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Information on EC 2.5.1.6 - methionine adenosyltransferase
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2.5.1.6 methionine adenosyltransferaseSpecify your search results
Word Map
- 2.5.1.6
- monolayers
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self-assembled
- gold
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film
- alkanethiols
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photoelectron
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infrared
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fabric
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electrode
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electrochemical
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tunnel
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voltammetry
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coverage
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interfacial
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ellipsometry
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impedance
- s-adenosylhomocysteine
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thiolate
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silicon
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photoemission
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electrochemistry
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well-ordered
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photovoltaic
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wafer
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large-area
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transistor
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transmethylation
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semiconductor
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nanoscopic
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field-effect
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close-packed
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stamp
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photolithography
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wettabl
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nanopatterns
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polycrystalline
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electroless
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thin-film
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chemisorption
- drug development
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lithography
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microcontact
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fermi
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headgroups
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wettability
- synthesis
- medicine
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micropatterned
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microbalance
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silane
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statin-associated
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transsulfuration
- ferrocene
The enzyme appears in viruses and cellular organisms
Synonyms
sams, mat2a, methionine adenosyltransferase, mat1a, s-adenosylmethionine synthetase, adomet synthetase, sam synthetase, mat ii, matalpha2, s-adenosyl-l-methionine synthetase, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
adenosylmethionine synthetase
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AdoMet synthetase
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ATP-methionine adenosyltransferase
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methionine adenosyltransferase
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methionine S-adenosyltransferase
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methionine-activating enzyme
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S-adenosyl-L-methionine synthetase
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S-adenosylmethionine synthase
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S-adenosylmethionine synthetase
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
adenosyl group transfer
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PATHWAY SOURCE
PATHWAYS
BRENDA
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-, -, -, -, -, -
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SYSTEMATIC NAME
IUBMB Comments
ATP:L-methionine S-adenosyltransferase
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CAS REGISTRY NUMBER
COMMENTARY
9012-52-6
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
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-
-
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + L-methionine + H2O
phosphate + diphosphate + S-adenosyl-L-methionine
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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acquired Immunodeficiency Syndrome
[Do ethical guidelines provide assistance in clinical practice?]
Adenocarcinoma
Polyamine and methionine adenosyltransferase 2A crosstalk in human colon and liver cancer.
adenosine kinase deficiency
Consensus recommendations for the diagnosis, treatment and follow-up of inherited methylation disorders.
Alzheimer Disease
APLP1 Is a Synaptic Cell Adhesion Molecule, Supporting Maintenance of Dendritic Spines and Basal Synaptic Transmission.
Alzheimer Disease
Decreased methionine adenosyltransferase activity in erythrocytes of patients with dementia disorders.
Alzheimer Disease
Influence of vitamin B12 on brain methionine adenosyltransferase activity in senile dementia of the Alzheimer's type.
Amyotrophic Lateral Sclerosis
Methionine adenosyltransferase activity in erythrocytes and spinal cord of patients with sporadic amyotrophic lateral sclerosis.
Aortic Aneurysm, Thoracic
MAT2A mutations predispose individuals to thoracic aortic aneurysms.
Asthma
Do family physicians choose self-assessment activities based on what they know or don't know?
Atherosclerosis
Elevated serum concentrations of soluble adhesion molecules in coronary artery disease and acute myocardial infarction.
Atherosclerosis
Statin-associated muscle symptoms: impact on statin therapy-European Atherosclerosis Society Consensus Panel Statement on Assessment, Aetiology and Management.
Atherosclerosis
[Severe hypercholesterolaemia--when to use the proprotein convertase subtilisin-kexin type 9 protease inhibitors (PCSK9 inhibitors)? Polish Society of Cardiology experts' group statement].
Breast Neoplasms
Gene signatures and potential therapeutic targets of amino acid metabolism in estrogen receptor-positive breast cancer.
Breast Neoplasms
Genetic Variants in CD44 and MAT1A Confer Susceptibility to Acute Skin Reaction in Breast Cancer Patients Undergoing Radiation Therapy.
Breast Neoplasms
Induction of methionine adenosyltransferase 2A in tamoxifen-resistant breast cancer cells.
Breast Neoplasms
MAT2A Localization and Its Independently Prognostic Relevance in Breast Cancer Patients.
Breast Neoplasms
Modulation of gene expression in human central nervous system tumors under methionine deprivation-induced stress.
Carcinogenesis
Chemopreventive N-(4-hydroxyphenyl)retinamide (fenretinide) targets deregulated NF-{kappa}B and Mat1A genes in the early stages of rat liver carcinogenesis.
Carcinogenesis
Deregulated 14-3-3? and methionine adenosyltransferase ?1 interplay promotes liver cancer tumorigenesis in mice and humans.
Carcinogenesis
Epigenetic regulation of methionine adenosyltransferase 1A; a role for microRNA-based treatment in liver cancer?
Carcinogenesis
Expression of methionine adenosyltransferase 2A in renal cell carcinomas and potential mechanism for kidney carcinogenesis.
Carcinogenesis
Forced expression of methionine adenosyltransferase 1A in human hepatoma cells suppresses in vivo tumorigenicity in mice.
Carcinogenesis
Methionine adenosyltransferases in cancers: Mechanisms of dysregulation and implications for therapy.
Carcinogenesis
MicroRNAs regulate methionine adenosyltransferase 1A expression in hepatocellular carcinoma.
Carcinogenesis
Reciprocal Regulation Between Forkhead Box M1/NF-kB and Methionine Adenosyltransferase 1A Drives Liver Cancer.
Carcinogenesis
Role of epigenetic and miR-22 and miR-29b alterations in the downregulation of Mat1a and Mthfr genes in early preneoplastic livers in rats induced by 2-acetylaminofluorene.
Carcinogenesis
THE X PROTEIN OF HEPATITIS B VIRUS INHIBITS APOPTOSIS IN HEPATOMA CELLS THROUGH ENHANCING THE METHIONINE ADENOSYLTRANSFERASE 2A GENE EXPRESSION AND REDUCING S-ADENOSYL-METHIONINE PRODUCTION.
Carcinoma
Diminished S-adenosylmethionine biosynthesis and its metabolism in a model of hepatocellular carcinoma is recuperated by an adenosine derivative.
Carcinoma
Expression of methionine adenosyltransferase 2A in renal cell carcinomas and potential mechanism for kidney carcinogenesis.
Carcinoma
Inhibition of hepatocelluar carcinoma MAT2A and MAT2beta gene expressions by single and dual small interfering RNA.
Carcinoma
Lentivirus mediated shRNA interference targeting MAT2B induces growth-inhibition and apoptosis in hepatocelluar carcinoma.
Carcinoma, Ehrlich Tumor
Translation in vitro and regulation of mouse liver S-adenosylmethionine synthetase messenger RNA.
Carcinoma, Hepatocellular
5-Aza-2<-deoxycytidine induces hepatoma cell apoptosis via enhancing methionine adenosyltransferase 1A expression and inducing S-adenosylmethionine production.
Carcinoma, Hepatocellular
A novel mechanism of the M1-M2 methionine adenosyltransferase switch-mediated hepatocellular carcinoma metastasis.
Carcinoma, Hepatocellular
Activation of LKB1-Akt pathway independent of phosphoinositide 3-kinase plays a critical role in the proliferation of hepatocellular carcinoma from nonalcoholic steatohepatitis.
Carcinoma, Hepatocellular
CD133+ liver cancer stem cells from methionine adenosyl transferase 1A-deficient mice demonstrate resistance to transforming growth factor (TGF)-beta-induced apoptosis.
Carcinoma, Hepatocellular
Changes in S-adenosylmethionine synthetase in human liver cancer: molecular characterization and significance.
