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EC Tree
The taxonomic range for the selected organisms is: Arabidopsis thaliana The enzyme appears in selected viruses and cellular organisms
Synonyms
dahp synthase, dahps, dah7ps, 3-deoxy-d-arabino-heptulosonate-7-phosphate synthase, ds-co, ds-mn, dah7p synthase, dahp synthase-phe, dah7p, 3-deoxy-d-arabinoheptulosonate 7-phosphate synthase,
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2-dehydro-3-deoxy-D-arabino-heptonate-7-phosphate D-erythrose-4-phosphate-lyase (pyruvate-phosphorylating)
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2-dehydro-3-deoxy-phosphoheptanoate aldolase
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2-dehydro-3-deoxy-phosphoheptonate aldolase
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2-keto-3-deoxy-D-arabino-heptonic acid 7-phosphate synthetase
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3-deoxy-D-arabino-2-heptulosonic acid 7-phosphate synthetase
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3-deoxy-D-arabino-heptolosonate-7-phosphate synthetase
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3-deoxy-D-arabino-heptulosonate 7-phosphate synthetase
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3-deoxy-D-arabino-heptulosonate-7-phosphate synthase
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7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate D-erythrose-4-phosphate-lyase (pyruvate-phosphorylating)
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7-phospho-2-keto-3-deoxy-D-arabino-heptonate D-erythrose-4-phosphate lyase (pyruvate-phosphorylating)
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aldolase, phospho-2-keto-3-deoxyheptanoate
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D-erythrose-4-phosphate-lyase
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D-erythrose-4-phosphate-lyase (pyruvate-phosphorylating)
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DAH7-P synthase (phe)
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DAHP synthase-phe
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DAHP synthase-trp
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DAHP synthase-tyr
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deoxy-D-arabino-heptulosonate-7-phosphate synthetase
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phospho-2-dehydro-3-deoxyheptonate aldolase
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phospho-2-keto-3-deoxyheptanoate aldolase
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Phospho-2-keto-3-deoxyheptonate aldolase
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phospho-2-keto-3-deoxyheptonic aldolase
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phospho-2-oxo-3-deoxyheptonate aldolase
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phosphoenolpyruvate:D-erythrose-4-phosphate C-(1-carboxyvinyl)transferase (phosphate-hydrolysing, 2-carboxy-2-oxoethyl-forming)
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phosphoenolpyruvate + D-erythrose 4-phosphate + H2O
2-dehydro-3-deoxy-D-arabino-heptonate 7-phosphate + phosphate
phosphoenolpyruvate + D-erythrose 4-phosphate + H2O
2-dehydro-3-deoxy-D-arabino-heptonate 7-phosphate + phosphate
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phosphoenolpyruvate + D-erythrose 4-phosphate + H2O
2-dehydro-3-deoxy-D-arabino-heptonate 7-phosphate + phosphate
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phosphoenolpyruvate + D-erythrose 4-phosphate + H2O
2-dehydro-3-deoxy-D-arabino-heptonate 7-phosphate + phosphate
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first enzyme in the shikimic pathway leading to biosynthesis of aromatic amino acids
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phosphoenolpyruvate + D-erythrose 4-phosphate + H2O
2-dehydro-3-deoxy-D-arabino-heptonate 7-phosphate + phosphate
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regulatory role of thioredoxin of photosystem I on the chloroplastic enzyme
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phosphoenolpyruvate + D-erythrose 4-phosphate + H2O
2-dehydro-3-deoxy-D-arabino-heptonate 7-phosphate + phosphate
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DSH1 RNA levels increase in Arabidopsis leaves subjected either to physical wounding or to infiltration with pathogenic Pseudomonas syringae strains, DSH2 RNA levels are not increased by these treatments
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phosphoenolpyruvate + D-erythrose 4-phosphate + H2O
2-dehydro-3-deoxy-D-arabino-heptonate 7-phosphate + phosphate
phosphoenolpyruvate + D-erythrose 4-phosphate + H2O
2-dehydro-3-deoxy-D-arabino-heptonate 7-phosphate + phosphate
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first enzyme in the shikimic pathway leading to biosynthesis of aromatic amino acids
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phosphoenolpyruvate + D-erythrose 4-phosphate + H2O
2-dehydro-3-deoxy-D-arabino-heptonate 7-phosphate + phosphate
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regulatory role of thioredoxin of photosystem I on the chloroplastic enzyme
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phosphoenolpyruvate + D-erythrose 4-phosphate + H2O
2-dehydro-3-deoxy-D-arabino-heptonate 7-phosphate + phosphate
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DSH1 RNA levels increase in Arabidopsis leaves subjected either to physical wounding or to infiltration with pathogenic Pseudomonas syringae strains, DSH2 RNA levels are not increased by these treatments
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Mg2+
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stimulating, can partly substitute for Mn2+
Mn2+
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absolutely required, can partly be substituted by Mg2+, but not by Ca2+, Fe2+, and Co2+
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iodoacetamide
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alkylation, abolishes the dependence on reducing agents
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dithiothreitol
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can partially substitute thioredoxin as activating agent
reduced thioredoxin
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required for activity, can be partially substituted by dithiothreitol
additional information
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DHS1 is induced 3-5fold by wounding of the leaf and pathogen attack
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UniProt
brenda
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DHS1 and DHS2
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additional information
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presence of amino-terminal extension characteristic of chloroplast transit peptides on DSH1 and DSH2 suggests that both proteins may be targeted to the chloroplast
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DHS1 and DHS2
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chloroplastidic isoenzyme DS-Mn
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AROF_ARATH
525
0
57979
Swiss-Prot
Chloroplast (Reliability: 2 )
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modeling of the three dimensional structure of the type II enzyme present in Arabidopsis thaliana and comparison with type I DAHPS. The enzyme belongs to the (beta/alpha)8 TIM barrel family. At the N-terminus of the Arabidopsis thaliana enzyme, there are three non-core helices, alpha0a (Ala72-Lys83), alpha0b (Ala94-Ala106) and alpha0c (Ala113-Val128), but no beta0, in contrast to the microbial type II DAHPS. Also, the (I/L)GAR motif in the type I DAHPS is substituted with xGxR in the case of type II DAHPS. A motif NK(/I)PGR(/K) is present in the sequences of type II DAHPS including At-DAHPS
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25
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t1/2: 5 h in absence of DTT
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DTT stabilizes the active protein, no influence on the alkylated enzyme
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recombinant from Escherichia coli, mature chloroplastic form, purified to homogeneity
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DHS1 and DHS2, complementation of Saccharomyces cerevisiae mutant strain YBK7
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expression of mature chloroplastic form, without signal sequence, in Escherichia coli
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Keith, B.; Dong, X.; Ausubel, F.M.; Fink, G.R.
Differential induction of 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase genes in Arabidopsis thaliana by wounding and pathogenic attack
Proc. Natl. Acad. Sci. USA
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8821-8825
1991
Arabidopsis thaliana, Solanum tuberosum
brenda
Entus, R.; Poling, M.; Herrmann, K.M.
Redox regulation of Arabidopsis 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase
Plant Physiol.
129
1866-1871
2002
Arabidopsis thaliana
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Bhattacharya, S.; Kumar, P.
An insilico approach to structural elucidation of 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase from Arabidopsis thaliana: hints for herbicide design
Phytochemistry
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7-14
2012
Arabidopsis thaliana (P29976), Arabidopsis thaliana
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