reaction after infection by Heterodera glycines (soybean cyst nematode).
Dementia
Decreased methionine adenosyltransferase activity in erythrocytes of patients with dementia disorders.
Demyelinating Diseases
Demyelination of the brain is associated with methionine adenosyltransferase I/III deficiency.
Methionine adenosyltransferase I/III deficiency: novel mutations and clinical variations.
Molecular genetics of hepatic methionine adenosyltransferase deficiency.
Normal brain myelination in a patient homozygous for a mutation that encodes a severely truncated methionine adenosyltransferase I/III.
Dental Caries
Multilevel Analysis of Dental Caries in Swedish Children and Adolescents in Relation to Socioeconomic Status.
Dermatomyositis
Exercise training attenuates insulin resistance and improves ?-cell function in patients with systemic autoimmune myopathies: a pilot study.
Diabetes Mellitus
Maintenance of Certification for Family Physicians (MC-FP) Self Assessment Modules (SAMs): The First Year.
Diabetes Mellitus, Type 2
Maintenance of Certification for Family Physicians (MC-FP) Self Assessment Modules (SAMs): The First Year.
Protocol for SAMS (Support and Advice for Medication Study): a randomised controlled trial of an intervention to support patients with type 2 diabetes with adherence to medication.
Drug-Related Side Effects and Adverse Reactions
Role of genetics in the prediction of statin-associated muscle symptoms and optimization of statin use and adherence.
Endocarditis
[Efficacy evaluation of cloxacillin and cloxacillin-gentamicin in an experimental model of methicillin-sensitive Staphylococcus aureus]
Endometriosis
Identification of endometriosis-related genes by representational difference analysis of cDNA.
Essential Hypertension
Maintenance of Certification for Family Physicians (MC-FP) Self Assessment Modules (SAMs): The First Year.
Fatty Liver
Metabolomic Identification of Subtypes of Nonalcoholic Steatohepatitis.
Methionine adenosyltransferase 1A gene deletion disrupts hepatic VLDL assembly in mice.
Proteome analysis of human hepatocellular carcinoma tissues by two-dimensional difference gel electrophoresis and mass spectrometry.
Role of abnormal methionine metabolism in alcoholic liver injury.
S-Adenosylmethionine in cell growth, apoptosis and liver cancer.
S-adenosylmethionine in liver health, injury, and cancer.
S-adenosylmethionine stabilizes cystathionine beta-synthase and modulates redox capacity.
Foot Deformities
Effects of botulinum toxin-A on gait velocity, step length, and base of support of patients with dynamic equinovarus foot.
Fragile X Syndrome
Identification of distinct genes with restricted expression in the somitic mesoderm in Xenopus embryo.
Glioma
Histologic and morphometric grading of gliomas. A comparative survival analysis.
Heart Diseases
Clinical features related to statin-associated muscle symptoms.
Hepatitis
Acidic sphingomyelinase downregulates the liver-specific methionine adenosyltransferase 1A, contributing to tumor necrosis factor-induced lethal hepatitis.
Alterations of Methionine Metabolism as Potential Targets for the Prevention and Therapy of Hepatocellular Carcinoma.
Decreased activities of S-adenosylmethionine synthetase isozymes in hereditary hepatitis in Long-Evans rats.
Hepatitis B
Glucocorticoid-induced S-adenosylmethionine enhances the interferon signaling pathway by restoring STAT1 protein methylation in hepatitis B virus-infected cells.
Hypermethylation-repressed methionine adenosyltransferase 1A as a potential biomarker for hepatocellular carcinoma.
THE X PROTEIN OF HEPATITIS B VIRUS INHIBITS APOPTOSIS IN HEPATOMA CELLS THROUGH ENHANCING THE METHIONINE ADENOSYLTRANSFERASE 2A GENE EXPRESSION AND REDUCING S-ADENOSYL-METHIONINE PRODUCTION.
