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Information on EC 2.5.1.43 - nicotianamine synthase
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EC Tree
2.5.1.43 nicotianamine synthaseSpecify your search results
Word Map
- 2.5.1.43
-
abstinence
- infant
-
opioids
- women
-
nursing
-
nucleostide
-
naphthenic
- nafld
- steatohepatitis
- withdrawal
-
sands
- methadone
-
nonalcoholic
- steatosis
- morphine
-
services
- accumbens
- nurses
-
entecavir
- n-acetylserotonin
- buprenorphine
-
virological
-
policy
- tenofovir
-
hbeag
- oseltamivir
-
opiate
-
academy
- lamivudine
-
adefovir
- zanamivir
-
strictures
-
hbeag-positive
-
ukraine
-
nonpharmacologic
-
alberta
-
seroconversion
- neuraminidases
-
caring
-
telbivudine
-
mother-infant
-
dipivoxil
-
fe-deficient
- lilacs
-
staffing
-
nanoassemblies
-
medicaid
-
peg-ifn
-
disoproxil
-
hbeag-negative
- agriculture
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Synonyms
nas, nicotianamine synthase, osnas2, osnas1, osnas3, chloronerva, atnas4, hvnas1, na synthase, atnas1, 
more
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
AtNAS1
AtNAS2
AtNAS3
AtNAS4
chloronerva
-
-
-
-
HvNAS1
HvNAS2
HvNAS3
HvNAS4
HvNAS6
HvNAS7
-
-
-
-
MtNAS
NA synthase
NAS
NAS2
NAS3
NASHOR1
nicotianamine synthase
nicotianamine synthase 1
nicotianamine synthase 2
nicotianamine synthase 4
OsNAS1
OsNAS2
OsNAS3
S-adenosyl-L-methionine:S-adenosyl-L-methionine:S-adenosyl-methionine 3-amino-3-carboxypropyltransferase
-
-
-
-
synthase, nicotianamine
-
-
-
-
TmNAS
-
ZmNAS1
ZmNAS10
ZmNAS2
ZmNAS3
ZmNAS4
ZmNAS5
ZmNAS6
ZmNAS7
ZmNAS8
ZmNAS9
AtNAS1
-
-
-
-
AtNAS2
-
-
-
-
AtNAS3
-
-
-
-
HvNAS1
-
-
-
-
HvNAS2
-
-
-
-
HvNAS3
-
-
-
-
HvNAS4
-
-
-
-
HvNAS6
-
-
-
-
NA synthase
-
-
-
-
NAS
-
-
-
-
NAS
-
NAS
-
NAS
-
-
nicotianamine synthase
-
-
-
-
nicotianamine synthase
-
OsNAS1
-
-
-
-
OsNAS2
-
-
-
-
OsNAS3
-
-
-
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
3 S-adenosyl-L-methionine = 3 S-methyl-5'-thioadenosine + nicotianamine
-
-
-
-
3 S-adenosyl-L-methionine = 3 S-methyl-5'-thioadenosine + nicotianamine
reaction mechanism of the archaeal enzyme, overview. The polymerization mechanism occurs at a single active site with stepwise translocation of the reaction intermediate N-(3-amino-3-carboxypropyl)glutamic acid
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
alkenyl group transfer
-
-
-
-
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SYSTEMATIC NAME
IUBMB Comments
S-adenosyl-L-methionine:S-adenosyl-L-methionine:S-adenosyl-Lmethionine 3-amino-3-carboxypropyltransferase
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CAS REGISTRY NUMBER
COMMENTARY
161515-44-2
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2 S-adenosyl-L-methionine + glutamate
2 S-methyl-5'-thioadenosine + thermoNicotianamine + 2 H+
additional information
?
-
-
the enzyme condenses three aminopropyl moieties of S-adenosylmethionine and the autocyclization of one moiety leads to the formation of an azetidine ring
-
-
?
2 S-adenosyl-L-methionine + glutamate
2 S-methyl-5'-thioadenosine + thermoNicotianamine + 2 H+
-
-
the archaeal product analogue thermoNicotianamine differs from nicotianamine in the carboxy azetidine moiety of nicotianamine that is replaced by a glutamate moiety in thermoNicotianamine, overview
-
?
