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Information on EC 2.5.1.44 - homospermidine synthase

for references in articles please use BRENDA:EC2.5.1.44
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IUBMB Comments
The reaction of this enzyme occurs in three steps, with some of the intermediates presumably remaining enzyme-bound: NAD+-dependent dehydrogenation of putrescine, transfer of the 4-aminobutylidene group from dehydroputrescine to a second molecule of putrescine and reduction of the imine intermediate to form homospermidine. Hence the overall reaction is transfer of a 4-aminobutyl group. Differs from EC 2.5.1.45, homospermidine synthase (spermidine-specific), which cannot use putrescine as donor of the aminobutyl group.
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Word Map
  • 2.5.1.44
  • knee
  • arthroplasty
  • postoperative
  • pain
  • tibial
  • osteoarthritis
  • preoperative
  • acquity
  • radiograph
  • fracture
  • acetonitrile
  • femoral
  • formic
  • osteotomy
  • flexion
  • radiological
  • loosening
  • varus
  • satisfaction
  • humic
  • ultra-performance
  • womac
  • cruciate
  • arthroscopic
  • patella
  • lysholm
  • prostheses
  • inter-day
  • cement
  • radiolucent
  • condylar
  • fulvic
  • hepatosplenic
  • femorotibial
  • precisions
  • tegner
  • resurfacing
  • deoxyhypusine
  • patellofemoral
  • kuopio
  • cementless
  • meniscal
  • osteochondral
  • pyrrolizidine
  • leadership
  • i-hypersensitive
  • mcmaster
  • uhplc
  • hallervorden-spatz
  • nonunion
The enzyme appears in viruses and cellular organisms
Synonyms
hss, bvhss, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2 putrescine = sym-homospermidine + NH3 + H+
show the reaction diagram
putrescine + spermidine = sym-homospermidine + propane-1,3-diamine
show the reaction diagram
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