Hepatoblastoma
Characterization of rat liver-specific methionine adenosyltransferase gene promoter. Role of distal upstream cis-acting elements in the regulation of the transcriptional activity.
Homocystinuria
Biochemical basis for the dominant inheritance of hypermethioninemia associated with the R264H mutation of the MAT1A gene. A monomeric methionine adenosyltransferase with tripolyphosphatase activity.
Clinical and metabolic findings in patients with methionine adenosyltransferase I/III deficiency detected by newborn screening.
Cystathionine-synthase-deficient patients do not use the transamination pathway of methionine to reduce hypermethioninemia and homocystinemia.
Effect of hypermethioninemia on some parameters of oxidative stress and on Na(+),K (+)-ATPase activity in hippocampus of rats.
Homocystinuria: studies on cystathionine beta-synthase, S-adenosylmethionine synthetase and cystathionase activities in skin fibroblasts.
Hypermethioninaemia due to methionine adenosyltransferase I/III (MAT I/III) deficiency: Diagnosis in an expanded neonatal screening programme.
Reversible white matter lesion in methionine adenosyltransferase I/III deficiency.
Hydrocephalus
Evaluation of polymer and self-assembled monolayer-coated silicone surfaces to reduce neural cell growth.
Hyperargininemia
[Screening for amino acid metabolic disorders of newborns in Zhejiang province:prevalence, outcome and follow-up].
Hyperhomocysteinemia
Acute exercise alters homocysteine plasma concentration in an intensity-dependent manner due increased methyl flux in liver of rats.
Hypersensitivity
Immunomodulatory effects of mineral fibres in occupationally exposed workers.
Hypertension
Do family physicians choose self-assessment activities based on what they know or don't know?
Maintenance of Certification for Family Physicians (MC-FP) Self Assessment Modules (SAMs): The First Year.
MAT1A variants are associated with hypertension, stroke, and markers of DNA damage and are modulated by plasma vitamin B-6 and folate.
Illusions
Real-time decreased sensitivity to an audio-visual illusion during goal-directed reaching.
Infections
Cotton Leaf Curl Multan virus C4 protein suppresses both transcriptional and post-transcriptional gene silencing by interacting with SAM synthetase.
Culture and adenoviral infection of sinoatrial node myocytes from adult mice.
Disruption of the methionine cycle and reduced cellular gluthathione levels underlie potex-potyvirus synergism in Nicotiana benthamiana.
Gene Expression Analysis of Plum pox virus (Sharka) Susceptibility/Resistance in Apricot (Prunus armeniaca L.).
Gene switching in Amoeba proteus caused by endosymbiotic bacteria.
Methods for the Isolation, Culture, and Functional Characterization of Sinoatrial Node Myocytes from Adult Mice.
Overexpression of the tomato Asc-1 gene mediates high insensitivity to AAL toxins and fumonisin B1 in tomato hairy roots and confers resistance to Alternaria alternata f. sp. lycopersici in Nicotiana umbratica plants.
Resistance against Ralstonia solanacearum in tomato depends on the methionine cycle and the ?-aminobutyric acid metabolic pathway.
THE X PROTEIN OF HEPATITIS B VIRUS INHIBITS APOPTOSIS IN HEPATOMA CELLS THROUGH ENHANCING THE METHIONINE ADENOSYLTRANSFERASE 2A GENE EXPRESSION AND REDUCING S-ADENOSYL-METHIONINE PRODUCTION.
Transcriptional regulation of genes involved in the pathways of biosynthesis and supply of methyl units in response to powdery mildew attack and abiotic stresses in wheat.
Infertility
Evaluation of various cleaning methods to remove bacillus spores from spacecraft hardware materials.
Influenza, Human
Detection of influenza virus by a biosensor based on the method combining electrochemiluminescence on binary SAMs modified Au electrode with an immunoliposome encapsulating Ru (II) complex.
Intellectual Disability
Identification of distinct genes with restricted expression in the somitic mesoderm in Xenopus embryo.