2 S-adenosyl-L-methionine + glutamate
2 S-methyl-5'-thioadenosine + thermoNicotianamine + 2 H+
-
substrate binding structures, overview
the archaeal product analogue thermoNicotianamine differs from nicotianamine in the carboxy azetidine moiety of nicotianamine that is replaced by a glutamate moiety in thermoNicotianamine, overview
-
?
3 S-adenosyl-L-methionine
3 S-methyl-5'-thioadenosine + nicotianamine
-
-
-
?
3 S-adenosyl-L-methionine
3 S-methyl-5'-thioadenosine + nicotianamine
-
-
-
?
3 S-adenosyl-L-methionine
3 S-methyl-5'-thioadenosine + nicotianamine
-
-
-
?
3 S-adenosyl-L-methionine
3 S-methyl-5'-thioadenosine + nicotianamine
-
-
-
?
3 S-adenosyl-L-methionine
3 S-methyl-5'-thioadenosine + nicotianamine
important role in production of nicotianamine under Fe-deficient conditions
-
-
?
3 S-adenosyl-L-methionine
3 S-methyl-5'-thioadenosine + nicotianamine
-
-
-
?
3 S-adenosyl-L-methionine
3 S-methyl-5'-thioadenosine + nicotianamine
-
-
-
-
?
3 S-adenosyl-L-methionine
3 S-methyl-5'-thioadenosine + nicotianamine
-
the enzyme is required for symbiotic nitrogen fixation in Medicago truncatula nodules
-
-
?
3 S-adenosyl-L-methionine
3 S-methyl-5'-thioadenosine + nicotianamine
-
-
-
?
3 S-adenosyl-L-methionine
3 S-methyl-5'-thioadenosine + nicotianamine
-
-
-
?
3 S-adenosyl-L-methionine
3 S-methyl-5'-thioadenosine + nicotianamine
-
-
-
?
3 S-adenosyl-L-methionine
3 S-methyl-5'-thioadenosine + nicotianamine
important role in production of nicotianamine under Fe-deficient conditions
-
-
?
3 S-adenosyl-L-methionine
3 S-methyl-5'-thioadenosine + nicotianamine
rice synthesizes nicotianamine with OsNAS3 under Fe excess in roots and shoots. Nicotianamine and deoxymugineic acid synthesized by OsNAS3 under excess Fe conditions contribute to Fe detoxification in rice
-
-
?
3 S-adenosyl-L-methionine
3 S-methyl-5'-thioadenosine + nicotianamine
-
-
-
?
3 S-adenosyl-L-methionine
3 S-methyl-5'-thioadenosine + nicotianamine
-
-
-
?
3 S-adenosyl-L-methionine
3 S-methyl-5'-thioadenosine + nicotianamine
-
-
-
?
3 S-adenosyl-L-methionine
3 S-methyl-5'-thioadenosine + nicotianamine
the enzyme catalyzes trimerization of S-adenosyl-L-methionine and ring formation to synthesize nicotinamine
-
-
?
3 S-adenosyl-L-methionine
3 S-methyl-5'-thioadenosine + nicotianamine
-
-
-
?
3 S-adenosyl-L-methionine
3 S-methyl-5'-thioadenosine + nicotianamine
the enzyme catalyzes trimerization of S-adenosyl-L-methionine and ring formation to synthesize nicotinamine
-
-
?
S-adenosyl-L-methionine
5'-S-methyl-5'-thioadenosine + nicotianamine
-
-
-
-
?
S-adenosyl-L-methionine
5'-S-methyl-5'-thioadenosine + nicotianamine
-
-
-
?
S-adenosyl-L-methionine
5'-S-methyl-5'-thioadenosine + nicotianamine
-
-
-
?
S-adenosyl-L-methionine
5'-S-methyl-5'-thioadenosine + nicotianamine
-
-
-
?
S-adenosyl-L-methionine
5'-S-methyl-5'-thioadenosine + nicotianamine
-
-
-
?
S-adenosyl-L-methionine
5'-S-methyl-5'-thioadenosine + nicotianamine
-
-
-
?