Carcinoma, Hepatocellular
Characterization of a full-length cDNA encoding human liver S-adenosylmethionine synthetase: tissue-specific gene expression and mRNA levels in hepatopathies.
Carcinoma, Hepatocellular
Characterization of rat liver-specific methionine adenosyltransferase gene promoter. Role of distal upstream cis-acting elements in the regulation of the transcriptional activity.
Carcinoma, Hepatocellular
Chemotherapeutic potential of methionine analogue inhibitors of tumor-derived methionine adenosyltransferases.
Carcinoma, Hepatocellular
Deregulated 14-3-3? and methionine adenosyltransferase ?1 interplay promotes liver cancer tumorigenesis in mice and humans.
Carcinoma, Hepatocellular
Deregulation of methionine metabolism as determinant of progression and prognosis of hepatocellular carcinoma.
Carcinoma, Hepatocellular
Differential effects of dimethylsulfoxide on S-adenosylmethionine synthetase from rat liver and hepatoma.
Carcinoma, Hepatocellular
Differential expression of methionine adenosyltransferase genes influences the rate of growth of human hepatocellular carcinoma cells.
Carcinoma, Hepatocellular
Effect of hepatocyte growth factor on methionine adenosyltransferase genes and growth is cell density-dependent in HepG2 cells.
Carcinoma, Hepatocellular
Epigenetic regulation of methionine adenosyltransferase 1A; a role for microRNA-based treatment in liver cancer?
Carcinoma, Hepatocellular
Expansion of liver cancer stem cells during aging in methionine adenosyltransferase 1A-deficient mice.
Carcinoma, Hepatocellular
Expression of non-hepatic-type S-adenosylmethionine synthetase isozyme in rat hepatomas induced by 3'-methyl-4-dimethylaminoazobenzene.
Carcinoma, Hepatocellular
Expression pattern, regulation, and functions of methionine adenosyltransferase 2beta splicing variants in hepatoma cells.
Carcinoma, Hepatocellular
Forced expression of methionine adenosyltransferase 1A in human hepatoma cells suppresses in vivo tumorigenicity in mice.
Carcinoma, Hepatocellular
Glucocorticoid regulation of hepatic S-adenosylmethionine synthetase gene expression.
Carcinoma, Hepatocellular
Histological expression of methionine adenosyl transferase (MAT) 2A as a post-surgical prognostic surrogate in patients with hepatocellular carcinoma.
Carcinoma, Hepatocellular
Hybrid immobilization of galactosyl lactose and cellobiose on a gold substrate to modulate biological responses
Carcinoma, Hepatocellular
Hybrid immobilization of galactosyl lactose and cellobiose on a gold substrate to modulate biological responses.
Carcinoma, Hepatocellular
Hypermethylation-repressed methionine adenosyltransferase 1A as a potential biomarker for hepatocellular carcinoma.
Carcinoma, Hepatocellular
Hypoxia induces genomic DNA demethylation through the activation of HIF-1{alpha} and transcriptional up-regulation of MAT2A in hepatoma cells.
Carcinoma, Hepatocellular
Impaired liver regeneration in mice lacking methionine adenosyltransferase 1A.
Carcinoma, Hepatocellular
Induction of human methionine adenosyltransferase 2A expression by tumor necrosis factor alpha. Role of NF-kappa B and AP-1.
Carcinoma, Hepatocellular
Inhibition of human methionine adenosyltransferase 1A transcription by coding region methylation.
Carcinoma, Hepatocellular
Liver cell proliferation requires methionine adenosyltransferase 2A mRNA up-regulation.
Carcinoma, Hepatocellular
Liver-specific deletion of prohibitin 1 results in spontaneous liver injury, fibrosis, and hepatocellular carcinoma in mice.
Carcinoma, Hepatocellular
Liver-specific methionine adenosyltransferase MAT1A gene expression is associated with a specific pattern of promoter methylation and histone acetylation: implications for MAT1A silencing during transformation.
Carcinoma, Hepatocellular
Methionine adenosyltransferase II beta subunit gene expression provides a proliferative advantage in human hepatoma.
Carcinoma, Hepatocellular
Methionine adenosyltransferases in cancers: Mechanisms of dysregulation and implications for therapy.
Carcinoma, Hepatocellular
Methionine metabolism in chronic liver diseases: an update on molecular mechanism and therapeutic implication.
Carcinoma, Hepatocellular
MicroRNA-203 impacts on the growth, aggressiveness and prognosis of hepatocellular carcinoma by targeting MAT2A and MAT2B genes.
Carcinoma, Hepatocellular
MicroRNA-21-3p, a Berberine-Induced miRNA, Directly Down-Regulates Human Methionine Adenosyltransferases 2A and 2B and Inhibits Hepatoma Cell Growth.
Carcinoma, Hepatocellular
MicroRNAs regulate methionine adenosyltransferase 1A expression in hepatocellular carcinoma.
Carcinoma, Hepatocellular
NADP+ binding to the regulatory subunit of methionine adenosyltransferase II increases intersubunit binding affinity in the hetero-trimer.
Carcinoma, Hepatocellular
Pleiotropic effects of methionine adenosyltransferases deregulation as determinants of liver cancer progression and prognosis.
Carcinoma, Hepatocellular
Proteome analysis of human hepatocellular carcinoma tissues by two-dimensional difference gel electrophoresis and mass spectrometry.
Carcinoma, Hepatocellular
Proteomic analysis of human hepatoma cells expressing methionine adenosyltransferase I/III Characterization of DDX3X as a target of S-adenosylmethionine.
Carcinoma, Hepatocellular
Reduced mRNA abundance of the main enzymes involved in methionine metabolism in human liver cirrhosis and hepatocellular carcinoma.
Carcinoma, Hepatocellular
Role of methionine adenosyltransferase and S-adenosylmethionine in alcohol-associated liver cancer.
Carcinoma, Hepatocellular
Role of promoter methylation in increased methionine adenosyltransferase 2A expression in human liver cancer.
Carcinoma, Hepatocellular
S-Adenosylmethionine Inhibits La Ribonucleoprotein Domain Family Member 1 in Murine Liver and Human Liver Cancer Cells.
Carcinoma, Hepatocellular
S-adenosylmethionine stabilizes cystathionine beta-synthase and modulates redox capacity.
Carcinoma, Hepatocellular
S-adenosylmethionine synthetase activity in some normal rat tissues and transplantable hepatomas.
Carcinoma, Hepatocellular
S-Adenosylmethionine synthetase isozyme patterns from rat hepatoma induced by N-2-fluorenylacetamide.
Carcinoma, Hepatocellular
Separation of different forms of S-adenosylmethionine synthetase by fast protein liquid chromatography.
Carcinoma, Hepatocellular
Silencing MAT2A gene by RNA interference inhibited cell growth and induced apoptosis in human hepatoma cells.
Carcinoma, Hepatocellular
Silencing of human methionine adenosyltransferase 1A expression by methylation of the coding region.
Carcinoma, Hepatocellular
SNHG6 Acts as a Genome-Wide Hypomethylation Trigger via Coupling of miR-1297-Mediated S-Adenosylmethionine-Dependent Positive Feedback Loops.
Carcinoma, Hepatocellular
Structure and function study of the complex that synthesizes S-adenosylmethionine.
Carcinoma, Hepatocellular
The Oncogene PDRG1 Is an Interaction Target of Methionine Adenosyltransferases.
Carcinoma, Hepatocellular
The role of c-Myb and Sp1 in the up-regulation of methionine adenosyltransferase 2A gene expression in human hepatocellular carcinoma.