Leukemia
Differential kinetic properties of L-2-amino-4-methylthio-cis-but-3-enoic acid, a methionine analog inhibitor of S-adenosylmethionine synthetase.
Estrogen-responsive gene networks in the teleost liver: What are the key molecular indicators?
S-adenosylmethionine synthetase is overexpressed in murine neuroblastoma cells resistant to nucleoside analogue inhibitors of S-adenosylhomocysteine hydrolase: a novel mechanism of drug resistance.
Leukemia, Erythroblastic, Acute
Effect of biomaterial surface properties on fibronectin-alpha5beta1 integrin interaction and cellular attachment.
Leukemia, Lymphocytic, Chronic, B-Cell
S-Adenosylmethionine synthetase from human lymphocytes. Purification and characterization.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Quercetin Promotes Cell Cycle Arrest and Apoptosis and Attenuates the Proliferation of Human Chronic Myeloid Leukemia Cell Line-K562 Through Interaction with HSPs (70 and 90), MAT2A and FOXM1.
Liver Cirrhosis
Activation of LKB1-Akt pathway independent of phosphoinositide 3-kinase plays a critical role in the proliferation of hepatocellular carcinoma from nonalcoholic steatohepatitis.
Ameliorative effect of Ganoderma lucidum on carbon tetrachloride-induced liver fibrosis in rats.
Inactivation and dissociation of S-adenosylmethionine synthetase by modification of sulfhydryl groups and its possible occurrence in cirrhosis.
Inhibition of liver methionine adenosyltransferase gene expression by 3-methylcolanthrene: protective effect of S-adenosylmethionine.
Reduced mRNA abundance of the main enzymes involved in methionine metabolism in human liver cirrhosis and hepatocellular carcinoma.
Scar-associated macrophages are a major source of hepatic matrix metalloproteinase-13 and facilitate the resolution of murine hepatic fibrosis.
Specific loss of the high-molecular-weight form of S-adenosyl-L-methionine synthetase in human liver cirrhosis.
Liver Cirrhosis, Alcoholic
Abnormal metabolism of S-adenosyl-L-methionine in hypoxic rat liver. Similarities to its abnormal metabolism in alcoholic cirrhosis.
Characterization of a full-length cDNA encoding human liver S-adenosylmethionine synthetase: tissue-specific gene expression and mRNA levels in hepatopathies.
Liver Diseases
Acidic sphingomyelinase downregulates the liver-specific methionine adenosyltransferase 1A, contributing to tumor necrosis factor-induced lethal hepatitis.
Expansion of liver cancer stem cells during aging in methionine adenosyltransferase 1A-deficient mice.
Methionine adenosyltransferase and liver disease: it's all about SAM.
Methionine adenosyltransferases in liver cancer.
Structure and function study of the complex that synthesizes S-adenosylmethionine.
Liver Diseases, Alcoholic
Inhibition of liver methionine adenosyltransferase gene expression by 3-methylcolanthrene: protective effect of S-adenosylmethionine.
Methionine adenosyltransferase and S-adenosylmethionine in alcoholic liver disease.
Role of methionine adenosyltransferase and S-adenosylmethionine in alcohol-associated liver cancer.
Liver Failure
Acidic sphingomyelinase downregulates the liver-specific methionine adenosyltransferase 1A, contributing to tumor necrosis factor-induced lethal hepatitis.
Liver Neoplasms
Changes in S-adenosylmethionine synthetase in human liver cancer: molecular characterization and significance.
Changes in the expression of methionine adenosyltransferase genes and S-adenosylmethionine homeostasis during hepatic stellate cell activation.
Cloning and functional characterization of the 5'-flanking region of human methionine adenosyltransferase 1A gene.
Differential effect of thioacetamide on hepatic methionine adenosyltransferase expression in the rat.
Differential expression of methionine adenosyltransferase genes influences the rate of growth of human hepatocellular carcinoma cells.
Epithelial-to-mesenchymal transition of murine liver tumor cells promotes invasion.