S-adenosyl-L-methionine
5'-S-methyl-5'-thioadenosine + nicotianamine
-
the product nictotinamine plays a critical role in metal detoxification
-
-
?
S-adenosyl-L-methionine
5'-S-methyl-5'-thioadenosine + nicotianamine
-
-
-
?
S-adenosyl-L-methionine
5'-S-methyl-5'-thioadenosine + nicotianamine
-
-
-
?
S-adenosyl-L-methionine
5'-S-methyl-5'-thioadenosine + nicotianamine
-
-
-
-
?
S-adenosyl-L-methionine
5'-S-methyl-5'-thioadenosine + nicotianamine
-
-
-
-
?
S-adenosyl-L-methionine
5'-S-methyl-5'-thioadenosine + nicotianamine
-
-
-
-
?
S-adenosyl-L-methionine
5'-S-methyl-5'-thioadenosine + nicotianamine
-
-
-
?
S-adenosyl-L-methionine
5'-S-methyl-5'-thioadenosine + nicotianamine
-
-
-
?
S-adenosyl-L-methionine
5'-S-methyl-5'-thioadenosine + nicotianamine
-
-
-
?
S-adenosyl-L-methionine
5'-S-methyl-5'-thioadenosine + nicotianamine
-
-
-
?
S-adenosyl-L-methionine
5'-S-methyl-5'-thioadenosine + nicotianamine
-
-
-
?
S-adenosyl-L-methionine
5'-S-methyl-5'-thioadenosine + nicotianamine
-
-
-
?
S-adenosyl-L-methionine
5'-S-methyl-5'-thioadenosine + nicotianamine
-
nicotinamine synthase and nicotinamine play an important role in long-distance transport of Fe in rice plants, in addition to their roles in phytosiderophore secretion from roots
-
-
?
S-adenosyl-L-methionine
5'-S-methyl-5'-thioadenosine + nicotianamine
-
-
-
?
S-adenosyl-L-methionine
5'-S-methyl-5'-thioadenosine + nicotianamine
-
-
-
?
S-adenosyl-L-methionine
5'-S-methyl-5'-thioadenosine + nicotianamine
-
-
-
?
S-adenosyl-L-methionine
?
-
enzyme activity is induced at the 3rd day after withholding Fe supply and declines within one day following the supply of Fe3+-epihydroxymugineic acid
-
-
?
S-adenosyl-L-methionine
?
-
synthesis of nicotianamide, the key precursor of the mugineic acid family phytosiderophores
-
-
?
S-adenosyl-L-methionine
?
-
key enzyme in the biosynthetic pathway for the mugineic acid family of phytosiderophores
-
-
?
S-adenosyl-L-methionine
?
-
strongly induced by Fe-deficiency treatment
-
-
?
S-adenosyl-L-methionine
?
-
enzyme in the biosynthetic pathway of mugineic acids
-
-
?
S-adenosyl-L-methionine
?
-
enzyme activity is not induced by Fe-deficiency
-
-
?
S-adenosyl-L-methionine
?
-
enzyme activity is not induced by Fe-deficiency
-
-
?
S-adenosyl-L-methionine
?
-
enzyme activity is not induced by Fe-deficiency
-
-
?
S-adenosyl-L-methionine
?
-
enzyme activity is not induced by Fe-deficiency
-
-
?
S-adenosyl-L-methionine
?
-
enzyme activity is not induced by Fe-deficiency
-
-
?
S-adenosyl-L-methionine
?
-
in agreement with the increased secretion of phytosiderophores with Fe deficiency, ZmNAS1 and ZmNAS2 are positively expressed only in Fe-deficient roots. In contrast ZmNAS3 is expressed under Fe-sufficient conditions, and is negatively regulated by Fe deficiency
-
-
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2 S-adenosyl-L-methionine + glutamate
2 S-methyl-5'-thioadenosine + thermoNicotianamine + 2 H+
-
-
the archaeal product analogue thermoNicotianamine differs from nicotianamine in the carboxy azetidine moiety of nicotianamine that is replaced by a glutamate moiety in thermoNicotianamine, overview
-
?
