Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

BRENDA Home
show all | hide all No of entries

Information on EC 2.5.1.43 - nicotianamine synthase and Organism(s) Arabidopsis thaliana and UniProt Accession Q9FF79

for references in articles please use BRENDA:EC2.5.1.43
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
Specify your search results
Select one or more organisms in this record: ?
This record set is specific for:
Arabidopsis thaliana
UNIPROT: Q9FF79 not found.
Show additional data
Do not include text mining results
Include (text mining) results
Include results (AMENDA + additional results, but less precise)
Word Map
hide
The taxonomic range for the selected organisms is: Arabidopsis thaliana
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Synonyms
nas, nicotianamine synthase, osnas2, osnas1, osnas3, chloronerva, atnas4, hvnas1, na synthase, atnas1, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
nicotianamine synthase
-
AtNAS1
-
-
-
-
AtNAS2
AtNAS3
chloronerva
-
-
-
-
HvNAS1
-
-
-
-
HvNAS2
-
-
-
-
HvNAS3
-
-
-
-
HvNAS4
-
-
-
-
HvNAS6
-
-
-
-
HvNAS7
-
-
-
-
NA synthase
-
-
-
-
NAS1
-
Arabidopsis thaliana contains four NAS genes
NAS2
-
Arabidopsis thaliana contains four NAS genes
NAS3
-
Arabidopsis thaliana contains four NAS genes
NAS4
-
Arabidopsis thaliana contains four NAS genes
nicotianamine synthase
nicotianamine synthase 4
-
OsNAS1
-
-
-
-
OsNAS2
-
-
-
-
OsNAS3
-
-
-
-
S-adenosyl-L-methionine:S-adenosyl-L-methionine:S-adenosyl-methionine 3-amino-3-carboxypropyltransferase
-
-
-
-
synthase, nicotianamine
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
alkenyl group transfer
-
-
-
-
PATHWAY SOURCE
PATHWAYS
-
-, -
SYSTEMATIC NAME
IUBMB Comments
S-adenosyl-L-methionine:S-adenosyl-L-methionine:S-adenosyl-Lmethionine 3-amino-3-carboxypropyltransferase
-
CAS REGISTRY NUMBER
COMMENTARY hide
161515-44-2
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
S-adenosyl-L-methionine
5'-S-methyl-5'-thioadenosine + nicotianamine
show the reaction diagram
-
-
-
?
3 S-adenosyl-L-methionine
3 S-methyl-5'-thioadenosine + nicotianamine
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine
5'-S-methyl-5'-thioadenosine + nicotianamine
show the reaction diagram
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
3 S-adenosyl-L-methionine
3 S-methyl-5'-thioadenosine + nicotianamine
show the reaction diagram
-
-
-
?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
S-adenosyl-L-methionine
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
intercellular transport of iron (Fe) in dicotyledonous plants
evolution
AtNAS4 is the fourth member of the Arabidopsis thaliana NAS gene family
malfunction
a mutant Salk 135507 carrying a T-DNA insertion in AtNAS4, as well as lines overexpressing AtNAS4 both in the mutant and the wild-type genetic backgrounds, are used to decipher the role of AtNAS4 in nicotinamine synthesis, iron homeostasis and the plant response to iron deficiency or cadmium supply, severe chlorotic phenotype in insertion mutant plants, young leaves displayed interveinal chlorosis, overexpression of AtNAS4 leads to enhanced nicotianamine accumulation. In the shoots, whereas the manganese concentration is unchanged, differences in zinc and copper are observed in iron sufficient-conditions but not in iron-deficient conditions
metabolism
-
biosynthesis of nicotianamine, which chelates and transports micronutrient metal ions in plants
physiological function
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