Expansion of liver cancer stem cells during aging in methionine adenosyltransferase 1A-deficient mice.
Fluorinated N,N-Dialkylaminostilbenes Repress Colon Cancer by Targeting Methionine S-Adenosyltransferase 2A.
Forced expression of methionine adenosyltransferase 1A in human hepatoma cells suppresses in vivo tumorigenicity in mice.
Hypoxia induces genomic DNA demethylation through the activation of HIF-1{alpha} and transcriptional up-regulation of MAT2A in hepatoma cells.
Leptin's mitogenic effect in human liver cancer cells requires induction of both methionine adenosyltransferase 2A and 2beta.
Liver-specific methionine adenosyltransferase MAT1A gene expression is associated with a specific pattern of promoter methylation and histone acetylation: implications for MAT1A silencing during transformation.
Methionine adenosyltransferase 2B, HuR, and sirtuin 1 protein cross-talk impacts on the effect of resveratrol on apoptosis and growth in liver cancer cells.
Methionine adenosyltransferase ?2 sumoylation positively regulate Bcl-2 expression in human colon and liver cancer cells.
Methionine adenosyltransferases in cancers: Mechanisms of dysregulation and implications for therapy.
MicroRNA-203 impacts on the growth, aggressiveness and prognosis of hepatocellular carcinoma by targeting MAT2A and MAT2B genes.
Polyamine and methionine adenosyltransferase 2A crosstalk in human colon and liver cancer.
Role of methionine adenosyltransferase and S-adenosylmethionine in alcohol-associated liver cancer.
Role of promoter methylation in increased methionine adenosyltransferase 2A expression in human liver cancer.
S-Adenosylmethionine and methylthioadenosine inhibit ?-catenin signaling by multiple mechanisms in liver and colon cancer.
Silencing MAT2A gene by RNA interference inhibited cell growth and induced apoptosis in human hepatoma cells.
THE X PROTEIN OF HEPATITIS B VIRUS INHIBITS APOPTOSIS IN HEPATOMA CELLS THROUGH ENHANCING THE METHIONINE ADENOSYLTRANSFERASE 2A GENE EXPRESSION AND REDUCING S-ADENOSYL-METHIONINE PRODUCTION.
Liver Neoplasms, Experimental
Changes in S-adenosylmethionine synthetase in human liver cancer: molecular characterization and significance.
Isozyme-specific enzyme inhibitors. 10. Adenosine 5'-triphosphate derivatives as substrates or inhibitors of methionine adenosyltransferases of rat normal and hepatoma tissues.
Lung Injury
Impaired alveolar macrophage function in smoke inhalation injury.
Maple Syrup Urine Disease
[Screening for amino acid metabolic disorders of newborns in Zhejiang province:prevalence, outcome and follow-up].
methionine adenosyltransferase deficiency
Association of demyelination with deficiency of cerebrospinal-fluid S-adenosylmethionine in inborn errors of methyl-transfer pathway.
Cystathionine-synthase-deficient patients do not use the transamination pathway of methionine to reduce hypermethioninemia and homocystinemia.
Effect of hypermethioninemia on some parameters of oxidative stress and on Na(+),K (+)-ATPase activity in hippocampus of rats.
Hepatic methionine adenosyltransferase deficiency in a 31-year-old man.
Hypermethioninemia associated with methionine adenosyltransferase deficiency: clinical, morphologic, and biochemical observations on four patients.
Hypermethioninemia in an infant.
Inherited disorders in the conversion of methionine to homocysteine.
Methionine adenosyltransferase deficiency: new enzymatic defect associated with hypermethioninemia.
Methionine Adenosyltransferase I/III Deficiency in Portugal: High Frequency of a Dominantly Inherited Form in a Small Area of Douro High Lands.
Mild Persistent Isolated Hypermethioninemia Identified through Newborn Screening in Michigan.
Molecular genetics of hepatic methionine adenosyltransferase deficiency.
