Any feedback?
Please rate this page

BRENDA support

show all | hide all No of entries

Information on EC - phosphoglycerol geranylgeranyltransferase

for references in articles please use BRENDA:EC2.5.1.41
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
IUBMB Comments
This cytosolic enzyme catalyses the first pathway-specific step in the biosynthesis of the core membrane diether lipids in archaebacteria . Requires Mg2+ for maximal activity . It catalyses the alkylation of the primary hydroxy group in sn-glycerol 1-phosphate by geranylgeranyl diphosphate (GGPP) in a prenyltransfer reaction where a hydroxy group is the nucleophile in the acceptor substrate . The other enzymes involved in the biosynthesis of polar lipids in Archaea are EC (sn-glycerol-1-phosphate dehydrogenase), EC (geranylgeranylglycerol-phosphate geranylgeranyltransferase) and EC (CDP-archaeol synthase), which lead to the formation of CDP-unsaturated archaeol. The final step in the pathway involves the addition of L-serine, with concomitant removal of CMP, leading to the production of unsaturated archaetidylserine .
Specify your search results
Select one or more organisms in this record: ?
Show additional data
Do not include text mining results
Include (text mining) results
Include results (AMENDA + additional results, but less precise)
Word Map
  • geranylgeranylation
  • farnesylation
  • prenylation
  • isoprenoids
  • prenyltransferases
  • ggtase
  • isoprenylation
  • escort
  • farnesyl-transferase
  • thermoplasma
  • tetraether
  • tim-barrel
  • hexamerization
The expected taxonomic range for this enzyme is: Bacteria, Archaea, Eukaryota
gggps, geranylgeranyl-transferase, geranylgeranyltransferase ii, gggp synthase, geranylgeranylglyceryl phosphate synthase, (s)-3-o-geranylgeranylglyceryl phosphate synthase, ((s)-gggp) synthase, more
geranylgeranyl diphosphate + sn-glycerol 1-phosphate = diphosphate + 3-(O-geranylgeranyl)-sn-glycerol 1-phosphate
show the reaction diagram
Select items on the left to see more content.