Carcinoma, Hepatocellular
THE X PROTEIN OF HEPATITIS B VIRUS INHIBITS APOPTOSIS IN HEPATOMA CELLS THROUGH ENHANCING THE METHIONINE ADENOSYLTRANSFERASE 2A GENE EXPRESSION AND REDUCING S-ADENOSYL-METHIONINE PRODUCTION.
Carcinoma, Hepatocellular
Theoretical mechanisms for synthesis of carcinogen-induced embryonic proteins: XXIV. Repeated embryonic genes in liver.
Carcinoma, Hepatocellular
Thyroid hormone receptor-mediated regulation of the methionine adenosyltransferase 1 gene is associated with cell invasion in hepatoma cell lines.
Carcinoma, Renal Cell
Expression of methionine adenosyltransferase 2A in renal cell carcinomas and potential mechanism for kidney carcinogenesis.
Cardiac Tamponade
Homemade cardiac and vein cannulation ultrasound phantoms for trauma management training in resource-limited settings.
Cardiovascular Diseases
MAT1A variants are associated with hypertension, stroke, and markers of DNA damage and are modulated by plasma vitamin B-6 and folate.
Cardiovascular Diseases
Practical aspects in the management of statin-associated muscle symptoms (SAMS).
Cholangiocarcinoma
Deregulated 14-3-3? and methionine adenosyltransferase ?1 interplay promotes liver cancer tumorigenesis in mice and humans.
Cholangiocarcinoma
Deregulated methionine adenosyltransferase ?1, c-myc and maf proteins interplay promotes cholangiocarcinoma growth in mice and humans.
Cholangiocarcinoma
Methionine adenosyltransferases in cancers: Mechanisms of dysregulation and implications for therapy.
Cholestasis
Deregulated methionine adenosyltransferase ?1, c-myc and maf proteins interplay promotes cholangiocarcinoma growth in mice and humans.
Cholestasis, Intrahepatic
[Screening for amino acid metabolic disorders of newborns in Zhejiang province:prevalence, outcome and follow-up].
Citrullinemia
[Screening for amino acid metabolic disorders of newborns in Zhejiang province:prevalence, outcome and follow-up].
Clubfoot
Effects of botulinum toxin-A on gait velocity, step length, and base of support of patients with dynamic equinovarus foot.
Colic
Semi-automated vs. manual 3D reconstruction of central mesenteric vascular models: the surgeon's verdict.
Colonic Neoplasms
Expression of methionine adenosyltransferase 2A in renal cell carcinomas and potential mechanism for kidney carcinogenesis.
Colonic Neoplasms
Fluorinated N,N-Dialkylaminostilbenes Repress Colon Cancer by Targeting Methionine S-Adenosyltransferase 2A.
Colonic Neoplasms
Insulin-like growth factor 1 activates methionine adenosyltransferase 2A transcription by multiple pathways in human colon cancer cells.
Colonic Neoplasms
Methionine adenosyltransferase 2B-GIT1 complex serves as a scaffold to regulate Ras/Raf/MEK1/2 activity in human liver and colon cancer cells.
Colonic Neoplasms
Methionine adenosyltransferase 2B-GIT1 interplay activates MEK1-ERK1/2 to induce growth in human liver and colon cancer.
Colonic Neoplasms
Methionine adenosyltransferase ?2 sumoylation positively regulate Bcl-2 expression in human colon and liver cancer cells.
Colonic Neoplasms
Polyamine and methionine adenosyltransferase 2A crosstalk in human colon and liver cancer.
Colonic Neoplasms
Role of methionine adenosyltransferase 2A and S-adenosylmethionine in mitogen-induced growth of human colon cancer cells.
Colonic Neoplasms
S-Adenosyl-l-Methionine Overcomes uL3-Mediated Drug Resistance in p53 Deleted Colon Cancer Cells.
Colorectal Neoplasms
Correlation between the expression of methionine adenosyltransferase and the stages of human colorectal carcinoma.
Colorectal Neoplasms
Cullin 3 targets methionine adenosyltransferase II? for ubiquitylation-mediated degradation and regulates colorectal cancer cell proliferation.
Colorectal Neoplasms
Fluorinated N,N-Dialkylaminostilbenes Repress Colon Cancer by Targeting Methionine S-Adenosyltransferase 2A.
Congenital Abnormalities
Constitutive overexpression of cystathionine gamma-synthase in Arabidopsis leads to accumulation of soluble methionine and S-methylmethionine.
Coronary Disease
Elevated serum concentrations of soluble adhesion molecules in coronary artery disease and acute myocardial infarction.
COVID-19
50-gene risk profiles in peripheral blood predict COVID-19 outcomes: A retrospective, multicenter cohort study.
COVID-19
Physicians' Acceptance of Triage Guidelines in the Context of the COVID-19 Pandemic: A Qualitative Study.
cystathionine beta-synthase deficiency
Clinical and metabolic findings in patients with methionine adenosyltransferase I/III deficiency detected by newborn screening.
cystathionine beta-synthase deficiency
Glycine N -methyltransferase deficiency: a new patient with a novel mutation.
cystathionine beta-synthase deficiency
Newborn screening for homocystinurias: recent recommendations versus current practice.
cystathionine beta-synthase deficiency
Newborn screening for homocystinurias: Recent recommendations versus current practice.
cystathionine gamma-synthase deficiency
Cystathionine-synthase-deficient patients do not use the transamination pathway of methionine to reduce hypermethioninemia and homocystinemia.
Cysts
Nucleotide sequence and developmental expression of Acanthamoeba S-adenosylmethionine synthetase gene.
Dehydration
4-Mercaptophenylboronic acid SAMs on gold: comparison with SAMs derived from thiophenol, 4-mercaptophenol, and 4-mercaptobenzoic acid.
Dehydration
A gene expression analysis of syncytia laser microdissected from the roots of the Glycine max (soybean) genotype PI 548402 (Peking) undergoing a resistant reaction after infection by Heterodera glycines (soybean cyst nematode).
Dementia
Decreased methionine adenosyltransferase activity in erythrocytes of patients with dementia disorders.
Demyelinating Diseases
Demyelination of the brain is associated with methionine adenosyltransferase I/III deficiency.
Demyelinating Diseases
Methionine adenosyltransferase I/III deficiency: novel mutations and clinical variations.
Demyelinating Diseases
Molecular genetics of hepatic methionine adenosyltransferase deficiency.
Demyelinating Diseases
Normal brain myelination in a patient homozygous for a mutation that encodes a severely truncated methionine adenosyltransferase I/III.
Dental Caries
Multilevel Analysis of Dental Caries in Swedish Children and Adolescents in Relation to Socioeconomic Status.
Dermatomyositis
Exercise training attenuates insulin resistance and improves ?-cell function in patients with systemic autoimmune myopathies: a pilot study.
Diabetes Mellitus
Maintenance of Certification for Family Physicians (MC-FP) Self Assessment Modules (SAMs): The First Year.
Diabetes Mellitus
Reported muscle symptoms during statin treatment amongst Italian dyslipidaemic patients in the real-life setting: the PROSISA Study.
Diabetes Mellitus, Type 2
Maintenance of Certification for Family Physicians (MC-FP) Self Assessment Modules (SAMs): The First Year.
Diabetes Mellitus, Type 2
Protocol for SAMS (Support and Advice for Medication Study): a randomised controlled trial of an intervention to support patients with type 2 diabetes with adherence to medication.
Diabetes Mellitus, Type 2
Reported muscle symptoms during statin treatment amongst Italian dyslipidaemic patients in the real-life setting: the PROSISA Study.
Disorders of Excessive Somnolence
Effect of Multilevel Upper Airway Surgery vs Medical Management on the Apnea-Hypopnea Index and Patient-Reported Daytime Sleepiness Among Patients With Moderate or Severe Obstructive Sleep Apnea: The SAMS Randomized Clinical Trial.