Molecular mechanisms of an inborn error of methionine pathway. Methionine adenosyltransferase deficiency.
Reversible leukoencephalopathy with acute neurological deterioration and permanent residua in classical homocystinuria: A case report.
Rickettsial metK-encoded methionine adenosyltransferase expression in an Escherichia coli metK deletion strain.
S-adenosylmethionine treatment in methionine adenosyltransferase deficiency, a case report.
Spectrum of hypermethioninemia in neonatal screening.
Transamination of methionine in humans.
Transsulfuration in an adult with hepatic methionine adenosyltransferase deficiency.
[Screening for amino acid metabolic disorders of newborns in Zhejiang province:prevalence, outcome and follow-up].
[Still another cause of hypermethioninemia in children: S-adenosylmethionine synthetase deficiency]
methylenetetrahydrofolate dehydrogenase (nad+) deficiency
Newborn screening for homocystinurias: recent recommendations versus current practice.
Newborn screening for homocystinurias: Recent recommendations versus current practice.
Reversible leukoencephalopathy with acute neurological deterioration and permanent residua in classical homocystinuria: A case report.
Multiple Sclerosis
A Randomized Controlled Trial of Cognitive Behavioral Therapy (CBT) for Adjusting to Multiple Sclerosis (the saMS Trial): Does CBT Work and for Whom Does It Work?
Protocol for the saMS trial (supportive adjustment for multiple sclerosis): a randomized controlled trial comparing cognitive behavioral therapy to supportive listening for adjustment to multiple sclerosis.
Muscle Weakness
Physical exercise among patients with systemic autoimmune myopathies.
Muscular Diseases
Curcumin: An effective adjunct in patients with statin-associated muscle symptoms?
Statin-associated muscle symptoms (SAMS) in primary prevention for cardiovascular disease in older adults: a protocol for a systematic review and meta-analysis of randomised controlled trials.
Statin-associated muscle symptoms: impact on statin therapy-European Atherosclerosis Society Consensus Panel Statement on Assessment, Aetiology and Management.
Myalgia
Does Coenzyme Q10 Supplementation Mitigate Statin-Associated Muscle Symptoms? Pharmacological and Methodological Considerations.
Low vitamin D does not predict statin associated muscle symptoms but is associated with transient increases in muscle damage and pain.
Statin-Associated Muscle Disease: Advances in Diagnosis and Management.
Statin-associated muscle symptoms: impact on statin therapy-European Atherosclerosis Society Consensus Panel Statement on Assessment, Aetiology and Management.
Statin-Associated Side Effects.
Validation of a clinically-relevant rodent model of statin-associated muscle symptoms for use in pharmacological studies.
Vitamin D Supplementation to Treat Statin-Associated Muscle Symptoms: A Review.
Myocardial Infarction
Elevated serum concentrations of soluble adhesion molecules in coronary artery disease and acute myocardial infarction.
Myotoxicity
Validation of a clinically-relevant rodent model of statin-associated muscle symptoms for use in pharmacological studies.
Myxoma
Giant superficial angiomyxoma of the vulva: a case report and review of the literature.
Neoplasm Metastasis
A novel mechanism of the M1-M2 methionine adenosyltransferase switch-mediated hepatocellular carcinoma metastasis.
Epigenetic regulation of methionine adenosyltransferase 1A; a role for microRNA-based treatment in liver cancer?
MicroRNAs regulate methionine adenosyltransferase 1A expression in hepatocellular carcinoma.
Overexpression of methionine adenosyltransferase II alpha (MAT2A) in gastric cancer and induction of cell cycle arrest and apoptosis in SGC-7901 cells by shRNA-mediated silencing of MAT2A gene.
Neoplasms
A novel mechanism of the M1-M2 methionine adenosyltransferase switch-mediated hepatocellular carcinoma metastasis.
Acetylation of MAT II? represses tumour cell growth and is decreased in human hepatocellular cancer.
