Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

BRENDA Home
show all | hide all No of entries

Information on EC 2.5.1.49 - O-acetylhomoserine aminocarboxypropyltransferase and Organism(s) Leptospira meyeri and UniProt Accession P94890

for references in articles please use BRENDA:EC2.5.1.49
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
IUBMB Comments
Also reacts with other thiols and H2S, producing homocysteine or thioethers. The name methionine synthase is more commonly applied to EC 2.1.1.13, methionine synthase. The enzyme from baker's yeast also catalyses the reaction of EC 2.5.1.47 cysteine synthase, but more slowly.
Specify your search results
Select one or more organisms in this record: ?
This record set is specific for:
Leptospira meyeri
UNIPROT: P94890
Show additional data
Do not include text mining results
Include (text mining) results
Include results (AMENDA + additional results, but less precise)
Word Map
The taxonomic range for the selected organisms is: Leptospira meyeri
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
o-acetylhomoserine sulfhydrylase, homocysteine synthase, o-acetyl-l-homoserine sulfhydrylase, gamma-cyano-alpha-aminobutyric acid synthase, oah sulfhydrylase, o-acetylhomoserine sulfhydrolase, o-acetylhomoserine (thiol)-lyase, oah shlase, oah-oas sulfhydrylase, o-acetylhomoserine aminocarboxypropyltransferase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
methionine synthase
-
-
-
-
O-acetyl-L-homoserine (thiol)-lyase
-
-
-
-
O-acetyl-L-homoserine acetate-lyase (adding methanethiol)
-
-
-
-
O-acetyl-L-homoserine sulfhydrolase
-
-
-
-
O-acetylhomoserine sulfhydrolase
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
elimination
-
-
-
-
PATHWAY SOURCE
PATHWAYS
-
-, -, -
SYSTEMATIC NAME
IUBMB Comments
O-acetyl-L-homoserine:methanethiol 3-amino-3-carboxypropyltransferase
Also reacts with other thiols and H2S, producing homocysteine or thioethers. The name methionine synthase is more commonly applied to EC 2.1.1.13, methionine synthase. The enzyme from baker's yeast also catalyses the reaction of EC 2.5.1.47 cysteine synthase, but more slowly.
CAS REGISTRY NUMBER
COMMENTARY hide
37290-90-7
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
O-acetyl-L-homoserine + H2S
L-homocysteine + acetic acid
show the reaction diagram
O-acetyl-L-serine + H2S
L-cysteine + acetic acid
show the reaction diagram
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
O-acetyl-L-homoserine + H2S
L-homocysteine + acetic acid
show the reaction diagram
direct sulfhydrylation pathway, methionine biosynthesis
-
-
?
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
MetY protein sequence
SwissProt
Manually annotated by BRENDA team
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
METY_LEPME
442
0
47961
Swiss-Prot
Mitochondrion (Reliability: 2)
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
MetY gene can complement the metB mutant of Escherichia coli
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Hacham, Y.; Gophna, U.; Amir, R.
In vivo analysis of various substrates utilized by cystathionine gamma-synthase and O-acetylhomoserine sulfhydrylase in methionine biosynthesis
Mol. Biol. Evol.
20
1513-1520
2003
Saccharomyces cerevisiae (P06106), Leptospira meyeri (P94890), Leptospira meyeri
Manually annotated by BRENDA team