Drug-Related Side Effects and Adverse Reactions
Role of genetics in the prediction of statin-associated muscle symptoms and optimization of statin use and adherence.
Dwarfism
A hypersensitive response-like reaction is involved in hybrid weakness in F1 plants of the cross Capsicum annuum × Capsicum chinense.
Endocarditis
[Efficacy evaluation of cloxacillin and cloxacillin-gentamicin in an experimental model of methicillin-sensitive Staphylococcus aureus]
Endometriosis
Identification of endometriosis-related genes by representational difference analysis of cDNA.
Endometriosis
PPAR? induces the paroxysm of endometriosis by regulating the transcription of MAT2A gene.
Essential Hypertension
Maintenance of Certification for Family Physicians (MC-FP) Self Assessment Modules (SAMs): The First Year.
Fatty Liver
Methionine adenosyltransferase 1A gene deletion disrupts hepatic VLDL assembly in mice.
Fatty Liver
Proteome analysis of human hepatocellular carcinoma tissues by two-dimensional difference gel electrophoresis and mass spectrometry.
Fatty Liver
S-Adenosylmethionine Inhibits La Ribonucleoprotein Domain Family Member 1 in Murine Liver and Human Liver Cancer Cells.
Fatty Liver
S-adenosylmethionine stabilizes cystathionine beta-synthase and modulates redox capacity.
Foot Deformities
Effects of botulinum toxin-A on gait velocity, step length, and base of support of patients with dynamic equinovarus foot.
Fragile X Syndrome
Identification of distinct genes with restricted expression in the somitic mesoderm in Xenopus embryo.
Glioma
Hsa_circ_0000337 promotes proliferation, migration and invasion in glioma by competitively binding miRNA-942-5p and thus upregulates MAT2A.
Hepatitis
Acidic sphingomyelinase downregulates the liver-specific methionine adenosyltransferase 1A, contributing to tumor necrosis factor-induced lethal hepatitis.
Hepatitis
Alterations of Methionine Metabolism as Potential Targets for the Prevention and Therapy of Hepatocellular Carcinoma.
Hepatitis
Decreased activities of S-adenosylmethionine synthetase isozymes in hereditary hepatitis in Long-Evans rats.
Hepatitis B
Glucocorticoid-induced S-adenosylmethionine enhances the interferon signaling pathway by restoring STAT1 protein methylation in hepatitis B virus-infected cells.
Hepatitis B
Hypermethylation-repressed methionine adenosyltransferase 1A as a potential biomarker for hepatocellular carcinoma.
Hepatitis B
THE X PROTEIN OF HEPATITIS B VIRUS INHIBITS APOPTOSIS IN HEPATOMA CELLS THROUGH ENHANCING THE METHIONINE ADENOSYLTRANSFERASE 2A GENE EXPRESSION AND REDUCING S-ADENOSYL-METHIONINE PRODUCTION.
Hepatitis C
dBMHCC: A comprehensive hepatocellular carcinoma (HCC) biomarker database provides a reliable prediction system for novel HCC phosphorylated biomarkers.
Hepatoblastoma
Characterization of rat liver-specific methionine adenosyltransferase gene promoter. Role of distal upstream cis-acting elements in the regulation of the transcriptional activity.
Homocystinuria
Biochemical basis for the dominant inheritance of hypermethioninemia associated with the R264H mutation of the MAT1A gene. A monomeric methionine adenosyltransferase with tripolyphosphatase activity.
Homocystinuria
Clinical and metabolic findings in patients with methionine adenosyltransferase I/III deficiency detected by newborn screening.
Homocystinuria
Cystathionine-synthase-deficient patients do not use the transamination pathway of methionine to reduce hypermethioninemia and homocystinemia.
Homocystinuria
Effect of hypermethioninemia on some parameters of oxidative stress and on Na(+),K (+)-ATPase activity in hippocampus of rats.
Homocystinuria
Homocystinuria: studies on cystathionine beta-synthase, S-adenosylmethionine synthetase and cystathionase activities in skin fibroblasts.
Homocystinuria
Hypermethioninaemia due to methionine adenosyltransferase I/III (MAT I/III) deficiency: Diagnosis in an expanded neonatal screening programme.
Homocystinuria
Reversible white matter lesion in methionine adenosyltransferase I/III deficiency.
Hydrocephalus
Evaluation of polymer and self-assembled monolayer-coated silicone surfaces to reduce neural cell growth.
Hyperargininemia
[Screening for amino acid metabolic disorders of newborns in Zhejiang province:prevalence, outcome and follow-up].
Hyperhomocysteinemia
Acute exercise alters homocysteine plasma concentration in an intensity-dependent manner due increased methyl flux in liver of rats.
Hyperlipidemias
Modeling statin myopathy in a human skeletal muscle microphysiological system.
Hypersensitivity
Immunomodulatory effects of mineral fibres in occupationally exposed workers.
Hypertension
Do family physicians choose self-assessment activities based on what they know or don't know?
Hypertension
Maintenance of Certification for Family Physicians (MC-FP) Self Assessment Modules (SAMs): The First Year.
Hypertension
MAT1A variants are associated with hypertension, stroke, and markers of DNA damage and are modulated by plasma vitamin B-6 and folate.
Illusions
Real-time decreased sensitivity to an audio-visual illusion during goal-directed reaching.
Infections
Cotton Leaf Curl Multan virus C4 protein suppresses both transcriptional and post-transcriptional gene silencing by interacting with SAM synthetase.
Infections
Disruption of the methionine cycle and reduced cellular gluthathione levels underlie potex-potyvirus synergism in Nicotiana benthamiana.
Infections
Gene Expression Analysis of Plum pox virus (Sharka) Susceptibility/Resistance in Apricot (Prunus armeniaca L.).
Infections
Methods for the Isolation, Culture, and Functional Characterization of Sinoatrial Node Myocytes from Adult Mice.
Infections
Overexpression of the tomato Asc-1 gene mediates high insensitivity to AAL toxins and fumonisin B1 in tomato hairy roots and confers resistance to Alternaria alternata f. sp. lycopersici in Nicotiana umbratica plants.
Infections
Resistance against Ralstonia solanacearum in tomato depends on the methionine cycle and the ?-aminobutyric acid metabolic pathway.
Infections
THE X PROTEIN OF HEPATITIS B VIRUS INHIBITS APOPTOSIS IN HEPATOMA CELLS THROUGH ENHANCING THE METHIONINE ADENOSYLTRANSFERASE 2A GENE EXPRESSION AND REDUCING S-ADENOSYL-METHIONINE PRODUCTION.
Infections
Transcriptional regulation of genes involved in the pathways of biosynthesis and supply of methyl units in response to powdery mildew attack and abiotic stresses in wheat.
Infertility
Evaluation of various cleaning methods to remove bacillus spores from spacecraft hardware materials.
Influenza, Human
Detection of influenza virus by a biosensor based on the method combining electrochemiluminescence on binary SAMs modified Au electrode with an immunoliposome encapsulating Ru (II) complex.
Intellectual Disability
Identification of distinct genes with restricted expression in the somitic mesoderm in Xenopus embryo.
Leukemia
Differential kinetic properties of L-2-amino-4-methylthio-cis-but-3-enoic acid, a methionine analog inhibitor of S-adenosylmethionine synthetase.
Leukemia
Estrogen-responsive gene networks in the teleost liver: What are the key molecular indicators?
Leukemia
S-adenosylmethionine synthetase is overexpressed in murine neuroblastoma cells resistant to nucleoside analogue inhibitors of S-adenosylhomocysteine hydrolase: a novel mechanism of drug resistance.