NAS1_ARATH
320
0
35547
Swiss-Prot
other Location (Reliability: 4)
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expressed in Oryza sativa cv. Tsukinohikari under control of the pGluB-1 promoter after transformation with Agrobacterium tumefaciens
analysis of upstream region of nicotianamide synthase gene from Arabidopsis thaliana: presence of putative ERE-like sequence
-
expressed in Nicotiana tabacum
-
gene AtNAS4, overexpression of AtNAS4 both in the Salk 135507 mutant and the wild-type genetic backgrounds
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
in leaves and roots, NAS4 were up-regulated 2- to 3fold by Ni treatment
-
in leaves, NAS3 is up-regulated 3fold by Ni treatment
-
in roots, NAS1 is up-regulated twice by Ni treatment
-
iron deficiency markedly increases expression of NAS4 in leaves
-
iron deficiency significantly decreases expression of NAS3 in leaves
-
iron deficiency slightly increases expression of NAS2 in roots
-
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Suzuki, K.; Nakanishi, H.; Nishizawa, N.K.; Mori, S.
Analysis of upstream region of nicotinamine synthase gene from Arabidopsis thaliana: presence of putative ERE-like sequence
Biosci. Biotechnol. Biochem.
65
2794-2797
2001
Arabidopsis thaliana
Manually annotated by BRENDA team
Douchkov, D.; Gryczka, C.; Stephan, U.W.; Hell, R.; Baeumlein, H.
Ectopic expression of nicotianamine synthase genes results in improved iron accumulation and increased nickel tolerance in transgenic tobacco
Plant Cell Environ.
28
365-374
2005
Arabidopsis thaliana
-
Manually annotated by BRENDA team
Wirth, J.; Poletti, S.; Aeschlimann, B.; Yakandawala, N.; Drosse, B.; Osorio, S.; Tohge, T.; Fernie, A.R.; Guenther, D.; Gruissem, W.; Sautter, C.
Rice endosperm iron biofortification by targeted and synergistic action of nicotianamine synthase and ferritin
Plant Biotechnol. J.
7
631-644
2009
Arabidopsis thaliana (Q9FF79)
Manually annotated by BRENDA team
Klatte, M.; Schuler, M.; Wirtz, M.; Fink-Straube, C.; Hell, R.; Bauer, P.
The analysis of Arabidopsis nicotianamine synthase mutants reveals functions for nicotianamine in seed iron loading and iron deficiency responses
Plant Physiol.
150
257-271
2009
Arabidopsis thaliana
Manually annotated by BRENDA team
Hakoyama, T.; Watanabe, H.; Tomita, J.; Yamamoto, A.; Sato, S.; Mori, Y.; Kouchi, H.; Suganuma, N.
Nicotianamine synthase specifically expressed in root nodules of Lotus japonicus
Planta
230
309-317
2009
Medicago truncatula (A2Q2X7), Oryza sativa Indica Group (A2XFU4), Oryza sativa Indica Group (A2XFU5), Oryza sativa Indica Group (A2YQ58), Lotus japonicus (B9A9Z1), Lotus japonicus (B9A9Z2), Lotus japonicus, Arabidopsis thaliana (O80483), Arabidopsis thaliana (Q6L5P3), Arabidopsis thaliana (Q9FF79), Arabidopsis thaliana (Q9FKT9), Zea mays (Q8LT22), Zea mays (Q8S9C5), Hordeum vulgare (Q9XFB6), Hordeum vulgare (Q9XFB7), Hordeum vulgare (Q9ZQV3), Hordeum vulgare (Q9ZQV6), Hordeum vulgare (Q9ZQV7), Hordeum vulgare (Q9ZQV8), Hordeum vulgare (Q9ZQV9), Solanum lycopersicum (Q9XGI7)
Manually annotated by BRENDA team
Koen, E.; Besson-Bard, A.; Duc, C.; Astier, J.; Gravot, A.; Richaud, P.; Lamotte, O.; Boucherez, J.; Gaymard, F.; Wendehenne, D.
Arabidopsis thaliana nicotianamine synthase 4 is required for proper response to iron deficiency and to cadmium exposure
Plant Sci.
209
1-11
2013
Arabidopsis thaliana (Q6L5P3), Arabidopsis thaliana, Arabidopsis thaliana Col-0 (Q6L5P3)
Manually annotated by BRENDA team