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Information on EC 2.5.1.44 - homospermidine synthase

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EC Tree
IUBMB Comments
The reaction of this bacterial enzyme occurs in three steps, with some of the intermediates presumably remaining enzyme-bound: (a) NAD+-dependent dehydrogenation of either putrescine or spermidine, forming 4-iminobutan-1-amine or (E)-(4-aminobutylidene)(3-aminopropyl)amine, respectively, (b) attack by water forming 4-aminobutanal (and releasing ammonia or propane-1,3-diamine, respectively), and (c) condensation of 4-aminobutanal with putrescine, which forms homospermidine and restores NAD+. Differs from the eukaryotic enzyme EC 2.5.1.45, homospermidine synthase (spermidine-specific), which cannot use putrescine as donor of the aminobutyl group.
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Word Map
  • 2.5.1.44
  • knee
  • arthroplasty
  • postoperative
  • pain
  • acquity
  • tibial
  • osteoarthritis
  • preoperative
  • fracture
  • radiograph
  • medial
  • formic
  • acetonitrile
  • radiological
  • femoral
  • loosening
  • flexion
  • osteotomy
  • varus
  • satisfaction
  • ultra-performance
  • humic
  • inter-day
  • womac
  • patella
  • radiolucent
  • uhplc
  • precisions
  • prostheses
  • cruciate
  • arthroscopic
  • mcmaster
  • lysholm
  • unicompartmental
  • meniscal
  • hepatosplenic
  • femorotibial
  • tegner
  • comminuted
  • heterostructures
  • malalignment
  • resurface
  • leadership
  • deoxyhypusine
  • nonunion
  • cementless
  • posterolateral
  • condylar
  • patellofemoral
  • kuopio
The enzyme appears in viruses and cellular organisms
Synonyms
Atu3768, BvHSS, homospermidine synthase orthologue, HSPD synthase, HSS, HSS orthologue, synthase, homospermidine, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2 putrescine = sym-homospermidine + NH3 + H+
show the reaction diagram
putrescine + spermidine = sym-homospermidine + propane-1,3-diamine
show the reaction diagram
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