Leukemia, Erythroblastic, Acute
Effect of biomaterial surface properties on fibronectin-alpha5beta1 integrin interaction and cellular attachment.
Leukemia, Lymphocytic, Chronic, B-Cell
S-Adenosylmethionine synthetase from human lymphocytes. Purification and characterization.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Quercetin Promotes Cell Cycle Arrest and Apoptosis and Attenuates the Proliferation of Human Chronic Myeloid Leukemia Cell Line-K562 Through Interaction with HSPs (70 and 90), MAT2A and FOXM1.
Liver Cirrhosis
Activation of LKB1-Akt pathway independent of phosphoinositide 3-kinase plays a critical role in the proliferation of hepatocellular carcinoma from nonalcoholic steatohepatitis.
Liver Cirrhosis
Ameliorative effect of Ganoderma lucidum on carbon tetrachloride-induced liver fibrosis in rats.
Liver Cirrhosis
Curcumin Affects Leptin-Induced Expression of Methionine Adenosyltransferase 2A in Hepatic Stellate Cells by Inhibition of JNK Signaling.
Liver Cirrhosis
Inactivation and dissociation of S-adenosylmethionine synthetase by modification of sulfhydryl groups and its possible occurrence in cirrhosis.
Liver Cirrhosis
Inhibition of liver methionine adenosyltransferase gene expression by 3-methylcolanthrene: protective effect of S-adenosylmethionine.
Liver Cirrhosis
Leptin promotes methionine adenosyltransferase 2A expression in hepatic stellate cells by the downregulation of E2F-4 via the ?-catenin pathway.
Liver Cirrhosis
Reduced mRNA abundance of the main enzymes involved in methionine metabolism in human liver cirrhosis and hepatocellular carcinoma.
Liver Cirrhosis
Scar-associated macrophages are a major source of hepatic matrix metalloproteinase-13 and facilitate the resolution of murine hepatic fibrosis.
Liver Cirrhosis
Specific loss of the high-molecular-weight form of S-adenosyl-L-methionine synthetase in human liver cirrhosis.
Liver Cirrhosis, Alcoholic
Abnormal metabolism of S-adenosyl-L-methionine in hypoxic rat liver. Similarities to its abnormal metabolism in alcoholic cirrhosis.
Liver Cirrhosis, Alcoholic
Characterization of a full-length cDNA encoding human liver S-adenosylmethionine synthetase: tissue-specific gene expression and mRNA levels in hepatopathies.
Liver Diseases
Acidic sphingomyelinase downregulates the liver-specific methionine adenosyltransferase 1A, contributing to tumor necrosis factor-induced lethal hepatitis.
Liver Diseases
Expansion of liver cancer stem cells during aging in methionine adenosyltransferase 1A-deficient mice.
Liver Diseases
Structure and function study of the complex that synthesizes S-adenosylmethionine.
Liver Diseases, Alcoholic
Inhibition of liver methionine adenosyltransferase gene expression by 3-methylcolanthrene: protective effect of S-adenosylmethionine.
Liver Diseases, Alcoholic
Methionine adenosyltransferase and S-adenosylmethionine in alcoholic liver disease.
Liver Diseases, Alcoholic
Role of methionine adenosyltransferase and S-adenosylmethionine in alcohol-associated liver cancer.
Liver Failure
Acidic sphingomyelinase downregulates the liver-specific methionine adenosyltransferase 1A, contributing to tumor necrosis factor-induced lethal hepatitis.
Liver Neoplasms
Changes in S-adenosylmethionine synthetase in human liver cancer: molecular characterization and significance.
Liver Neoplasms
Changes in the expression of methionine adenosyltransferase genes and S-adenosylmethionine homeostasis during hepatic stellate cell activation.
Liver Neoplasms
Cloning and functional characterization of the 5'-flanking region of human methionine adenosyltransferase 1A gene.
Liver Neoplasms
Deregulated 14-3-3? and methionine adenosyltransferase ?1 interplay promotes liver cancer tumorigenesis in mice and humans.
Liver Neoplasms
Differential effect of thioacetamide on hepatic methionine adenosyltransferase expression in the rat.
Liver Neoplasms
Differential expression of methionine adenosyltransferase genes influences the rate of growth of human hepatocellular carcinoma cells.
Liver Neoplasms
Epithelial-to-mesenchymal transition of murine liver tumor cells promotes invasion.
Liver Neoplasms
Expansion of liver cancer stem cells during aging in methionine adenosyltransferase 1A-deficient mice.
Liver Neoplasms
Fluorinated N,N-Dialkylaminostilbenes Repress Colon Cancer by Targeting Methionine S-Adenosyltransferase 2A.
Liver Neoplasms
Forced expression of methionine adenosyltransferase 1A in human hepatoma cells suppresses in vivo tumorigenicity in mice.
Liver Neoplasms
Hypoxia induces genomic DNA demethylation through the activation of HIF-1{alpha} and transcriptional up-regulation of MAT2A in hepatoma cells.
Liver Neoplasms
Leptin's mitogenic effect in human liver cancer cells requires induction of both methionine adenosyltransferase 2A and 2beta.
Liver Neoplasms
Liver-specific methionine adenosyltransferase MAT1A gene expression is associated with a specific pattern of promoter methylation and histone acetylation: implications for MAT1A silencing during transformation.
Liver Neoplasms
Methionine adenosyltransferase 2B, HuR, and sirtuin 1 protein cross-talk impacts on the effect of resveratrol on apoptosis and growth in liver cancer cells.
Liver Neoplasms
Methionine adenosyltransferase ?2 sumoylation positively regulate Bcl-2 expression in human colon and liver cancer cells.
Liver Neoplasms
Methionine adenosyltransferases in cancers: Mechanisms of dysregulation and implications for therapy.
Liver Neoplasms
MicroRNA-203 impacts on the growth, aggressiveness and prognosis of hepatocellular carcinoma by targeting MAT2A and MAT2B genes.
Liver Neoplasms
Polyamine and methionine adenosyltransferase 2A crosstalk in human colon and liver cancer.
Liver Neoplasms
Reciprocal Regulation Between Forkhead Box M1/NF-kB and Methionine Adenosyltransferase 1A Drives Liver Cancer.
Liver Neoplasms
Role of methionine adenosyltransferase and S-adenosylmethionine in alcohol-associated liver cancer.
Liver Neoplasms
Role of promoter methylation in increased methionine adenosyltransferase 2A expression in human liver cancer.
Liver Neoplasms
S-Adenosylmethionine and methylthioadenosine inhibit ?-catenin signaling by multiple mechanisms in liver and colon cancer.
Liver Neoplasms
Silencing MAT2A gene by RNA interference inhibited cell growth and induced apoptosis in human hepatoma cells.
Liver Neoplasms
THE X PROTEIN OF HEPATITIS B VIRUS INHIBITS APOPTOSIS IN HEPATOMA CELLS THROUGH ENHANCING THE METHIONINE ADENOSYLTRANSFERASE 2A GENE EXPRESSION AND REDUCING S-ADENOSYL-METHIONINE PRODUCTION.
Liver Neoplasms, Experimental
Changes in S-adenosylmethionine synthetase in human liver cancer: molecular characterization and significance.
Liver Neoplasms, Experimental
Isozyme-specific enzyme inhibitors. 10. Adenosine 5'-triphosphate derivatives as substrates or inhibitors of methionine adenosyltransferases of rat normal and hepatoma tissues.
Lung Neoplasms
Circ_0044516 Regulates miR-136/MAT2A Pathway to Facilitate Lung Cancer Development.
Lymphatic Metastasis
Overexpression of methionine adenosyltransferase II alpha (MAT2A) in gastric cancer and induction of cell cycle arrest and apoptosis in SGC-7901 cells by shRNA-mediated silencing of MAT2A gene.