Acidic sphingomyelinase downregulates the liver-specific methionine adenosyltransferase 1A, contributing to tumor necrosis factor-induced lethal hepatitis.
Activation of LKB1-Akt pathway independent of phosphoinositide 3-kinase plays a critical role in the proliferation of hepatocellular carcinoma from nonalcoholic steatohepatitis.
Alterations of Methionine Metabolism as Potential Targets for the Prevention and Therapy of Hepatocellular Carcinoma.
Bone resorbing activity of surface-associated material from Actinobacillus actinomycetemcomitans and Eikenella corrodens.
Demonstration of an altered S-adenosylmethionine synthetase in human malignant tumors xenografted into athymic nude mice.
Dendritic cell responses to self-assembled monolayers of defined chemistries.
Differences in the active-site region of tumor versus normal isozymes of mammalian ATP:L-methionine S-adenosyltransferase.
Epithelial-to-mesenchymal transition of murine liver tumor cells promotes invasion.
Expression and subcellular localization of Ewing sarcoma (EWS) protein is affected by the methylation process.
Expression of methionine adenosyltransferase 2A in renal cell carcinomas and potential mechanism for kidney carcinogenesis.
Expression pattern, regulation, and functions of methionine adenosyltransferase 2beta splicing variants in hepatoma cells.
Fluorinated N,N-Dialkylaminostilbenes Repress Colon Cancer by Targeting Methionine S-Adenosyltransferase 2A.
Forced expression of methionine adenosyltransferase 1A in human hepatoma cells suppresses in vivo tumorigenicity in mice.
Generation, annotation, analysis and database integration of 16,500 white spruce EST clusters.
Giant superficial angiomyxoma of the vulva: a case report and review of the literature.
Histological expression of methionine adenosyl transferase (MAT) 2A as a post-surgical prognostic surrogate in patients with hepatocellular carcinoma.
Hypermethylation-repressed methionine adenosyltransferase 1A as a potential biomarker for hepatocellular carcinoma.
Hypoxia induces genomic DNA demethylation through the activation of HIF-1{alpha} and transcriptional up-regulation of MAT2A in hepatoma cells.
Induction of human methionine adenosyltransferase 2A expression by tumor necrosis factor alpha. Role of NF-kappa B and AP-1.
Mechanisms of MAFG Dysregulation in Cholestatic Liver Injury and Development of Liver Cancer.
Methionine adenosyltransferase ?2 sumoylation positively regulate Bcl-2 expression in human colon and liver cancer cells.
Methionine adenosyltransferase II beta subunit gene expression provides a proliferative advantage in human hepatoma.
Methionine adenosyltransferases in cancers: Mechanisms of dysregulation and implications for therapy.
Methionine is a metabolic dependency of tumor-initiating cells.
MicroRNA-21-3p, a Berberine-Induced miRNA, Directly Down-Regulates Human Methionine Adenosyltransferases 2A and 2B and Inhibits Hepatoma Cell Growth.
Mixed self-assembled monolayers (SAMs) consisting of methoxy-tri(ethylene glycol)-terminated and alkyl-terminated dimethylchlorosilanes control the non-specific adsorption of proteins at oxidic surfaces.
Mutations in the S-Adenosylmethionine Synthetase Genes SAM1 and SAM2 Differentially Affect Genome Stability in Saccharomyces cerevisiae.
Overexpression of methionine adenosyltransferase II alpha (MAT2A) in gastric cancer and induction of cell cycle arrest and apoptosis in SGC-7901 cells by shRNA-mediated silencing of MAT2A gene.
Oxygen nanobubbles revert hypoxia by methylation programming.
Partial purification and characterization of tumor and liver S-adenosylmethionine synthetases.
PARTICLE - The RNA podium for genomic silencers.
PARTICLE, a Triplex-Forming Long ncRNA, Regulates Locus-Specific Methylation in Response to Low-Dose Irradiation.
Prostate-specific genes and their regulation by dihydrotestosterone.