3 S-adenosyl-L-methionine
3 S-methyl-5'-thioadenosine + nicotianamine
-
-
-
?
3 S-adenosyl-L-methionine
3 S-methyl-5'-thioadenosine + nicotianamine
-
-
-
?
3 S-adenosyl-L-methionine
3 S-methyl-5'-thioadenosine + nicotianamine
-
-
-
?
3 S-adenosyl-L-methionine
3 S-methyl-5'-thioadenosine + nicotianamine
important role in production of nicotianamine under Fe-deficient conditions
-
-
?
3 S-adenosyl-L-methionine
3 S-methyl-5'-thioadenosine + nicotianamine
-
-
-
?
3 S-adenosyl-L-methionine
3 S-methyl-5'-thioadenosine + nicotianamine
-
-
-
-
?
3 S-adenosyl-L-methionine
3 S-methyl-5'-thioadenosine + nicotianamine
-
-
-
?
3 S-adenosyl-L-methionine
3 S-methyl-5'-thioadenosine + nicotianamine
important role in production of nicotianamine under Fe-deficient conditions
-
-
?
3 S-adenosyl-L-methionine
3 S-methyl-5'-thioadenosine + nicotianamine
rice synthesizes nicotianamine with OsNAS3 under Fe excess in roots and shoots. Nicotianamine and deoxymugineic acid synthesized by OsNAS3 under excess Fe conditions contribute to Fe detoxification in rice
-
-
?
3 S-adenosyl-L-methionine
3 S-methyl-5'-thioadenosine + nicotianamine
-
-
-
?
3 S-adenosyl-L-methionine
3 S-methyl-5'-thioadenosine + nicotianamine
-
-
-
?
3 S-adenosyl-L-methionine
3 S-methyl-5'-thioadenosine + nicotianamine
-
-
-
?
3 S-adenosyl-L-methionine
3 S-methyl-5'-thioadenosine + nicotianamine
-
-
-
?
S-adenosyl-L-methionine
5'-S-methyl-5'-thioadenosine + nicotianamine
-
the product nictotinamine plays a critical role in metal detoxification
-
-
?
S-adenosyl-L-methionine
5'-S-methyl-5'-thioadenosine + nicotianamine
-
-
-
-
?
S-adenosyl-L-methionine
5'-S-methyl-5'-thioadenosine + nicotianamine
-
nicotinamine synthase and nicotinamine play an important role in long-distance transport of Fe in rice plants, in addition to their roles in phytosiderophore secretion from roots
-
-
?
S-adenosyl-L-methionine
?
-
enzyme activity is induced at the 3rd day after withholding Fe supply and declines within one day following the supply of Fe3+-epihydroxymugineic acid
-
-
?
S-adenosyl-L-methionine
?
-
synthesis of nicotianamide, the key precursor of the mugineic acid family phytosiderophores
-
-
?
S-adenosyl-L-methionine
?
-
key enzyme in the biosynthetic pathway for the mugineic acid family of phytosiderophores
-
-
?
S-adenosyl-L-methionine
?
-
strongly induced by Fe-deficiency treatment
-
-
?
S-adenosyl-L-methionine
?
-
enzyme in the biosynthetic pathway of mugineic acids
-
-
?
S-adenosyl-L-methionine
?
-
enzyme activity is not induced by Fe-deficiency
-
-
?
S-adenosyl-L-methionine
?
-
enzyme activity is not induced by Fe-deficiency
-
-
?
S-adenosyl-L-methionine
?
-
enzyme activity is not induced by Fe-deficiency
-
-
?
S-adenosyl-L-methionine
?
-
enzyme activity is not induced by Fe-deficiency
-
-
?
S-adenosyl-L-methionine
?
-
enzyme activity is not induced by Fe-deficiency
-
-
?
S-adenosyl-L-methionine
?
-
in agreement with the increased secretion of phytosiderophores with Fe deficiency, ZmNAS1 and ZmNAS2 are positively expressed only in Fe-deficient roots. In contrast ZmNAS3 is expressed under Fe-sufficient conditions, and is negatively regulated by Fe deficiency
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
S-adenosyl-L-methionine
-
S-adenosyl-L-methionine
-