Mania
Abnormalities of one-carbon metabolism in psychiatric disorders: study of methionine adenosyltransferase kinetics and lipid composition of erythrocyte membranes.
Maple Syrup Urine Disease
[Screening for amino acid metabolic disorders of newborns in Zhejiang province:prevalence, outcome and follow-up].
methionine adenosyltransferase deficiency
Association of demyelination with deficiency of cerebrospinal-fluid S-adenosylmethionine in inborn errors of methyl-transfer pathway.
methionine adenosyltransferase deficiency
Cystathionine-synthase-deficient patients do not use the transamination pathway of methionine to reduce hypermethioninemia and homocystinemia.
methionine adenosyltransferase deficiency
Effect of hypermethioninemia on some parameters of oxidative stress and on Na(+),K (+)-ATPase activity in hippocampus of rats.
methionine adenosyltransferase deficiency
Hepatic methionine adenosyltransferase deficiency in a 31-year-old man.
methionine adenosyltransferase deficiency
Hypermethioninemia associated with methionine adenosyltransferase deficiency: clinical, morphologic, and biochemical observations on four patients.
methionine adenosyltransferase deficiency
Inherited disorders in the conversion of methionine to homocysteine.
methionine adenosyltransferase deficiency
Methionine adenosyltransferase deficiency: new enzymatic defect associated with hypermethioninemia.
methionine adenosyltransferase deficiency
Methionine Adenosyltransferase I/III Deficiency in Portugal: High Frequency of a Dominantly Inherited Form in a Small Area of Douro High Lands.
methionine adenosyltransferase deficiency
Mild Persistent Isolated Hypermethioninemia Identified through Newborn Screening in Michigan.
methionine adenosyltransferase deficiency
Molecular genetics of hepatic methionine adenosyltransferase deficiency.
methionine adenosyltransferase deficiency
Molecular mechanisms of an inborn error of methionine pathway. Methionine adenosyltransferase deficiency.
methionine adenosyltransferase deficiency
Reversible leukoencephalopathy with acute neurological deterioration and permanent residua in classical homocystinuria: A case report.
methionine adenosyltransferase deficiency
Rickettsial metK-encoded methionine adenosyltransferase expression in an Escherichia coli metK deletion strain.
methionine adenosyltransferase deficiency
S-adenosylmethionine treatment in methionine adenosyltransferase deficiency, a case report.
methionine adenosyltransferase deficiency
Spectrum of hypermethioninemia in neonatal screening.
methionine adenosyltransferase deficiency
Transsulfuration in an adult with hepatic methionine adenosyltransferase deficiency.
methionine adenosyltransferase deficiency
[Screening for amino acid metabolic disorders of newborns in Zhejiang province:prevalence, outcome and follow-up].
methionine adenosyltransferase deficiency
[Still another cause of hypermethioninemia in children: S-adenosylmethionine synthetase deficiency]
methylenetetrahydrofolate dehydrogenase (nad+) deficiency
Newborn screening for homocystinurias: recent recommendations versus current practice.
methylenetetrahydrofolate dehydrogenase (nad+) deficiency
Newborn screening for homocystinurias: Recent recommendations versus current practice.
methylenetetrahydrofolate dehydrogenase (nad+) deficiency
Reversible leukoencephalopathy with acute neurological deterioration and permanent residua in classical homocystinuria: A case report.
Multiple Sclerosis
A Randomized Controlled Trial of Cognitive Behavioral Therapy (CBT) for Adjusting to Multiple Sclerosis (the saMS Trial): Does CBT Work and for Whom Does It Work?
Multiple Sclerosis
Protocol for the saMS trial (supportive adjustment for multiple sclerosis): a randomized controlled trial comparing cognitive behavioral therapy to supportive listening for adjustment to multiple sclerosis.
Muscle Cramp
A practical algorithm for the management of patients with statin-associated muscle symptoms.
Muscular Atrophy
Rationale for the use of metformin and exercise to counteract statin-associated side effects.
Muscular Diseases
Curcumin: An effective adjunct in patients with statin-associated muscle symptoms?
Muscular Diseases
Effect of Pharmacogenetic Testing for Statin Myopathy Risk vs Usual Care on Blood Cholesterol: A Randomized Clinical Trial.
Muscular Diseases
Statin-associated muscle symptoms (SAMS) in primary prevention for cardiovascular disease in older adults: a protocol for a systematic review and meta-analysis of randomised controlled trials.
Muscular Diseases
Statin-associated muscle symptoms: impact on statin therapy-European Atherosclerosis Society Consensus Panel Statement on Assessment, Aetiology and Management.
Muscular Diseases
The insidious impact of under-diagnosed proximal weakness induced by statins.
Myalgia
Does Coenzyme Q10 Supplementation Mitigate Statin-Associated Muscle Symptoms? Pharmacological and Methodological Considerations.
Myalgia
Low vitamin D does not predict statin associated muscle symptoms but is associated with transient increases in muscle damage and pain.
Myalgia
Statin-associated muscle symptoms: impact on statin therapy-European Atherosclerosis Society Consensus Panel Statement on Assessment, Aetiology and Management.
Myalgia
Validation of a clinically-relevant rodent model of statin-associated muscle symptoms for use in pharmacological studies.
Myocardial Infarction
Elevated serum concentrations of soluble adhesion molecules in coronary artery disease and acute myocardial infarction.
Myotoxicity
Validation of a clinically-relevant rodent model of statin-associated muscle symptoms for use in pharmacological studies.
Myxoma
Giant superficial angiomyxoma of the vulva: a case report and review of the literature.
Neoplasm Metastasis
A novel mechanism of the M1-M2 methionine adenosyltransferase switch-mediated hepatocellular carcinoma metastasis.
Neoplasm Metastasis
Epigenetic regulation of methionine adenosyltransferase 1A; a role for microRNA-based treatment in liver cancer?
Neoplasm Metastasis
MicroRNAs regulate methionine adenosyltransferase 1A expression in hepatocellular carcinoma.
Neoplasm Metastasis
Overexpression of methionine adenosyltransferase II alpha (MAT2A) in gastric cancer and induction of cell cycle arrest and apoptosis in SGC-7901 cells by shRNA-mediated silencing of MAT2A gene.
Neoplasms
A novel mechanism of the M1-M2 methionine adenosyltransferase switch-mediated hepatocellular carcinoma metastasis.
Neoplasms
Acetylation of MAT II? represses tumour cell growth and is decreased in human hepatocellular cancer.
Neoplasms
Acidic sphingomyelinase downregulates the liver-specific methionine adenosyltransferase 1A, contributing to tumor necrosis factor-induced lethal hepatitis.
Neoplasms
Activation of LKB1-Akt pathway independent of phosphoinositide 3-kinase plays a critical role in the proliferation of hepatocellular carcinoma from nonalcoholic steatohepatitis.
Neoplasms
Alterations of Methionine Metabolism as Potential Targets for the Prevention and Therapy of Hepatocellular Carcinoma.
Neoplasms
Bone resorbing activity of surface-associated material from Actinobacillus actinomycetemcomitans and Eikenella corrodens.
Neoplasms
Demonstration of an altered S-adenosylmethionine synthetase in human malignant tumors xenografted into athymic nude mice.
Neoplasms
Deregulated 14-3-3? and methionine adenosyltransferase ?1 interplay promotes liver cancer tumorigenesis in mice and humans.
Neoplasms
Differences in the active-site region of tumor versus normal isozymes of mammalian ATP:L-methionine S-adenosyltransferase.
Neoplasms
Discovery of AG-270, a First-in-Class Oral MAT2A Inhibitor for the Treatment of Tumors with Homozygous MTAP Deletion.