Protein expression during lag phase and growth initiation in Saccharomyces cerevisiae.
Resistance to inhibitors of S-adenosyl-L-homocysteine hydrolase in C1300 murine neuroblastoma tumor cells is associated with increased methionine adenosyltransferase activity.
Role of promoter methylation in increased methionine adenosyltransferase 2A expression in human liver cancer.
S-adenosylmethionine biosynthesis is a targetable metabolic vulnerability of cancer stem cells.
S-Adenosylmethionine in cell growth, apoptosis and liver cancer.
Silencing MAT2A gene by RNA interference inhibited cell growth and induced apoptosis in human hepatoma cells.
Spontaneous oxidative stress and liver tumors in mice lacking methionine adenosyltransferase 1A.
Studies on the activities of some methyltransferases in the livers and tumor cells from tumor-bearing mice.
Targeting S-adenosylmethionine biosynthesis with a novel allosteric inhibitor of Mat2A.
The role of c-Myb and Sp1 in the up-regulation of methionine adenosyltransferase 2A gene expression in human hepatocellular carcinoma.
The Transition-State Structure for Human MAT2A from Isotope Effects.
THE X PROTEIN OF HEPATITIS B VIRUS INHIBITS APOPTOSIS IN HEPATOMA CELLS THROUGH ENHANCING THE METHIONINE ADENOSYLTRANSFERASE 2A GENE EXPRESSION AND REDUCING S-ADENOSYL-METHIONINE PRODUCTION.
Transcription of the MAT2A gene, coding for methionine adenosyltransferase, is up-regulated by E2F and Sp1 at a chromatin level during proliferation of liver cells.
Translation in vitro and regulation of mouse liver S-adenosylmethionine synthetase messenger RNA.
Unfolding IGDQ Peptides for Engineering Motogenic Interfaces.
Neuroblastoma
Regulation of methionine adenosyltransferase catalytic activity and messenger RNA in SH-SY5Y human neuroblastoma cells.
Resistance to inhibitors of S-adenosyl-L-homocysteine hydrolase in C1300 murine neuroblastoma tumor cells is associated with increased methionine adenosyltransferase activity.
S-adenosylmethionine synthetase is overexpressed in murine neuroblastoma cells resistant to nucleoside analogue inhibitors of S-adenosylhomocysteine hydrolase: a novel mechanism of drug resistance.
Neurologic Manifestations
Methionine adenosyltransferase I/III deficiency: Neurological manifestations and relevance of S-adenosylmethionine.
Non-alcoholic Fatty Liver Disease
Activation of LKB1-Akt pathway independent of phosphoinositide 3-kinase plays a critical role in the proliferation of hepatocellular carcinoma from nonalcoholic steatohepatitis.
Methionine adenosyltransferase 1A gene deletion disrupts hepatic VLDL assembly in mice.
Spontaneous oxidative stress and liver tumors in mice lacking methionine adenosyltransferase 1A.
Obesity
Differential representation of liver proteins in obese human subjects suggests novel biomarkers and promising targets for drug development in obesity.
Effect of maternal folic acid supplementation on hepatic one-carbon unit associated gene expressions in newborn piglets.
Macrophages in obesity.
Spontaneous oxidative stress and liver tumors in mice lacking methionine adenosyltransferase 1A.
Sympathetic neuron-associated macrophages contribute to obesity by importing and metabolizing norepinephrine.
Osteoporosis
Statistical Shape and Appearance Models in Osteoporosis.
Pancreatitis
Role of S-adenosylmethionine in two experimental models of pancreatitis.
Phenylketonurias
[Screening for amino acid metabolic disorders of newborns in Zhejiang province:prevalence, outcome and follow-up].
Precancerous Conditions
A signature of six genes highlights defects on cell growth and specific metabolic pathways in murine and human hepatocellular carcinoma.
Prostatic Neoplasms
Editorial Comment to: SAMS: A randomized study comparing two different follow-up schedules for active surveillance of low-risk prostate cancer.
