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IUBMB CommentsThe enzyme is highly specific for acetylserine and pyrazole. Not identical with EC 2.5.1.52 L-mimosine synthase.
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Synonyms
beta-pyrazolealanine synthase,
more
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beta-(1-Pyrazolyl)alanine synthase
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beta-pyrazolealanine synthase
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beta-pyrazolylalanine synthase (acetylserine)
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EC 4.2.99.14
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formerly
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EC 4.2.99.17
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formerly
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Pyrazolealanine synthase
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pyrazolylalaninase
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synthase, pyrazolealanine
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O-acetyl-L-serine + pyrazole = 3-(pyrazol-1-yl)-L-alanine + acetate
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aminopropanoyl-group transfer
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O3-acetyl-L-serine:pyrazole 1-(2-amino-2-carboxyethyl)transferase
The enzyme is highly specific for acetylserine and pyrazole. Not identical with EC 2.5.1.52 L-mimosine synthase.
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37290-81-6
not distinguished from EC 4.2.1.50 in Chemical Abstracts
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O-succinyl-L-serine + pyrazole
3-(pyrazol-1-yl)-L-alanine + succinate
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at 16% the rate of O-acetyl-L-serine
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O-sulfo-L-serine + pyrazole
3-(pyrazol-1-yl)-L-alanine + SO42-
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at 2.5% the rate of O-acetyl-L-serine
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O3-acetyl-L-serine + 3-amino-1,2,4-triazole
3-(3-amino-1,2,4-triazol-1-yl)-L-alanine + acetate
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at 11% the rate of pyrazole
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O3-acetyl-L-serine + N-hydroxyurea
O-ureidoserine + acetate
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at 9% the rate of pyrazole
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O3-acetyl-L-serine + pyrazole
3-(pyrazol-1-yl)-L-alanine + acetate
O3-acetyl-L-serine + pyrazole

3-(pyrazol-1-yl)-L-alanine + acetate
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highly specific
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O3-acetyl-L-serine + pyrazole
3-(pyrazol-1-yl)-L-alanine + acetate
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highly specific
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O3-acetyl-L-serine + pyrazole
3-(pyrazol-1-yl)-L-alanine + acetate
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involved in biosynthesis of heterocyclic beta-substituted alanines
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O3-acetyl-L-serine + pyrazole
3-(pyrazol-1-yl)-L-alanine + acetate
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involved in biosynthesis of heterocyclic beta-substituted alanines
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pyridoxal 5'-phosphate
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requirement, enzyme bound, 1 mol pyridoxal 5'-phosphate per mol subunit, further increase of activity by 40% by adding pyridoxal phosphate
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hydroxylamine
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50 mM, almost complete inhibition
KCN
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10 mM, almost complete inhibition
additional information
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no inhibition by pyridoxal phosphate
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6.5 - 8.5
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about half-maximal activity at pH 6.5 and 8.5
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brenda
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additional information
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barely detectable in dry seeds
brenda
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brenda
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cotyledons removed, 1 week old
brenda
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CYSK_CITLA
325
0
34343
Swiss-Prot
other Location (Reliability: 2)
B9RET8_RICCO
332
0
35416
TrEMBL
other Location (Reliability: 1)
A0A1S7SGV8_9HYPH
318
0
34722
TrEMBL
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A0A0B2QJ56_GLYSO
186
0
19764
TrEMBL
other Location (Reliability: 2)
A0A0B2RF53_GLYSO
74
0
7832
TrEMBL
other Location (Reliability: 2)
A0A1S5WDF8_STRGY
489
0
56608
TrEMBL
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B9RET6_RICCO
256
0
27515
TrEMBL
other Location (Reliability: 2)
A0A0B2Q4K7_GLYSO
346
0
36846
TrEMBL
other Location (Reliability: 3)
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32000
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2 * 32000, SDS-PAGE
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dimer
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2 * 32000, SDS-PAGE
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freeze-thawing or lyophilization inactivates
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sensitive to freezing even in the presence of 20% glycerol
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0-2°C, stable for at least 1 month
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0°C, crude enzyme preparation, 25% loss of activity within 22 h
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Murakoshi, I.; Ikegami, F.; Hinuma, Y.; Hanma, Y.
Purification and characterization of beta-(pyrazol-1-yl)-L-alanine synthase from Citrullus vulgaris
Phytochemistry
23
973-977
1984
Citrullus lanatus subsp. vulgaris
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brenda
Murakoshi, I.; Kuramoto, H.; Haginiwa, J.
The enzymic synthesis of beta-substituted alanines
Phytochemistry
11
177-182
1972
Citrullus lanatus subsp. vulgaris
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brenda
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