Information on EC - phosphoglycerol geranylgeranyltransferase

for references in articles please use BRENDA:EC2.5.1.41
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EC Tree
IUBMB Comments
This cytosolic enzyme catalyses the first pathway-specific step in the biosynthesis of the core membrane diether lipids in archaebacteria . Requires Mg2+ for maximal activity . It catalyses the alkylation of the primary hydroxy group in sn-glycerol 1-phosphate by geranylgeranyl diphosphate (GGPP) in a prenyltransfer reaction where a hydroxy group is the nucleophile in the acceptor substrate . The other enzymes involved in the biosynthesis of polar lipids in Archaea are EC (sn-glycerol-1-phosphate dehydrogenase), EC (geranylgeranylglycerol-phosphate geranylgeranyltransferase) and EC (CDP-archaeol synthase), which lead to the formation of CDP-unsaturated archaeol. The final step in the pathway involves the addition of L-serine, with concomitant removal of CMP, leading to the production of unsaturated archaetidylserine .
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Word Map
  • geranylgeranylation
  • farnesylation
  • prenylation
  • isoprenoids
  • prenyltransferases
  • isoprenylation
  • ggtase
  • farnesyl-transferase
  • escort
  • hexamerization
  • tetraether
  • thermoplasma
  • tim-barrel
The expected taxonomic range for this enzyme is: Bacteria, Archaea
((S)-GGGP) synthase, (S)-3-O-geranylgeranylglyceryl phosphate synthase, (S)-3-O-geranylgeranylglycerylphosphate, geranylgeranyl diphosphate:sn-3-O-(geranylgeranyl)glycerol 1-phosphate geranylgeranyltransferase, geranylgeranyl-transferase, geranylgeranylglycerol-phosphate geranylgeranyltransferase, geranylgeranylglyceryl phosphate synthase, geranylgeranyltransferase II, geranylgeranyltransferase, geranylgeranyloxyglycerol phosphate, GGGP synthase, more
geranylgeranyl diphosphate + sn-glycerol 1-phosphate = diphosphate + 3-(O-geranylgeranyl)-sn-glycerol 1-phosphate
show the reaction diagram
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