Methionine adenosyltransferases in cancers: Mechanisms of dysregulation and implications for therapy.
The Study of Active Monitoring in Sweden (SAMS): A randomized study comparing two different follow-up schedules for active surveillance of low-risk prostate cancer.
Renal Insufficiency
Messenger RNA for enzymes of ornithine and polyamine metabolism are selectively underexpressed in kidney of 5/6 nephrectomized rats.
Rhabdomyolysis
Curcumin: An effective adjunct in patients with statin-associated muscle symptoms?
Statin intolerance.
Statin-associated muscle symptoms (SAMS) in primary prevention for cardiovascular disease in older adults: a protocol for a systematic review and meta-analysis of randomised controlled trials.
Treatment Options for Statin-Associated Muscle Symptoms.
Sarcoma
Giant superficial angiomyxoma of the vulva: a case report and review of the literature.
Sarcoma, Avian
Cycloleucine blocks 5'-terminal and internal methylations of avian sarcoma virus genome RNA.
Shock, Septic
Regulation of rat liver S-adenosylmethionine synthetase during septic shock: role of nitric oxide.
Spinal Cord Diseases
Exclusively epidural spinal metameric arteriovenous shunts: case report and literature review.
Spinal Cord Vascular Diseases
Exclusively epidural spinal metameric arteriovenous shunts: case report and literature review.
Starvation
A dual regulatory circuit consisting of S-adenosylmethionine decarboxylase protein and its reaction product controls expression of the paralogous activator prozyme in Trypanosoma brucei.
L-methionine availability regulates expression of the methionine adenosyltransferase 2A gene in human hepatocarcinoma cells: role of S-adenosylmethionine.
Positive regulation of transcription of homeoprotein-encoding YHP1 by the two-component regulator Sln1 in Saccharomyces cerevisiae.
Requirement of ATP in bacterial chemotaxis.
The U6 snRNA m(6)A Methyltransferase METTL16 Regulates SAM Synthetase Intron Retention.
Transcription termination control of the S box system: direct measurement of S-adenosylmethionine by the leader RNA.
YHP1 encodes a new homeoprotein that binds to the IME1 promoter in Saccharomyces cerevisiae.
[Differential protein analysis on the root response of rice with high phosphorous uptake efficiency to low phosphorous stress].
Stomach Neoplasms
Overexpression of methionine adenosyltransferase II alpha (MAT2A) in gastric cancer and induction of cell cycle arrest and apoptosis in SGC-7901 cells by shRNA-mediated silencing of MAT2A gene.
Stroke
MAT1A variants are associated with hypertension, stroke, and markers of DNA damage and are modulated by plasma vitamin B-6 and folate.
Subacute Combined Degeneration
Distal motor axonopathy and central nervous system myelin vacuolation caused by cycloleucine, an inhibitor of methionine adenosyltransferase.
Subarachnoid Hemorrhage
Exclusively epidural spinal metameric arteriovenous shunts: case report and literature review.
Thrombosis
Study of fibrinogen adsorption on self-assembled monolayers on Au(111) by atomic force microscopy.
Tics
Methionine is a metabolic dependency of tumor-initiating cells.
Trypanosomiasis, African
S-adenosylmethionine synthetase in bloodstream Trypanosoma brucei.
Tuberculosis
Characterisation of methionine adenosyltransferase from Mycobacterium smegmatis and M. tuberculosis.
Comparative protein modeling of methionine S-adenosyltransferase (MAT) enzyme from Mycobacterium tuberculosis: a potential target for antituberculosis drug discovery.
Tyrosinemias
Hypermethioninemia in an infant.
Virus Diseases
A viral protein promotes host SAMS1 activity and ethylene production for the benefit of virus infection.
Vitamin D Deficiency
Vitamin D Serum Levels in Patients with Statin-Induced Musculoskeletal Pain.
Vitamin D Supplementation to Treat Statin-Associated Muscle Symptoms: A Review.