Any feedback?
Please rate this page

BRENDA support

show all | hide all No of entries

Information on EC - homospermidine synthase

for references in articles please use BRENDA:EC2.5.1.44
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
IUBMB Comments
The reaction of this bacterial enzyme occurs in three steps, with some of the intermediates presumably remaining enzyme-bound: (a) NAD+-dependent dehydrogenation of either putrescine or spermidine, forming 4-iminobutan-1-amine or (E)-(4-aminobutylidene)(3-aminopropyl)amine, respectively, (b) attack by water forming 4-aminobutanal (and releasing ammonia or propane-1,3-diamine, respectively), and (c) condensation of 4-aminobutanal with putrescine, which forms homospermidine and restores NAD+. Differs from the eukaryotic enzyme EC, homospermidine synthase (spermidine-specific), which cannot use putrescine as donor of the aminobutyl group.
Specify your search results
Select one or more organisms in this record: ?
Show additional data
Do not include text mining results
Include (text mining) results
Include results (AMENDA + additional results, but less precise)
Word Map
  • knee
  • arthroplasty
  • postoperative
  • pain
  • tibial
  • osteoarthritis
  • acquity
  • preoperative
  • fracture
  • acetonitrile
  • radiograph
  • formic
  • medial
  • femoral
  • radiological
  • osteotomy
  • loosening
  • flexion
  • varus
  • ultra-performance
  • satisfaction
  • inter-day
  • humic
  • womac
  • cement
  • radiolucent
  • cruciate
  • patella
  • mcmaster
  • arthroscopic
  • unicompartmental
  • uhplc
  • prostheses
  • lysholm
  • hepatosplenic
  • leadership
  • tegner
  • heterostructures
  • cementless
  • deoxyhypusine
  • malalignment
  • kellgren-lawrence
  • resurface
  • condylar
  • nonunion
  • precisions
  • posterolateral
  • meniscal
  • curricula
  • patellofemoral
The enzyme appears in viruses and cellular organisms
Atu3768, BvHSS, homospermidine synthase orthologue, HSPD synthase, HSS, HSS orthologue, synthase, homospermidine, more
2 putrescine = sym-homospermidine + NH3 + H+
show the reaction diagram
putrescine + spermidine = sym-homospermidine + propane-1,3-diamine
show the reaction diagram