Neoplasms
Epithelial-to-mesenchymal transition of murine liver tumor cells promotes invasion.
Neoplasms
Expression and subcellular localization of Ewing sarcoma (EWS) protein is affected by the methylation process.
Neoplasms
Expression of methionine adenosyltransferase 2A in renal cell carcinomas and potential mechanism for kidney carcinogenesis.
Neoplasms
Expression pattern, regulation, and functions of methionine adenosyltransferase 2beta splicing variants in hepatoma cells.
Neoplasms
Fluorinated N,N-Dialkylaminostilbenes Repress Colon Cancer by Targeting Methionine S-Adenosyltransferase 2A.
Neoplasms
Forced expression of methionine adenosyltransferase 1A in human hepatoma cells suppresses in vivo tumorigenicity in mice.
Neoplasms
Fragment-Based Design of a Potent MAT2a Inhibitor and in Vivo Evaluation in an MTAP Null Xenograft Model.
Neoplasms
Generation, annotation, analysis and database integration of 16,500 white spruce EST clusters.
Neoplasms
Giant superficial angiomyxoma of the vulva: a case report and review of the literature.
Neoplasms
Histological expression of methionine adenosyl transferase (MAT) 2A as a post-surgical prognostic surrogate in patients with hepatocellular carcinoma.
Neoplasms
Hypermethylation-repressed methionine adenosyltransferase 1A as a potential biomarker for hepatocellular carcinoma.
Neoplasms
Hypoxia induces genomic DNA demethylation through the activation of HIF-1{alpha} and transcriptional up-regulation of MAT2A in hepatoma cells.
Neoplasms
Induction of human methionine adenosyltransferase 2A expression by tumor necrosis factor alpha. Role of NF-kappa B and AP-1.
Neoplasms
MAT2A Inhibition Blocks the Growth of MTAP-Deleted Cancer Cells by Reducing PRMT5-Dependent mRNA Splicing and Inducing DNA Damage.
Neoplasms
Mechanisms of MAFG Dysregulation in Cholestatic Liver Injury and Development of Liver Cancer.
Neoplasms
Methionine Adenosyltransferase 1a (MAT1A) Enhances Cell Survival During Chemotherapy Treatment and is Associated with Drug Resistance in Bladder Cancer PDX Mice.
Neoplasms
Methionine adenosyltransferase ?2 sumoylation positively regulate Bcl-2 expression in human colon and liver cancer cells.
Neoplasms
Methionine adenosyltransferase II beta subunit gene expression provides a proliferative advantage in human hepatoma.
Neoplasms
Methionine adenosyltransferases in cancers: Mechanisms of dysregulation and implications for therapy.
Neoplasms
MicroRNA-21-3p, a Berberine-Induced miRNA, Directly Down-Regulates Human Methionine Adenosyltransferases 2A and 2B and Inhibits Hepatoma Cell Growth.
Neoplasms
Mixed self-assembled monolayers (SAMs) consisting of methoxy-tri(ethylene glycol)-terminated and alkyl-terminated dimethylchlorosilanes control the non-specific adsorption of proteins at oxidic surfaces.
Neoplasms
mTORC1 stimulates cell growth through SAM synthesis and m6A mRNA-dependent control of protein synthesis.
Neoplasms
Mutations in the S-Adenosylmethionine Synthetase Genes SAM1 and SAM2 Differentially Affect Genome Stability in Saccharomyces cerevisiae.
Neoplasms
Overexpression of methionine adenosyltransferase II alpha (MAT2A) in gastric cancer and induction of cell cycle arrest and apoptosis in SGC-7901 cells by shRNA-mediated silencing of MAT2A gene.
Neoplasms
Partial purification and characterization of tumor and liver S-adenosylmethionine synthetases.
Neoplasms
PARTICLE, a Triplex-Forming Long ncRNA, Regulates Locus-Specific Methylation in Response to Low-Dose Irradiation.
Neoplasms
Protein expression during lag phase and growth initiation in Saccharomyces cerevisiae.
Neoplasms
Reciprocal Regulation Between Forkhead Box M1/NF-kB and Methionine Adenosyltransferase 1A Drives Liver Cancer.
Neoplasms
Resistance to inhibitors of S-adenosyl-L-homocysteine hydrolase in C1300 murine neuroblastoma tumor cells is associated with increased methionine adenosyltransferase activity.
Neoplasms
Role of promoter methylation in increased methionine adenosyltransferase 2A expression in human liver cancer.
Neoplasms
S-adenosylmethionine biosynthesis is a targetable metabolic vulnerability of cancer stem cells.
Neoplasms
Silencing MAT2A gene by RNA interference inhibited cell growth and induced apoptosis in human hepatoma cells.
Neoplasms
Spontaneous oxidative stress and liver tumors in mice lacking methionine adenosyltransferase 1A.
Neoplasms
Studies on the activities of some methyltransferases in the livers and tumor cells from tumor-bearing mice.
Neoplasms
Targeting S-adenosylmethionine biosynthesis with a novel allosteric inhibitor of Mat2A.
Neoplasms
The role of c-Myb and Sp1 in the up-regulation of methionine adenosyltransferase 2A gene expression in human hepatocellular carcinoma.
Neoplasms
THE X PROTEIN OF HEPATITIS B VIRUS INHIBITS APOPTOSIS IN HEPATOMA CELLS THROUGH ENHANCING THE METHIONINE ADENOSYLTRANSFERASE 2A GENE EXPRESSION AND REDUCING S-ADENOSYL-METHIONINE PRODUCTION.
Neoplasms
Transcription of the MAT2A gene, coding for methionine adenosyltransferase, is up-regulated by E2F and Sp1 at a chromatin level during proliferation of liver cells.
Neoplasms
Translation in vitro and regulation of mouse liver S-adenosylmethionine synthetase messenger RNA.
Neuroblastoma
Regulation of methionine adenosyltransferase catalytic activity and messenger RNA in SH-SY5Y human neuroblastoma cells.
Neuroblastoma
Resistance to inhibitors of S-adenosyl-L-homocysteine hydrolase in C1300 murine neuroblastoma tumor cells is associated with increased methionine adenosyltransferase activity.
Neuroblastoma
S-adenosylmethionine synthetase is overexpressed in murine neuroblastoma cells resistant to nucleoside analogue inhibitors of S-adenosylhomocysteine hydrolase: a novel mechanism of drug resistance.
Neurologic Manifestations
Methionine adenosyltransferase I/III deficiency: Neurological manifestations and relevance of S-adenosylmethionine.
Non-alcoholic Fatty Liver Disease
Activation of LKB1-Akt pathway independent of phosphoinositide 3-kinase plays a critical role in the proliferation of hepatocellular carcinoma from nonalcoholic steatohepatitis.
Non-alcoholic Fatty Liver Disease
Metabolic Landscape of the Mouse Liver by Quantitative 31 P Nuclear Magnetic Resonance Analysis of the Phosphorome.
Non-alcoholic Fatty Liver Disease
Methionine adenosyltransferase 1A gene deletion disrupts hepatic VLDL assembly in mice.
Non-alcoholic Fatty Liver Disease
Spontaneous oxidative stress and liver tumors in mice lacking methionine adenosyltransferase 1A.
Obesity
Differential representation of liver proteins in obese human subjects suggests novel biomarkers and promising targets for drug development in obesity.
Obesity
Effect of maternal folic acid supplementation on hepatic one-carbon unit associated gene expressions in newborn piglets.
Obesity
Spontaneous oxidative stress and liver tumors in mice lacking methionine adenosyltransferase 1A.
Obesity
Sympathetic neuron-associated macrophages contribute to obesity by importing and metabolizing norepinephrine.
Phenylketonurias
Expanded Newborn Screening for Inborn Errors of Metabolism by Tandem Mass Spectrometry in Suzhou, China: Disease Spectrum, Prevalence, Genetic Characteristics in a Chinese Population.
Phenylketonurias
[Screening for amino acid metabolic disorders of newborns in Zhejiang province:prevalence, outcome and follow-up].
Porphyria, Erythropoietic
Metabolic Landscape of the Mouse Liver by Quantitative 31 P Nuclear Magnetic Resonance Analysis of the Phosphorome.
Precancerous Conditions
A signature of six genes highlights defects on cell growth and specific metabolic pathways in murine and human hepatocellular carcinoma.
Prostatic Neoplasms
Editorial Comment to: SAMS: A randomized study comparing two different follow-up schedules for active surveillance of low-risk prostate cancer.
Prostatic Neoplasms
Methionine adenosyltransferases in cancers: Mechanisms of dysregulation and implications for therapy.
Prostatic Neoplasms
The Study of Active Monitoring in Sweden (SAMS): A randomized study comparing two different follow-up schedules for active surveillance of low-risk prostate cancer.
Prostatic Neoplasms
The value of a first MRI and targeted biopsies after several years of active surveillance for low-risk prostate cancer - results from the SAMS trial.
Renal Insufficiency
Messenger RNA for enzymes of ornithine and polyamine metabolism are selectively underexpressed in kidney of 5/6 nephrectomized rats.
Rhabdomyolysis
A practical algorithm for the management of patients with statin-associated muscle symptoms.
Rhabdomyolysis
Curcumin: An effective adjunct in patients with statin-associated muscle symptoms?
Rhabdomyolysis
Statin-associated muscle symptoms (SAMS) in primary prevention for cardiovascular disease in older adults: a protocol for a systematic review and meta-analysis of randomised controlled trials.
Sarcoma
Giant superficial angiomyxoma of the vulva: a case report and review of the literature.
Sarcoma, Avian
Cycloleucine blocks 5'-terminal and internal methylations of avian sarcoma virus genome RNA.
Shock, Septic
Regulation of rat liver S-adenosylmethionine synthetase during septic shock: role of nitric oxide.
Sleep Apnea, Obstructive
Effect of Multilevel Upper Airway Surgery vs Medical Management on the Apnea-Hypopnea Index and Patient-Reported Daytime Sleepiness Among Patients With Moderate or Severe Obstructive Sleep Apnea: The SAMS Randomized Clinical Trial.
Spinal Cord Diseases
Exclusively epidural spinal metameric arteriovenous shunts: case report and literature review.
Spinal Cord Vascular Diseases
Exclusively epidural spinal metameric arteriovenous shunts: case report and literature review.
Starvation
A dual regulatory circuit consisting of S-adenosylmethionine decarboxylase protein and its reaction product controls expression of the paralogous activator prozyme in Trypanosoma brucei.
Starvation
L-methionine availability regulates expression of the methionine adenosyltransferase 2A gene in human hepatocarcinoma cells: role of S-adenosylmethionine.
Starvation
Positive regulation of transcription of homeoprotein-encoding YHP1 by the two-component regulator Sln1 in Saccharomyces cerevisiae.
Starvation
Pre- sowing seed treatment with salicylic acid and sodium hydrosulfide confers Pb toxicity tolerance in maize (Zea mays L.).
Starvation
The U6 snRNA m(6)A Methyltransferase METTL16 Regulates SAM Synthetase Intron Retention.
Starvation
Transcription termination control of the S box system: direct measurement of S-adenosylmethionine by the leader RNA.
Starvation
YHP1 encodes a new homeoprotein that binds to the IME1 promoter in Saccharomyces cerevisiae.
Starvation
[Differential protein analysis on the root response of rice with high phosphorous uptake efficiency to low phosphorous stress].
Stomach Neoplasms
Overexpression of methionine adenosyltransferase II alpha (MAT2A) in gastric cancer and induction of cell cycle arrest and apoptosis in SGC-7901 cells by shRNA-mediated silencing of MAT2A gene.
Stroke
MAT1A variants are associated with hypertension, stroke, and markers of DNA damage and are modulated by plasma vitamin B-6 and folate.
Subacute Combined Degeneration
Distal motor axonopathy and central nervous system myelin vacuolation caused by cycloleucine, an inhibitor of methionine adenosyltransferase.
Subarachnoid Hemorrhage
Exclusively epidural spinal metameric arteriovenous shunts: case report and literature review.
Thrombosis
Study of fibrinogen adsorption on self-assembled monolayers on Au(111) by atomic force microscopy.
Tuberculosis
A systematic review of the quality of conduct and reporting of survival analyses of tuberculosis outcomes in Africa.
Tuberculosis
Characterisation of methionine adenosyltransferase from Mycobacterium smegmatis and M. tuberculosis.
Tuberculosis
Comparative protein modeling of methionine S-adenosyltransferase (MAT) enzyme from Mycobacterium tuberculosis: a potential target for antituberculosis drug discovery.
Urinary Bladder Neoplasms
Methionine Adenosyltransferase 1a (MAT1A) Enhances Cell Survival During Chemotherapy Treatment and is Associated with Drug Resistance in Bladder Cancer PDX Mice.
Uterine Cervical Neoplasms
Circular RNA hsa_circ_0007364 increases cervical cancer progression through activating methionine adenosyltransferase II alpha (MAT2A) expression by restraining microRNA-101-5p.
Virus Diseases
A viral protein promotes host SAMS1 activity and ethylene production for the benefit of virus infection.
Virus Diseases
dBMHCC: A comprehensive hepatocellular carcinoma (HCC) biomarker database provides a reliable prediction system for novel HCC phosphorylated biomarkers.
Vitamin D Deficiency
Vitamin D Serum Levels in Patients with Statin-Induced Musculoskeletal Pain.
Vitamin D Deficiency
Vitamin D Supplementation to Treat Statin-Associated Muscle Symptoms: A Review.
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.022
L-methionine
one kinetic form of alpha-two subunit in the presence of beta subunit
0.076
L-methionine
one kinetic form of alpha-two subunit in the presence of beta subunit
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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SUBUNIT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
additional information
-
beta subunit has a regulatory function. MAT II beta subunit associates spontaneously with Escherichia coli MAT alpha subunit as well as with the recombinant human MAT II alpha-two subunit
additional information
beta subunit has a regulatory function. MAT II beta subunit associates spontaneously with Escherichia coli MAT alpha subunit as well as with the recombinant human MAT II alpha-two subunit
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CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
in complex with S-adenosyl-L-methionine, L-methionine, and 4-nitrophenyl phosphate, vapor diffusion method, using 0.1 M HEPES pH 7.5 and 30% (w/v) PEG 600
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PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
two methods: the first involved purification of the His-tagged protein under denaturing conditions of 8M urea and the second involved separation of SDS-PAGE
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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
LeGros, H.L., Jr.; Halim, A.B.; Geller, A.M.; Kotb, M.
Cloning, expression, and functional characterization of the b regulatory subunit of human methionine adenosyltransferase (MAT II)
J. Biol. Chem.
275
2359-2366
2000
Escherichia coli, Homo sapiens, Homo sapiens (Q9NZL9)
brenda
Murray, B.; Antonyuk, S.V.; Marina, A.; Lu, S.C.; Mato, J.M.; Hasnain, S.S.; Rojas, A.L.
Crystallography captures catalytic steps in human methionine adenosyltransferase enzymes
Proc. Natl. Acad. Sci. USA
113
2104-2109
2016
Homo sapiens (Q9NZL9), Homo sapiens
brenda
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Release 2023.1 (January 2023)
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